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Bethyl Laboratories
Nectin-2/CD112 Recombinant Rabbit Monoclonal Antibody (BLR071G)
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Nectin-2/CD112 Antibody (A700-071) in ICC/IF
Detection of human Nectin-2/CD112 by immunocytochemistry. Sample: FFPE section of OVCAR-8 cells. Antibody: Rabbit anti-Nectin-2/CD112 recombinant monoclonal antibody [BLR071G] (Product # A700-071) (lot 1) used at 1:200. Secondary: HRP-conjugated goat anti-rabbit IgG (A120-501P). Substrate: DAB.
Product Details
A700-071
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR071G
Immunogen
Peptide representing a region between residue 50 and 100 of human Nectin cell adhesion molecule 2.
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
purified
Storage buffer
BBS, pH 7.8 to 8.6
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; Nectin cell adhesion molecule 2; Nectin-2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); Poliovirus receptor-related protein 2
Gene Aliases: CD112; HVEB; NECTIN2; PRR2; PVRL2; PVRR2
UniProt ID: (Human) Q92692
Entrez Gene ID: (Human) 5819
acrosome assembly
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of immunoglobulin mediated immune response
cytoskeleton organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
signal transduction
spermatid development
spermatid nucleus differentiation
cell recognition
fertilization
fusion of virus membrane with host plasma membrane
sperm mitochondrion organization
cell part morphogenesis
positive regulation of mast cell activation
adherens junction organization
susceptibility to natural killer cell mediated cytotoxicity
adhesion of symbiont to host
cilium organization
positive regulation of natural killer cell mediated cytotoxicity
regulation of viral entry into host cell
coreceptor-mediated virion attachment to host cell
regulation of immune response
establishment of mitochondrion localization
susceptibility to T cell mediated cytotoxicity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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