Product References
Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures.
Cell reports
Cossec JC,Traboulsi T,Sart S,Loe-Mie Y,Guthmann M,Hendriks IA,Theurillat I,Nielsen ML,Torres-Padilla ME,Baroud CN,Dejean A
14-5761-80 was used in Immunocytochemistry-immunofluorescence to show that mouse embryonic stem cells (ESCs) solely exposed to chemical inhibition of SUMOylation generate embryo-like structures comprising anterior neural and trunk-associated regions.
Tue Apr 25 00:00:00 UTC 2023
The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency.
Nature communications
Athanasouli P,Balli M,De Jaime-Soguero A,Boel A,Papanikolaou S,van der Veer BK,Janiszewski A,Vanhessche T,Francis A,El Laithy Y,Nigro AL,Aulicino F,Koh KP,Pasque V,Cosma MP,Verfaillie C,Zwijsen A,Heindryckx B,Nikolaou C,Lluis F
14-5761-80 was used in Immunocytochemistry to demonstrate that transcriptional repression exerted by Wnt/TCF7L1 promotes PE differentiation of mESCs and in preimplantation inner cell mass.
Fri Mar 03 00:00:00 UTC 2023
Regulatory Elements Outside Established Pou5f1 Gene Boundaries Are Required for Multilineage Differentiation of Embryonic Stem Cells.
International journal of molecular sciences
Ermakova VV,Fokin NP,Aksenov ND,Bakhmet EI,Aleksandrova EV,Kuzmin AA,Tomilin AN
14-5761-80 was used in Immunocytochemistry to show that translocation of the Pou5f1 gene fragment purported to span all essential cis-elements, including the well-known distal and proximal enhancers (DE and PE), into the Rosa26 locus impairs the self-renewal of mouse embryonic stem cells (ESCs) in the naïve pluripotency state, as well as their further advancement through the formative and primed pluripotency states, inducing overall differentiation failure.
Sat Oct 21 00:00:00 UTC 2023
Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm.
Nucleic acids research
Zuo ZY,Yang GH,Wang HY,Liu SY,Zhang YJ,Cai Y,Chen F,Dai H,Xiao Y,Cheng MB,Huang Y,Zhang Y
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunocytochemistry
Mon Feb 28 00:00:00 UTC 2022
STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity.
Nature communications
Ohishi H,Shimada S,Uchino S,Li J,Sato Y,Shintani M,Owada H,Ohkawa Y,Pertsinidis A,Yamamoto T,Kimura H,Ochiai H
14-5761-80 was used in Western Blotting to develop a STREAMING-tag system and quantitatively understand transcriptional regulation in living cells.
Tue Dec 20 00:00:00 UTC 2022
STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity.
Nature communications
Ohishi H,Shimada S,Uchino S,Li J,Sato Y,Shintani M,Owada H,Ohkawa Y,Pertsinidis A,Yamamoto T,Kimura H,Ochiai H
14-5761-80 was used in Western Blotting to develop a STREAMING-tag system and quantitatively understand transcriptional regulation in living cells.
Tue Dec 20 00:00:00 UTC 2022
A balanced Oct4 interactome is crucial for maintaining pluripotency.
Science advances
Han D,Wu G,Chen R,Drexler HCA,MacCarthy CM,Kim KP,Adachi K,Gerovska D,Mavrommatis L,Bedzhov I,Araúzo-Bravo MJ,Schöler HR
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunocytochemistry
Fri Feb 18 00:00:00 UTC 2022
Pramef12 enhances reprogramming into naïve iPS cells.
Biochemistry and biophysics reports
Haraguchi D,Nakamura T
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Western Blot
Fri Jul 01 00:00:00 UTC 2022
Progression of the pluripotent epiblast depends upon the NMD factor UPF2.
Development (Cambridge, England)
Chousal JN,Sohni A,Vitting-Seerup K,Cho K,Kim M,Tan K,Porse B,Wilkinson MF,Cook-Andersen H
14-5761-80 was used in Immunocytochemistry to reveal developmental and molecular functions of the NMD pathway in the early embryo.
Tue Nov 01 00:00:00 UTC 2022
Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation.
Cell stem cell
Bergert M,Lembo S,Sharma S,Russo L,Milovanović D,Gretarsson KH,Börmel M,Neveu PA,Hackett JA,Petsalaki E,Diz-Muñoz A
14-5761 was used in Immunocytochemistry-immunoflourescence to show that membrane mechanics gate exit from naive pluripotency of mouse embryonic stem cells.
Thu Feb 04 00:00:00 UTC 2021
Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation.
Cell stem cell
Bergert M,Lembo S,Sharma S,Russo L,Milovanović D,Gretarsson KH,Börmel M,Neveu PA,Hackett JA,Petsalaki E,Diz-Muñoz A
14-5761 was used in Immunocytochemistry-immunoflourescence to show that membrane mechanics gate exit from naive pluripotency of mouse embryonic stem cells.
