Proteintech

OGFR Polyclonal Antibody

OGFR Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

OGFR Antibody (11177-1-AP) in ICC/IF

Immunofluorescent analysis of COLO 320 cells using 11177-1-AP (OGFR antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

OGFR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

OGFR Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11177-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OGFR Fusion Protein Ag1671 (358-658 aa encoded by BC014137)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LERSQGDEA GGHGEDRPEP LSPKESKKRK LELSRREQPP TEPGPQSASE VEKIALNLEG CALSQGSLRT GTQEVGGQDP GEAVQPCRQP LGARVADKVR KRRKVDEGAG DSAAVASGGA QTLALAGSPA PSGHPKAGHS ENGVEEDTEG RTGPKEGTPG SPSETPGPSP AGPAGDEPAE SPSETPGPRP AGPAGDEPAE SPSETPGPSP AGPTRDEPAE SPSETPGPRP AGPAGDEPAE SPSETPGPRP AGPAGDEPAE SPSETPGPSP AGPTRDEPAK AGEAAELQDA EVESSAKSGK P (358-658 aa encoded by BC014137)

Target Information

The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Methionine enkephalin suppresses lung cancer metastasis by regulating the polarization of tumor-associated macrophages and the distribution of myeloid-derived suppressor cells in the tumor microenvironment and inhibiting epithelial-mesenchymal transition.

International immunopharmacology

Zhang S,Geng J,Shan F,Shan Y,Griffin N,Wu B,Wang X

Mon May 01 00:00:00 UTC 2023

CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by chemotherapy.

International journal of biological sciences

Liu C,Cheng X,Xing J,Li J,Li Z,Jian D,Wang Y,Wang S,Li R,Zhang W,Shao D,Ma X,Chen X,Shen J,Shi C,Guo Z,Wang W,Fan T,Liu L,Tang H

Thu May 12 00:00:00 UTC 2022

Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor.

International immunopharmacology

Qu N,Wang R,Meng Y,Liu N,Zhai J,Shan F

Thu Sep 01 00:00:00 UTC 2022

Opioid Receptor Expression in Colorectal Cancer: A Nested Matched Case-Control Study.

Frontiers in oncology

Belltall A,Mazzinari G,Garrido-Cano I,Giner F,Marí AM,Eroles P,Argente-Navarro MP,Cata JP,Diaz-Cambronero O

Mon Aug 26 00:00:00 UTC 2024

Methionine enkephalin inhibits colorectal cancer by remodeling the immune status of the tumor microenvironment.

International immunopharmacology

Wang X,Li S,Yan S,Shan Y,Wang X,Jingbo Z,Wang Y,Shan F,Griffin N,Sun X

Sat Oct 01 00:00:00 UTC 2022

Regulatory role of methionine enkephalin in myeloid-derived suppressor cells and macrophages in human cutaneous squamous cell carcinoma.

International immunopharmacology

Bai X,Shan F,Qu N,Huang H,Handley M,Griffin N,Zhang S,Cao X

Fri Oct 01 00:00:00 UTC 2021

Regulatory role of methionine enkephalin in myeloid-derived suppressor cells and macrophages in human cutaneous squamous cell carcinoma.

International immunopharmacology

Bai X,Shan F,Qu N,Huang H,Handley M,Griffin N,Zhang S,Cao X

Fri Oct 01 00:00:00 UTC 2021

Regulatory role of methionine enkephalin in myeloid-derived suppressor cells and macrophages in human cutaneous squamous cell carcinoma.

International immunopharmacology

Bai X,Shan F,Qu N,Huang H,Handley M,Griffin N,Zhang S,Cao X

Fri Oct 01 00:00:00 UTC 2021

Methionine enkephalin activates autophagy and stimulates tumour cell immunogenicity in human cutaneous squamous cell carcinoma.

