Proteintech

OAS2 Polyclonal Antibody

OAS2 Antibody in Immunocytochemistry (ICC/IF)

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OAS2 Antibody (19279-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using (Product # 19279-1-AP) (OAS2 antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

OAS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

OAS2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19279-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OAS2 Fusion Protein Ag6170 (334-687 aa encoded by BC049215)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to isoform p71 and isoform p69 of OAS2.

Immunogen sequence: NVLPAPLFT TPGHLLDKFI KEFLQPNKCF LEQIDSAVNI IRTFLKENCF RQSTAKIQIV RGGSTAKGTA LKTGSDADLV VFHNSLKSYT SQKNERHKIV KEIHEQLKAF WREKEEELEV SFEPPKWKAP RVLSFSLKSK VLNESVSFDV LPAFNALGQL SSGSTPSPEV YAGLIDLYKS SDLPGGEFST CFTVLQRNFI RSRPTKLKDL IRLVKHWYKE CERKLKPKGS LPPKYALELL TIYAWEQGSG VPDFDTAEGF RTVLELVTQY QQLCIFWKVN YNFEDETVRK FLLSQLQKTR PVILDPAEPT GDVGGGDRWC WHLLAKEAKE WLSSPCFKDG TGNPIPPWKV PVKVI (334-687 aa encoded by BC049215)

Target Information

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates. These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.

Science (New York, N.Y.)

Lee D,Le Pen J,Yatim A,Dong B,Aquino Y,Ogishi M,Pescarmona R,Talouarn E,Rinchai D,Zhang P,Perret M,Liu Z,Jordan I,Elmas Bozdemir S,Bayhan GI,Beaufils C,Bizien L,Bisiaux A,Lei W,Hasan M,Chen J,Gaughan C,Asthana A,Libri V,Luna JM,Jaffré F,Hoffmann HH,Michailidis E,Moreews M,Seeleuthner Y,Bilguvar K,Mane S,Flores C,Zhang Y,Arias AA,Bailey R,Schlüter A,Milisavljevic B,Bigio B,Le Voyer T,Materna M,Gervais A,Moncada-Velez M,Pala F,Lazarov T,Levy R,Neehus AL,Rosain J,Peel J,Chan YH,Morin MP,Pino-Ramirez RM,Belkaya S,Lorenzo L,Anton J,Delafontaine S,Toubiana J,Bajolle F,Fumadó V,DeDiego ML,Fidouh N,Rozenberg F,Pérez-Tur J,Chen S,Evans T,Geissmann F,Lebon P,Weiss SR,Bonnet D,Duval X,Pan-Hammarström Q,Planas AM,Meyts I,Haerynck F,Pujol A,Sancho-Shimizu V,Dalgard CL,Bustamante J,Puel A,Boisson-Dupuis S,Boisson B,Maniatis T,Zhang Q,Bastard P,Notarangelo L,Béziat V,Perez de Diego R,Rodriguez-Gallego C,Su HC,Lifton RP,Jouanguy E,Cobat A,Alsina L,Keles S,Haddad E,Abel L,Belot A,Quintana-Murci L,Rice CM,Silverman RH,Zhang SY,Casanova JL

Fri Feb 10 00:00:00 UTC 2023

IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.

Environmental pollution (Barking, Essex : 1987)

Zeng Y,Chen HQ,Zhang Z,Fan J,Li JZ,Zhou SM,Wang N,Yan SP,Cao J,Liu JY,Zhou ZY,Liu WB

Wed Feb 15 00:00:00 UTC 2023

Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.

The Journal of investigative dermatology

Lei V,Handfield C,Kwock JT,Kirchner SJ,Lee MJ,Coates M,Wang K,Han Q,Wang Z,Powers JG,Wolfe S,Corcoran DL,Fanelli B,Dadlani M,Ji RR,Zhang JY,MacLeod AS

Mon Aug 01 00:00:00 UTC 2022

Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.

Oxidative medicine and cellular longevity

Ke M

Tue Dec 27 00:00:00 UTC 2022

OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.

The Journal of investigative dermatology

Huang YZ,Zheng YX,Zhou Y,Xu F,Cui YZ,Chen XY,Wang ZY,Yan BX,Zheng M,Man XY

Sat Oct 01 00:00:00 UTC 2022

A prenylated dsRNA sensor protects against severe COVID-19.

Science (New York, N.Y.)