Thu Feb 04 00:00:00 UTC 2021
Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
Cell stem cell
Kinoshita M,Barber M,Mansfield W,Cui Y,Spindlow D,Stirparo GG,Dietmann S,Nichols J,Smith A
14-5761-80 was used in Immunocytochemistry to suggest that formative stem cells which respond directly to germ cell induction can be cultured from mice and humans.
Thu Mar 04 00:00:00 UTC 2021
Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.
Cell stem cell
Kinoshita M,Barber M,Mansfield W,Cui Y,Spindlow D,Stirparo GG,Dietmann S,Nichols J,Smith A
14-5761-80 was used in Immunocytochemistry to suggest that formative stem cells which respond directly to germ cell induction can be cultured from mice and humans.
Thu Mar 04 00:00:00 UTC 2021
Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells.
Development (Cambridge, England)
Raina D,Bahadori A,Stanoev A,Protzek M,Koseska A,Schröter C
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunocytochemistry
Mon Nov 01 00:00:00 UTC 2021
Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre.
Nature communications
Xu PF,Borges RM,Fillatre J,de Oliveira-Melo M,Cheng T,Thisse B,Thisse C
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunohistochemistry
Wed Jun 02 00:00:00 UTC 2021
Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre.
Nature communications
Xu PF,Borges RM,Fillatre J,de Oliveira-Melo M,Cheng T,Thisse B,Thisse C
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunohistochemistry
Wed Jun 02 00:00:00 UTC 2021
Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division.
eLife
Junyent S,Reeves JC,Szczerkowski J,Garcin CL,Trieu TJ,Wilson M,Lundie-Brown J,Habib SJ
14-5761-80 was used in Flow Cytometry to show that Wnt-iGluR crosstalk may prove pervasive throughout embryonic and adult stem cell signalling.
Mon May 24 00:00:00 UTC 2021
Context-dependent functional compensation between Ythdf m6A reader proteins.
Genes & development
Lasman L,Krupalnik V,Viukov S,Mor N,Aguilera-Castrejon A,Schneir D,Bayerl J,Mizrahi O,Peles S,Tawil S,Sathe S,Nachshon A,Shani T,Zerbib M,Kilimnik I,Aigner S,Shankar A,Mueller JR,Schwartz S,Stern-Ginossar N,Yeo GW,Geula S,Novershtern N,Hanna JH
14-5761-80 was used in Immunohistochemistry to suggest a new model for the Ythdf readers function, in which there is profound dosage-dependent redundancy when all three readers are equivalently coexpressed in the same cell types.
Thu Oct 01 00:00:00 UTC 2020
The transcription factor E2A drives neural differentiation in pluripotent cells.
Development (Cambridge, England)
Rao C,Malaguti M,Mason JO,Lowell S
14-5761 was used in Immunocytochemistry to demonstrate that overexpression of a forced E2A homodimer is sufficient to drive robust neural commitment in pluripotent cells, even under non-permissive conditions.
Mon Jun 22 00:00:00 UTC 2020
The transcription factor E2A drives neural differentiation in pluripotent cells.
Development (Cambridge, England)
Rao C,Malaguti M,Mason JO,Lowell S
14-5761 was used in Immunocytochemistry to demonstrate that overexpression of a forced E2A homodimer is sufficient to drive robust neural commitment in pluripotent cells, even under non-permissive conditions.
Mon Jun 22 00:00:00 UTC 2020
The PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency.
Journal of cell science
Yamamoto M,Suwa Y,Sugiyama K,Okashita N,Kawaguchi M,Tani N,Matsubara K,Nakamura A,Seki Y
14-5761-80 was used in Immunocytochemistry to identify C-terminal binding protein 1 and 2 (CtBP1 and CtBP2; generically referred to as CtBP1/2) as components of the PRDM14-mediated repressive complex.
Fri Aug 14 00:00:00 UTC 2020
The transition from local to global patterns governs the differentiation of mouse blastocysts.
PloS one
Fischer SC,Corujo-Simon E,Lilao-Garzon J,Stelzer EHK,Muñoz-Descalzo S
14-5761 was used in Immunohistochemistry to investigate the spatio-temporal distribution of transcription factors NANOG and GATA6 within murine blastocysts.
Fri Aug 07 00:00:00 UTC 2020
The transition from local to global patterns governs the differentiation of mouse blastocysts.
PloS one
Fischer SC,Corujo-Simon E,Lilao-Garzon J,Stelzer EHK,Muñoz-Descalzo S
14-5761 was used in Immunohistochemistry to investigate the spatio-temporal distribution of transcription factors NANOG and GATA6 within murine blastocysts.
