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Product Details
BS-10227R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Nanos3, amino acids 101-173.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In Drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nanos homolog 3; NOS-3
Gene Aliases: NANOS1L; NANOS3; NOS3; ZC2HC12C
UniProt ID: (Human) P60323, (Mouse) P60324
Entrez Gene ID: (Human) 342977, (Mouse) 244551, (Rat) 288909
regulation of translation
multicellular organism development
germ cell development
spermatogenesis
negative regulation of translation
cell differentiation
oogenesis
regulation of cell cycle
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of apoptotic signaling pathway
Performance Guarantee
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