Osenses

Neucrin Polyclonal Antibody

Product Details

OSD00032W-100UL

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:2,000

Immunohistochemistry (IHC)

1:300-1:2,000

Miscellaneous PubMed (MISC)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from the internal region of human Dorsal repulsive axon guidance protein (Draxin, Neucrin) conjugated to an immunogenic carrier protein was used as the antigen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: Draxin.

Target Information

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The DNA sequence and biological annotation of human chromosome 1.

Nature

Gregory SG,Barlow KF,McLay KE,Kaul R,Swarbreck D,Dunham A,Scott CE,Howe KL,Woodfine K,Spencer CC,Jones MC,Gillson C,Searle S,Zhou Y,Kokocinski F,McDonald L,Evans R,Phillips K,Atkinson A,Cooper R,Jones C,Hall RE,Andrews TD,Lloyd C,Ainscough R,Almeida JP,Ambrose KD,Anderson F,Andrew RW,Ashwell RI,Aubin K,Babbage AK,Bagguley CL,Bailey J,Beasley H,Bethel G,Bird CP,Bray-Allen S,Brown JY,Brown AJ,Buckley D,Burton J,Bye J,Carder C,Chapman JC,Clark SY,Clarke G,Clee C,Cobley V,Collier RE,Corby N,Coville GJ,Davies J,Deadman R,Dunn M,Earthrowl M,Ellington AG,Errington H,Frankish A,Frankland J,French L,Garner P,Garnett J,Gay L,Ghori MR,Gibson R,Gilby LM,Gillett W,Glithero RJ,Grafham DV,Griffiths C,Griffiths-Jones S,Grocock R,Hammond S,Harrison ES,Hart E,Haugen E,Heath PD,Holmes S,Holt K,Howden PJ,Hunt AR,Hunt SE,Hunter G,Isherwood J,James R,Johnson C,Johnson D,Joy A,Kay M,Kershaw JK,Kibukawa M,Kimberley AM,King A,Knights AJ,Lad H,Laird G,Lawlor S,Leongamornlert DA,Lloyd DM,Loveland J,Lovell J,Lush MJ,Lyne R,Martin S,Mashreghi-Mohammadi M,Matthews L,Matthews NS,McLaren S,Milne S,Mistry S,Moore MJ,Nickerson T,O'Dell CN,Oliver K,Palmeiri A,Palmer SA,Parker A,Patel D,Pearce AV,Peck AI,Pelan S,Phelps K,Phillimore BJ,Plumb R,Rajan J,Raymond C,Rouse G,Saenphimmachak C,Sehra HK,Sheridan E,Shownkeen R,Sims S,Skuce CD,Smith M,Steward C,Subramanian S,Sycamore N,Tracey A,Tromans A,Van Helmond Z,Wall M,Wallis JM,White S,Whitehead SL,Wilkinson JE,Willey DL,Williams H,Wilming L,Wray PW,Wu Z,Coulson A,Vaudin M,Sulston JE,Durbin R,Hubbard T,Wooster R,Dunham I,Carter NP,McVean G,Ross MT,Harrow J,Olson MV,Beck S,Rogers J,Bentley DR,Banerjee R,Bryant SP,Burford DC,Burrill WD,Clegg SM,Dhami P,Dovey O,Faulkner LM,Gribble SM,Langford CF,Pandian RD,Porter KM,Prigmore E

Thu May 18 00:00:00 UTC 2006

Signal peptide prediction based on analysis of experimentally verified cleavage sites.

Protein science : a publication of the Protein Society

Zhang Z,Henzel WJ

Fri Oct 01 00:00:00 UTC 2004

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

Genome research

Clark HF,Gurney AL,Abaya E,Baker K,Baldwin D,Brush J,Chen J,Chow B,Chui C,Crowley C,Currell B,Deuel B,Dowd P,Eaton D,Foster J,Grimaldi C,Gu Q,Hass PE,Heldens S,Huang A,Kim HS,Klimowski L,Jin Y,Johnson S,Lee J,Lewis L,Liao D,Mark M,Robbie E,Sanchez C,Schoenfeld J,Seshagiri S,Simmons L,Singh J,Smith V,Stinson J,Vagts A,Vandlen R,Watanabe C,Wieand D,Woods K,Xie MH,Yansura D,Yi S,Yu G,Yuan J,Zhang M,Zhang Z,Goddard A,Wood WI,Godowski P,Gray A

Wed Oct 01 00:00:00 UTC 2003

Bioinformatics

Protein Aliases: Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Draxin; FLJ34999; MGC117222; Neucrin; neural tissue-specific cysteine-rich protein

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Gene Aliases: AGPA3119; C1orf187; DRAXIN; neucrin; PSEC0258; UNQ3119; UNQ3119/PRO10268

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UniProt ID: (Human) Q8NBI3

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Entrez Gene ID: (Human) 374946

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Function(s)

protein binding

Process(es)

axon guidance Wnt signaling pathway dorsal spinal cord development commissural neuron differentiation in spinal cord negative regulation of axon extension forebrain development negative regulation of neuron apoptotic process negative regulation of canonical Wnt signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Neucrin Polyclonal Antibody

Product Details

OSD00032W-100UL

Western Blot (WB)

Immunohistochemistry (IHC)

Miscellaneous PubMed (MISC)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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