Product References
O-GlcNAcylation regulates extracellular signal-regulated kinase (ERK) activation in Alzheimer's disease.
Frontiers in aging neuroscience
Ephrame SJ,Cork GK,Marshall V,Johnston MA,Shawa J,Alghusen I,Qiang A,Denson AR,Carman MS,Fedosyuk H,Swerdlow RH,Slawson C
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Sat Feb 24 00:00:00 UTC 2024
Cancer-associated fibroblast-secreted glucosamine alters the androgen biosynthesis program in prostate cancer via HSD3B1 upregulation.
The Journal of clinical investigation
Cui D,Li J,Zhu Z,Berk M,Hardaway A,McManus J,Chung YM,Alyamani M,Valle S,Tiwari R,Han B,Goudarzi M,Willard B,Sharifi N
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Mon Apr 03 00:00:00 UTC 2023
O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.
Respiratory research
Xuefei Y,Dongyan L,Tianming L,Hejuan Z,Jianhua F
MA1-072 was used in ChIP Assay, Dot Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry to reveal that the decreased O-GlcNAc levels and increased O-GlcNAcylation of Parkin might cause hyperoxia-induced alveolar type II cells injurys.
Mon Jan 16 00:00:00 UTC 2023
O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.
Respiratory research
Xuefei Y,Dongyan L,Tianming L,Hejuan Z,Jianhua F
MA1-072 was used in ChIP Assay, Dot Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry to reveal that the decreased O-GlcNAc levels and increased O-GlcNAcylation of Parkin might cause hyperoxia-induced alveolar type II cells injurys.
Mon Jan 16 00:00:00 UTC 2023
O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.
Respiratory research
Xuefei Y,Dongyan L,Tianming L,Hejuan Z,Jianhua F
MA1-072 was used in ChIP Assay, Dot Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry to reveal that the decreased O-GlcNAc levels and increased O-GlcNAcylation of Parkin might cause hyperoxia-induced alveolar type II cells injurys.
Mon Jan 16 00:00:00 UTC 2023
O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.
Respiratory research
Xuefei Y,Dongyan L,Tianming L,Hejuan Z,Jianhua F
MA1-072 was used in ChIP Assay, Dot Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry to reveal that the decreased O-GlcNAc levels and increased O-GlcNAcylation of Parkin might cause hyperoxia-induced alveolar type II cells injurys.
Mon Jan 16 00:00:00 UTC 2023
Inhibition of O-GlcNAcylation protects from Shiga toxin-mediated cell injury and lethality in host.
EMBO molecular medicine
Lee KS,Lee J,Lee P,Jeon BC,Song MY,Kwak S,Lee J,Kim JS,Kim DJ,Kim JH,Tesh VL,Lee MS,Park SK
MA1-072 was used in Western Blotting to report that O-GlcNAcylation was acutely increased upon induction of endoplasmic reticulum stress in host cells by Shiga toxins.
Tue Jan 11 00:00:00 UTC 2022
O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression.
Cell death and differentiation
Liu YY,Liu HY,Yu TJ,Lu Q,Zhang FL,Liu GY,Shao ZM,Li DQ
MA1-072 was used in Immunohistochemistry to uncover a previously unrecognized mechanistic role for MORC2 O-GlcNAcylation in breast cancer progression and provide evidence for targeting MORC2-dependent breast cancer through blocking its O-GlcNAcylation.
Fri Apr 01 00:00:00 UTC 2022
Evaluation of the expression of fatty acid synthase and O-GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches.
Oncology letters
Raab S,Very N,Duchêne B,Rybarczyk P,Jonckheere N,El Yazidi-Belkoura I,Lefebvre T
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Fri Apr 01 00:00:00 UTC 2022
O-GlcNAcylation and Regulation of Galectin-3 in Extraembryonic Endoderm Differentiation.
Biomolecules
Gatie MI,Spice DM,Garha A,McTague A,Ahmer M,Timoshenko AV,Kelly GM
MA1-072 was used in Western Blot to explore galectin-3 as a candidate protein known to have various intracellular and extracellular functions.
Fri Apr 22 00:00:00 UTC 2022
O-GlcNAc transferase plays a non-catalytic role in C. elegans male fertility.
PLoS genetics
Konzman D,Fukushige T,Dagnachew M,Krause M,Hanover JA
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Tue Nov 01 00:00:00 UTC 2022
O-GlcNAc transferase plays a non-catalytic role in C. elegans male fertility.
PLoS genetics
Konzman D,Fukushige T,Dagnachew M,Krause M,Hanover JA
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Tue Nov 01 00:00:00 UTC 2022
Chronically Elevated O-GlcNAcylation Limits Nitric Oxide Production and Deregulates Specific Pro-Inflammatory Cytokines.
Frontiers in immunology
Abramowitz LK,Hanover JA
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Tue Apr 19 00:00:00 UTC 2022
O-GlcNAc-Mediated Regulation of Galectin Expression and Secretion in Human Promyelocytic HL-60 Cells Undergoing Neutrophilic Differentiation.
Biomolecules
McTague A,Tazhitdinova R,Timoshenko AV
MA1-072 was used in Western Blotting to demonstrate that O-GlcNAc homeostasis is essential not only for regulation of galectin expression in cells but also for the secretion of multiple members of this protein family, which can be an important novel aspect of unconventional secretion mechanisms.
Sun Nov 27 00:00:00 UTC 2022
Global O-GlcNAcylation changes impact desmin phosphorylation and its partition toward cytoskeleton in C2C12 skeletal muscle cells differentiated into myotubes.
Scientific reports
Claeyssen C,Bastide B,Cieniewski-Bernard C
MA1-072 was used in Western Blotting to show that phosphorylation/O-GlcNAcylation interplay is highly complex on desmin, supporting that a PTMs signature could occur on desmin to finely regulate its partition (i.e. distribution) with a spatio-temporal regulation.
Tue Jun 14 00:00:00 UTC 2022
O-GlcNAcylation in Ventral Tegmental Area Dopaminergic Neurons Regulates Motor Learning and the Response to Natural Reward.
Neuroscience bulletin
Shao MS,Yang X,Zhang CC,Jiang CY,Mao Y,Xu WD,Ma L,Wang FF
MA1-072 was used in Immunohistochemistry to suggest that protein O-GlcNAcylation of DAergic neurons in the VTA plays an important role in regulating the response to natural reward and motor learning in mice.
Tue Mar 01 00:00:00 UTC 2022
Relationship Between O-GlcNAcase Expression and Prognosis of Patients With Osteosarcoma.
Applied immunohistochemistry & molecular morphology : AIMM
Sombutthaweesri T,Wu S,Chamusri N,Settakorn J,Pruksakorn D,Chaiyawat P,Sastraruji T,Krisanaprakornkit S,Supanchart C
MA1-072 was used in Immunohistochemistry (Paraffin) to investigate the levels of O-GlcNAc and the expressions of O-linked N-acetylglucosamine transferase (OGT) and O-GlcNAcase (OGA) in human osteosarcoma tissues.
Sat Jan 01 00:00:00 UTC 2022
O-GlcNAc transferase regulates p21 protein levels and cell proliferation through the FoxM1-Skp2 axis in a p53-independent manner.
The Journal of biological chemistry
de Queiroz RM,Moon SH,Prives C
MA1-072 was used in Western Blotting to show that pharmacological inhibition or siRNA-mediated reduction of O-GlcNAc transferase (OGT), the enzyme responsible for glycosylation of intracellular proteins, increases expression of p21 in both p53-dependent and p53-independent manners in nontransformed and cancer cells.
Thu Sep 01 00:00:00 UTC 2022
The WNK1 kinase regulates the stability of transcription factors during wound healing of human corneal epithelial cells.
Journal of cellular physiology
Desjardins P,Le-Bel G,Ghio SC,Germain L,Guérin SL
MA1-072 was used in ChIP Assay, Dot Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to demonstrate that WNK1 plays a critical function by orienting hCECs into the appropriate biological response during the process of corneal wound healing.
Sun May 01 00:00:00 UTC 2022
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.
Nature chemical biology
Shu XE,Mao Y,Jia L,Qian SB
MA1-072 was used in ChIP Assay, Dot Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to illustrate a mechanism in balancing ribosome recycling and reinitiation, thereby linking the nutrient stress response and translational reprogramming.
Tue Feb 01 00:00:00 UTC 2022
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.
Nature chemical biology
Shu XE,Mao Y,Jia L,Qian SB
MA1-072 was used in ChIP Assay, Dot Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to illustrate a mechanism in balancing ribosome recycling and reinitiation, thereby linking the nutrient stress response and translational reprogramming.
Tue Feb 01 00:00:00 UTC 2022
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity.
