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Invitrogen
Neuropilin 1 Polyclonal Antibody
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Product Details
PA5-81295
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the center region of the Mouse Neuropilin-1/NRP1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2788514
Product Specific Information
This antibody has specificity for Mouse Neuropilin-1.
Target Information
Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A5 protein; CD304; Neuropilin; Neuropilin-1; Neuropilin-1 precursor (A5 protein); Neuropilin1; NRP 1; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor
Gene Aliases: C530029I03; NP-1; NPN-1; Npn1; Nrp; Nrp1
UniProt ID: (Mouse) P97333
Entrez Gene ID: (Mouse) 18186
angiogenesis
patterning of blood vessels
neuron migration
sprouting angiogenesis
cell migration involved in sprouting angiogenesis
multicellular organism development
nervous system development
axon guidance
axonal fasciculation
heart development
motor neuron axon guidance
organ morphogenesis
dendrite development
cell migration
peptidyl-tyrosine phosphorylation
facial nerve structural organization
trigeminal nerve morphogenesis
trigeminal nerve structural organization
vestibulocochlear nerve structural organization
nerve development
branchiomotor neuron axon guidance
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
cell differentiation
negative regulation of axon extension
retinal ganglion cell axon guidance
cellular response to hepatocyte growth factor stimulus
endothelial cell chemotaxis
cellular response to vascular endothelial growth factor stimulus
ventral trunk neural crest cell migration
vascular endothelial growth factor signaling pathway
VEGF-activated neuropilin signaling pathway
otic placode formation
negative regulation of neuron apoptotic process
platelet-derived growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
hepatocyte growth factor receptor signaling pathway
sympathetic nervous system development
neuron development
regulation of axon extension involved in axon guidance
positive regulation of axon extension involved in axon guidance
negative regulation of axon extension involved in axon guidance
artery morphogenesis
axon extension involved in axon guidance
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
axonogenesis involved in innervation
dichotomous subdivision of terminal units involved in salivary gland branching
angiogenesis involved in coronary vascular morphogenesis
cell migration involved in coronary vasculogenesis
coronary artery morphogenesis
retina vasculature morphogenesis in camera-type eye
renal artery morphogenesis
sympathetic ganglion development
trigeminal ganglion development
ganglion morphogenesis
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
commissural neuron axon guidance
regulation of retinal ganglion cell axon guidance
sensory neuron axon guidance
sympathetic neuron projection extension
sympathetic neuron projection guidance
neural crest cell migration involved in autonomic nervous system development
toxin transport
semaphorin-plexin signaling pathway involved in neuron projection guidance
semaphorin-plexin signaling pathway involved in axon guidance
positive regulation of retinal ganglion cell axon guidance
VEGF-activated neuropilin signaling pathway involved in axon guidance
protein localization to early endosome
facioacoustic ganglion development
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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