Invitrogen

OLIG2 Polyclonal Antibody

1 Published Figure

8 References

View all (44) OLIG2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)
Published Figures (1)

FIGURE: 1 / 2

OLIG2 Antibody (P21954) in WB

Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~32 kDa Olig2 protein.

OLIG2 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

Product Details

P21954

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Immunohistochemistry (IHC)

Assay-dependent

View 6 publications 6 publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant mouse Olig2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

0.2M tris, pH 8, with 0.1M glycine

Contains

no preservative

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2539836

Target Information

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Novel therapeutic for multiple sclerosis protects white matter function in EAE mouse model.

Frontiers in molecular medicine

Zerimech S,Nguyen H,Vandenbark AA,Offner H,Baltan S

P21954 was used in Immunohistochemistry to demonstrate that DRhQ administered after the onset of EAE promotes WM integrity and function, and reduces subsequent vulnerability to ischemic injury, suggesting important therapeutic potential for treatment of progressive MS.

Sat Feb 10 00:00:00 UTC 2024

Tumor microenvironment in a minipig model of spinal cord glioma.

Journal of translational medicine

Tora MS,Neill SG,Lakhina Y,Assed H,Zhang M,Nagarajan PP,Federici T,Gutierrez J,Hoang KB,Du Y,Lei K,Boulis NM

P21954 was used in Immunohistochemistry to support the utility of a high-grade spinal cord glioma (SCG) model in Göttingen minipigs as a means for investigating therapeutic approaches targeting the more aggressive and surgically unresectable tumor border.

Wed Sep 27 00:00:00 UTC 2023

Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Schuster KH,Zalon AJ,Zhang H,DiFranco DM,Stec NR,Haque Z,Blumenstein KG,Pierce AM,Guan Y,Paulson HL,McLoughlin HS

P21954 was used in Immunohistochemistry to provide evidence for severe dysfunction in oligodendrocyte maturation early in SCA3 pathogenesis.

Wed Feb 23 00:00:00 UTC 2022

Lentiviral-Induced Spinal Cord Gliomas in Rat Model.

International journal of molecular sciences

Nagarajan PP,Tora MS,Neill SG,Federici T,Texakalidis P,Donsante A,Canoll P,Lei K,Boulis NM

P21954 was used in Immunohistochemistry to evaluate the ability of each vector alone and combinations of vectors to produce high-grade spinal cord gliomas.

Tue Nov 30 00:00:00 UTC 2021

Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence.

Communications biology

Pan JX,Sun D,Lee D,Xiong L,Ren X,Guo HH,Yao LL,Lu Y,Jung C,Xiong WC

P21954 was used in Immunohistochemistry to show that TgAPPsweOCN mice also exhibit Alzheimer's disease-relevant brain pathologies and behavior phenotypes.

Thu Nov 25 00:00:00 UTC 2021

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.

Cell

Nguyen PT,Dorman LC,Pan S,Vainchtein ID,Han RT,Nakao-Inoue H,Taloma SE,Barron JJ,Molofsky AB,Kheirbek MA,Molofsky AV

P21954 was used in Flow Cytometry to study a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.

Thu Jul 23 00:00:00 UTC 2020

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy.

Acta neuropathologica communications

Dhillon RS,Parker J,Syed YA,Edgley S,Young A,Fawcett JW,Jeffery ND,Franklin RJ,Kotter MR

P21954 was used in immunohistochemistry - frozen section test if axonal plasticity contributes to recovery following surgical decompression

Tue Aug 23 00:00:00 UTC 2016

TREM2 sustains microglial expansion during aging and response to demyelination.

The Journal of clinical investigation

Poliani PL,Wang Y,Fontana E,Robinette ML,Yamanishi Y,Gilfillan S,Colonna M

Published figure using OLIG2 polyclonal antibody (Product # P21954) in Immunohistochemistry

Fri May 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: basic domain, helix-loop-helix protein, class B, 1; Basic helix loop helix protein class B1 (bHLHB1); basic helix-loop-helix protein 19 (bHLHe19); bHLHb1; bHLHe19; Class B basic helix-loop-helix protein 1; Class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; olig-2; Oligo2; Oligo2 antibody; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein 2; Protein kinase C-binding protein 2 (PRKCBP2); Protein kinase C-binding protein RACK17

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Gene Aliases: AI604895; BHLHB1; BHLHE19; Olg-2; OLIG2; OLIGO2; PRKCBP2; RACK17; RK17

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UniProt ID: (Human) Q13516, (Mouse) Q9EQW6

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Entrez Gene ID: (Human) 10215, (Mouse) 50913, (Rat) 304103

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Function(s)

DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein homodimerization activity HMG box domain binding transcription factor activity, sequence-specific DNA binding protein binding protein dimerization activity

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated spinal cord motor neuron differentiation spinal cord oligodendrocyte cell fate specification thalamus development myelination negative regulation of neuron differentiation neuron fate commitment positive regulation of oligodendrocyte differentiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development nervous system development spinal cord oligodendrocyte cell differentiation oligodendrocyte differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OLIG2 Polyclonal Antibody

OLIG2 Antibody (P21954) in WB

Product Details

P21954

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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