Fri Aug 07 00:00:00 UTC 2020
Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells.
Science advances
Ochiai H,Hayashi T,Umeda M,Yoshimura M,Harada A,Shimizu Y,Nakano K,Saitoh N,Liu Z,Yamamoto T,Okamura T,Ohkawa Y,Kimura H,Nikaido I
14-5761-80 was used in Western Blot, Immunocytochemistry to analyse the intrinsic noise and mRNA levels during transcriptional bursting in mouse embryonic stem cells.
Mon Jun 01 00:00:00 UTC 2020
Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells.
Science advances
Ochiai H,Hayashi T,Umeda M,Yoshimura M,Harada A,Shimizu Y,Nakano K,Saitoh N,Liu Z,Yamamoto T,Okamura T,Ohkawa Y,Kimura H,Nikaido I
14-5761-80 was used in Western Blot, Immunocytochemistry to analyse the intrinsic noise and mRNA levels during transcriptional bursting in mouse embryonic stem cells.
Mon Jun 01 00:00:00 UTC 2020
Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells.
Science advances
Ochiai H,Hayashi T,Umeda M,Yoshimura M,Harada A,Shimizu Y,Nakano K,Saitoh N,Liu Z,Yamamoto T,Okamura T,Ohkawa Y,Kimura H,Nikaido I
14-5761-80 was used in Western Blot, Immunocytochemistry to analyse the intrinsic noise and mRNA levels during transcriptional bursting in mouse embryonic stem cells.
Mon Jun 01 00:00:00 UTC 2020
Fast In Vitro Procedure to Identify Extraembryonic Differentiation Defect of Mouse Embryonic Stem Cells.
STAR protocols
Ngondo RP,Cohen-Tannoudji M,Ciaudo C
14-5761-80 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to identify a differentiation defect of mESCs toward ExEn in vitro through the molecular and cellular characterization of embryoid bodies, followed by direct differentiation of mESCs into ExEn.
Fri Dec 18 00:00:00 UTC 2020
Microfluidic platform for 3D cell culture with live imaging and clone retrieval.
Lab on a chip
Mulas C,Hodgson AC,Kohler TN,Agley CC,Humphreys P,Kleine-Brüggeney H,Hollfelder F,Smith A,Chalut KJ
14-5761-80 was used in Immunocytochemistry to present a highly flexible 3D cell encapsulation and microfluidic platform that enables both monitoring of cellular dynamics and retrieval for molecular and functional assays.
Tue Jul 14 00:00:00 UTC 2020
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.
Cell
Li R,Zhong C,Yu Y,Liu H,Sakurai M,Yu L,Min Z,Shi L,Wei Y,Takahashi Y,Liao HK,Qiao J,Deng H,Nuñez-Delicado E,Rodriguez Esteban C,Wu J,Izpisua Belmonte JC
14-5761 was used in Immunocytochemistry-Immunofluorescence to study the generation of blastoids from mouse extended pluripotent stemcells using a newly developed 3D differentiation system.
Thu Oct 17 00:00:00 UTC 2019
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
Cell stem cell
Stuart HT,Stirparo GG,Lohoff T,Bates LE,Kinoshita M,Lim CY,Sousa EJ,Maskalenka K,Radzisheuskaya A,Malcolm AA,Alves MRP,Lloyd RL,Nestorowa S,Humphreys P,Mansfield W,Reik W,Bertone P,Nichols J,Göttgens B,Silva JCR
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunofluorescence
Thu Sep 05 00:00:00 UTC 2019
PDGF Signaling in Primitive Endoderm Cell Survival Is Mediated by PI3K-mTOR Through p53-Independent Mechanism.
Stem cells (Dayton, Ohio)
Bessonnard S,Vandormael-Pournin S,Coqueran S,Cohen-Tannoudji M,Artus J
14-5761-80 was used in Immunohistochemistry to investigate possible functional redundancies among FGF, PDGF, and KIT signaling and showed that only PDGF signaling is involved in primitive endoderm (PrE) cell survival.
Mon Jul 01 00:00:00 UTC 2019
Tox4 modulates cell fate reprogramming.
Journal of cell science
Vanheer L,Song J,De Geest N,Janiszewski A,Talon I,Provenzano C,Oh T,Chappell J,Pasque V
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunocytochemistry
Tue Oct 22 00:00:00 UTC 2019
Glutamine independence is a selectable feature of pluripotent stem cells.
Nature metabolism
Vardhana SA,Arnold PK,Rosen BP,Chen Y,Carey BW,Huangfu D,Carmona Fontaine C,Thompson CB,Finley LWS
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunofluorescence
Mon Jul 01 00:00:00 UTC 2019
Glutamine independence is a selectable feature of pluripotent stem cells.
