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Invitrogen
OLIG2 Recombinant Rabbit Monoclonal Antibody (SP07-02)
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Product Details
MA5-32039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SP07-02
Immunogen
Synthetic peptide within Human Olig2 aa 238-287
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809333
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basic domain, helix-loop-helix protein, class B, 1; Basic helix loop helix protein class B1 (bHLHB1); basic helix-loop-helix protein 19 (bHLHe19); bHLHb1; bHLHe19; Class B basic helix-loop-helix protein 1; Class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; olig-2; Oligo2; Oligo2 antibody; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein 2; Protein kinase C-binding protein 2 (PRKCBP2); Protein kinase C-binding protein RACK17
Gene Aliases: AI604895; BHLHB1; BHLHE19; Olg-2; OLIG2; OLIGO2; PRKCBP2; RACK17; RK17
UniProt ID: (Human) Q13516, (Mouse) Q9EQW6
Entrez Gene ID: (Human) 10215, (Mouse) 50913, (Rat) 304103
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
spinal cord motor neuron differentiation
spinal cord oligodendrocyte cell fate specification
thalamus development
myelination
negative regulation of neuron differentiation
neuron fate commitment
positive regulation of oligodendrocyte differentiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
nervous system development
spinal cord oligodendrocyte cell differentiation
oligodendrocyte differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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