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Nectin 1 Antibody (MA5-28593) in Flow
Separation of human CD34 positive stem cells (blue) from lymphocytes (red) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD111 (R1.302) PE Monoclonal antibody (Product # MA5-28593), concentration in sample 1 µg/mL.
Product Details
MA5-28593
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
R1.302
Immunogen
Human CD111- transfected NIH/3T3 cells
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745552
Product Specific Information
This antibody recognizes an extracellular epitope on CD111 (also known as Nectin 1), a 75 kDa type I transmembrane glycoprotein broadly expressed on endothelial cells, epithelial cells, neuronal cells, megakaryocytes, and CD34-positive stem cells.
Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension.
Target Information
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic region. This protein acts as a receptor for glycoprotein D of herpes simplex viruses 1 and 2, and pseudorabies virus and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome as well as non-syndromic cleft lip with or without cleft palate. Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD111; ectodermal dysplasia 4 (Margarita Island type); herpes simplex virus type 1 sensitivity; Herpes virus entry mediator C; Herpesvirus entry mediator C; Herpesvirus Ig-like receptor; HIgR; nectin 1; Nectin cell adhesion molecule 1; Nectin-1; poliovirus receptor-like 1; poliovirus receptor-related 1 (herpesvirus entry mediator C); Poliovirus receptor-related protein 1
Gene Aliases: CD111; CLPED1; ED4; HIgR; HV1S; HVEC; nectin-1; NECTIN1; OFC7; PRR; PRR1; PVRL1; PVRR; PVRR1; SK-12
UniProt ID: (Human) Q15223
Entrez Gene ID: (Human) 5818
lens morphogenesis in camera-type eye
desmosome organization
iron ion transport
immune response
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
signal transduction
axon guidance
cell recognition
single organismal cell-cell adhesion
adherens junction organization
viral entry into host cell
regulation of synapse assembly
retina development in camera-type eye
enamel mineralization
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