Nature chemistry
Balana AT,Levine PM,Craven TW,Mukherjee S,Pedowitz NJ,Moon SP,Takahashi TT,Becker CFW,Baker D,Pratt MR
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Sat May 01 00:00:00 UTC 2021
MYPT1 O-GlcNAc modification regulates sphingosine-1-phosphate mediated contraction.
Nature chemical biology
Pedowitz NJ,Batt AR,Darabedian N,Pratt MR
MA1-072 was used in Western Blotting to describe the role of O-GlcNAc in fibroblast motility and differentiation, particularly in diabetic wound healing.
Mon Feb 01 00:00:00 UTC 2021
Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction.
Burns & trauma
Zhang J,Yang P,Liu D,Gao M,Wang J,Yu T,Zhang X,Liu Y
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Wed Apr 27 00:00:00 UTC 2022
O-GlcNAcylation protein disruption by Thiamet G promotes changes on the GBM U87-MG cells secretome molecular signature.
Clinical proteomics
Oliveira-Nunes MC,Julião G,Menezes A,Mariath F,Hanover JA,Evaristo JAM,Nogueira FCS,Dias WB,de Abreu Pereira D,Carneiro K
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Mon Apr 26 00:00:00 UTC 2021
Suppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor.
Cells
Ricciardiello F,Bergamaschi L,De Vitto H,Gang Y,Zhang T,Palorini R,Chiaradonna F
MA1-072 was used in Western Blotting to demonstrate that pancreatic ductal adenocarcinoma cells expressing oncogenic KRAS, owing to an increase in the HBP flux, become strongly reliant on HBP for both proliferation and survival.
Thu Feb 18 00:00:00 UTC 2021
Suppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor.
Cells
Ricciardiello F,Bergamaschi L,De Vitto H,Gang Y,Zhang T,Palorini R,Chiaradonna F
MA1-072 was used in Western Blotting to demonstrate that pancreatic ductal adenocarcinoma cells expressing oncogenic KRAS, owing to an increase in the HBP flux, become strongly reliant on HBP for both proliferation and survival.
Thu Feb 18 00:00:00 UTC 2021
O-GlcNAc modification of MYPT1 modulates lysophosphatidic acid-induced cell contraction in fibroblasts.
The Journal of biological chemistry
Morales MM,Pedowitz NJ,Pratt MR
MA1-072 was used in Functional Assay to solidify the importance of O-GlcNAc in regulating the biology of fibroblasts in response to procontractile stimuli.
Tue Aug 31 00:00:00 UTC 2021
Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass.
Scientific reports
Akinbiyi EO,Abramowitz LK,Bauer BL,Stoll MSK,Hoppel CL,Hsiao CP,Hanover JA,Mears JA
MA1-072 was used in Immunoprecipitation to highlight the impact of O-GlcNAcylation on mitochondrial dynamics and ETC function and mimic the changes that may occur during glucose toxicity from hyperglycemia.
Thu Nov 11 00:00:00 UTC 2021
O-GlcNAcylation Affects the Pathway Choice of DNA Double-Strand Break Repair.
International journal of molecular sciences
Averbek S,Jakob B,Durante M,Averbeck NB
MA1-072 was used in Immunoprecipitation to study the role of the post-translational modification, O-linked β-N-acetylglucosaminylation, on the cellular DNA damage response.
Thu May 27 00:00:00 UTC 2021
Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells.
The EMBO journal
Maffei B,Laverrière M,Wu Y,Triboulet S,Perrinet S,Duchateau M,Matondo M,Hollis RL,Gourley C,Rupp J,Keillor JW,Subtil A
MA1-072 was used in Western Blot to study the expression profile and downstream effects of transglutaminase 2 during cellular infection with Chlamydia trachomatis.
Wed Apr 15 00:00:00 UTC 2020
Blockage of O-linked GlcNAcylation induces AMPK-dependent autophagy in bladder cancer cells.
Cellular & molecular biology letters
Jin L,Yuan F,Dai G,Yao Q,Xiang H,Wang L,Xue B,Shan Y,Liu X
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Fri Dec 04 00:00:00 UTC 2020
O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes.
Oxidative medicine and cellular longevity
Yu H,Wen L,Mu Y
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Immunoprecipitation
Fri May 14 00:00:00 UTC 2021
O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes.
Oxidative medicine and cellular longevity
Yu H,Wen L,Mu Y
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Immunoprecipitation
Fri May 14 00:00:00 UTC 2021
OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer's Disease Cytoplasmic Hybrids.
Journal of Alzheimer's disease : JAD
Flax J,Wilkins HM,Miller R,Griffith S,Cork GK,Qiang A,Thompson J,Swerdlow RH,Slawson C
MA1-072 was used in Western Blotting to suggest that modulation of O-GlcNAc is essential for proper energetic function of the mitochondria, and AD mitochondrial capacity to handle nutrient-excess is limited.
Wed Sep 29 00:00:00 UTC 2021
O-GlcNAcylation promotes malignant phenotypes of bladder cancer cells.
Neoplasma
Jin L,Lu MH,Dai GC,Yao Q,Xiang H,Wang LX,Xue BX,Liu X
MA1-072 was used in Western Blotting to evaluate the expression and function of both OGT and OGA in bladder cancer cells in vitro and in vivo.
Wed Jul 01 00:00:00 UTC 2020
Evidence of a compensatory regulation of colonic O-GlcNAc transferase and O-GlcNAcase expression in response to disruption of O-GlcNAc homeostasis.
Biochemical and biophysical research communications
Decourcelle A,Loison I,Baldini S,Leprince D,Dehennaut V
MA1-072 was used in Western Blotting to suggest that the regulation of colonic OGA expression in response to changes in O-GlcNAc homeostasis occurs mostly at the transcriptional level whereas OGT regulation seems to rely mainly on post-transcriptional mechanisms.
Wed Jan 01 00:00:00 UTC 2020
Enhancement of O-linked N-acetylglucosamine modification promotes metastasis in patients with colorectal cancer and concurrent type 2 diabetes mellitus.
Oncology letters
Naka Y,Okada T,Nakagawa T,Kobayashi E,Kawasaki Y,Tanaka Y,Tawa H,Hirata Y,Kawakami K,Kakimoto K,Inoue T,Takeuchi T,Fukunishi S,Hirose Y,Uchiyama K,Asahi M,Higuchi K
MA1-072 was used in Immunohistochemistry to evaluate the level of O-GlcNAcylation in patients with colorectal cancer with or without type 2 diabetes mellitus (T2DM).
Sat Aug 01 00:00:00 UTC 2020
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization.
Journal of the American Heart Association
Brahma MK,Ha CM,Pepin ME,Mia S,Sun Z,Chatham JC,Habegger KM,Abel ED,Paterson AJ,Young ME,Wende AR
MA1-072 was used in Immunoprecipitation to show cardiac ketolytic capacity can be suppressed with increased glucose.
Tue Aug 04 00:00:00 UTC 2020
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization.
Journal of the American Heart Association
Brahma MK,Ha CM,Pepin ME,Mia S,Sun Z,Chatham JC,Habegger KM,Abel ED,Paterson AJ,Young ME,Wende AR
MA1-072 was used in Immunoprecipitation to show cardiac ketolytic capacity can be suppressed with increased glucose.
Tue Aug 04 00:00:00 UTC 2020
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization.
Journal of the American Heart Association
Brahma MK,Ha CM,Pepin ME,Mia S,Sun Z,Chatham JC,Habegger KM,Abel ED,Paterson AJ,Young ME,Wende AR
MA1-072 was used in Immunoprecipitation to show cardiac ketolytic capacity can be suppressed with increased glucose.
Tue Aug 04 00:00:00 UTC 2020
O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity.
Frontiers in immunology
Seo J,Park YS,Kweon TH,Kang J,Son S,Kim HB,Seo YR,Kang MJ,Yi EC,Lee YH,Kim JH,Park B,Yang WH,Cho JW
MA1-072 was used in Western Blotting to suggest that O-GlcNAcylation of MAVS may be a master regulatory event that promotes host defense against RNA viruses.
Thu Jul 15 00:00:00 UTC 2021
O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity.
Frontiers in immunology
Seo J,Park YS,Kweon TH,Kang J,Son S,Kim HB,Seo YR,Kang MJ,Yi EC,Lee YH,Kim JH,Park B,Yang WH,Cho JW
MA1-072 was used in Western Blotting to suggest that O-GlcNAcylation of MAVS may be a master regulatory event that promotes host defense against RNA viruses.
Thu Jul 15 00:00:00 UTC 2021
Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes.
Cells
Mytych J,Sołek P,Będzińska A,Rusinek K,Warzybok A,Tabęcka-Łonczyńska A,Koziorowski M
MA1-072 was used in Western Blotting to provide evidence of klotho involvement in the crosstalk on the line ER-Golgi, which may, in turn, affect activation of SASP.
