Proteintech

ONECUT2 Polyclonal Antibody

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ONECUT2 Antibody (21916-1-AP) in WB

Mouse skin tissue were subjected to SDS PAGE followed by western blot with 21916-1-AP ( ONECUT2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

ONECUT2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21916-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

ChIP assay (ChIP)

View 3 publications 3 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ONECUT2 Fusion Protein Ag16162 (226-332 aa encoded by BC108925)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PLAATPLGN GLGGLHNAQQ SLPNYGPPGH DKMLSPNFDA HHTAMLTRGE QHLSRGLGTP PAAMMSHLNG LHHPGHTQSH GPVLAPSRER PPSSSSGSQV ATSGQLEE (226-332 aa encoded by BC108925)

Target Information

ONECUT2 is a member of the transcription factors of the ONECUT class, whose prototype is hepatocyte nuclear factor (HNF)-6. The distribution of OC-2 mRNA in humans is tissue-restricted, the strongest expression being detected in the liver and skin. ONECUT2 participates in the network of transcription factors required for liver differentiation and metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study.

Nucleic acids research

Luna Velez MV,Neikes HK,Snabel RR,Quint Y,Qian C,Martens A,Veenstra GJC,Freeman MR,van Heeringen SJ,Vermeulen M

Wed Feb 22 00:00:00 UTC 2023

Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.

Science advances

Abu El Maaty MA,Terzic J,Keime C,Rovito D,Lutzing R,Yanushko D,Parisotto M,Grelet E,Namer IJ,Lindner V,Laverny G,Metzger D

Fri Jul 22 00:00:00 UTC 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 UTC 2022

Activation of ONECUT2 by RB1 loss in castration-resistant prostate cancer.

American journal of clinical and experimental urology

Qian C,Yang Q,Freedland SJ,Di Vizio D,Ellis L,You S,Freeman MR

Mon Sep 23 00:00:00 UTC 2024

Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America

Shi L,Tan X,Liu X,Yu J,Bota-Rabassedas N,Niu Y,Luo J,Xi Y,Zong C,Creighton CJ,Glenn JS,Wang J,Kurie JM

Tue Jun 22 00:00:00 UTC 2021

ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.

Cell death & disease

Liu D,Zhang T,Chen X,Zhang B,Wang Y,Xie M,Ji X,Sun M,Huang W,Xia L

Sat Nov 27 00:00:00 UTC 2021

ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.

Cell death & disease

Liu D,Zhang T,Chen X,Zhang B,Wang Y,Xie M,Ji X,Sun M,Huang W,Xia L

Sat Nov 27 00:00:00 UTC 2021

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.

Cancer cell

LaFave LM,Kartha VK,Ma S,Meli K,Del Priore I,Lareau C,Naranjo S,Westcott PMK,Duarte FM,Sankar V,Chiang Z,Brack A,Law T,Hauck H,Okimoto A,Regev A,Buenrostro JD,Jacks T

Mon Aug 10 00:00:00 UTC 2020

ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.

International journal of cancer

Seo EH,Kim HJ,Kim JH,Lim B,Park JL,Kim SY,Lee SI,Jeong HY,Song KS,Kim YS

Mon Jun 15 00:00:00 UTC 2020

ONECUT2 is a driver of neuroendocrine prostate cancer.

Nature communications

Guo H,Ci X,Ahmed M,Hua JT,Soares F,Lin D,Puca L,Vosoughi A,Xue H,Li E,Su P,Chen S,Nguyen T,Liang Y,Zhang Y,Xu X,Xu J,Sheahan AV,Ba-Alawi W,Zhang S,Mahamud O,Vellanki RN,Gleave M,Bristow RG,Haibe-Kains B,Poirier JT,Rudin CM,Tsao MS,Wouters BG,Fazli L,Feng FY,Ellis L,van der Kwast T,Berlin A,Koritzinsky M,Boutros PC,Zoubeidi A,Beltran H,Wang Y,He HH

Thu Jan 17 00:00:00 UTC 2019

ONECUT2 is a driver of neuroendocrine prostate cancer.

Nature communications

Thu Jan 17 00:00:00 UTC 2019

ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.

Nature medicine

Rotinen M,You S,Yang J,Coetzee SG,Reis-Sobreiro M,Huang WC,Huang F,Pan X,Yáñez A,Hazelett DJ,Chu CY,Steadman K,Morrissey CM,Nelson PS,Corey E,Chung LWK,Freedland SJ,Di Vizio D,Garraway IP,Murali R,Knudsen BS,Freeman MR

Sat Dec 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Hepatocyte nuclear factor 6-beta; HNF-6-beta; HNF-6B; OC-2; One cut domain family member 2; one cut domain, family member 2; One cut homeobox 2; onecut 2; ONECUT-2 homeodomain transcription factor; Transcription factor ONECUT-2; transcription factor ONECUT2

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Gene Aliases: C730009D12; HNF6B; OC-2; OC2; ONECUT2

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UniProt ID: (Human) O95948, (Mouse) Q6XBJ3

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Entrez Gene ID: (Human) 9480, (Mouse) 225631

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding

Process(es)

liver development regulation of cell-matrix adhesion epithelial cell development transcription from RNA polymerase II promoter organ morphogenesis cell differentiation positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway endocrine pancreas development cilium assembly cell fate commitment positive regulation of transcription from RNA polymerase II promoter peripheral nervous system neuron development transcription, DNA-templated regulation of transcription, DNA-templated anatomical structure morphogenesis pancreas development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ONECUT2 Polyclonal Antibody

ONECUT2 Antibody (21916-1-AP) in WB

Product Details

21916-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Miscellaneous PubMed (MISC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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