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Invitrogen
Nurr1 Polyclonal Antibody
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Product Details
PA5-13416
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human NURR1 (NR4A2)
Conjugate
Form
Liquid
Concentration
2.0 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2153896
Product Specific Information
This antibody is predicted to react with bovine and rat based on sequence homology.
Target Information
The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HZF3; Immediate-early response protein NOT; intermediate-early receptor protein; NGFI-B; NGFI-B beta; NGFI-B/nur77 beta-type transcription factor homolog; nuclear receptor related 1; Nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4, group A, member 2; nur related protein 1; nur related protein-1, human homolog of; NUR-related factor 1; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; T-cell nuclear receptor NOT; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor
Gene Aliases: HZF-3; NOT; NR4A2; NURR1; RNR-1; RNR1; TINOR; TINUR
UniProt ID: (Human) P43354, (Mouse) Q06219
Entrez Gene ID: (Human) 4929, (Mouse) 18227
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
beta-catenin binding
zinc ion binding
glucocorticoid receptor binding
protein homodimerization activity
retinoid X receptor binding
protein heterodimerization activity
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
response to hypoxia
neuron migration
response to amphetamine
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
adult locomotory behavior
post-embryonic development
response to inorganic substance
gene expression
regulation of gene expression
obsolete death
response to insecticide
central nervous system projection neuron axonogenesis
central nervous system neuron differentiation
habenula development
neuron differentiation
intracellular receptor signaling pathway
cellular response to extracellular stimulus
cellular response to oxidative stress
regulation of dopamine metabolic process
dopamine biosynthetic process
dopamine metabolic process
neuron maturation
positive regulation of catalytic activity
steroid hormone mediated signaling pathway
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
general adaptation syndrome
dopaminergic neuron differentiation
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
signal transduction
fat cell differentiation
canonical Wnt signaling pathway
cellular response to corticotropin-releasing hormone stimulus
midbrain dopaminergic neuron differentiation
negative regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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