Tue Jan 21 00:00:00 UTC 2020
O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.
PLoS genetics
Mu Y,Yu H,Wu T,Zhang J,Evans SM,Chen J
MA1-072 was used in Western Blotting to demonstrate that OGT plays an essential role in regulating heart development through activating expression of cardiomyocyte Angiopoietin-1.
Wed Apr 01 00:00:00 UTC 2020
O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.
PLoS genetics
Mu Y,Yu H,Wu T,Zhang J,Evans SM,Chen J
MA1-072 was used in Western Blotting to demonstrate that OGT plays an essential role in regulating heart development through activating expression of cardiomyocyte Angiopoietin-1.
Wed Apr 01 00:00:00 UTC 2020
O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.
PLoS genetics
Mu Y,Yu H,Wu T,Zhang J,Evans SM,Chen J
MA1-072 was used in Western Blotting to demonstrate that OGT plays an essential role in regulating heart development through activating expression of cardiomyocyte Angiopoietin-1.
Wed Apr 01 00:00:00 UTC 2020
O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.
PLoS genetics
Mu Y,Yu H,Wu T,Zhang J,Evans SM,Chen J
MA1-072 was used in Western Blotting to demonstrate that OGT plays an essential role in regulating heart development through activating expression of cardiomyocyte Angiopoietin-1.
Wed Apr 01 00:00:00 UTC 2020
The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma.
Aging
Wang J,Wang Z,Yuan J,Wang J,Shen X
MA1-072 was used in Immunohistochemistry to investigate whether and how O-GlcNAcylation and ACSL4 regulate each other and HCC progression.
Fri May 01 00:00:00 UTC 2020
The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma.
Aging
Wang J,Wang Z,Yuan J,Wang J,Shen X
MA1-072 was used in Immunohistochemistry to investigate whether and how O-GlcNAcylation and ACSL4 regulate each other and HCC progression.
Fri May 01 00:00:00 UTC 2020
The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma.
Aging
Wang J,Wang Z,Yuan J,Wang J,Shen X
MA1-072 was used in Immunohistochemistry to investigate whether and how O-GlcNAcylation and ACSL4 regulate each other and HCC progression.
Fri May 01 00:00:00 UTC 2020
The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma.
Aging
Wang J,Wang Z,Yuan J,Wang J,Shen X
MA1-072 was used in Immunohistochemistry to investigate whether and how O-GlcNAcylation and ACSL4 regulate each other and HCC progression.
Fri May 01 00:00:00 UTC 2020
O-GlcNAc stabilizes SMAD4 by inhibiting GSK-3β-mediated proteasomal degradation.
Scientific reports
Kim YJ,Kang MJ,Kim E,Kweon TH,Park YS,Ji S,Yang WH,Yi EC,Cho JW
MA1-072 was used in Western Blotting to show cellular O-linked β-N-acetylglucosamine may regulate TGF-β/SMAD signaling pathway by stabilizing SMAD4.
Mon Nov 16 00:00:00 UTC 2020
O-GlcNAc stabilizes SMAD4 by inhibiting GSK-3β-mediated proteasomal degradation.
Scientific reports
Kim YJ,Kang MJ,Kim E,Kweon TH,Park YS,Ji S,Yang WH,Yi EC,Cho JW
MA1-072 was used in Western Blotting to show cellular O-linked β-N-acetylglucosamine may regulate TGF-β/SMAD signaling pathway by stabilizing SMAD4.
Mon Nov 16 00:00:00 UTC 2020
Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex.
Scientific reports
Cho Y,Hwang H,Rahman MA,Chung C,Rhim H
MA1-072 was used in Immunohistochemistry to explore the association of O-GlcNAcylation with depressive disorder.
Fri Apr 24 00:00:00 UTC 2020
Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex.
Scientific reports
Cho Y,Hwang H,Rahman MA,Chung C,Rhim H
MA1-072 was used in Immunohistochemistry to explore the association of O-GlcNAcylation with depressive disorder.
Fri Apr 24 00:00:00 UTC 2020
Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex.
Scientific reports
Cho Y,Hwang H,Rahman MA,Chung C,Rhim H
MA1-072 was used in Immunohistochemistry to explore the association of O-GlcNAcylation with depressive disorder.
Fri Apr 24 00:00:00 UTC 2020
Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex.
Scientific reports
Cho Y,Hwang H,Rahman MA,Chung C,Rhim H
MA1-072 was used in Immunohistochemistry to explore the association of O-GlcNAcylation with depressive disorder.
Fri Apr 24 00:00:00 UTC 2020
O-GlcNAcylation Links Nutrition to the Epigenetic Downregulation of UNC5A during Colon Carcinogenesis.
Cancers
Decourcelle A,Very N,Djouina M,Loison I,Thévenet J,Body-Malapel M,Lelièvre E,Coqueret O,Leprince D,El Yazidi-Belkoura I,Dehennaut V
MA1-072 was used in Western Blotting to discover whether O-GlcNAcylation could represent one link between nutrition and epigenetic downregulation of key tumor suppressor genes governing colon carcinogenesis including UNC5A.
Wed Oct 28 00:00:00 UTC 2020
Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling.
Nature communications
Tran DH,May HI,Li Q,Luo X,Huang J,Zhang G,Niewold E,Wang X,Gillette TG,Deng Y,Wang ZV
MA1-072 was used in Western Blotting to demonstrate that the hexosamine biosynthetic pathway (HBP) is induced in cardiomyocytes during hypertrophic growth.
Tue Apr 14 00:00:00 UTC 2020
O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E.
Journal of cellular and molecular medicine
Cao B,Duan M,Xing Y,Liu C,Yang F,Li Y,Yang T,Wei Y,Gao Q,Jiang J
MA1-072 was used in Western Blotting to analyse the contribution of O-GlcNAc transferase in hepatoma cell proliferation and stem-like cell potential.
Mon Apr 01 00:00:00 UTC 2019
O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E.
Journal of cellular and molecular medicine
Cao B,Duan M,Xing Y,Liu C,Yang F,Li Y,Yang T,Wei Y,Gao Q,Jiang J
MA1-072 was used in Western Blotting to analyse the contribution of O-GlcNAc transferase in hepatoma cell proliferation and stem-like cell potential.
Mon Apr 01 00:00:00 UTC 2019
O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E.
Journal of cellular and molecular medicine
Cao B,Duan M,Xing Y,Liu C,Yang F,Li Y,Yang T,Wei Y,Gao Q,Jiang J
MA1-072 was used in Western Blotting to analyse the contribution of O-GlcNAc transferase in hepatoma cell proliferation and stem-like cell potential.
Mon Apr 01 00:00:00 UTC 2019
Mechanical stress alters protein O-GlcNAc in human periodontal ligament cells.
Journal of cellular and molecular medicine
Frank D,Cser A,Kolarovszki B,Farkas N,Miseta A,Nagy T
MA1-072 was used in Western Blotting to suggest that structural changes stimulated by compression forces have a significant effect on the regulation of O-GlcNAc; thus, it might play a role in the mechanical stress adaptation of PDL cells.
Sun Sep 01 00:00:00 UTC 2019
Disruption of O-GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization.
Molecular reproduction and development
Zhou LT,Romar R,Pavone ME,Soriano-Úbeda C,Zhang J,Slawson C,Duncan FE
MA1-072 was used in Immunocytochemistry to investigated O-GlcNAcylation dynamics in bovine and human oocytes during meiosis and determined the developmental sequelae of its perturbation.
Wed May 01 00:00:00 UTC 2019
Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development.
Scientific reports
Abramowitz LK,Harly C,Das A,Bhandoola A,Hanover JA
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Thu Aug 29 00:00:00 UTC 2019
Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise.
Frontiers in immunology
Nagy T,Kátai E,Fisi V,Takács TT,Stréda A,Wittmann I,Miseta A
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Flow Cytometry
Wed Jul 03 00:00:00 UTC 2019
Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise.
Frontiers in immunology
Nagy T,Kátai E,Fisi V,Takács TT,Stréda A,Wittmann I,Miseta A
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Flow Cytometry
Wed Jul 03 00:00:00 UTC 2019
Changes in Protein O-GlcNAcylation During Mouse Epididymal Sperm Maturation.
Frontiers in cell and developmental biology
Tourzani DA,Paudel B,Miranda PV,Visconti PE,Gervasi MG
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Sat Oct 24 00:00:00 UTC 2020
Synaptic protein changes after a chronic period of sensorimotor perturbation in adult rats: a potential role of phosphorylation/O-GlcNAcylation interplay.
