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Immunogen sequence: NVDSFVELG QVALRTSLEL WMHTDPVSQK NESVRNQVED LLATLEKSGA GVPAVILRRP NQSQPLPPSS LQRFLRARNI SGVVLADHSG AFHNKYYQSI YDTAENINVS YPEWLSPEED LNFVTDTAKA LADVATVLGR ALYELAGGTN FSDTVQADPQ TVTRLLYGFL IKANNSWFQS ILRQDLRSYL GDGPLQHYIA VSSPTNTTYV VQYALANLTG TVVNLTREQC QDPSKVPSEN KDLYEYSWVQ GPLHSNETDR LPRCVRSTAR LARALSPAFE LSQWSSTEYS TWTESRWKDI HARIFLIASK ELELITLTVG FGILIFSLIV TYCINAKADV LFIAPREPGA VSY (338-689 aa encoded by BC047621)
NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
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Protein Aliases: anterior pharynx-defective 2; Nicastrin; OTTHUMP00000031840
Gene Aliases: 9430068N19Rik; AA727311; Aph2; ATAG1874; D1Dau13e; KIAA0253; mKIAA0253; NCSTN; Nct; UNQ1874/PRO4317
UniProt ID: (Human) Q92542, (Mouse) P57716, (Rat) Q8CGU6
Entrez Gene ID: (Human) 23385, (Mouse) 59287, (Rat) 289231
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