Nature metabolism
Vardhana SA,Arnold PK,Rosen BP,Chen Y,Carey BW,Huangfu D,Carmona Fontaine C,Thompson CB,Finley LWS
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunofluorescence
Mon Jul 01 00:00:00 UTC 2019
Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells.
Development (Cambridge, England)
Deathridge J,Antolović V,Parsons M,Chubb JR
14-5761-80 was used in Immunocytochemistry to suggest a combination of cell lineage and niche contributes to the absolute level of ERK signalling in mouse ESCs.
Mon Jun 03 00:00:00 UTC 2019
Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker.
Life science alliance
Pantier R,Tatar T,Colby D,Chambers I
14-5761 was used in Immunohistochemistry to show that TET2 binds to the transcription factor NANOG.
Tue Oct 01 00:00:00 UTC 2019
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.
Nature cell biology
Finley LWS,Vardhana SA,Carey BW,Alonso-Curbelo D,Koche R,Chen Y,Wen D,King B,Radler MR,Rafii S,Lowe SW,Allis CD,Thompson CB
14-5761 was used in Western Blotting to assess the role of Brd4 in the self-renewal and pluripotency of embryonic stem cells.
Tue May 01 00:00:00 UTC 2018
Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.
Molecular systems biology
Yachie-Kinoshita A,Onishi K,Ostblom J,Langley MA,Posfai E,Rossant J,Zandstra PW
14-5761 was used in an In vitro assay to develop a model to predict stabilised pluripotent stem cell gene regulatory network states in response to input signals.
Mon Jan 29 00:00:00 UTC 2018
Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.
Molecular systems biology
Yachie-Kinoshita A,Onishi K,Ostblom J,Langley MA,Posfai E,Rossant J,Zandstra PW
14-5761 was used in an In vitro assay to develop a model to predict stabilised pluripotent stem cell gene regulatory network states in response to input signals.
Mon Jan 29 00:00:00 UTC 2018
Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency.
Cell stem cell
Adachi K,Kopp W,Wu G,Heising S,Greber B,Stehling M,Araúzo-Bravo MJ,Boerno ST,Timmermann B,Vingron M,Schöler HR
14-5761 was used in Immunocytochemistry-immunoflourescence to suggest that TFs can drive rapid remodeling of the local chromatin structure, highlighting the remarkable plasticity of stable epigenetic information.
Thu Aug 02 00:00:00 UTC 2018
An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells.
Science advances
Cao K,Collings CK,Morgan MA,Marshall SA,Rendleman EJ,Ozark PA,Smith ER,Shilatifard A
14-5761 was used in Immunocytochemistry to define the epigenetic activity of Mll4 and propose Lsd1 opposing regulatory axis which regulates exit of ground-state pluripotency in murine embryonic stem cells.
Mon Jan 01 00:00:00 UTC 2018
Cooperative Binding of Transcription Factors Orchestrates Reprogramming.
Cell
Chronis C,Fiziev P,Papp B,Butz S,Bonora G,Sabri S,Ernst J,Plath K
14-5761 was used in Immunocytochemistry-immunofluorescence to elucidate the mechanisms by which Oct4, Sox2, Klf4, and cMyc reprogram somatic cells to pluripotency.
Thu Jan 26 00:00:00 UTC 2017
An Interaction Landscape of Ubiquitin Signaling.
Molecular cell
Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M
14-5761-80 was used in Immunoaffinity-mass spec to develop a quantitative interaction proteomics method that makes use of chemically synthesised diubiquitin to enrich and identify ubiquitin linkage interactors from crude cell lysates.
Thu Mar 02 00:00:00 UTC 2017
Four simple rules that are sufficient to generate the mammalian blastocyst.
PLoS biology
Nissen SB,Perera M,Gonzalez JM,Morgani SM,Jensen MH,Sneppen K,Brickman JM,Trusina A
Sat Jul 01 00:00:00 UTC 2017
Four simple rules that are sufficient to generate the mammalian blastocyst.
PLoS biology
Nissen SB,Perera M,Gonzalez JM,Morgani SM,Jensen MH,Sneppen K,Brickman JM,Trusina A
Sat Jul 01 00:00:00 UTC 2017
Four simple rules that are sufficient to generate the mammalian blastocyst.
PLoS biology
Nissen SB,Perera M,Gonzalez JM,Morgani SM,Jensen MH,Sneppen K,Brickman JM,Trusina A
Sat Jul 01 00:00:00 UTC 2017
Changing POU dimerization preferences converts Oct6 into a pluripotency inducer.
EMBO reports
Jerabek S,Ng CK,Wu G,Arauzo-Bravo MJ,Kim KP,Esch D,Malik V,Chen Y,Velychko S,MacCarthy CM,Yang X,Cojocaru V,Schöler HR,Jauch R
14-5761 was used in Immunohistochemistry to identify molecular features determining the differential DNA-binding and reprogramming activity of Oct4 and Oct6.