Journal of neurochemistry
Fourneau J,Canu MH,Cieniewski-Bernard C,Bastide B,Dupont E
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Mon Oct 01 00:00:00 UTC 2018
O-Linked N-Acetylglucosamine Transiently Elevates in HeLa Cells during Mitosis.
Molecules (Basel, Switzerland)
Fisi V,Kátai E,Orbán J,Dossena S,Miseta A,Nagy T
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Sat May 26 00:00:00 UTC 2018
O-GlcNAc transferase missense mutations linked to X-linked intellectual disability deregulate genes involved in cell fate determination and signaling.
The Journal of biological chemistry
Selvan N,George S,Serajee FJ,Shaw M,Hobson L,Kalscheuer V,Prasad N,Levy SE,Taylor J,Aftimos S,Schwartz CE,Huq AM,Gecz J,Wells L
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Fri Jul 06 00:00:00 UTC 2018
O-GlcNAc transferase missense mutations linked to X-linked intellectual disability deregulate genes involved in cell fate determination and signaling.
The Journal of biological chemistry
Selvan N,George S,Serajee FJ,Shaw M,Hobson L,Kalscheuer V,Prasad N,Levy SE,Taylor J,Aftimos S,Schwartz CE,Huq AM,Gecz J,Wells L
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Fri Jul 06 00:00:00 UTC 2018
A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts.
The Journal of biological chemistry
St Amand MM,Bond MR,Riedy J,Comly M,Shiloach J,Hanover JA
MA1-072 was used in Western Blotting to develop an immortalized MEF cell line on which the role of O-GlcNAc cycling in mammalian biological processes can be studied.
Fri Aug 31 00:00:00 UTC 2018
A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts.
The Journal of biological chemistry
St Amand MM,Bond MR,Riedy J,Comly M,Shiloach J,Hanover JA
MA1-072 was used in Western Blotting to develop an immortalized MEF cell line on which the role of O-GlcNAc cycling in mammalian biological processes can be studied.
Fri Aug 31 00:00:00 UTC 2018
O-GlcNAc Signaling Orchestrates the Regenerative Response to Neuronal Injury in Caenorhabditis elegans.
Cell reports
Taub DG,Awal MR,Gabel CV
MA1-072 was used in Western Blotting to show that O-GlcNAc signalling conveys cellular nutrient status to orchestrate metabolism in a damaged neuron and maximise the regenerative response.
Tue Aug 21 00:00:00 UTC 2018
Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis.
Cell death & disease
Ricciardiello F,Votta G,Palorini R,Raccagni I,Brunelli L,Paiotta A,Tinelli F,D'Orazio G,Valtorta S,De Gioia L,Pastorelli R,Moresco RM,La Ferla B,Chiaradonna F
MA1-072 was used in Western Blotting to report the preclinical evaluation of FR054, a novel inhibitor of the Hexosamine Biosynthetic Pathway enzyme PGM3, with a remarkable anti-breast cancer effect.
Wed Mar 07 00:00:00 UTC 2018
Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice.
Diabetologia
Ida S,Morino K,Sekine O,Ohashi N,Kume S,Chano T,Iwasaki K,Harada N,Inagaki N,Ugi S,Maegawa H
MA1-072 was used in Western Blotting to investigate whether the loss of O-GlcNAcylation globally and in specific organs affects glucose metabolism in mammals under physiological conditions.
Fri Sep 01 00:00:00 UTC 2017
Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis.
Diabetes
Ohashi N,Morino K,Ida S,Sekine O,Lemecha M,Kume S,Park SY,Choi CS,Ugi S,Maegawa H
MA1-072 was used in Western Blotting to examine the role of O-linked N-acetylglucosamine modification in adipose tissues.
Fri Sep 01 00:00:00 UTC 2017
Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells.
The Journal of biological chemistry
Sacoman JL,Dagda RY,Burnham-Marusich AR,Dagda RK,Berninsone PM
MA1-072 was used in western blot to study the role of O-linked N-acetylglucosamine transferase in mitochondria
Fri Mar 17 00:00:00 UTC 2017
Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells.
The Journal of biological chemistry
Sacoman JL,Dagda RY,Burnham-Marusich AR,Dagda RK,Berninsone PM
MA1-072 was used in western blot to study the role of O-linked N-acetylglucosamine transferase in mitochondria
Fri Mar 17 00:00:00 UTC 2017
A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis.
Cell reports
Park SK,Zhou X,Pendleton KE,Hunter OV,Kohler JJ,O'Donnell KA,Conrad NK
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Tue Aug 01 00:00:00 UTC 2017
LXRα Regulates Hepatic ChREBPα Activity and Lipogenesis upon Glucose, but Not Fructose Feeding in Mice.
Nutrients
Fan Q,Nørgaard RC,Bindesbøll C,Lucas C,Dalen KT,Babaie E,Itkonen HM,Matthews J,Nebb HI,Grønning-Wang LM
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Thu Jun 29 00:00:00 UTC 2017
Identification and characterization of a missense mutation in the O-linked β-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability.
The Journal of biological chemistry
Vaidyanathan K,Niranjan T,Selvan N,Teo CF,May M,Patel S,Weatherly B,Skinner C,Opitz J,Carey J,Viskochil D,Gecz J,Shaw M,Peng Y,Alexov E,Wang T,Schwartz C,Wells L
MA1-072 was used in Western Blotting to identify a single amino acid substitution in the regulatory domain of OGT, which appears causal for X-linked intellectual disability.
Fri May 26 00:00:00 UTC 2017
Nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) is regulated by O-GlcNAc transferase.
Free radical biology & medicine
Han JW,Valdez JL,Ho DV,Lee CS,Kim HM,Wang X,Huang L,Chan JY
MA1-072 was used in Western Blotting to find that overexpression of HCF1 and OGT leads to increased Nrf1a protein stability.
Fri Sep 01 00:00:00 UTC 2017
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
Wang AC,Jensen EH,Rexach JE,Vinters HV,Hsieh-Wilson LC
MA1-072 was used in immunohistochemistry and western blot to characterize mice with a forebrain-specific loss of O-GlcNAc glycosylation
Tue Dec 27 00:00:00 UTC 2016
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America
Wang AC,Jensen EH,Rexach JE,Vinters HV,Hsieh-Wilson LC
MA1-072 was used in immunohistochemistry and western blot to characterize mice with a forebrain-specific loss of O-GlcNAc glycosylation
Tue Dec 27 00:00:00 UTC 2016
Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease.
Pharmacological research
Gatta E,Lefebvre T,Gaetani S,dos Santos M,Marrocco J,Mir AM,Cassano T,Maccari S,Nicoletti F,Mairesse J
MA1-072 was used in western blot to study tau phosphorylation and O-GlcNAcylation in a mouse model of Alzheimer's disease
Tue Mar 01 00:00:00 UTC 2016
O-GlcNAcylation enhances anaplastic thyroid carcinoma malignancy.
Oncology letters
Cheng YU,Li H,Li J,Li J,Gao Y,Liu B
MA1-072 was used in western blot to assess the enhancement of anaplastic thyroid carcinoma malignancy by O-GlcNAcylation
Fri Jul 01 00:00:00 UTC 2016
Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells.
Oncology letters
Qiao Z,Dang C,Zhou B,Li S,Zhang W,Jiang J,Zhang J,Ma Y,Kong R,Ma Z
MA1-072 was used in western blot to investigate a decreased MMP9 expression in human esophageal cancer cells cause by downregulation of O-linked N-acetylgucosamine transferase by RNA intereference
Sun May 01 00:00:00 UTC 2016
Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18.
The Journal of biological chemistry
Kakade PS,Budnar S,Kalraiya RD,Vaidya MM
MA1-072 was used in western blot to characterize O-GlcNAcylation-dependent phosphorylation and functional implications at a proximal site on keratin 18
Fri Jun 03 00:00:00 UTC 2016
Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18.
The Journal of biological chemistry
Kakade PS,Budnar S,Kalraiya RD,Vaidya MM
MA1-072 was used in western blot to characterize O-GlcNAcylation-dependent phosphorylation and functional implications at a proximal site on keratin 18
Fri Jun 03 00:00:00 UTC 2016
Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation.
The Journal of biological chemistry
Akan I,Love DC,Harwood KR,Bond MR,Hanover JA
MA1-072 was used in western blot to analyze global pertubing of chromatin O-GlcNAcylation after drosophila O-GlcNAcase deletion
Fri May 06 00:00:00 UTC 2016
Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation.
