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Invitrogen
OAS3 Polyclonal Antibody
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Product Details
PA5-97217
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 320-620 of human OAS3 (NP_0061782)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809019
Product Specific Information
Immunogen sequence: AASCYDHPCF LRGMGDPVQS WKGPGLPRAG CSGLGHPIQL DPNQKTPENS KSLNAVYPRA GSKPPSCPAP GPTGAASIVP SVPGMALDLS QIPTKELDRF IQDHLKPSPQ FQEQVKKAID IILRCLHENC VHKASRVSKG GSFGRGTDLR DGCDVELIIF LNCFTDYKDQ GPRRAEILDE MRAQLESWWQ DQVPSLSLQF PEQNVPEALQ FQLVSTALKS WTDVSLLPAF DAVGQLSSGT KPNPQVYSRL LTSGCQEGEH KACFAELRRN FMNIRPVKLK NLILLVKHWY RQVAAQNKGK G; Positive Samples: U-87MG, DU145, HeLa; Cellular Location: Cytoplasm, Nucleus
Target Information
OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (2-5')oligo(A) synthase 3; (2-5')oligo(A) synthetase 3; 2',5'-oligoadenylate synthetase-like 10; 2'-5' oligoadenylate synthetase-like 10; 2'-5'-oligoadenylate synthase 3; 2'-5'-oligoadenylate synthetase 3, 100kDa; 2'-5'oligoadenylate synthetase p100; 2-5A synthase 3; 2-5A synthetase 3; p100 OAS; p100OAS
Gene Aliases: OAS3; Oasl10; P/OKcl.4; p100; p100OAS
UniProt ID: (Human) Q9Y6K5, (Rat) Q5MYT7, (Mouse) Q8VI93
Entrez Gene ID: (Human) 4940, (Rat) 494202, (Mouse) 246727
metabolic process
response to virus
negative regulation of viral genome replication
innate immune response
defense response to virus
regulation of ribonuclease activity
nucleobase-containing compound metabolic process
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
immune system process
immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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