Wed Feb 01 00:00:00 UTC 2017
Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states.
eLife
Jang S,Choubey S,Furchtgott L,Zou LN,Doyle A,Menon V,Loew EB,Krostag AR,Martinez RA,Madisen L,Levi BP,Ramanathan S
14576180 was used in immunocytochemistry to investigate the gene expression dynamics of early mouse embryonic stem cell differentiation
Wed Mar 15 00:00:00 UTC 2017
Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states.
eLife
Jang S,Choubey S,Furchtgott L,Zou LN,Doyle A,Menon V,Loew EB,Krostag AR,Martinez RA,Madisen L,Levi BP,Ramanathan S
14576180 was used in immunocytochemistry to investigate the gene expression dynamics of early mouse embryonic stem cell differentiation
Wed Mar 15 00:00:00 UTC 2017
A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation.
eLife
Li MA,Amaral PP,Cheung P,Bergmann JH,Kinoshita M,Kalkan T,Ralser M,Robson S,von Meyenn F,Paramor M,Yang F,Chen C,Nichols J,Spector DL,Kouzarides T,He L,Smith A
14-5761 was used in Immunocytochemistry to determine the mechanism by which a novel rodent-specific lncRNA delays embryonic stem cells pluripotent execution.
Fri Aug 18 00:00:00 UTC 2017
A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation.
eLife
Li MA,Amaral PP,Cheung P,Bergmann JH,Kinoshita M,Kalkan T,Ralser M,Robson S,von Meyenn F,Paramor M,Yang F,Chen C,Nichols J,Spector DL,Kouzarides T,He L,Smith A
14-5761 was used in Immunocytochemistry to determine the mechanism by which a novel rodent-specific lncRNA delays embryonic stem cells pluripotent execution.
Fri Aug 18 00:00:00 UTC 2017
Distinct SoxB1 networks are required for naïve and primed pluripotency.
eLife
Corsinotti A,Wong FC,Tatar T,Szczerbinska I,Halbritter F,Colby D,Gogolok S,Pantier R,Liggat K,Mirfazeli ES,Hall-Ponsele E,Mullin NP,Wilson V,Chambers I
14-5761 was used in Immunocytochemistry-immunoflourescence to demonstrate that optimal SOXB1 levels are critical for each pluripotent state and cell fate decisions during exit from naive pluripotency.
Tue Dec 19 00:00:00 UTC 2017
A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells.
Nature communications
Ju Lee H,Bartsch D,Xiao C,Guerrero S,Ahuja G,Schindler C,Moresco JJ,Yates JR,Gebauer F,Bazzi H,Dieterich C,Kurian L,Vilchez D
14-5761 was used in Immunocytochemistry to identify CSDE1 as a central post-transcriptional regulator of human embryonic stem cells identity and neurogenesis.
Mon Nov 13 00:00:00 UTC 2017
ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation.
Scientific reports
Bessonnard S,Coqueran S,Vandormael-Pournin S,Dufour A,Artus J,Cohen-Tannoudji M
14-5761 was used in Immunohistochemistry-immunofluorescence to examine the timing and mechanisms involved in the process of inner cell mass specification.
Mon Sep 25 00:00:00 UTC 2017
Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm.
Nature cell biology
Anderson KGV,Hamilton WB,Roske FV,Azad A,Knudsen TE,Canham MA,Forrester LM,Brickman JM
14-5761-80 was used in Sample Preparation to study the effects of insulin on endoderm differentiation and the self-renewal in pluripotent cells.
Sun Oct 01 00:00:00 UTC 2017
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Nature
Murakami K,Günesdogan U,Zylicz JJ,Tang WWC,Sengupta R,Kobayashi T,Kim S,Butler R,Dietmann S,Surani MA
14-5761 was used in Western Blotting to investigate the role of nanog in unipotent primordial germ cells in mice.
Thu Jan 21 00:00:00 UTC 2016
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Nature
Murakami K,Günesdogan U,Zylicz JJ,Tang WWC,Sengupta R,Kobayashi T,Kim S,Butler R,Dietmann S,Surani MA
14-5761 was used in Western Blotting to investigate the role of nanog in unipotent primordial germ cells in mice.
Thu Jan 21 00:00:00 UTC 2016
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Nature
Murakami K,Günesdogan U,Zylicz JJ,Tang WWC,Sengupta R,Kobayashi T,Kim S,Butler R,Dietmann S,Surani MA
14-5761 was used in Western Blotting to investigate the role of nanog in unipotent primordial germ cells in mice.
