Proteintech

OCTN2 Polyclonal Antibody

OCTN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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OCTN2 Antibody (16331-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 16331-1-AP ( OCTN2 antibody at dilution of 1:50 (under 40x lens).

OCTN2 Antibody in Immunoprecipitation (IP)

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Product Details

16331-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OCTN2 Fusion Protein Ag9450 (1-142 aa encoded by BC012325)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRDYDEVTA FLGEWGPFQR LIFFLLSASI IPNGFTGLSS VFLIATPEHR CRVPDAANLS SAWRNHTVPL RLRDGREVPH SCRRYRLATI ANFSALGLEP GRDVDLGQLE QESCPDGWEF SQDVYLSTIV TEWNLVCEDD WKA (1-142 aa encoded by BC012325)

Target Information

Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ferulic acid supplementation alleviates hyperuricemia in high-fructose/fat diet-fed rats via promoting uric acid excretion and mediating the gut microbiota.

Food & function

Zhang N,Zhou J,Zhao L,Zhao Z,Wang S,Zhang L,Zhou F

Mon Feb 06 00:00:00 UTC 2023

L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy.

Frontiers in pharmacology

Jing Z,Iba T,Naito H,Xu P,Morishige JI,Nagata N,Okubo H,Ando H

Tue Apr 25 00:00:00 UTC 2023

Lenvatinib causes reduced expression of carnitine/organic cation transporter 2 and carnitine deficiency in the skeletal muscle of rats.

Toxicology letters

Jing Z,Okubo H,Morishige JI,Xu P,Hasan N,Nagata N,Ando H

Mon Aug 01 00:00:00 UTC 2022

The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang S,Fang Y,Yu X,Guo L,Zhang X,Xia D

Fri Mar 01 00:00:00 UTC 2019

The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang S,Fang Y,Yu X,Guo L,Zhang X,Xia D

Fri Mar 01 00:00:00 UTC 2019

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy.

Journal of neurochemistry

Fujita S,Hirota T,Sakiyama R,Baba M,Ieiri I

Fri Feb 01 00:00:00 UTC 2019

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy.

Journal of neurochemistry

Fujita S,Hirota T,Sakiyama R,Baba M,Ieiri I

Fri Feb 01 00:00:00 UTC 2019

Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.

Cell metabolism

Simcox J,Geoghegan G,Maschek JA,Bensard CL,Pasquali M,Miao R,Lee S,Jiang L,Huck I,Kershaw EE,Donato AJ,Apte U,Longo N,Rutter J,Schreiber R,Zechner R,Cox J,Villanueva CJ

Tue Sep 05 00:00:00 UTC 2017

Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.

Cell metabolism

Simcox J,Geoghegan G,Maschek JA,Bensard CL,Pasquali M,Miao R,Lee S,Jiang L,Huck I,Kershaw EE,Donato AJ,Apte U,Longo N,Rutter J,Schreiber R,Zechner R,Cox J,Villanueva CJ

Tue Sep 05 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: CT1; high-affinity carnitine transporter; high-affinity sodium dependent carnitine cotransporter; High-affinity sodium-dependent carnitine cotransporter; integral membrane transport protein; juvenile visceral steatosis; OCTN2VT; Organic cation/carnitine transporter 2; S22A5; solute carrier family 22 (organic cation transporter), member 5; Solute carrier family 22 member 5; solute carrier family 22, member 5; UST2r

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Gene Aliases: CDSP; CT1; jvs; Lstpl; OCTN2; SLC22A5; UST2r

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UniProt ID: (Human) O76082, (Mouse) Q9Z0E8, (Rat) O70594

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Entrez Gene ID: (Human) 6584, (Mouse) 20520, (Rat) 29726

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Function(s)

protein binding ATP binding carnitine transmembrane transporter activity drug transmembrane transporter activity symporter activity cation:cation antiporter activity quaternary ammonium group transmembrane transporter activity PDZ domain binding nucleotide binding transporter activity ion transmembrane transporter activity transmembrane transporter activity antibiotic transporter activity

Process(es)

transport ion transport sodium ion transport mitochondrion organization adult heart development locomotory behavior carnitine metabolic process organic cation transport quaternary ammonium group transport carnitine transport ion transmembrane transport antibiotic transport reproductive structure development quorum sensing involved in interaction with host transmembrane transport positive regulation of intestinal epithelial structure maintenance sodium-dependent organic cation transport modified amino acid transport carnitine transmembrane transport drug transmembrane transport drug transport cation transmembrane transport amino acid transmembrane transport triglyceride metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OCTN2 Polyclonal Antibody

OCTN2 Antibody (16331-1-AP) in IHC (P)

Product Details

16331-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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