Alomone Labs, LTD

Neuroligin 3 (extracellular) Polyclonal Antibody

View all (20) NLGN3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ANR-037-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)SHITRRPNGKTWSTKR, corresponding to amino acid residues 656-671 of rat NLGN3, Extracellular, N-terminus
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASPGX1; AUTSX1; Gliotactin homolog; neuroligin 3 protein; Neuroligin-3

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Gene Aliases: A230085M13Rik; HNL3; KIAA1480; NL3; NLGN3

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UniProt ID: (Human) Q9NZ94, (Mouse) Q8BYM5, (Rat) Q62889

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Entrez Gene ID: (Human) 54413, (Mouse) 245537, (Rat) 171297

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Function(s)
receptor activity protein binding neurexin family protein binding cell adhesion molecule binding carboxylic ester hydrolase activity scaffold protein binding
Process(es)
regulation of respiratory gaseous exchange by neurological system process receptor-mediated endocytosis neuron cell-cell adhesion synapse assembly learning visual learning adult behavior social behavior axon extension oligodendrocyte differentiation modulation of synaptic transmission synapse organization positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic rhythmic synaptic transmission excitatory postsynaptic potential inhibitory postsynaptic potential long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine morphogenesis vocalization behavior negative regulation of excitatory postsynaptic potential postsynaptic membrane assembly presynaptic membrane assembly positive regulation of inhibitory postsynaptic potential regulation of long-term synaptic potentiation positive regulation of protein localization to synapse regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of terminal button organization positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity cell adhesion regulation of synaptic transmission, glutamatergic regulation of dendritic spine morphogenesis regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity metabolic process
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