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Invitrogen
OPRM1 Polyclonal Antibody
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OPRM1 Antibody (PA5-26138) in IHC (P)
Immunohistochemistry analysis of OPRM1 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with OPRM1 polyclonal antibody (Product # PA5-26138) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-26138
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 161-187 amino acids from the central region of human OPRM1
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2543638
Product Specific Information
This antibody is predicted to react with porcine, non-human primate and rat based on sequence homology.
Target Information
The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hMOP; KIAA0403; M-OR-1; MOP; MOP receptor; MOR-1C; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant mMOR-1Z; Mu-type opioid receptor; Opioid mu receptor; Opioid Receptor; opioid receptor, mu 1; OTTHUMP00000017463
Gene Aliases: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; muOR; OPRM; OPRM1
UniProt ID: (Human) P35372, (Mouse) P42866
Entrez Gene ID: (Human) 4988, (Mouse) 18390
G-protein alpha-subunit binding
G-protein coupled receptor activity
beta-endorphin receptor activity
voltage-gated calcium channel activity
protein binding
protein C-terminus binding
protein domain specific binding
filamin binding
G-protein beta-subunit binding
morphine receptor activity
neuropeptide binding
signal transducer activity
opioid receptor activity
acute inflammatory response to antigenic stimulus
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating dopamine receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
sensory perception
locomotory behavior
negative regulation of cell proliferation
response to radiation
sensory perception of pain
adenylate cyclase-inhibiting opioid receptor signaling pathway
response to food
positive regulation of appetite
response to lipopolysaccharide
cellular response to stress
wound healing
response to cocaine
eating behavior
estrous cycle
behavioral response to ethanol
positive regulation of neurogenesis
regulation of sensory perception of pain
excitatory postsynaptic potential
negative regulation of Wnt protein secretion
positive regulation of ERK1 and ERK2 cascade
calcium ion transmembrane transport
response to growth factor
cellular response to morphine
regulation of N-methyl-D-aspartate selective glutamate receptor activity
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of cAMP biosynthetic process
opioid receptor signaling pathway
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
negative regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
negative regulation of cytosolic calcium ion concentration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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