Invitrogen

Nkx2.2 Polyclonal Antibody

View all (34) Nkx2.2 antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-78079

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human Nkx2.2. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736230

Product Specific Information

Positive Control: Nkx2.2-transfected 293T

Predicted Reactivity: Mouse (100%), Chicken (89%), Bovine (94%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Drosophila NK2 transcription factor related, locus 2; glycoprotein GP330, renal; Homeobox protein NK-2 homolog B; Homeobox protein Nkx-2.2; homeobox protein Nkx2-2; NK2 transcription factor related, locus 2; Nkx2.2

View more View less

Gene Aliases: Nkx-2.2; Nkx2-2; Nkx2.2; Nkx2b; tinman

View more View less

UniProt ID: (Mouse) P42586

View more View less

Entrez Gene ID: (Rat) 366214, (Mouse) 18088

View more View less

Function(s)
RNA polymerase II distal enhancer sequence-specific DNA binding core promoter proximal region DNA binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription factor binding sequence-specific DNA binding DNA binding protein binding
Process(es)
type B pancreatic cell development pancreatic A cell fate commitment type B pancreatic cell fate commitment pancreatic PP cell fate commitment regulation of transcription, DNA-templated transcription from RNA polymerase II promoter smoothened signaling pathway nervous system development response to glucose positive regulation of gene expression oligodendrocyte development response to organic cyclic compound spinal cord motor neuron differentiation spinal cord oligodendrocyte cell differentiation spinal cord oligodendrocyte cell fate specification optic nerve development cell differentiation endocrine pancreas development response to progesterone regulation of cell differentiation positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter cell development digestive tract development neuron fate specification astrocyte differentiation positive regulation of oligodendrocyte differentiation positive regulation of sequence-specific DNA binding transcription factor activity ventral spinal cord interneuron fate determination transcription, DNA-templated multicellular organism development
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support