Invitrogen

OPRM1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA1-24628

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NHQLENLEAETAPLP
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_795076

Product Specific Information

PA1-24628 is expected to cross react with bovine (93% conserved), guinea pig (100% conserved), Macaque monkey (100% conserved), and porcine (100% conserved) due to sequence homology.

The molecular weight of the protein detected by PA1-24628 is 65 kDa.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hMOP; KIAA0403; M-OR-1; MOP; MOP receptor; MOR-1; MOR-1C; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant mMOR-1Z; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; Mu-type opioid receptor; MUOR1; Opioid mu receptor; Opioid Receptor; Opioid receptor B; opioid receptor, mu 1; OTTHUMP00000017463

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Gene Aliases: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; MORA; muOR; OPRM; OPRM1; Oprrm1; Ror-b

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UniProt ID: (Human) P35372, (Rat) P33535, (Mouse) P42866

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Entrez Gene ID: (Human) 4988, (Rat) 25601, (Mouse) 18390

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Function(s)
G-protein alpha-subunit binding G-protein coupled receptor activity beta-endorphin receptor activity voltage-gated calcium channel activity protein binding protein C-terminus binding protein domain specific binding filamin binding G-protein beta-subunit binding morphine receptor activity neuropeptide binding opioid receptor activity signal transducer activity
Process(es)
acute inflammatory response to antigenic stimulus immune response G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway locomotory behavior sensory perception of pain adenylate cyclase-inhibiting opioid receptor signaling pathway response to food positive regulation of appetite response to lipopolysaccharide opioid receptor signaling pathway wound healing response to cocaine response to morphine positive regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling negative regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process response to ethanol behavioral response to ethanol positive regulation of neurogenesis negative regulation of cytosolic calcium ion concentration regulation of sensory perception of pain excitatory postsynaptic potential negative regulation of Wnt protein secretion positive regulation of ERK1 and ERK2 cascade calcium ion transmembrane transport response to growth factor cellular response to morphine regulation of N-methyl-D-aspartate selective glutamate receptor activity G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission sensory perception negative regulation of cell proliferation response to radiation cellular response to stress eating behavior estrous cycle signal transduction negative regulation of cAMP biosynthetic process
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