Rockland

NeuroD1 Polyclonal Antibody

View all (28) NeuroD1 antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

600-101-MN7

Applications
Tested Dilution
Publications

Western Blot (WB)

5.0 µg/mL
-

ELISA (ELISA)

1:10,000-1:50,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-NEUROD1 Antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a N-terminal region of human Neurogenic differentiation factor 1 conjugated to Keyhole Limpet Hemocyanin (KLH).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity purified antibody is directed against human NEUROD1. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse, rat, and golden hamster.

Target Information

NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD

View more View less

Gene Aliases: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1

View more View less

UniProt ID: (Human) Q13562

View more View less

Entrez Gene ID: (Human) 4760

View more View less

Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding sequence-specific DNA binding protein heterodimerization activity E-box binding
Process(es)
pancreatic A cell fate commitment pancreatic PP cell fate commitment transcription from RNA polymerase II promoter nucleocytoplasmic transport nitric oxide mediated signal transduction response to glucose anterior/posterior pattern specification dentate gyrus development cerebellum development neurogenesis signal transduction involved in regulation of gene expression insulin secretion endocrine pancreas development amacrine cell differentiation enteroendocrine cell differentiation response to drug glucose homeostasis positive regulation of apoptotic process positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JAK-STAT cascade embryonic organ morphogenesis neuron development inner ear development regulation of insulin secretion positive regulation of sequence-specific DNA binding transcription factor activity regulation of intestinal epithelial structure maintenance regulation of cell cycle arrest cellular response to glucose stimulus negative regulation of type B pancreatic cell apoptotic process positive regulation of transcription regulatory region DNA binding
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support