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Invitrogen
Neuropilin 1 Recombinant Rabbit Monoclonal Antibody (042)
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Product Details
MA5-43129
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
042
Immunogen
Recombinant Human Neuropilin-1/NRP1/CD304 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2912266
Product Specific Information
Specificity: Human Neuropilin-1/NRP1/CD304
Target Information
Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD304; Neuropilin; Neuropilin-1; Neuropilin1; NRP 1; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor; Vascular endothelial cell growth factor 165 receptor
Gene Aliases: BDCA4; CD304; NP1; NRP; NRP1; VEGF165R
UniProt ID: (Human) O14786
Entrez Gene ID: (Human) 8829
angiogenesis
patterning of blood vessels
neuron migration
positive regulation of endothelial cell proliferation
sprouting angiogenesis
cell migration involved in sprouting angiogenesis
signal transduction
cell-cell signaling
axon guidance
axonal fasciculation
response to wounding
organ morphogenesis
positive regulation of endothelial cell migration
positive regulation of smooth muscle cell migration
dendrite development
facial nerve structural organization
trigeminal nerve structural organization
vestibulocochlear nerve structural organization
nerve development
branchiomotor neuron axon guidance
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
retinal ganglion cell axon guidance
cellular response to hepatocyte growth factor stimulus
endothelial cell chemotaxis
cellular response to vascular endothelial growth factor stimulus
ventral trunk neural crest cell migration
VEGF-activated neuropilin signaling pathway
otic placode formation
negative regulation of neuron apoptotic process
platelet-derived growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
hepatocyte growth factor receptor signaling pathway
positive regulation of axon extension involved in axon guidance
negative regulation of axon extension involved in axon guidance
artery morphogenesis
axon extension involved in axon guidance
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of cytokine activity
axonogenesis involved in innervation
regulation of vesicle-mediated transport
dichotomous subdivision of terminal units involved in salivary gland branching
angiogenesis involved in coronary vascular morphogenesis
coronary artery morphogenesis
retina vasculature morphogenesis in camera-type eye
renal artery morphogenesis
sympathetic ganglion development
trigeminal ganglion development
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
commissural neuron axon guidance
regulation of retinal ganglion cell axon guidance
endothelial tip cell fate specification
sensory neuron axon guidance
sympathetic neuron projection extension
sympathetic neuron projection guidance
neural crest cell migration involved in autonomic nervous system development
toxin transport
semaphorin-plexin signaling pathway involved in neuron projection guidance
semaphorin-plexin signaling pathway involved in axon guidance
positive regulation of retinal ganglion cell axon guidance
VEGF-activated neuropilin signaling pathway involved in axon guidance
protein localization to early endosome
facioacoustic ganglion development
dorsal root ganglion morphogenesis
negative regulation of extrinsic apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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