Invitrogen

Nkx2.5 Polyclonal Antibody

View all (23) Nkx2.5 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-88705

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human NKX2-5 (NP_0043781)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.73 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805080

Product Specific Information

Immunogen sequence: AFKPEAYAGP EAAAPGLPEL RAELGRAPSP AKCASAFPAA PAFYPRAYSD PDPAKDPRAE KKELCALQKA VELEKTEADN AERPRARRRR KPRVLFSQAQ V; Positive Samples: Mouse heart, Rat heart; Cellular Location: Nucleus

Target Information

This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cardiac-specific homeobox; Drosophila NK2 transcription factor related, locus 5; FLJ52202; FLJ97166; FLJ97195; FLJ97197; FLJ99536; Homeobox protein CSX; Homeobox protein NK-2 homolog E; Homeobox protein Nkx-2.5; NK2 transcription factor related, locus 5; Nkx-25; rNKx-2.5

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Gene Aliases: Csx; Nkx-2.5; Nkx2-5; Nkx2.5; Nkx2e; tinman

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UniProt ID: (Rat) O35767, (Mouse) P42582

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Entrez Gene ID: (Rat) 114109, (Mouse) 18091

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription cofactor activity transcriptional activator activity, RNA polymerase II transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription factor binding serum response element binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis heart looping heart morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis cardiac conduction system development atrioventricular node development bundle of His development Purkinje myocyte differentiation cardiac ventricle morphogenesis cardiac ventricle formation right ventricular cardiac muscle tissue morphogenesis ventricular trabecula myocardium morphogenesis apoptotic process involved in heart morphogenesis septum secundum development proepicardium development pulmonary myocardium development regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development adult heart development positive regulation of cell proliferation positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of transcription via serum response element binding positive regulation of sodium ion transport negative regulation of myotube differentiation hemopoiesis cell differentiation BMP signaling pathway thyroid gland development response to estradiol embryonic heart tube development negative regulation of apoptotic process sarcomere organization positive regulation of neuron differentiation positive regulation of heart contraction positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development cardiac muscle tissue development positive regulation of cardioblast differentiation ventricular cardiac myofibril assembly cardiac muscle cell differentiation cardiac muscle tissue morphogenesis regulation of cardiac muscle contraction pharyngeal system development cardiac muscle cell proliferation regulation of cardiac muscle cell proliferation heart contraction cardiac muscle contraction canonical Wnt signaling pathway positive regulation of transcription initiation from RNA polymerase II promoter heart trabecula formation ventricular septum morphogenesis atrial septum morphogenesis atrioventricular node cell development atrioventricular node cell fate commitment embryonic heart tube left/right pattern formation cellular response to growth factor stimulus cardiovascular system development negative regulation of canonical Wnt signaling pathway positive regulation of voltage-gated calcium channel activity regulation of transcription, DNA-templated multicellular organism development endoderm development tongue development atrial cardiac muscle cell development ventricular cardiac muscle cell development
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