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Product Details
PA5-40478
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human NEUROG1 (aa 180-229).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606240
Product Specific Information
Peptide sequence: ASDAESWGSG AAAASPLSDP SSPAASEDFT YRPGDPVFSF PSLPKDLLHT
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 79%; Rat: 93%
Target Information
Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa6; Class A basic helix-loop-helix protein 6; Helix-loop-helix protein mATH-4C; mATH4C; NeuroD3; Neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; Neurogenic differentiation factor 3; Neurogenin-1; NGN-1
Gene Aliases: AKA; Ath4c; BHLHA6; Math4C; NEUROD3; NEUROG1; NGN; NGN1
UniProt ID: (Human) Q92886, (Mouse) P70660
Entrez Gene ID: (Human) 4762, (Mouse) 18014
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
nervous system development
neurogenesis
cell differentiation
neuron differentiation
positive regulation of exit from mitosis
inner ear morphogenesis
cell fate commitment
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of transcription from RNA polymerase II promoter
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