Alomone Labs, LTD

Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (extracellular) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

ANC-007-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:200
-

Immunocytochemistry (ICC/IF)

1:25
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)KELVKNYNPLER, corresponding to amino acid residues 31-42 of rat nAChR alpha 7, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: a7 nicotinic acetylcholine receptor; acetylcholine receptor; acetylcholine receptor alpha 7 neural; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; alpha7 nicotinic receptor; alpha7-nAChR; bungarotoxin alpha; C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor; cholinergic receptor, nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; CHRFAM7A; CHRNA7-DR1; D-10; nAChR alpha7; neuronal acetylcholine receptor protein, alpha-7 chain; Neuronal acetylcholine receptor subunit alpha-7; neuronal nicotinic acetycholine receptor alpha 7; nicotinic receptor alpha 7 subunit

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Gene Aliases: Acra7; alpha7; BTX; CHRNA7; CHRNA7-2; nAchR; NACHRA7; NARAD

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UniProt ID: (Human) P36544, (Rat) Q05941, (Mouse) P49582

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Entrez Gene ID: (Human) 1139, (Rat) 25302, (Mouse) 11441

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Function(s)
beta-amyloid binding acetylcholine-activated cation-selective channel activity ligand-gated ion channel activity acetylcholine receptor activity toxic substance binding chloride channel regulator activity acetylcholine-gated cation channel activity acetylcholine binding protein homodimerization activity protein binding drug binding adenylate cyclase binding protein kinase binding ATPase binding scaffold protein binding ion channel activity extracellular ligand-gated ion channel activity
Process(es)
activation of MAPK activity response to hypoxia ion transport calcium ion transport cellular calcium ion homeostasis signal transduction synaptic transmission, cholinergic memory positive regulation of cell proliferation negative regulation of tumor necrosis factor production ion transmembrane transport response to nicotine positive regulation of angiogenesis cognition cation transmembrane transport positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure endocytosis associative learning regulation of norepinephrine secretion neuronal action potential sperm motility response to food regulation of synaptic transmission, dopaminergic negative regulation of interleukin-1 beta production negative regulation of interleukin-6 production behavioral response to nicotine T cell activation B cell activation regulation of membrane potential dopamine biosynthetic process ovulation cycle response to ethanol behavioral response to ethanol regulation of inflammatory response negative regulation of inflammatory response generation of ovulation cycle rhythm transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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