Osenses

Neuroligin 1, 2 Polyclonal Antibody

1 Reference
View all (2) Neuroligin 1/2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

OSN00035W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:2,000
-

Immunohistochemistry (IHC)

1:300-1:2,000
-

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide to human Neuroligin 1 conjugated to blue carrier protein was used as the antigen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The antigen is homologous with Neuroligin 2.

Specificity of this antibody: Neuroligin 1, 2.

Target Information

Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain (1,2). Members of the neuroligin family include Neuroligin 1, Neuroligin 2 and Neuroligin 3. Neuroligins are expressed in excitatory neuronal synaptic clefts. Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins. Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion. Neuroligins also bind to PSD-95, which may recruit ion channels and neurotransmitter receptors to the synapses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Neuroligin I; Neuroligin-1; Neuroligin-2; ortholog of human and rat neuroligin 2 NLGN2

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Gene Aliases: 6330415N05Rik; BB179718; KIAA1070; KIAA1366; mKIAA1070; NL1; NL2; Nlg1; NLGN1; NLGN2

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UniProt ID: (Human) Q8N2Q7, (Human) Q8NFZ4, (Mouse) Q99K10, (Rat) Q62765, (Rat) Q62888, (Mouse) Q69ZK9

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Entrez Gene ID: (Human) 22871, (Human) 57555, (Mouse) 192167, (Rat) 116647, (Rat) 117096, (Mouse) 216856

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Function(s)
receptor activity PDZ domain binding neurexin family protein binding protein dimerization activity cell adhesion molecule binding carboxylic ester hydrolase activity scaffold protein binding protein binding
Process(es)
regulation of respiratory gaseous exchange by neurological system process neuron cell-cell adhesion synapse assembly single organismal cell-cell adhesion sensory perception of pain positive regulation of insulin secretion positive regulation of synaptic transmission, GABAergic protein localization to synapse locomotory exploration behavior cell-cell junction maintenance modulation of synaptic transmission synapse organization neuromuscular process controlling balance positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic terminal button organization postsynaptic membrane assembly presynaptic membrane assembly gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering positive regulation of inhibitory postsynaptic potential positive regulation of protein localization to synapse regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering thigmotaxis cell adhesion jump response metabolic process social behavior protein targeting heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nervous system development positive regulation of circadian sleep/wake cycle, wakefulness synaptic vesicle targeting calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules neuron projection development establishment of protein localization regulation of neuron differentiation synaptic vesicle transport rhythmic process cytoskeletal matrix organization at active zone protein homooligomerization protein heterotetramerization positive regulation of filopodium assembly inhibitory postsynaptic potential long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine morphogenesis synaptic vesicle clustering AMPA glutamate receptor clustering NMDA glutamate receptor clustering neurexin clustering involved in presynaptic membrane assembly receptor localization to synapse positive regulation of ruffle assembly positive regulation of synaptic vesicle endocytosis positive regulation of intracellular signal transduction positive regulation of synaptic vesicle exocytosis regulation of N-methyl-D-aspartate selective glutamate receptor activity neuronal signal transduction positive regulation of cell proliferation insulin metabolic process positive regulation of t-SNARE clustering neuronal ion channel clustering
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