The Journal of biological chemistry
Akan I,Love DC,Harwood KR,Bond MR,Hanover JA
MA1-072 was used in western blot to analyze global pertubing of chromatin O-GlcNAcylation after drosophila O-GlcNAcase deletion
Fri May 06 00:00:00 UTC 2016
SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells.
eLife
Myers SA,Peddada S,Chatterjee N,Friedrich T,Tomoda K,Krings G,Thomas S,Maynard J,Broeker M,Thomson M,Pollard K,Yamanaka S,Burlingame AL,Panning B
MA1-072 was used in western blot to elucidate modulation of gene expression in pluripotent cells by SOX2 O-GlcNAcylation altering protein-protein interactions and genomic occupancy
Mon Mar 07 00:00:00 UTC 2016
Gold Nanoparticles Impinge on Nucleoli and the Stress Response in MCF7 Breast Cancer Cells.
Nanobiomedicine
Kodiha M,Mahboubi H,Maysinger D,Stochaj U
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Sun Nov 12 00:00:00 UTC 2023
4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition.
The Journal of biological chemistry
Ishizuka S,Askew EB,Ishizuka N,Knudson CB,Knudson W
MA1072 was used in western blot to elucidate the mechanism of chondrocyte activation due to hyaluronan loss
Fri Jun 03 00:00:00 UTC 2016
O-GlcNAcylation is a key modulator of skeletal muscle sarcomeric morphometry associated to modulation of protein-protein interactions.
Biochimica et biophysica acta
Lambert M,Richard E,Duban-Deweer S,Krzewinski F,Deracinois B,Dupont E,Bastide B,Cieniewski-Bernard C
MA1-072 was used in immunoprecipitation and western blot to investigate the modulator of skeletal muscle sarcomeric morphometry associated to modulation of protein-protein interactions by O-GlcNAcylation
Thu Sep 01 00:00:00 UTC 2016
Exercise training increases protein O-GlcNAcylation in rat skeletal muscle.
Physiological reports
Hortemo KH,Lunde PK,Anonsen JH,Kvaløy H,Munkvik M,Rehn TA,Sjaastad I,Lunde IG,Aronsen JM,Sejersted OM
MA1-072 was used in western blot determine the role of protein O-GlcNAcylation in skeletal muscle
Thu Sep 01 00:00:00 UTC 2016
O-GlcNAc modification is essential for the regulation of autophagy in Drosophila melanogaster.
Cellular and molecular life sciences : CMLS
Park S,Lee Y,Pak JW,Kim H,Choi H,Kim JW,Roth J,Cho JW
MA1-072 was used in western blot to investigate the role of O-GlcNAcylation in autophagy
Sat Aug 01 00:00:00 UTC 2015
O-GlcNAc cycling enzymes control vascular development of the placenta by modulating the levels of HIF-1α.
Placenta
Yang YR,Jang HJ,Lee YH,Kim IS,Lee H,Ryu SH,Suh PG
MA1-072 was used in western blot to discuss how hypoxia is influenced by O-GlcNAcylation
Thu Oct 01 00:00:00 UTC 2015
Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling.
Oncotarget
Yang YR,Kim DH,Seo YK,Park D,Jang HJ,Choi SY,Lee YH,Lee GH,Nakajima K,Taniguchi N,Kim JM,Choi EJ,Moon HY,Kim IS,Choi JH,Lee H,Ryu SH,Cocco L,Suh PG
MA1-072 was used in western blot to demonstrate that O-GlcNAcylation contributes to colitis by altering NF-kappaB signaling.
Wed May 20 00:00:00 UTC 2015
Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling.
Oncotarget
Yang YR,Kim DH,Seo YK,Park D,Jang HJ,Choi SY,Lee YH,Lee GH,Nakajima K,Taniguchi N,Kim JM,Choi EJ,Moon HY,Kim IS,Choi JH,Lee H,Ryu SH,Cocco L,Suh PG
MA1-072 was used in western blot to demonstrate that O-GlcNAcylation contributes to colitis by altering NF-kappaB signaling.
Wed May 20 00:00:00 UTC 2015
Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis.
The Journal of biological chemistry
Keembiyehetty C,Love DC,Harwood KR,Gavrilova O,Comly ME,Hanover JA
MA1-072 was used in western blot to investigate the role of O-GlcNAc in insulin-glucose homeostasis
Fri Mar 13 00:00:00 UTC 2015
Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis.
The Journal of biological chemistry
Keembiyehetty C,Love DC,Harwood KR,Gavrilova O,Comly ME,Hanover JA
MA1-072 was used in western blot to investigate the role of O-GlcNAc in insulin-glucose homeostasis
Fri Mar 13 00:00:00 UTC 2015
Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis.
The Journal of biological chemistry
Keembiyehetty C,Love DC,Harwood KR,Gavrilova O,Comly ME,Hanover JA
MA1-072 was used in western blot to investigate the role of O-GlcNAc in insulin-glucose homeostasis
Fri Mar 13 00:00:00 UTC 2015
Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle.
Physiological reports
Hortemo KH,Aronsen JM,Lunde IG,Sjaastad I,Lunde PK,Sejersted OM
MA1-072 was used in western blot to test if exhausting in vivo treadmill running induces dephosphorylation, and if there are reciprocal changes in O-GlcNAcylation, of MLC2
Sun Feb 01 00:00:00 UTC 2015
OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice.
Oncogenesis
Yang YR,Jang HJ,Yoon S,Lee YH,Nam D,Kim IS,Lee H,Kim H,Choi JH,Kang BH,Ryu SH,Suh PG
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Mon Jul 07 00:00:00 UTC 2014
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Neuropharmacology
Graham DL,Gray AJ,Joyce JA,Yu D,O'Moore J,Carlson GA,Shearman MS,Dellovade TL,Hering H
MA1-072 was used in western blot to study the mechanism by which O-GlcNAcylation prevents pathological agregation of tau in a murine tauopathy model
Tue Apr 01 00:00:00 UTC 2014
Phospho-GlcNAc modulation of slow MLC2 during soleus atrophy through a multienzymatic and sarcomeric complex.
Pflugers Archiv : European journal of physiology
Cieniewski-Bernard C,Dupont E,Richard E,Bastide B
MA1-072 was used in immunoprecipitation to study the changes in slow isoform MLC2 phosphorylation and O-GlcNAcylation status during soleus muscle atrophy and the mechanisms involved
Sat Nov 01 00:00:00 UTC 2014
Inhibition of mTOR affects protein stability of OGT.
Biochemical and biophysical research communications
Park S,Pak J,Jang I,Cho JW
MA1-072 was used in western blot to study the decrease in protein O-GlcNAcylation and OGT following inhibition of mTOR catalytic activity
Fri Oct 17 00:00:00 UTC 2014
Oral glucosamine sulfate supplementation does not induce endoplasmic reticulum stress or activate the unfolded protein response in circulating leukocytes of human subjects.
Canadian journal of physiology and pharmacology
McAlpine CS,Beriault DR,Behdinan T,Shi Y,Werstuck GH
MA1-072 was used in western blot to determine if glucosamine sulfate supplementation activates the UPR in circulating human leukocytes
Tue Apr 01 00:00:00 UTC 2014
Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity.
PloS one
Bond MR,Ghosh SK,Wang P,Hanover JA
MA1-072 was used in western blot to investigate the role of O-GlcNAc transferase in the innate immune response of C. elegans
Mon Aug 10 00:00:00 UTC 2015
X-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body.
Frontiers in genetics
Olivier-Van Stichelen S,Hanover JA
MA1-072 was used in western blot to assess O-GlcNAc transferase expression in male, female, and triple-X female human fibroblasts
Tue Aug 19 00:00:00 UTC 2014
X-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body.
Frontiers in genetics
Olivier-Van Stichelen S,Hanover JA
MA1-072 was used in western blot to assess O-GlcNAc transferase expression in male, female, and triple-X female human fibroblasts
Tue Aug 19 00:00:00 UTC 2014
Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers.
The Journal of biological chemistry
Kizuka Y,Kitazume S,Okahara K,Villagra A,Sotomayor EM,Taniguchi N
MA1-072 was used in ChIP assay and western blot to study the epigenetic regulatory mechanisms underlying the brain-specific expression of N-acetylglucosaminyltransferase-IX
Fri Apr 18 00:00:00 UTC 2014
CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease.
Nucleic acids research
Jin N,Qian W,Yin X,Zhang L,Iqbal K,Grundke-Iqbal I,Gong CX,Liu F
MA1-072 was used in western blot to study the regulation of neuronal Glut3 expression by CREB and the significance for the lowered Glut3 expression and glucose uptake observed in Alzheimer's disease brain
Fri Mar 01 00:00:00 UTC 2013
Potential regulation of human muscle plasticity by MLC2 post-translational modifications during bed rest and countermeasures.
