Proteintech

OGG1 Polyclonal Antibody

OGG1 Antibody in Immunocytochemistry (ICC/IF)

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OGG1 Antibody (15125-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using (Product # 15125-1-AP) (OGG1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

OGG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

OGG1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15125-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 22 publications 22 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OGG1 Fusion Protein Ag7204 (1-345 aa encoded by BC000657)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody has been cited in more than 4 publications, WB and IHC detection in mouse and human.

Immunogen sequence: MPARALLPR RMGHRTLAST PALWASIPCP RSELRLDLVL PSGQSFRWRE QSPAHWSGVL ADQVWTLTQT EEQLHCTVYR GDKSQASRPT PDELEAVRKY FQLDVTLAQL YHHWGSVDSH FQEVAQKFQG VRLLRQDPIE CLFSFICSSN NNIARITGMV ERLCQAFGPR LIQLDDVTYH GFPSLQALAG PEVEAHLRKL GLGYRARYVS ASARAILEEQ GGLAWLQQLR ESSYEEAHKA LCILPGVGTK VADCICLMAL DKPQAVPVDV HMWHIAQRDY SWHPTTSQAK GPSPQTNKEL GNFFRSLWGP YAGWAQAVLF SADLRQCRHA QEPPAKRRKG SKGPEG (1-345 aa encoded by B C000657)

Target Information

8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

OGG1 inhibition suppresses African swine fever virus replication.

Virologica Sinica

Fan J,Lv X,Yang S,Geng S,Yang J,Zhao Y,Zhang Z,Liu Z,Guan G,Luo J,Zeng Q,Yin H,Niu Q

Wed Feb 01 00:00:00 UTC 2023

OGG1 inhibition suppresses African swine fever virus replication.

Virologica Sinica

Fan J,Lv X,Yang S,Geng S,Yang J,Zhao Y,Zhang Z,Liu Z,Guan G,Luo J,Zeng Q,Yin H,Niu Q

Wed Feb 01 00:00:00 UTC 2023

Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice.

Cellular and molecular gastroenterology and hepatology

Zheng Z,Xie J,Ma L,Hao Z,Zhang W,Li L

Tue Mar 21 00:00:00 UTC 2023

MitoQ ameliorates PM_2.5-induced pulmonary fibrosis through regulating the mitochondria DNA homeostasis.

Chemosphere

Li Y,Du Z,Li T,Ren X,Yu Y,Duan J,Sun Z

Sat Jul 01 00:00:00 UTC 2023

TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling.

JHEP reports : innovation in hepatology

Su W,Gao W,Zhang R,Wang Q,Li L,Bu Q,Xu Z,Liu Z,Wang M,Zhu Y,Wu G,Zhou H,Wang X,Lu L

Mon May 01 00:00:00 UTC 2023

Specnuezhenide ameliorates ultraviolet-induced skin photoaging in mice by regulating the Sirtuin 3/8-Oxoguanine DNA glycosylase signal.

Photodermatology, photoimmunology & photomedicine

Tang N,Ren YY,Wu HT,Lv XT,Liu XT,Li QL,Wang GE,Wu YH

Fri Sep 01 00:00:00 UTC 2023

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration.

Nature communications

Jhanji M,Rao CN,Massey JC,Hope MC,Zhou X,Keene CD,Ma T,Wyatt MD,Stewart JA,Sajish M

Fri Jun 10 00:00:00 UTC 2022

Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway.

Reproductive biology

Xia J,Wu S,Wu G,Yang J

Thu Sep 01 00:00:00 UTC 2022

Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway.

Reproductive biology

Xia J,Wu S,Wu G,Yang J

Thu Sep 01 00:00:00 UTC 2022

Geniposidic Acid from Eucommia ulmoides Oliver Staminate Flower Tea Mitigates Cellular Oxidative Stress via Activating AKT/NRF2 Signaling.

Molecules (Basel, Switzerland)

Cheng S,Jia H,Zhang Y,Zhou J,Chen X,Wu L,Wang J

Mon Dec 05 00:00:00 UTC 2022

Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.

Critical care (London, England)

Zhang L,Zhang Y,Qin X,Jiang X,Zhang J,Mao L,Jiang Z,Jiang Y,Liu G,Qiu J,Chen C,Qiu F,Zou Z

Thu Jun 09 00:00:00 UTC 2022

HIV Promotes Neurocognitive Impairment by Damaging the Hippocampal Microvessels.

Molecular neurobiology

Sharma AL,Wang H,Zhang Z,Millien G,Tyagi M,Hongpaisan J

Mon Aug 01 00:00:00 UTC 2022

Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.

International journal of molecular sciences

Gombos Z,Koltai E,Torma F,Bakonyi P,Kolonics A,Aczel D,Ditroi T,Nagy P,Kawamura T,Radak Z

Thu Jul 15 00:00:00 UTC 2021

Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.

Free radical biology & medicine

Jia R,Yang F,Yan P,Ma L,Yang L,Li L

Tue Jun 01 00:00:00 UTC 2021

Induction of apoptosis in Ogg1-null mouse embryonic fibroblasts by GSH depletion is independent of DNA damage.

Toxicology letters

Higgs EB,Godschalk R,Coltman NJ,Stewart GS,van Schooten FJ,Hodges NJ

Sat Oct 10 00:00:00 UTC 2020

Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM_2.5 from Beijing, China, in Winter.

International journal of environmental research and public health

Niu BY,Li WK,Li JS,Hong QH,Khodahemmati S,Gao JF,Zhou ZX

Mon Jul 06 00:00:00 UTC 2020

Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.

