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Invitrogen
ONECUT2 Monoclonal Antibody (606014)
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FIGURE: 1 / 2
ONECUT2 Antibody (MA5-24275) in ICC/IF
Immunocytochemistry analysis of ONECUT2 in immersion fixed HepG2 human hepatocellular carcinoma cell line. Samples were incubated in ONECUT2 monoclonal antibody (Product # MA5-24275) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to nuclei.
Product Details
MA5-24275
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
606014
Immunogen
E. coli-derived recombinant human ONECUT2/OC-2 Gln185-Thr326
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609863
Product Specific Information
No cross-reactivity with recombinant human ONECUT is observed.
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
ONECUT2 is a member of the transcription factors of the ONECUT class, whose prototype is hepatocyte nuclear factor (HNF)-6. The distribution of OC-2 mRNA in humans is tissue-restricted, the strongest expression being detected in the liver and skin. ONECUT2 participates in the network of transcription factors required for liver differentiation and metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepatocyte nuclear factor 6-beta; HNF-6-beta; HNF-6B; OC-2; One cut domain family member 2; one cut domain, family member 2; One cut homeobox 2; onecut 2; ONECUT-2 homeodomain transcription factor; Transcription factor ONECUT-2
Gene Aliases: HNF6B; OC-2; OC2; ONECUT2
UniProt ID: (Human) O95948
Entrez Gene ID: (Human) 9480
liver development
regulation of cell-matrix adhesion
epithelial cell development
transcription from RNA polymerase II promoter
organ morphogenesis
cell differentiation
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
endocrine pancreas development
cilium assembly
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
peripheral nervous system neuron development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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