Archives of biochemistry and biophysics
Stevens L,Bastide B,Hedou J,Cieniewski-Bernard C,Montel V,Cochon L,Dupont E,Mounier Y
MA1-072 was used in western blot to study the post-translation modification of soleus MLC2 during 60 days of bed rest and the effects of exercise and nutritional countermeasures
Sun Dec 01 00:00:00 UTC 2013
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
FEBS letters
Cameron A,Giacomozzi B,Joyce J,Gray A,Graham D,Ousson S,Neny M,Beher D,Carlson G,O'Moore J,Shearman M,Hering H
MA1-072 was used in western blot to study a site-specific rabbit monoclonal antibody that recognozes serine 400 O-GlcNAcylated tau
Fri Nov 15 00:00:00 UTC 2013
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
FEBS letters
Cameron A,Giacomozzi B,Joyce J,Gray A,Graham D,Ousson S,Neny M,Beher D,Carlson G,O'Moore J,Shearman M,Hering H
MA1-072 was used in western blot to study a site-specific rabbit monoclonal antibody that recognozes serine 400 O-GlcNAcylated tau
Fri Nov 15 00:00:00 UTC 2013
Requirement of decreased O-GlcNAc glycosylation of Mef2D for its recruitment to the myogenin promoter.
Biochemical and biophysical research communications
Ogawa M,Sakakibara Y,Kamemura K
MA1-072 was used in immunoprecipitation to study the inverse relationship between Mef2D O-GlcNAc glycosylation and its recruitment to the myogenin promoter
Fri Apr 19 00:00:00 UTC 2013
Hexosamine biosynthesis is a possible mechanism underlying hypoxia's effects on lipid metabolism in human adipocytes.
PloS one
O'Rourke RW,Meyer KA,Gaston G,White AE,Lumeng CN,Marks DL
MA1-072 was used in immunocytochemistry and western blot to study the role of hexosamine biosynthesis in the mechanism by which hypoxia modulates human adipocyte lipid metabolism
Tue Mar 18 00:00:00 UTC 2014
Hexosamine biosynthesis is a possible mechanism underlying hypoxia's effects on lipid metabolism in human adipocytes.
PloS one
O'Rourke RW,Meyer KA,Gaston G,White AE,Lumeng CN,Marks DL
MA1-072 was used in immunocytochemistry and western blot to study the role of hexosamine biosynthesis in the mechanism by which hypoxia modulates human adipocyte lipid metabolism
Tue Mar 18 00:00:00 UTC 2014
A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2.
Cell reports
Palaniappan KK,Hangauer MJ,Smith TJ,Smart BP,Pitcher AA,Cheng EH,Bertozzi CR,Boyce M
MA1-072 was used in western blot to study mitochondrial VDAC-2 O-GlcNAcylation using a glycoproteomics approach
Thu Oct 31 00:00:00 UTC 2013
Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.
PloS one
Borghgraef P,Menuet C,Theunis C,Louis JV,Devijver H,Maurin H,Smet-Nocca C,Lippens G,Hilaire G,Gijsen H,Moechars D,Van Leuven F
MA1-072 was used in immunohistochemistry and western blot to study the beneficial effects of increasing the O-GlucNAcylation of brain proteins on the survival and breathing of aged tau P301L transgenic mice
Mon Oct 13 00:00:00 UTC 2014
A role for O-GlcNAcylation in setting circadian clock speed.
Genes & development
Kim EY,Jeong EH,Park S,Jeong HJ,Edery I,Cho JW
MA1-072 was used in western blot to study the setting of the Drosophila circadian clock pace and the role played by O-GlcNAcylation
Thu Mar 01 00:00:00 UTC 2012
The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking.
Aging cell
Kim SY,Kang HT,Han JA,Park SC
MA1-072 was used in western blot to study the role of the Sp1 transcription factor as a key regulator of nucleocytoplasmic trafficking-related genes
Sat Dec 01 00:00:00 UTC 2012
Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.
Diabetologia
Habegger KM,Penque BA,Sealls W,Tackett L,Bell LN,Blue EK,Gallagher PJ,Sturek M,Alloosh MA,Steinberg HO,Considine RV,Elmendorf JS
MA1-072 was used in immunocytochemistry to investigate the destabilisation of cortical filamentous actin and dysfunction of glucose transport induced by accrual
Wed Feb 01 00:00:00 UTC 2012
Rescue of the transcription factors Sp1 and NFI in human skin keratinocytes through a feeder-layer-dependent suppression of the proteasome activity.
Journal of molecular biology
Duval C,Gaudreault M,Vigneault F,Touzel-Deschênes L,Rochette PJ,Masson-Gadais B,Germain L,Guérin SL
MA1-072 was used in western blot to study the role of a feeder layer in suppressing proteasome degradation of Sp1 and NF1 transcription factors in human skin keratinocytes
Fri May 18 00:00:00 UTC 2012
Engulfment and clearance of apoptotic cells based on a GlcNAc-binding lectin-like property of surface vimentin.
Glycobiology
Ise H,Goto M,Komura K,Akaike T
MA1-072 was used in immunocytochemistry and immunohistochemistry to study the role of the interaction of surface vimentin with O-GlcNAc-modified proteins in the engulfment clearance of apoptotic cells
Fri Jun 01 00:00:00 UTC 2012
O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy.
American journal of physiology. Heart and circulatory physiology
Facundo HT,Brainard RE,Watson LJ,Ngoh GA,Hamid T,Prabhu SD,Jones SP
MA1-072 was used in western blot to study the role of O-GlcNAc signaling in NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy
Tue May 15 00:00:00 UTC 2012
Altered calcium signaling in colonic smooth muscle of type 1 diabetic mice.
American journal of physiology. Gastrointestinal and liver physiology
Touw K,Chakraborty S,Zhang W,Obukhov AG,Tune JD,Gunst SJ,Herring BP
MA1-072 was used in western blot to investigate the changes of calcium levels in colonic smooth muscle of type 1 diabetic mice
Sun Jan 01 00:00:00 UTC 2012
Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes.
The Journal of biological chemistry
Gawlowski T,Suarez J,Scott B,Torres-Gonzalez M,Wang H,Schwappacher R,Han X,Yates JR,Hoshijima M,Dillmann W
MA1-072 was used in western blot to study the role of O-linked-beta-N-acetylglucosamine modification in regulating DRP1 functionality in cardiac muscle cells
Fri Aug 24 00:00:00 UTC 2012
The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo.
The Journal of biological chemistry
Andrés-Bergós J,Tardio L,Larranaga-Vera A,Gómez R,Herrero-Beaumont G,Largo R
MA1-072 was used in western blot to study the role of O-linked N-acetylglucosamine protein modification in insulin-induced chondrocyte differentiation
Fri Sep 28 00:00:00 UTC 2012
O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver.
Diabetes
Guinez C,Filhoulaud G,Rayah-Benhamed F,Marmier S,Dubuquoy C,Dentin R,Moldes M,Burnol AF,Yang X,Lefebvre T,Girard J,Postic C
MA1-072 was used in immunoprecipitation to study the regulation of carbohydrate-responsive element-binding protein (ChREBP) in the liver
Sun May 01 00:00:00 UTC 2011
Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway.
Cellular and molecular life sciences : CMLS
Park S,Park SH,Baek JY,Jy YJ,Kim KS,Roth J,Cho JW,Choe KM
MA1-072 was used in western blot to study the effect of orotein O-GlcNAcylation on Drosophila growth and its mechanism
Sat Oct 01 00:00:00 UTC 2011
Glucosamine-supplementation promotes endoplasmic reticulum stress, hepatic steatosis and accelerated atherogenesis in apoE-/- mice.
Atherosclerosis
Beriault DR,Sharma S,Shi Y,Khan MI,Werstuck GH
MA1-072 was used in western blot to investigate the effect of glucosamine-supplementation on endoplasmic reticulum, hepatic steatosis and atherogenesis in apoE-/- mice
Tue Nov 01 00:00:00 UTC 2011
Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor.
Journal of neurochemistry
Kommaddi RP,Dickson KM,Barker PA
MA1-072 was used in ChIP assay to investigate the role of transcription factor Sp1 glycosylation during stress-induced expression of p75 neurotrophin receptor
Tue Feb 01 00:00:00 UTC 2011
O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.
Genetics
Mondoux MA,Love DC,Ghosh SK,Fukushige T,Bond M,Weerasinghe GR,Hanover JA,Krause MW
MA1-072 was used in western blot to investigate the involvement of insulin signaling and O-GlcNAcylation in glucose stress response in C. elegans
Wed Jun 01 00:00:00 UTC 2011
Characterization of O-GlcNAcylation in starfish (Asterina pectinifera) development from fertilization to bipinnaria larva.
Bioscience, biotechnology, and biochemistry
Ogawa M,Adachi T,Ikegami S,Kato KH,Yamamoto A,Kamemura K
MA1-072 was used in western blot to investigate the role of protein O-GlcNAcylation in Starfish development
Mon Jun 06 00:00:00 UTC 2011
Isoform-specific regulation of the inositol 1,4,5-trisphosphate receptor by O-linked glycosylation.