Redox biology

Zhang N,Zhang Y,Wu B,You S,Sun Y

Sat Feb 01 00:00:00 UTC 2020

Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis.

Toxicology in vitro : an international journal published in association with BIBRA

Yang YX,Yu S,Jia BX,Liu N,Wu A

Sat Aug 01 00:00:00 UTC 2020

Potent and specific MTH1 inhibitors targeting gastric cancer.

Cell death & disease

Zhou W,Ma L,Yang J,Qiao H,Li L,Guo Q,Ma J,Zhao L,Wang J,Jiang G,Wan X,Adam Goscinski M,Ding L,Zheng Y,Li W,Liu H,Suo Z,Zhao W

Tue Jun 04 00:00:00 UTC 2019

Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.

Free radical biology & medicine

Li R,Liu Y,Xie J,Huang X,Zhang L,Liu H,Li L

Wed May 01 00:00:00 UTC 2019

Protective Effect of Hydrogen on Sodium Iodate-Induced Age-Related Macular Degeneration in Mice.

Frontiers in aging neuroscience

Liu Y,Li R,Xie J,Hu J,Huang X,Ren F,Li L

Tue Sep 29 00:00:00 UTC 2020

Protective Effect of Hydrogen on Sodium Iodate-Induced Age-Related Macular Degeneration in Mice.

Frontiers in aging neuroscience

Liu Y,Li R,Xie J,Hu J,Huang X,Ren F,Li L

Tue Sep 29 00:00:00 UTC 2020

Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study.

PeerJ

Hu XN,Wang JF,Huang YQ,Wang Z,Dong FY,Ma HF,Bao ZJ

Fri Mar 18 00:00:00 UTC 2022

Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study.

PeerJ

Hu XN,Wang JF,Huang YQ,Wang Z,Dong FY,Ma HF,Bao ZJ

Fri Mar 18 00:00:00 UTC 2022

Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells.

Toxicological sciences : an official journal of the Society of Toxicology

Yang Y,Yu S,Liu N,Xu H,Gong Y,Wu Y,Wang P,Su X,Liao Y,De Saeger S,Humpf HU,Wu A

Sat Dec 01 00:00:00 UTC 2018

Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells.

Toxicological sciences : an official journal of the Society of Toxicology

Yang Y,Yu S,Liu N,Xu H,Gong Y,Wu Y,Wang P,Su X,Liao Y,De Saeger S,Humpf HU,Wu A

Sat Dec 01 00:00:00 UTC 2018

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders.

PLoS genetics

Lokanga RA,Senejani AG,Sweasy JB,Usdin K

Wed Apr 01 00:00:00 UTC 2015

Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders.

PLoS genetics

Lokanga RA,Senejani AG,Sweasy JB,Usdin K

Wed Apr 01 00:00:00 UTC 2015

X inactivation plays a major role in the gender bias in somatic expansion in a mouse model of the fragile X-related disorders: implications for the mechanism of repeat expansion.

Human molecular genetics

Adihe Lokanga R,Zhao XN,Entezam A,Usdin K

Mon Sep 15 00:00:00 UTC 2014

X inactivation plays a major role in the gender bias in somatic expansion in a mouse model of the fragile X-related disorders: implications for the mechanism of repeat expansion.

Human molecular genetics

Adihe Lokanga R,Zhao XN,Entezam A,Usdin K

Mon Sep 15 00:00:00 UTC 2014

Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice.

The Journal of biological chemistry

Sriram S,Subramanian S,Juvvuna PK,McFarlane C,Salerno MS,Kambadur R,Sharma M

Fri Feb 28 00:00:00 UTC 2014

Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice.

The Journal of biological chemistry

Sriram S,Subramanian S,Juvvuna PK,McFarlane C,Salerno MS,Kambadur R,Sharma M

Fri Feb 28 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: 8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; N-glycosylase/DNA lyase; OGG1 type 1f

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Gene Aliases: HMMH; HOGG1; MMH; MUTM; OGG1; OGH1

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UniProt ID: (Human) O15527, (Mouse) O35617, (Rat) O70249

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Entrez Gene ID: (Human) 4968, (Mouse) 18294, (Rat) 81528

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Function(s)

damaged DNA binding endonuclease activity protein binding microtubule binding oxidized purine nucleobase lesion DNA N-glycosylase activity oxidized purine DNA binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity purine-specific mismatch base pair DNA N-glycosylase activity oxidized base lesion DNA N-glycosylase activity DNA binding catalytic activity DNA-(apurinic or apyrimidinic site) lyase activity uracil DNA N-glycosylase activity hydrolase activity hydrolase activity, acting on glycosyl bonds lyase activity single-strand selective uracil DNA N-glycosylase activity DNA N-glycosylase activity DNA-3-methylbase glycosylase activity nicotinamide riboside hydrolase activity nicotinic acid riboside hydrolase activity deoxyribonucleoside 5'-monophosphate N-glycosidase activity

Process(es)

acute inflammatory response base-excision repair regulation of transcription, DNA-templated cellular response to DNA damage stimulus response to oxidative stress aging response to radiation response to light stimulus response to estradiol regulation of protein import into nucleus, translocation nucleotide-excision repair, DNA incision response to drug negative regulation of apoptotic process depurination depyrimidination response to ethanol response to folic acid cellular response to cadmium ion negative regulation of double-strand break repair via single-strand annealing DNA repair nucleotide-excision repair metabolic process nucleic acid phosphodiester bond hydrolysis DNA catabolic process, endonucleolytic

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OGG1 Polyclonal Antibody

OGG1 Antibody (15125-1-AP) in ICC/IF

Product Details

15125-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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