Invitrogen

Noggin Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-22795

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide comprising an internal sequence of the human Noggin protein. Sequence is 100% conserved in rat and mouse.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11153633

Product Specific Information

Suggested positive control: antigen standard for NOG (transient overexpression lysate).

Target Information

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Noggin; Noggin precursor; symphalangism 1 (proximal)

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Gene Aliases: NOG; SYM1; SYNS1; SYNS1A

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UniProt ID: (Human) Q13253, (Mouse) P97466

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Entrez Gene ID: (Human) 9241, (Rat) 25495, (Mouse) 18121

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Function(s)
protein binding cytokine binding protein complex binding protein homodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation urogenital system development ureteric bud development in utero embryonic development endoderm formation mesoderm formation epithelial to mesenchymal transition neural plate morphogenesis neural tube closure pattern specification process axon guidance central nervous system development brain development motor neuron axon guidance dorsal/ventral pattern formation negative regulation of gene expression spinal cord development cell differentiation in hindbrain neural tube development pituitary gland development negative regulation of cell migration BMP signaling pathway regulation of BMP signaling pathway negative regulation of BMP signaling pathway forebrain development somatic stem cell population maintenance wound healing middle ear morphogenesis embryonic digit morphogenesis regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter axial mesoderm development notochord morphogenesis anatomical structure formation involved in morphogenesis embryonic skeletal system development negative regulation of astrocyte differentiation mesenchymal cell differentiation positive regulation of epithelial cell proliferation cartilage development negative regulation of cardiac muscle cell proliferation limb development embryonic skeletal joint morphogenesis negative regulation of cytokine activity face morphogenesis negative regulation of pathway-restricted SMAD protein phosphorylation lung morphogenesis prostatic bud formation ureteric bud formation fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of cartilage development somite development cellular response to BMP stimulus negative regulation of canonical Wnt signaling pathway positive regulation of branching involved in ureteric bud morphogenesis positive regulation of glomerulus development regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of apoptotic signaling pathway multicellular organism development cell differentiation negative regulation of cell differentiation nervous system development
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