The Journal of biological chemistry
Bimboese P,Gibson CJ,Schmidt S,Xiang W,Ehrlich BE
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Fri May 06 00:00:00 UTC 2011
Isoform-specific regulation of the inositol 1,4,5-trisphosphate receptor by O-linked glycosylation.
The Journal of biological chemistry
Bimboese P,Gibson CJ,Schmidt S,Xiang W,Ehrlich BE
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in Western Blot
Fri May 06 00:00:00 UTC 2011
O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy.
Biochimica et biophysica acta
Mi W,Gu Y,Han C,Liu H,Fan Q,Zhang X,Cong Q,Yu W
MA1-072 was used in immunohistochemistry to investigate the O-GlcNAcylation level in the lung and colon tumor tissues
Fri Apr 01 00:00:00 UTC 2011
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.
The Journal of clinical investigation
D'Apolito M,Du X,Zong H,Catucci A,Maiuri L,Trivisano T,Pettoello-Mantovani M,Campanozzi A,Raia V,Pessin JE,Brownlee M,Giardino I
MA1-072 was used in western blot to investigate the effect of ROS on insulin resistance
Fri Jan 01 00:00:00 UTC 2010
Influence of glucosamine on glomerular mesangial cell turnover: implications for hyperglycemia and hexosamine pathway flux.
American journal of physiology. Endocrinology and metabolism
James LR,Le C,Scholey JW
MA1-072 was used in western blot to investigate the effect of glucosamine on glomerular mesangial cell proliferation and death and its mechanism
Mon Feb 01 00:00:00 UTC 2010
OGA inhibition by GlcNAc-selenazoline.
Bioorganic & medicinal chemistry
Kim EJ,Love DC,Darout E,Abdo M,Rempel B,Withers SG,Rablen PR,Hanover JA,Knapp S
MA1-072 was used in western blot to investigate the inhibitory effect of GlcNAc-selenazoline on O-GlcNAcase
Fri Oct 01 00:00:00 UTC 2010
Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose.
The Journal of biological chemistry
Anthonisen EH,Berven L,Holm S,Nygård M,Nebb HI,Grønning-Wang LM
MA1-072 was used in western blot to investigate the modification of liver X receptor after glucose treatment
Fri Jan 15 00:00:00 UTC 2010
Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose.
The Journal of biological chemistry
Anthonisen EH,Berven L,Holm S,Nygård M,Nebb HI,Grønning-Wang LM
MA1-072 was used in western blot to investigate the modification of liver X receptor after glucose treatment
Fri Jan 15 00:00:00 UTC 2010
O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of delta-lactoferrin.
The Journal of biological chemistry
Hardivillé S,Hoedt E,Mariller C,Benaïssa M,Pierce A
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in ChIP assay
Fri Jun 18 00:00:00 UTC 2010
O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of delta-lactoferrin.
The Journal of biological chemistry
Hardivillé S,Hoedt E,Mariller C,Benaïssa M,Pierce A
Published figure using O-linked N-acetylglucosamine (O-GlcNAc) monoclonal antibody (Product # MA1-072) in ChIP assay
Fri Jun 18 00:00:00 UTC 2010
O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.
The Journal of biological chemistry
Srikanth B,Vaidya MM,Kalraiya RD
MA1-072 was used in western blot to investigate the effect of O-GlcNAcylation on keratins 8 and 18
Fri Oct 29 00:00:00 UTC 2010
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes.
The Journal of biological chemistry
Whelan SA,Dias WB,Thiruneelakantapillai L,Lane MD,Hart GW
MA1-072 was used in western blot to investigate the effect of O-linked beta-N-acetylglucosamine on insulin signalling in 3T3-L1 adipocytes
Fri Feb 19 00:00:00 UTC 2010
Mapping of O-linked beta-N-acetylglucosamine modification sites in key contractile proteins of rat skeletal muscle.
Proteomics
Hédou J,Bastide B,Page A,Michalski JC,Morelle W
MA1-072 was used in western blot to map the O-linked beta-N-acetylglucosamine modification sites in key contractile proteins of rat skeletal muscle
Wed Apr 01 00:00:00 UTC 2009
Dissecting the signaling events that impact classical nuclear import and target nuclear transport factors.
PloS one
Kodiha M,Tran D,Morogan A,Qian C,Stochaj U
MA1-072 was used in western blot to investigate the effect of stress on nuclear trafficking
Thu Dec 24 00:00:00 UTC 2009
Immunochemical methods for the rapid screening of the o-glycosidically linked N-acetylglucosamine modification of proteins.
Methods in molecular biology (Clifton, N.J.)
Ahrend M,Käberich A,Fergen MT,Schmitz B
MA1-072 was used in ELISA to evaluate the efficacy and applications of two monoclonal antibodies against o-glycosidically linked N-acetylglucosamine modification of proteins
Tue Jun 03 00:00:00 UTC 2008
Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism
Robinson KA,Ball LE,Buse MG
MA1-072 was used in western blot to study the role of O-GlcNAc protein modification in insulin resistance.
Thu Mar 01 00:00:00 UTC 2007
Galectin-4 is involved in p27-mediated activation of the myelin basic protein promoter.
Journal of neurochemistry
Wei Q,Eviatar-Ribak T,Miskimins WK,Miskimins R
MA1-072 was used in western blot to investigate the effect of galectin-4 on the p27-mediated activation of the MBP gene
Fri Jun 01 00:00:00 UTC 2007
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
The Journal of biological chemistry
Yao D,Taguchi T,Matsumura T,Pestell R,Edelstein D,Giardino I,Suske G,Rabbani N,Thornalley PJ,Sarthy VP,Hammes HP,Brownlee M
MA1-072 was used in immunoprecipitation to investigate the role of high glucose in the increase of angiopoietin-2 transcription.
Fri Oct 19 00:00:00 UTC 2007
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
The Journal of biological chemistry
Yao D,Taguchi T,Matsumura T,Pestell R,Edelstein D,Giardino I,Suske G,Rabbani N,Thornalley PJ,Sarthy VP,Hammes HP,Brownlee M
MA1-072 was used in immunoprecipitation to investigate the role of high glucose in the increase of angiopoietin-2 transcription.
Fri Oct 19 00:00:00 UTC 2007
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
The Journal of biological chemistry
Yao D,Taguchi T,Matsumura T,Pestell R,Edelstein D,Giardino I,Suske G,Rabbani N,Thornalley PJ,Sarthy VP,Hammes HP,Brownlee M
MA1-072 was used in immunoprecipitation to investigate the role of high glucose in the increase of angiopoietin-2 transcription.
Fri Oct 19 00:00:00 UTC 2007
O-linked N-acetylglucosaminyltransferase inhibition prevents G2/M transition in Xenopus laevis oocytes.
The Journal of biological chemistry
Dehennaut V,Lefebvre T,Sellier C,Leroy Y,Gross B,Walker S,Cacan R,Michalski JC,Vilain JP,Bodart JF
MA1-072 was used in western blot to investigate the relationship between O-GlcNAc glycosylation and the regulation of G2/M transition in Xenopus oocytes
Fri Apr 27 00:00:00 UTC 2007
Myosin16b: The COOH-tail region directs localization to the nucleus and overexpression delays S-phase progression.
Cell motility and the cytoskeleton
Cameron RS,Liu C,Mixon AS,Pihkala JP,Rahn RJ,Cameron PL
MA1-072 was used in immunohistochemistry to study the role of the myosin16b COOH-tail region in localization to the nucleus and S-phase progression
Mon Jan 01 00:00:00 UTC 2007
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.
Proceedings of the National Academy of Sciences of the United States of America
Forsythe ME,Love DC,Lazarus BD,Kim EJ,Prinz WA,Ashwell G,Krause MW,Hanover JA
MA1-072 was used in western blot to study the effect of O-GlcNAcase knockout in C. elegans.
Tue Aug 08 00:00:00 UTC 2006
Why does acute hyperglycemia worsen the outcome of transient focal cerebral ischemia? Role of corticosteroids, inflammation, and protein O-glycosylation.
Stroke
Martín A,Rojas S,Chamorro A,Falcón C,Bargalló N,Planas AM
MA1-072 was used in western blot to study why acute hyperglycemia worsens the outcome of transient focal cerebral ischemia
Mon May 01 00:00:00 UTC 2006
The feeder layer-mediated extended lifetime of cultured human skin keratinocytes is associated with altered levels of the transcription factors Sp1 and Sp3.
Journal of cellular physiology
Masson-Gadais B,Fugère C,Paquet C,Leclerc S,Lefort NR,Germain L,Guérin SL
MA1-072 was used in western blot to study the role of Sp1 and Sp3 transcription factors in feeder layer-mediated extention of cultured keratinocyte lifespan
Wed Mar 01 00:00:00 UTC 2006
Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells.
