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Invitrogen
Npr2 Recombinant Rabbit Monoclonal Antibody (1S1H1)
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FIGURE: 1 / 1
Npr2 Antibody (MA5-37887) in WB
Western blot analysis of Npr2 in extracts of various cell lines. Samples were incubated with Npr2 Monoclonal antibody (Product # MA5-37887) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
MA5-37887
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1S1H1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human ANPRB/NRP2 (P20594)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897807
Product Specific Information
Positive Samples: Mouse lung, Mouse spleen
Immunogen sequence: NLLLRMEQYA NNLEKLVEER TQAYLEEKRK AEALLYQILP HSVAEQLKRG ETVQAEAFDS VTIYFSDIVG FTALSAESTP MQVVTLLNDL YTCFDAIIDN F
Target Information
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANP-B; ANPR-B; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; GC-B; Guanylate cyclase B; guanylyl cyclase-B; natriuretic peptide receptor B type; Nppb receptor; NPR-B
Gene Aliases: cn; GC-B; GC-B2; GC-B3; mNPR-B; Npr2; pwe
UniProt ID: (Mouse) Q6VVW5
Entrez Gene ID: (Mouse) 230103
nucleotide binding
guanylate cyclase activity
protein kinase activity
ATP binding
GTP binding
transferase activity, transferring phosphorus-containing groups
lyase activity
phosphorus-oxygen lyase activity
natriuretic peptide receptor activity
peptide hormone binding
hormone binding
identical protein binding
ossification
cGMP biosynthetic process
protein phosphorylation
signal transduction
receptor guanylyl cyclase signaling pathway
cyclic nucleotide biosynthetic process
intracellular signal transduction
single organism reproductive process
negative regulation of meiotic cell cycle
bone development
negative regulation of oocyte maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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