Proteintech

OMA1 Polyclonal Antibody

OMA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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OMA1 Antibody (17116-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver tissue slide using (Product # 17116-1-AP) (OMA1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

17116-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OMA1 Fusion Protein Ag10803 (361-524 aa encoded by BC012915)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to OMA1.

Immunogen sequence: ICPRDSLAL LCQWIQSKLQ EYMFNRPYSR KLEAEADKIG LLLAAKACAD IRASSVFWQQ MEFVDSLHGQ PKMPEWLSTH PSHGNRVEYL DRLIPQALKI REMCNCPPLS NPDPRLLFKL STKHFLEESE KEDLNITKKQ KMDTLPIQKQ EQIPLTYIVE KRTGS (361-524 aa encoded by BC012915)

Target Information

OMA1 (Overlapping with the m-AAA protease 1 homolog) is also named as MPRP1(Metalloprotease-related protein 1) and belongs to the peptidase M48 family. It is a zinc metalloprotease that spans the inner mitochondrial membrane with a number of predicted membrane spanning domains and the 60 kDa form of OMA1 rapidly accumulated concomitantly with the cleavage of all OPA1 variants, and the 40 kDa form of OMA1 may be the inactive form, with the 60 kDa form being the active enzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.

Cell death & disease

Noguchi M,Kohno S,Pellattiero A,Machida Y,Shibata K,Shintani N,Kohno T,Gotoh N,Takahashi C,Hirao A,Scorrano L,Kasahara A

Wed Apr 05 00:00:00 UTC 2023

A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.

eLife

Mann JP,Duan X,Patel S,Tábara LC,Scurria F,Alvarez-Guaita A,Haider A,Luijten I,Page M,Protasoni M,Lim K,Virtue S,O'Rahilly S,Armstrong M,Prudent J,Semple RK,Savage DB

Wed Feb 01 00:00:00 UTC 2023

TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.

Cell reports

Akabane S,Watanabe K,Kosako H,Yamashita SI,Nishino K,Kato M,Sekine S,Kanki T,Matsuda N,Endo T,Oka T

Tue May 30 00:00:00 UTC 2023

The adenosine A_2A receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs.

Neuropharmacology

Fang G,Zhou Y,Zhou X,Zhou H,Ge YY,Luo S,Chen JF,Zhang L

Sun May 01 00:00:00 UTC 2022

Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.

International journal of molecular sciences

Sun H,Shen L,Zhang P,Lin F,Ma J,Wu Y,Yu H,Sun L

Tue Oct 04 00:00:00 UTC 2022

Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control.

Redox biology

Sonn SK,Song EJ,Seo S,Kim YY,Um JH,Yeo FJ,Lee DS,Jeon S,Lee MN,Jin J,Kweon HY,Kim TK,Kim S,Moon SH,Rhee SG,Chung J,Yang J,Han J,Choi EY,Lee SB,Yun J,Oh GT

Sun May 01 00:00:00 UTC 2022

Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice.

The Science of the total environment

Zhou GX,Liu WB,Dai LM,Zhu HL,Xiong YW,Li DX,Xu DX,Wang H

Tue Mar 01 00:00:00 UTC 2022

The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.

International journal of molecular sciences

Cheng M,Yu H,Kong Q,Wang B,Shen L,Dong D,Sun L

Tue Jan 25 00:00:00 UTC 2022

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.

Human molecular genetics

Liu YT,Huang X,Nguyen D,Shammas MK,Wu BP,Dombi E,Springer DA,Poulton J,Sekine S,Narendra DP

Wed Jun 03 00:00:00 UTC 2020

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

Nature

Fessler E,Eckl EM,Schmitt S,Mancilla IA,Meyer-Bender MF,Hanf M,Philippou-Massier J,Krebs S,Zischka H,Jae LT

Sun Mar 01 00:00:00 UTC 2020

Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics.

Journal of Cancer

Shangguan F,Liu Y,Ma L,Qu G,Lv Q,An J,Yang S,Lu B,Cao Q

Mon Sep 28 00:00:00 UTC 2020

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.

Molecular cell

Sekine S,Wang C,Sideris DP,Bunker E,Zhang Z,Youle RJ

Thu Mar 07 00:00:00 UTC 2019

Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.

Journal of cellular physiology

Wu LH,Chang HC,Ting PC,Wang DL

Fri Jun 01 00:00:00 UTC 2018

Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.

Journal of cellular physiology

Wu LH,Chang HC,Ting PC,Wang DL

Fri Jun 01 00:00:00 UTC 2018

Nitric oxide triggers the assembly of "type II" stress granules linked to decreased cell viability.

Cell death & disease

Aulas A,Lyons SM,Fay MM,Anderson P,Ivanov P

Tue Nov 13 00:00:00 UTC 2018

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Science advances

Perks KL,Ferreira N,Richman TR,Ermer JA,Kuznetsova I,Shearwood AJ,Lee RG,Viola HM,Johnstone VPA,Matthews V,Hool LC,Rackham O,Filipovska A

Tue Aug 01 00:00:00 UTC 2017

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Science advances

Perks KL,Ferreira N,Richman TR,Ermer JA,Kuznetsova I,Shearwood AJ,Lee RG,Viola HM,Johnstone VPA,Matthews V,Hool LC,Rackham O,Filipovska A

Tue Aug 01 00:00:00 UTC 2017

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.

International journal of molecular sciences

Baburamani AA,Hurling C,Stolp H,Sobotka K,Gressens P,Hagberg H,Thornton C

Thu Sep 17 00:00:00 UTC 2015

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.

International journal of molecular sciences

Baburamani AA,Hurling C,Stolp H,Sobotka K,Gressens P,Hagberg H,Thornton C

Thu Sep 17 00:00:00 UTC 2015

The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.

Cell reports

Joshi S,Tolkunov D,Aviv H,Hakimi AA,Yao M,Hsieh JJ,Ganesan S,Chan CS,White E

Tue Dec 01 00:00:00 UTC 2015

The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.

Cell reports

Joshi S,Tolkunov D,Aviv H,Hakimi AA,Yao M,Hsieh JJ,Ganesan S,Chan CS,White E

Tue Dec 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Metalloendopeptidase OMA1, mitochondrial; metalloprotease related protein 1; Metalloprotease-related protein 1; MPRP-1; OMA1 homolog, zinc metallopeptidase; OMA1 zinc metallopeptidase homolog; overlapping activity with M-AAA protease; Overlapping with the m-AAA protease 1 homolog; zinc metallopeptidase OMA1

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Gene Aliases: 2010001O09Rik; DAB1; MPRP-1; MPRP1; OMA1; peptidase; YKR087C; ZMPOMA1

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UniProt ID: (Human) Q96E52

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Entrez Gene ID: (Human) 115209

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Function(s)

metalloendopeptidase activity metal ion binding

Process(es)

diet induced thermogenesis glucose metabolic process misfolded or incompletely synthesized protein catabolic process lipid metabolic process response to stress negative regulation of mitochondrial fusion mitochondrial protein processing cristae formation energy homeostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OMA1 Polyclonal Antibody

OMA1 Antibody (17116-1-AP) in IHC (P)

Product Details

17116-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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