Invitrogen

Nuclear Pore Complex Monoclonal Antibody (39C7)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-33097

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

39C7

Immunogen

Yeast nuclear preparations

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

10mM sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2802647

Target Information

The nuclear pore complex (NPC) serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. Each NPC consists of ~1,000 protein subunits, termed nucleoporins, and totals to a molecular mass of ~110 Mda. NPCs maintain the integrity of the nuclear compartment by preventing macromolecules from freely diffusing in or out of the nucleus. (Annu Rev Biochem, 2019. PMID 30883195)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 107 kDa nucleoporin; 133 kDa nucleoporin; 153 kDa nucleoporin; 155 kDa nucleoporin; 160 kDa nucleoporin; 205 kDa nucleoporin; 214 kDa nucleoporin; 35 kDa nucleoporin; 50 kDa nucleoporin; 62 kDa nucleoporin; 85 kDa nucleoporin; 88 kDa nuclear pore complex protein; 88 kDa nucleoporin; 93 kDa nucleoporin; 98 kDa nucleoporin; CAN protein, putative oncogene; CBP-interacting protein 4; FROUNT; Gene trap locus 1-13 protein; gene trap locus-13; GLFG-repeat containing nucleoporin; GTL-13; karyoporin; Mitotic phosphoprotein 44; MP-44; Nuclear envelope pore membrane protein POM 210; nuclear pore associated protein 60 kDa; nuclear pore complex 1; nuclear pore complex protein 88; nuclear pore complex protein hnup153; Nuclear pore complex protein Nup107; Nuclear pore complex protein Nup133; Nuclear pore complex protein Nup153; Nuclear pore complex protein Nup155; Nuclear pore complex protein Nup160; Nuclear pore complex protein Nup205; Nuclear pore complex protein Nup214; Nuclear pore complex protein Nup50; Nuclear pore complex protein Nup53; Nuclear pore complex protein Nup85; Nuclear pore complex protein Nup88; Nuclear pore complex protein Nup93; nuclear pore complex protein Nup98; Nuclear pore complex protein Nup98-Nup96; nuclear pore glycoprotein 62; Nuclear pore glycoprotein p62; Nuclear pore membrane glycoprotein 210; nuclear pore membrane protein 210; Nuclear pore protein gp210; Nuclear pore-associated protein 60 kDa-like; nuclear pore-associated protein 60L; nucleoporin 107kDa; nucleoporin 133; nucleoporin 133kD; nucleoporin 133kDa; nucleoporin 153kD; nucleoporin 153kDa; nucleoporin 155kD; nucleoporin 155kDa; nucleoporin 160kD; nucleoporin 160kDa; nucleoporin 205kDa; nucleoporin 210; nuclear pore membrane glycoprotein 210; nuclear pore membrane protein 210; nucleoporin 210kDa; nucleoporin 214kDa; nucleoporin 35kDa; nucleoporin 50 kDa; nucleoporin 50kD; nucleoporin 50kDa; nucleoporin 62kD; nucleoporin 62kDa; nucleoporin 85kDa; nucleoporin 88kDa; nucleoporin 93kDa; nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup107; Nucleoporin Nup133; Nucleoporin Nup153; Nucleoporin Nup155; Nucleoporin Nup160; Nucleoporin Nup205; Nucleoporin Nup210; Nucleoporin Nup214; Nucleoporin NUP35; Nucleoporin Nup50; Nucleoporin NUP53; Nucleoporin Nup62; Nucleoporin Nup75; Nucleoporin Nup84; Nucleoporin Nup85; Nucleoporin Nup88; Nucleoporin Nup93; nucleoporin Nup98; nucleoprotein 50; Nucleoprotein 50kD; Nup98-Nup96; NUP98/PHF23 fusion 2 protein; p105; P140; pericentrin 1; Pericentrin-1; POM210; Pore membrane protein of 210 kDa; preimplantation protein 2; Protein CAN

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Gene Aliases: 160kDa; 1700030K07Rik; 2310006I24Rik; 2410008G02Rik; 2810011M03Rik; 35kDa; 3830404O05Rik; 4732457F17; 5330402E05Rik; 9830001L10; AA414952; AA589433; ADAR2; ADIR2; AI413123; AI426861; AI790512; AI836801; AI849286; ATFB15; AU020188; AU045898; AV248391; AW541137; B130015D15Rik; BC039282; C76801; C7orf14; C88147; CAIN; CAN; Cip4; D2H9S46E; D7Ertd649e; D930027M19Rik; FROUNT; gp190; GP210; Gtl-13; Gtl1-13; Gtl13; hNUP133; HNUP153; IBSN; KIAA0023; KIAA0095; KIAA0197; KIAA0225; KIAA0791; KIAA0906; mermaid; mKIAA0197; mKIAA0225; mKIAA0791; MP-44; MP44; N153; N155; NIC96; NO44; NP44; Np62; NPAP60; NPAP60L; NPHS11; NPHS12; NPHS13; NUCZINK; NUP107; NUP120; NUP133; NUP153; NUP155; NUP160; NUP196; NUP205; NUP210; NUP214; NUP35; NUP50; NUP53; NUP62; NUP75; NUP84; NUP85; NUP88; NUP93; NUP96; NUP98; Nupc1; p62; PCNT1; POM210; Prei2; PRO1146; PSEC0245; RGD1304977; Rtp60; SNDI

