Proteintech

OPA3 Polyclonal Antibody

OPA3 Antibody in Immunocytochemistry (ICC/IF)

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OPA3 Antibody (15638-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 15638-1-AP (OPA3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

OPA3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

OPA3 Antibody in Immunoprecipitation (IP)

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Product Details

15638-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OPA3 Fusion Protein Ag8103 (24-179 aa encoded by BC005059)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ANRIKEAAR RSEFFKTYIC LPPAQLYHWV EMRTKMRIMG FRGTVIKPLN EEAAAELGAE LLGEATIFIV GGGCLVLEYW RHQAQQRHKE EEQRAAWNAL RDEVGHLALA LEALQAQVQA APPQGALEEL RTELQEVRAQ LCNPGRSASH AVPASKK (24-179 aa encoded by BC005059)

Target Information

The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant optic atrophy and cataract. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.

Cellular signalling

Wang Y,Ying X,Wang Y,Zou Z,Yuan A,Xiao Z,Geng N,Qiao Z,Li W,Lu X,Pu J

Sat Jul 01 00:00:00 UTC 2023

Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.

Cellular signalling

Wang Y,Ying X,Wang Y,Zou Z,Yuan A,Xiao Z,Geng N,Qiao Z,Li W,Lu X,Pu J

Sat Jul 01 00:00:00 UTC 2023

Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.

Cellular signalling

Wang Y,Ying X,Wang Y,Zou Z,Yuan A,Xiao Z,Geng N,Qiao Z,Li W,Lu X,Pu J

Sat Jul 01 00:00:00 UTC 2023

Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.

Cellular signalling

Wang Y,Ying X,Wang Y,Zou Z,Yuan A,Xiao Z,Geng N,Qiao Z,Li W,Lu X,Pu J

Sat Jul 01 00:00:00 UTC 2023

MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression.

Bioengineered

Liu M,Du Q,Mao G,Dai N,Zhang F

Tue Mar 01 00:00:00 UTC 2022

Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells.

Cancers

Meng N,Glorieux C,Zhang Y,Liang L,Zeng P,Lu W,Huang P

Wed Dec 25 00:00:00 UTC 2019

Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity.

Human molecular genetics

Navein AE,Cooke EJ,Davies JR,Smith TG,Wells LH,Ohazama A,Healy C,Sharpe PT,Evans SL,Evans BA,Votruba M,Wells T

Wed Jun 15 00:00:00 UTC 2016

Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity.

Human molecular genetics

Navein AE,Cooke EJ,Davies JR,Smith TG,Wells LH,Ohazama A,Healy C,Sharpe PT,Evans SL,Evans BA,Votruba M,Wells T

Wed Jun 15 00:00:00 UTC 2016

Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III.

Investigative ophthalmology & visual science

Powell KA,Davies JR,Taylor E,Wride MA,Votruba M

Tue Jun 21 00:00:00 UTC 2011

Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III.

Investigative ophthalmology & visual science

Powell KA,Davies JR,Taylor E,Wride MA,Votruba M

Tue Jun 21 00:00:00 UTC 2011

Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III.

Investigative ophthalmology & visual science

Powell KA,Davies JR,Taylor E,Wride MA,Votruba M

Tue Jun 21 00:00:00 UTC 2011

Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III.

Investigative ophthalmology & visual science

Powell KA,Davies JR,Taylor E,Wride MA,Votruba M

Tue Jun 21 00:00:00 UTC 2011

A nonsense mutation in the optic atrophy 3 gene (OPA3) causes dilated cardiomyopathy in Red Holstein cattle.

Genomics

Owczarek-Lipska M,Plattet P,Zipperle L,Drögemüller C,Posthaus H,Dolf G,Braunschweig MH

Sat Jan 01 00:00:00 UTC 2011

A nonsense mutation in the optic atrophy 3 gene (OPA3) causes dilated cardiomyopathy in Red Holstein cattle.

Genomics

Owczarek-Lipska M,Plattet P,Zipperle L,Drögemüller C,Posthaus H,Dolf G,Braunschweig MH

Sat Jan 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: FLJ22187; FLJ25932; MGC75494; optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); Optic atrophy 3 (Iraqi-Jewish 'optic atrophy plus'); Optic atrophy 3 protein; Optic atrophy 3 protein homolog

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Gene Aliases: D630048P19Rik; Gm1425; Gm472; MGA3; OPA3

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UniProt ID: (Human) Q9H6K4, (Mouse) Q505D7

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Entrez Gene ID: (Human) 80207, (Mouse) 403187, (Rat) 308409

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Function(s)

molecular_function

Process(es)

visual perception regulation of lipid metabolic process growth neuromuscular process mitochondrion morphogenesis response to stimulus biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OPA3 Polyclonal Antibody

OPA3 Antibody (15638-1-AP) in ICC/IF

Product Details

15638-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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