Thu Jan 21 00:00:00 UTC 2016
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Nature
Murakami K,Günesdogan U,Zylicz JJ,Tang WWC,Sengupta R,Kobayashi T,Kim S,Butler R,Dietmann S,Surani MA
14-5761 was used in Western Blotting to investigate the role of nanog in unipotent primordial germ cells in mice.
Thu Jan 21 00:00:00 UTC 2016
Selection and dynamics of embryonic stem cell integration into early mouse embryos.
Development (Cambridge, England)
Alexandrova S,Kalkan T,Humphreys P,Riddell A,Scognamiglio R,Trumpp A,Nichols J
14-5761 was used in Immunohistochemistry to examine the role of cellular heterogeneity in the incorporation of pluripotent cells into host embryos.
Fri Jan 01 00:00:00 UTC 2016
Selection and dynamics of embryonic stem cell integration into early mouse embryos.
Development (Cambridge, England)
Alexandrova S,Kalkan T,Humphreys P,Riddell A,Scognamiglio R,Trumpp A,Nichols J
14-5761 was used in Immunohistochemistry to examine the role of cellular heterogeneity in the incorporation of pluripotent cells into host embryos.
Fri Jan 01 00:00:00 UTC 2016
Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor.
Journal of cellular physiology
Li Y,Adomat H,Guns ET,Hojabrpour P,Duronio V,Curran TA,Jalili RB,Jia W,Delwar Z,Zhang Y,Elizei SS,Ghahary A
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunocytochemistry
Wed Jun 01 00:00:00 UTC 2016
Specific Direct Small Molecule p300/β-Catenin Antagonists Maintain Stem Cell Potency.
Current molecular pharmacology
Higuchi Y,Nguyen C,Yasuda SY,McMillan M,Hasegawa K,Kahn M
14576180 was used in immunocytochemistry to identify p300/beta-catenin antagonists and verify their ability to maintain pluripotency in ESC
Mon Oct 30 00:00:00 UTC 2017
Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency.
Stem cell reports
Martin Gonzalez J,Morgani SM,Bone RA,Bonderup K,Abelchian S,Brakebusch C,Brickman JM
14-5761 was used in Immunofluorescence to assess the impact of derivation and culture conditions on both functional potency and ESC transcriptional identity.
Tue Aug 09 00:00:00 UTC 2016
p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development.
Open biology
Thamodaran V,Bruce AW
14576180 was used in immunohistochemistry to discover that p38 family mitogen-activated protein kinases contribute to primitive endoderm formation
Thu Sep 01 00:00:00 UTC 2016
p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development.
Open biology
Thamodaran V,Bruce AW
14576180 was used in immunohistochemistry to discover that p38 family mitogen-activated protein kinases contribute to primitive endoderm formation
Thu Sep 01 00:00:00 UTC 2016
piggyBac Transposon Mediated Reprogramming and Flow Cytometry Analysis of CD44 and ICAM1 Cell-Surface Marker Changes.
Methods in molecular biology (Clifton, N.J.)
Brightwell S,Kaji K
14-5761-80 was used in Immunocytochemistry to observe clear cell population changes undergoing reprogramming using two novel cell surface markers, ICAM1 and CD44 with piggyBac transposon.
Fri Oct 14 00:00:00 UTC 2016
Polycomb enables primitive endoderm lineage priming in embryonic stem cells.
eLife
Illingworth RS,Hölzenspies JJ,Roske FV,Bickmore WA,Brickman JM
14-5761 was used in Immunocytochemistry to show that altered transcription is the driver of lineage priming, exploiting novel polycomb activities.
Mon Oct 10 00:00:00 UTC 2016
Lineage specificity of primary cilia in the mouse embryo.
Nature cell biology
Bangs FK,Schrode N,Hadjantonakis AK,Anderson KV
14-5761 was used in Immunohistochemistry-immunofluorescence to define when and where primary cilia appear in the mouse embryo using a transgenic line.
Sun Feb 01 00:00:00 UTC 2015
SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression.
Nucleic acids research
Nakamura T,Yabuta Y,Okamoto I,Aramaki S,Yokobayashi S,Kurimoto K,Sekiguchi K,Nakagawa M,Yamamoto T,Saitou M
14576180 was used in immunocytochemistry to analyze single-cell gene expression in human-induced pluripotent stem cells.
Tue May 19 00:00:00 UTC 2015
FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells.
Development (Cambridge, England)
Schröter C,Rué P,Mackenzie JP,Martinez Arias A
Tue Dec 15 00:00:00 UTC 2015
FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells.
Development (Cambridge, England)
Schröter C,Rué P,Mackenzie JP,Martinez Arias A
Tue Dec 15 00:00:00 UTC 2015
LIF supports primitive endoderm expansion during pre-implantation development.