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UniProt ID: (Human) P57740, (Human) Q8WUM0, (Human) P49790, (Human) O75694, (Human) Q12769, (Human) Q92621, (Human) Q8TEM1, (Human) P35658, (Human) Q8NFH5, (Human) Q9UKX7, (Human) P37198, (Human) Q9BW27, (Human) Q99567, (Human) Q8N1F7, (Human) P52948, (Rat) O08587, (Mouse) Q8BH74, (Mouse) Q8R0G9, (Rat) P37199, (Mouse) Q99P88, (Mouse) Q9Z0W3, (Rat) P11654, (Mouse) Q9QY81, (Mouse) Q80U93, (Rat) Q68FY1, (Mouse) Q8R4R6, (Mouse) Q9JIH2, (Rat) P17955, (Mouse) Q63850, (Rat) Q4QQS8, (Mouse) Q8R480, (Mouse) Q8CEC0, (Rat) O08658, (Mouse) Q8BJ71, (Rat) Q66HC5, (Mouse) Q6PFD9, (Rat) P49793

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Entrez Gene ID: (Human) 57122, (Human) 55746, (Human) 9972, (Human) 9631, (Human) 23279, (Human) 23165, (Human) 23225, (Human) 8021, (Human) 129401, (Human) 10762, (Human) 23636, (Human) 79902, (Human) 4927, (Human) 9688, (Human) 4928, (Rat) 25497, (Rat) 116555, (Mouse) 103468, (Mouse) 234865, (Rat) 292085, (Rat) 25281, (Mouse) 218210, (Rat) 117021, (Mouse) 170762, (Mouse) 59015, (Rat) 311182, (Mouse) 70699, (Rat) 362335, (Rat) 58958, (Mouse) 54563, (Mouse) 227720, (Rat) 296634, (Rat) 295692, (Mouse) 69482, (Mouse) 18141, (Rat) 65274, (Mouse) 18226, (Rat) 287830, (Mouse) 445007, (Mouse) 19069, (Rat) 113929, (Mouse) 71805, (Rat) 291874, (Mouse) 269966, (Rat) 81738

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Function(s)
nucleocytoplasmic transporter activity protein binding structural constituent of nuclear pore chromatin binding double-stranded DNA binding nuclear localization sequence binding zinc ion binding Ran GTPase binding identical protein binding protein anchor transporter activity protein dimerization activity nuclear export signal receptor activity nucleotide binding single-stranded DNA binding phospholipid binding kinesin binding receptor signaling complex scaffold activity Hsp70 protein binding SH2 domain binding ubiquitin binding thyroid hormone receptor binding PTB domain binding Hsp90 protein binding RNA binding porin activity DNA binding protein homodimerization activity CCR2 chemokine receptor binding peptide binding
Process(es)
protein transport mRNA transport nucleocytoplasmic transport negative regulation of RNA export from nucleus nuclear pore complex assembly transmembrane transport protein import into nucleus, docking DNA replication transport neural tube formation mRNA export from nucleus nuclear pore organization paraxial mesoderm development positive regulation of defense response to virus by host tRNA export from nucleus protein import into nucleus nuclear envelope organization mitotic nuclear envelope disassembly regulation of glucose transport viral process protein sumoylation poly(A)+ mRNA export from nucleus viral transcription gene silencing by RNA positive regulation of SMAD protein import into nucleus SMAD protein signal transduction renal system development glomerular visceral epithelial cell development intracellular transport of virus glomerular visceral epithelial cell migration mitophagy in response to mitochondrial depolarization xenophagy regulation of cellular response to heat negative regulation of hydrogen peroxide-induced cell death protein export from nucleus regulation of cell cycle posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery regulation of transcription, DNA-templated sister chromatid cohesion transcription, DNA-templated RNA export from nucleus mitotic nuclear division cell surface receptor signaling pathway spermatogenesis cell aging cell death negative regulation of cell proliferation hormone-mediated signaling pathway regulation of signal transduction negative regulation of epidermal growth factor receptor signaling pathway regulation of protein import into nucleus negative regulation of apoptotic process negative regulation of programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated regulation of Ras protein signal transduction negative regulation of Ras protein signal transduction protein heterotrimerization ribonucleoprotein complex export from nucleus regulation of mRNA stability biological_process lamellipodium assembly macrophage chemotaxis transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery chromatin organization neural tube development neurogenesis nuclear pore distribution somite development ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus protein targeting to nuclear inner membrane atrial cardiac muscle cell action potential NLS-bearing protein import into nucleus chemotaxis viral entry into host cell viral penetration into host nucleus cell migration cytokine-mediated signaling pathway intracellular transport telomere tethering at nuclear periphery
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