Wickenhagen A,Sugrue E,Lytras S,Kuchi S,Noerenberg M,Turnbull ML,Loney C,Herder V,Allan J,Jarmson I,Cameron-Ruiz N,Varjak M,Pinto RM,Lee JY,Iselin L,Palmalux N,Stewart DG,Swingler S,Greenwood EJD,Crozier TWM,Gu Q,Davies EL,Clohisey S,Wang B,Trindade Maranhão Costa F,Freire Santana M,de Lima Ferreira LC,Murphy L,Fawkes A,Meynert A,Grimes G,Da Silva Filho JL,Marti M,Hughes J,Stanton RJ,Wang ECY,Ho A,Davis I,Jarrett RF,Castello A,Robertson DL,Semple MG,Openshaw PJM,Palmarini M,Lehner PJ,Baillie JK,Rihn SJ,Wilson SJ

Fri Oct 29 00:00:00 UTC 2021

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.

Nature communications

Le Thomas A,Ferri E,Marsters S,Harnoss JM,Lawrence DA,Zuazo-Gaztelu I,Modrusan Z,Chan S,Solon M,Chalouni C,Li W,Koeppen H,Rudolph J,Wang W,Wu TD,Walter P,Ashkenazi A

Wed Dec 15 00:00:00 UTC 2021

OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.

Science immunology

Boehmer DFR,Formisano S,de Oliveira Mann CC,Mueller SA,Kluge M,Metzger P,Rohlfs M,Hörth C,Kocheise L,Lichtenthaler SF,Hopfner KP,Endres S,Rothenfusser S,Friedel CC,Duewell P,Schnurr M,Koenig LM

Fri Jul 16 00:00:00 UTC 2021

IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.

Science advances

Kwock JT,Handfield C,Suwanpradid J,Hoang P,McFadden MJ,Labagnara KF,Floyd L,Shannon J,Uppala R,Sarkar MK,Gudjonsson JE,Corcoran DL,Lazear HM,Sempowski G,Horner SM,MacLeod AS

Wed Apr 01 00:00:00 UTC 2020

Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2).

Biochemistry and cell biology = Biochimie et biologie cellulaire

Koul A,Deo S,Booy EP,Orriss GL,Genung M,McKenna SA

Sat Feb 01 00:00:00 UTC 2020

Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.

Frontiers in immunology

Benninghoff AD,Bates MA,Chauhan PS,Wierenga KA,Gilley KN,Holian A,Harkema JR,Pestka JJ

Wed Nov 04 00:00:00 UTC 2020

Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.

Journal of virology

Zhang L,Wang J,Muñoz-Moreno R,Kim M,Sakthivel R,Mo W,Shao D,Anantharaman A,García-Sastre A,Conrad NK,Fontoura BMA

Sat Dec 15 00:00:00 UTC 2018

Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.

Journal of virology

Zhang L,Wang J,Muñoz-Moreno R,Kim M,Sakthivel R,Mo W,Shao D,Anantharaman A,García-Sastre A,Conrad NK,Fontoura BMA

Sat Dec 15 00:00:00 UTC 2018

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes.

American journal of physiology. Lung cellular and molecular physiology

Turcatel G,Millette K,Thornton M,Leguizamon S,Grubbs B,Shi W,Warburton D

Wed Feb 01 00:00:00 UTC 2017

Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes.

American journal of physiology. Lung cellular and molecular physiology

Turcatel G,Millette K,Thornton M,Leguizamon S,Grubbs B,Shi W,Warburton D

Wed Feb 01 00:00:00 UTC 2017

Spleen tyrosine kinase (SYK) is a potential target for the treatment of cutaneous lupus erythematosus patients.

Experimental dermatology

Braegelmann C,Hölzel M,Ludbrook V,Dickson M,Turan N,Ferring-Schmitt S,Sternberg S,Bieber T,Kuhn A,Wenzel J

Sun May 01 00:00:00 UTC 2016

Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection.

Mediators of inflammation

Li Y,Zhu C,Wang F,Zhu T,Li J,Liu S,Xiao F

Fri Aug 04 00:00:00 UTC 2017

Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling.

PloS one

Grammatikos AP,Ghosh D,Devlin A,Kyttaris VC,Tsokos GC

Mon Mar 31 00:00:00 UTC 2014

Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling.

PloS one

Grammatikos AP,Ghosh D,Devlin A,Kyttaris VC,Tsokos GC

Mon Mar 31 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: (2'-5')oligo(A) synthetase 2; (2-5')oligo(A) synthase 2; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2; A synthetase 2; MGC78578; p69 OAS / p71 OAS; p69OAS / p71OAS

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Gene Aliases: OAS2

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UniProt ID: (Human) P29728

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Entrez Gene ID: (Human) 4939

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Function(s)

2'-5'-oligoadenylate synthetase activity double-stranded RNA binding protein binding ATP binding metal ion binding

Process(es)

nucleobase-containing compound metabolic process RNA catabolic process protein glycosylation response to virus protein myristoylation defense response to virus interferon-gamma-mediated signaling pathway type I interferon signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OAS2 Polyclonal Antibody

OAS2 Antibody (19279-1-AP) in ICC/IF

Product Details

19279-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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