Development (Cambridge, England)
Morgani SM,Brickman JM
14-5761 was used in Immunocytochemistry to study the roles of LIF in maintaining self renewal of embryonic stem cells which express extra-embryonic markers.
Thu Oct 15 00:00:00 UTC 2015
Reprogramming Roadblocks Are System Dependent.
Stem cell reports
Chantzoura E,Skylaki S,Menendez S,Kim SI,Johnsson A,Linnarsson S,Woltjen K,Chambers I,Kaji K
14-5761 was used in Immunofluorescence to investigate reprogramming systems for the study of iPSCs.
Tue Sep 08 00:00:00 UTC 2015
Reprogramming Roadblocks Are System Dependent.
Stem cell reports
Chantzoura E,Skylaki S,Menendez S,Kim SI,Johnsson A,Linnarsson S,Woltjen K,Chambers I,Kaji K
14-5761 was used in Immunofluorescence to investigate reprogramming systems for the study of iPSCs.
Tue Sep 08 00:00:00 UTC 2015
Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation.
BMC developmental biology
Economou C,Tsakiridis A,Wymeersch FJ,Gordon-Keylock S,Dewhurst RE,Fisher D,Medvinsky A,Smith AJ,Wilson V
14-5761 was used in Immunofluorescence to investigate experimental models for the persistence or reactivation of pluripotency during embryonic development.
Fri Oct 09 00:00:00 UTC 2015
X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency.
Cell
Pasque V,Tchieu J,Karnik R,Uyeda M,Sadhu Dimashkie A,Case D,Papp B,Bonora G,Patel S,Ho R,Schmidt R,McKee R,Sado T,Tada T,Meissner A,Plath K
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunocytochemistry
Thu Dec 18 00:00:00 UTC 2014
Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.
EMBO molecular medicine
Huijbers IJ,Bin Ali R,Pritchard C,Cozijnsen M,Kwon MC,Proost N,Song JY,de Vries H,Badhai J,Sutherland K,Krimpenfort P,Michalak EM,Jonkers J,Berns A
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Flow Cytometry
Sat Feb 01 00:00:00 UTC 2014
In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
PLoS biology
Gouti M,Tsakiridis A,Wymeersch FJ,Huang Y,Kleinjung J,Wilson V,Briscoe J
14-5761 was used in Immunofluorescence-cell culture cells to show that neuromesodermal progenitors can be generated in vitro from pluripotent stem cells by activating Wnt and Fgf signalling.
Fri Aug 01 00:00:00 UTC 2014
Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors.
Development (Cambridge, England)
Tsakiridis A,Huang Y,Blin G,Skylaki S,Wymeersch F,Osorno R,Economou C,Karagianni E,Zhao S,Lowell S,Wilson V
Sat Mar 01 00:00:00 UTC 2014
Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors.
Development (Cambridge, England)
Tsakiridis A,Huang Y,Blin G,Skylaki S,Wymeersch F,Osorno R,Economou C,Karagianni E,Zhao S,Lowell S,Wilson V
Sat Mar 01 00:00:00 UTC 2014
Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst.
Development (Cambridge, England)
Le Bin GC,Muñoz-Descalzo S,Kurowski A,Leitch H,Lou X,Mansfield W,Etienne-Dumeau C,Grabole N,Mulas C,Niwa H,Hadjantonakis AK,Nichols J
14-5761 was used in Immunohistochemistry to conclude that cell fate decisions within the inner cell mass are dependent upon Oct4 and that Oct4 is not cell-autonomously required for the differentiation of primitive endoderm derivatives.
Sat Mar 01 00:00:00 UTC 2014
Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling.
PloS one
Doughton G,Wei J,Tapon N,Welham MJ,Chalmers AD
Wed Jan 14 00:00:00 UTC 2015
Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling.
PloS one
Doughton G,Wei J,Tapon N,Welham MJ,Chalmers AD
Wed Jan 14 00:00:00 UTC 2015
Brachyury cooperates with Wnt/β-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells.
BMC biology
Turner DA,Rué P,Mackenzie JP,Davies E,Martinez Arias A
14-5761 was used in Immunofluorescence to investigate to what extent events in the embryo are able to be reproduced in culture.
Wed Aug 13 00:00:00 UTC 2014
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes.
Nature
Kumar R,DiMenna L,Schrode N,Liu TC,Franck P,Muñoz-Descalzo S,Hadjantonakis AK,Zarrin AA,Chaudhuri J,Elemento O,Evans T
Thu Aug 01 00:00:00 UTC 2013
A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages.
Nature cell biology
Radzisheuskaya A,Chia Gle B,dos Santos RL,Theunissen TW,Castro LF,Nichols J,Silva JC
Sat Jun 01 00:00:00 UTC 2013
A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages.
