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Invitrogen
Nectin 2 Polyclonal Antibody
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FIGURE: 1 / 3
Nectin 2 Antibody (PA5-92433) in WB
Western blot was performed using Anti-Nectin 2 Polyclonal Antibody (Product # PA5-92433) and a 58 kDa band corresponding to Nectin-2 was observed across cell lines tested except Daudi and MOLT-4. This SKU does not show reactivity to mouse and rat tissues. Whole cell extracts (30 µg lysate) of Caco-2 (Lane 1), HT-29 (Lane 2), MCF7 (Lane 3), MDA-MB-231 (Lane 4), Daudi (Lane 5), MOLT-4 (Lane 6), Mouse Testis (Lane 7), Rat Testis (Lane 8) and Mouse Adipose (Lane 9) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322... View More
Product Details
PA5-92433
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 382-479 of human Nectin 2/CD112 (NP_0028471)
Conjugate
Form
Liquid
Concentration
1.41 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2806497
Product Specific Information
Immunogen sequence: FILLRVRRRR KSPGGAGGGA SGDGGFYDPK AQVLGNGDPV FWTPVVPGPM EPDGKDEEEE EEEEKAEKGL MLPPPPALED DMESQLDGSL ISRRAVYV; Positive Samples: MCF-7, SW620, A-549, SKOV3; Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; Nectin cell adhesion molecule 2; Nectin-2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); Poliovirus receptor-related protein 2
Gene Aliases: CD112; HVEB; NECTIN2; PRR2; PVRL2; PVRR2
UniProt ID: (Human) Q92692
Entrez Gene ID: (Human) 5819
acrosome assembly
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of immunoglobulin mediated immune response
cytoskeleton organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
signal transduction
spermatid development
spermatid nucleus differentiation
cell recognition
fertilization
fusion of virus membrane with host plasma membrane
sperm mitochondrion organization
cell part morphogenesis
positive regulation of mast cell activation
adherens junction organization
susceptibility to natural killer cell mediated cytotoxicity
adhesion of symbiont to host
cilium organization
positive regulation of natural killer cell mediated cytotoxicity
regulation of viral entry into host cell
coreceptor-mediated virion attachment to host cell
regulation of immune response
establishment of mitochondrion localization
susceptibility to T cell mediated cytotoxicity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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