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Invitrogen
OFD1 Polyclonal Antibody
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FIGURE: 1 / 5
OFD1 Antibody (PA5-115684) in ICC/IF
Immunocytochemistry analysis of OFD1 in HepG2 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115684). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Product Details
PA5-115684
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human OFD1(Accession O75665), corresponding to amino acid residues G754-L804.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900319
Product Specific Information
Antibody detects endogenous levels of total OFD1.
Target Information
This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Centriole and centriolar satellite protein OFD1; oral-facial-digital syndrome 1 gene homolog; Oral-facial-digital syndrome 1 protein; Oral-facial-digital syndrome 1 protein homolog; Protein 71-7A
Gene Aliases: 71-7A; CXorf5; DXGgc7e; JBTS10; OFD1; ORF2; RGD1562231; RP23; SGBS2
UniProt ID: (Human) O75665, (Mouse) Q80Z25
Entrez Gene ID: (Human) 8481, (Mouse) 237222, (Rat) 302661
G2/M transition of mitotic cell cycle
mitotic nuclear division
centriole replication
cilium morphogenesis
epithelial cilium movement involved in determination of left/right asymmetry
mitotic spindle assembly
embryonic body morphogenesis
cell projection organization
axoneme assembly
negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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