Nature cell biology
Radzisheuskaya A,Chia Gle B,dos Santos RL,Theunissen TW,Castro LF,Nichols J,Silva JC
Sat Jun 01 00:00:00 UTC 2013
Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization.
Cell stem cell
Denholtz M,Bonora G,Chronis C,Splinter E,de Laat W,Ernst J,Pellegrini M,Plath K
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunocytochemistry
Thu Nov 07 00:00:00 UTC 2013
Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.
Molecular cell
Payer B,Rosenberg M,Yamaji M,Yabuta Y,Koyanagi-Aoi M,Hayashi K,Yamanaka S,Saitou M,Lee JT
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunohistochemistry
Thu Dec 26 00:00:00 UTC 2013
Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin.
eLife
Malaguti M,Nistor PA,Blin G,Pegg A,Zhou X,Lowell S
14-5761 was used in Immunofluorescence to investigate the mechanisms by which BMP controls differentiation.
Tue Dec 17 00:00:00 UTC 2013
A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells.
Development (Cambridge, England)
Faunes F,Hayward P,Descalzo SM,Chatterjee SS,Balayo T,Trott J,Christoforou A,Ferrer-Vaquer A,Hadjantonakis AK,Dasgupta R,Arias AM
14-5761 was used in Western Blotting to investigate the role of a β-catenin/Oct4 complex on pluripotency.
Fri Mar 01 00:00:00 UTC 2013
A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells.
Development (Cambridge, England)
Faunes F,Hayward P,Descalzo SM,Chatterjee SS,Balayo T,Trott J,Christoforou A,Ferrer-Vaquer A,Hadjantonakis AK,Dasgupta R,Arias AM
14-5761 was used in Western Blotting to investigate the role of a β-catenin/Oct4 complex on pluripotency.
Fri Mar 01 00:00:00 UTC 2013
Totipotent embryonic stem cells arise in ground-state culture conditions.
Cell reports
Morgani SM,Canham MA,Nichols J,Sharov AA,Migueles RP,Ko MS,Brickman JM
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Flow Cytometry
Thu Jun 27 00:00:00 UTC 2013
Totipotent embryonic stem cells arise in ground-state culture conditions.
Cell reports
Morgani SM,Canham MA,Nichols J,Sharov AA,Migueles RP,Ko MS,Brickman JM
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Flow Cytometry
Thu Jun 27 00:00:00 UTC 2013
The transcriptional and epigenomic foundations of ground state pluripotency.
Cell
Marks H,Kalkan T,Menafra R,Denissov S,Jones K,Hofemeister H,Nichols J,Kranz A,Stewart AF,Smith A,Stunnenberg HG
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Flow Cytometry
Fri Apr 27 00:00:00 UTC 2012
The transcriptional and epigenomic foundations of ground state pluripotency.
Cell
Marks H,Kalkan T,Menafra R,Denissov S,Jones K,Hofemeister H,Nichols J,Kranz A,Stewart AF,Smith A,Stunnenberg HG
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Flow Cytometry
Fri Apr 27 00:00:00 UTC 2012
Correlations between the levels of Oct4 and Nanog as a signature for naïve pluripotency in mouse embryonic stem cells.
Stem cells (Dayton, Ohio)
Muñoz Descalzo S,Rué P,Garcia-Ojalvo J,Martinez Arias A
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunofluorescence
Sat Dec 01 00:00:00 UTC 2012
Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency.
Journal of cell science
Pasque V,Radzisheuskaya A,Gillich A,Halley-Stott RP,Panamarova M,Zernicka-Goetz M,Surani MA,Silva JC
Sat Dec 15 00:00:00 UTC 2012
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.
Nature cell biology
Wray J,Kalkan T,Gomez-Lopez S,Eckardt D,Cook A,Kemler R,Smith A
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Immunofluorescence
Sun Jun 19 00:00:00 UTC 2011
A PiggyBac-based recessive screening method to identify pluripotency regulators.
PloS one
Guo G,Huang Y,Humphreys P,Wang X,Smith A
14-5761 was used in Immunofluorescence to investigate methods to isolate regulators of mammalian pluripotency based on conversion to homozygosity of PiggyBac gene trap insertions.
Mon Apr 18 00:00:00 UTC 2011
A PiggyBac-based recessive screening method to identify pluripotency regulators.
PloS one
Guo G,Huang Y,Humphreys P,Wang X,Smith A
14-5761 was used in Immunofluorescence to investigate methods to isolate regulators of mammalian pluripotency based on conversion to homozygosity of PiggyBac gene trap insertions.
Mon Apr 18 00:00:00 UTC 2011
Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes.
Toxicological sciences : an official journal of the Society of Toxicology
Wang Y,Fan Y,Puga A
Published figure using Nanog monoclonal antibody (Product # 14-5761-80) in Western Blot
Sat May 01 00:00:00 UTC 2010