International immunopharmacology

Bai X,Cao X,Qu N,Huang H,Handley M,Zhang S,Shan F

Thu Jul 01 00:00:00 UTC 2021

Methionine enkephalin activates autophagy and stimulates tumour cell immunogenicity in human cutaneous squamous cell carcinoma.

International immunopharmacology

Bai X,Cao X,Qu N,Huang H,Handley M,Zhang S,Shan F

Thu Jul 01 00:00:00 UTC 2021

A novel mechanism of lung cancer inhibition by methionine enkephalin through remodeling the immune status of the tumor microenvironment.

International immunopharmacology

Zhang S,Huang H,Handley M,Griffin N,Bai X,Shan F

Fri Oct 01 00:00:00 UTC 2021

A novel mechanism of lung cancer inhibition by methionine enkephalin through remodeling the immune status of the tumor microenvironment.

International immunopharmacology

Zhang S,Huang H,Handley M,Griffin N,Bai X,Shan F

Fri Oct 01 00:00:00 UTC 2021

Methionine enkephalin (MENK) inhibits human gastric cancer through regulating tumor associated macrophages (TAMs) and PI3K/AKT/mTOR signaling pathway inside cancer cells.

International immunopharmacology

Wang X,Jiao X,Meng Y,Chen H,Griffin N,Gao X,Shan F

Sat Dec 01 00:00:00 UTC 2018

Methionine enkephalin (MENK) inhibits human gastric cancer through regulating tumor associated macrophages (TAMs) and PI3K/AKT/mTOR signaling pathway inside cancer cells.

International immunopharmacology

Wang X,Jiao X,Meng Y,Chen H,Griffin N,Gao X,Shan F

Sat Dec 01 00:00:00 UTC 2018

The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin.

Cancer management and research

Wang X,Tian J,Jiao X,Geng J,Wang R,Liu N,Gao X,Griffin N,Gao Y,Shan F

Wed Mar 30 00:00:00 UTC 2022

The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin.

Cancer management and research

Wang X,Tian J,Jiao X,Geng J,Wang R,Liu N,Gao X,Griffin N,Gao Y,Shan F

Wed Mar 30 00:00:00 UTC 2022

Androgen represses opioid growth factor receptor (OGFR) in human prostate cancer LNCaP cells and OGFR expression in human prostate cancer tissue.

American journal of clinical and experimental urology

Yamashita H,Shuman L,Warrick JI,Raman JD,Degraff DJ

Thu Oct 01 00:00:00 UTC 2020

Androgen represses opioid growth factor receptor (OGFR) in human prostate cancer LNCaP cells and OGFR expression in human prostate cancer tissue.

American journal of clinical and experimental urology

Yamashita H,Shuman L,Warrick JI,Raman JD,Degraff DJ

Thu Oct 01 00:00:00 UTC 2020

Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.

PloS one

Suzuki M,Chiwaki F,Sawada Y,Ashikawa M,Aoyagi K,Fujita T,Yanagihara K,Komatsu M,Narita M,Suzuki T,Nagase H,Kushima R,Sakamoto H,Fukagawa T,Katai H,Nakagama H,Yoshida T,Uezono Y,Sasaki H

Fri Mar 25 00:00:00 UTC 2016

Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.

PloS one

Suzuki M,Chiwaki F,Sawada Y,Ashikawa M,Aoyagi K,Fujita T,Yanagihara K,Komatsu M,Narita M,Suzuki T,Nagase H,Kushima R,Sakamoto H,Fukagawa T,Katai H,Nakagama H,Yoshida T,Uezono Y,Sasaki H

Fri Mar 25 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 7-60 protein; OGFr; Opioid growth factor receptor; Protein 7-60; Zeta-type opioid receptor

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Gene Aliases: OGFR

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UniProt ID: (Human) Q9NZT2

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Entrez Gene ID: (Human) 11054

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Function(s)

opioid receptor activity protein binding

Process(es)

regulation of cell growth opioid receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OGFR Polyclonal Antibody

OGFR Antibody (11177-1-AP) in ICC/IF

Product Details

11177-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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