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NeoBiotechnologies
Neurofilament (H+L) (Neuronal Marker) Monoclonal Antibody (2F11)
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Product Details
MSM2-2439
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2F11
Immunogen
Human NF-H from isolated brain cells
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 200 kDa neurofilament protein; 68 kDa neurofilament protein; light molecular weight neurofilament protein; neurofilament 200kDa; Neurofilament heavy polypeptide; Neurofilament light polypeptide; neurofilament protein L; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet H protein; Neurofilament triplet L protein; neurofilament, heavy polypeptide 200kDa; neurofilament, light polypeptide 68kDa; NF-H; NF-L; protein phosphatase 1, regulatory subunit 110
Gene Aliases: AI847934; CMT1F; CMT2CC; CMT2E; KIAA0845; mKIAA0845; NEFH; NEFL; NF-H; NF-L; NF200; NF68; NFH; NFL; PPP1R110
UniProt ID: (Human) Q9UJS7, (Human) P07196, (Mouse) P19246, (Mouse) P08551, (Rat) P19527
Entrez Gene ID: (Human) 4744, (Human) 4747, (Rat) 24587, (Mouse) 380684, (Mouse) 18039, (Rat) 83613
structural molecule activity
structural constituent of cytoskeleton
microtubule binding
toxic substance binding
kinesin binding
protein kinase binding
protein binding, bridging
dynein binding
protein heterodimerization activity
Ras guanyl-nucleotide exchange factor activity
protein binding
protein C-terminus binding
protein domain specific binding
identical protein binding
phospholipase binding
nutrient reservoir activity
MAPK cascade
microtubule cytoskeleton organization
anterograde axonal transport
retrograde axonal transport
response to toxic substance
peripheral nervous system axon regeneration
axonal transport of mitochondrion
spinal cord development
hippocampus development
cerebral cortex development
regulation of axon diameter
neurofilament bundle assembly
locomotion
response to peptide hormone
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
intermediate filament polymerization or depolymerization
intermediate filament organization
neuron projection morphogenesis
positive regulation of axonogenesis
neuromuscular process controlling balance
protein polymerization
response to corticosterone
response to sodium arsenite
response to acrylamide
ovarian follicle atresia
axonogenesis
cell projection assembly
axon regeneration
cellular response to oxidative stress
response to cocaine
peripheral nervous system neuron axonogenesis
axon development
cellular response to estradiol stimulus
regulation of organelle transport along microtubule
intermediate filament bundle assembly
neurofilament cytoskeleton organization
brain development
embryo development
neuron projection development
intermediate filament cytoskeleton organization
response to organic substance
response to organonitrogen compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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