Endocrinology
Goldberg HJ,Whiteside CI,Hart GW,Fantus IG
MA1-072 was used in western blot to investigate the effect of O-glycosylation on plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells..
Sun Jan 01 00:00:00 UTC 2006
Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cells.
The Journal of biological chemistry
Majumdar G,Harrington A,Hungerford J,Martinez-Hernandez A,Gerling IC,Raghow R,Solomon S
MA1-072 was used in western blot to investigate the mechanism for insulin regulation of calmodulin gene expression in liver cells..
Fri Feb 10 00:00:00 UTC 2006
Stabilization of plakoglobin and enhanced keratinocyte cell-cell adhesion by intracellular O-glycosylation.
The Journal of biological chemistry
Hu P,Berkowitz P,Madden VJ,Rubenstein DS
MA1-072 was used in western blot to study the effect of intracellular O-glycosylation on plakoglobin stabilization and keratinocyte cell-cell adhesion.
Fri May 05 00:00:00 UTC 2006
Nuclear localization of STAT5A modified with O-linked N-acetylglucosamine and early involution in the mammary gland of Hirosaki hairless rat.
The Journal of biological chemistry
Nanashima N,Asano J,Hayakari M,Nakamura T,Nakano H,Yamada T,Shimizu T,Akita M,Fan Y,Tsuchida S
MA1-072 was used in western blot to investigate the O-linked N-acetylglucosamine modification of STAT5A and its effect
Fri Dec 30 00:00:00 UTC 2005
Relationship between protein O-linked glycosylation and insulin-stimulated glucose transport in rat skeletal muscle following calorie restriction or exposure to O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate.
Acta physiologica Scandinavica
Arias EB,Cartee GD
MA1-072 was used in ChIP Assay, Dot Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to conclude that the delay between O-linked glycosylation and insulin resistance in muscle incubated with PUGNAc suggests an indirect, relatively slow mechanism for insulin resistance.
Tue Mar 01 00:00:00 UTC 2005
Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1.
Diabetes
Majumdar G,Wright J,Markowitz P,Martinez-Hernandez A,Raghow R,Solomon SS
MA1-072 was used in western blot to investigate the changes of O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1 during insulin stimulation and diabetes
Wed Dec 01 00:00:00 UTC 2004
Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
Endocrinology
Andreozzi F,D'Alessandris C,Federici M,Laratta E,Del Guerra S,Del Prato S,Marchetti P,Lauro R,Perticone F,Sesti G
MA1-072 was used in western blot to study the effect of HBP activation on glucose-induced serine phosphorylation of IRS-1.
Tue Jun 01 00:00:00 UTC 2004
Regulation of a COPII component by cytosolic O-glycosylation during mitosis.
FEBS letters
Dudognon P,Maeder-Garavaglia C,Carpentier JL,Paccaud JP
MA1-072 was used in western blot to elucidate how endoplasmic reticulum-to-Golgi transport is blocked during mitosis
Fri Mar 12 00:00:00 UTC 2004
The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated.
European journal of biochemistry
Lefebvre T,Pinte S,Guérardel C,Deltour S,Martin-Soudant N,Slomianny MC,Michalski JC,Leprince D
MA1-072 was used in immunoprecipitation to investigate the O-GlcNAc modification of HIC1 (hypermethylated in cancer 1)
Fri Oct 01 00:00:00 UTC 2004
The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated.
European journal of biochemistry
Lefebvre T,Pinte S,Guérardel C,Deltour S,Martin-Soudant N,Slomianny MC,Michalski JC,Leprince D
MA1-072 was used in immunoprecipitation to investigate the O-GlcNAc modification of HIC1 (hypermethylated in cancer 1)
Fri Oct 01 00:00:00 UTC 2004
Identification of O-linked N-acetylglucosamine proteins in rat skeletal muscle using two-dimensional gel electrophoresis and mass spectrometry.
Molecular & cellular proteomics : MCP
Cieniewski-Bernard C,Bastide B,Lefebvre T,Lemoine J,Mounier Y,Michalski JC
MA1-072 was used in western blot to suggest that O-GlcNAc modification could regulate skeletal muscle physiology
Tue Jun 01 00:00:00 UTC 2004
High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin.
American journal of physiology. Endocrinology and metabolism
Walgren JL,Vincent TS,Schey KL,Buse MG
MA1-072 was used in western blot to study the role of high glucose and insulin in the O-GlcNAc modification of proteins
Sat Feb 01 00:00:00 UTC 2003
Elevated expression of O-GlcNAc-modified proteins and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rats.
Investigative ophthalmology & visual science
Akimoto Y,Kawakami H,Yamamoto K,Munetomo E,Hida T,Hirano H
MA1-072 was used in immunohistochemistry to elucidate the role of O-GlcNAc modification in the pathogenesis of diabetic keratopathy.
Mon Sep 01 00:00:00 UTC 2003
26S proteasome subunits are O-linked N-acetylglucosamine-modified in Drosophila melanogaster.
Biochemical and biophysical research communications
Sümegi M,Hunyadi-Gulyás E,Medzihradszky KF,Udvardy A
MA1-072 was used in western blot to study the glycosylation of 26S proteasome subunits in Drosophila melanogaster
Fri Dec 26 00:00:00 UTC 2003
Down-regulation of Sp1 activity through modulation of O-glycosylation by treatment with a low glucose mimetic, 2-deoxyglucose.
The Journal of biological chemistry
Kang HT,Ju JW,Cho JW,Hwang ES
MA1-072 was used in western blot to study the mechanism of down-regulation of SP1 activity by 2-DG.
Fri Dec 19 00:00:00 UTC 2003
Glutamine stimulates argininosuccinate synthetase gene expression through cytosolic O-glycosylation of Sp1 in Caco-2 cells.
The Journal of biological chemistry
Brasse-Lagnel C,Fairand A,Lavoinne A,Husson A
MA1-072 was used in western blot to study the functional relationship among the regulating signal glutamine, the transcription factor Sp1, and ASS gene transcription.
Fri Dec 26 00:00:00 UTC 2003
Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.
Circulation
Federici M,Menghini R,Mauriello A,Hribal ML,Ferrelli F,Lauro D,Sbraccia P,Spagnoli LG,Sesti G,Lauro R
MA1-072 was used in immunohistochemistry to investigate the role of O-linked glycosylation modification of signaling proteins in insulin-dependent activation of endothelial nitric oxide synthase
Tue Jul 23 00:00:00 UTC 2002
Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation.
Diabetes
James LR,Tang D,Ingram A,Ly H,Thai K,Cai L,Scholey JW
MA1-072 was used in western blot to study the effect of the increased flux through the hexosamine pathway on NF-kappaB-dependent promoter activation
Mon Apr 01 00:00:00 UTC 2002
Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles.
American journal of physiology. Endocrinology and metabolism
Buse MG,Robinson KA,Marshall BA,Hresko RC,Mueckler MM
MA1-072 was used in western blot to investigate the role of the O-GlcNAc protein modification in insulin resistance
Thu Aug 01 00:00:00 UTC 2002
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.
The Journal of clinical investigation
Du XL,Edelstein D,Dimmeler S,Ju Q,Sui C,Brownlee M
MA1-072 was used in Western Blotting to evaluate the effect of hyperglycaemia and the hexosamine pathway on endothelial nitric oxide synthase.
Thu Nov 01 00:00:00 UTC 2001
Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis.
The EMBO journal
Zhu W,Leber B,Andrews DW
MA1-072 was used in immunoprecipitation to study the role of cytosolic O-glycosylation of E-cadherin in blocking its transport to the cell surface during apoptosis
Thu Nov 01 00:00:00 UTC 2001
The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.
The Biochemical journal
Konrad RJ,Mikolaenko I,Tolar JF,Liu K,Kudlow JE
MA1-072 was used in immunoprecipitation to study the inhibition of O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase as the potential diabetogenic mechanism of streptozotocin
Tue May 15 00:00:00 UTC 2001
Modulation of CCAAT/enhancer-binding protein-alpha gene expression by metabolic signals in rodent adipocytes.
Endocrinology
Wang Y,Lee-Kwon W,Martindale JL,Adams L,Heller P,Egan JM,Bernier M
MA1-072 was used in western blot to study the role of the metabolic signals during the modulation of CCAAT/enhancer-binding protein-alpha gene expression
Thu Jul 01 00:00:00 UTC 1999
Interaction of the transcription factor Sp1 with the nuclear pore protein p62 requires the C-terminal domain of p62.
Journal of cellular biochemistry
Han I,Roos MD,Kudlow JE
MA1-072 was used in western blot to investigate the interaction between Sp1 and p62
Thu Jan 01 00:00:00 UTC 1998
