Alomone Labs, LTD

Neurokinin 1 Receptor (NK1R) (extracellular) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ATR-001-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunocytochemistry (ICC/IF)

1:50
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CMIEWPEHPNRTYEK, corresponding to amino acid residues 180-194 of rat NK1 receptor, 2nd extracellular loop
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: neurokinin 1 receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)

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Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1

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UniProt ID: (Human) P25103, (Mouse) P30548, (Rat) P14600

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Entrez Gene ID: (Human) 6869, (Mouse) 21336, (Rat) 24807

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Function(s)
tachykinin receptor activity protein binding substance P receptor activity signal transducer activity G-protein coupled receptor activity
Process(es)
aggressive behavior positive regulation of leukocyte migration angiotensin-mediated drinking behavior signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway neuropeptide signaling pathway chemical synaptic transmission learning or memory long-term memory regulation of blood pressure associative learning response to heat response to hormone response to ozone positive regulation of epithelial cell migration response to auditory stimulus response to organic cyclic compound regulation of smooth muscle cell migration sensory perception of pain positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to nicotine operant conditioning positive regulation of renal sodium excretion sperm ejaculation eating behavior positive regulation of vascular permeability response to ethanol positive regulation of action potential positive regulation of blood pressure positive regulation of ossification positive regulation of vasoconstriction positive regulation of saliva secretion positive regulation of hormone secretion response to pain behavioral response to pain regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation positive regulation of epithelial cell proliferation positive regulation of stress fiber assembly smooth muscle contraction involved in micturition positive regulation of uterine smooth muscle contraction acute inflammatory response response to estradiol response to progesterone response to morphine response to electrical stimulus inflammatory response cell surface receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway detection of abiotic stimulus positive regulation of smooth muscle contraction
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