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Invitrogen
Nogo-A Polyclonal Antibody
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Nogo-A Antibody (PA5-142449) in IHC (P)
Immunohistochemistry analysis of Nogo-A in human brain, cortex. Samples were incubated with Nogo-A polyclonal antibody (Product # PA5-142449) using a dilution of 2.5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-142449
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-KAQIVTEKNTSTKTS.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933097
Product Specific Information
Additional Information: This antibody is expected to recognize reported isoform A (NP_065393.1) and isoform E (NP_997404.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Foocen; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; Nogo protein; NSP; reticulon 5; Reticulon-4; Reticulon-5; RTN-x
Gene Aliases: ASY; KIAA0886; My043; Nbla00271; Nbla10545; NI220/250; NOGO; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507
UniProt ID: (Human) Q9NQC3
Entrez Gene ID: (Human) 57142
apoptotic process
axonal fasciculation
cerebral cortex radial glia guided migration
negative regulation of cell growth
negative regulation of axon extension
regulation of apoptotic process
negative regulation of axonogenesis
nuclear pore complex assembly
cardiac epithelial to mesenchymal transition
endoplasmic reticulum tubular network organization
endoplasmic reticulum tubular network assembly
cell-cell adhesion
regulation of branching morphogenesis of a nerve
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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