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Invitrogen
OPRM1 Recombinant Rabbit Monoclonal Antibody (13H5L13)
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FIGURE: 1 / 6
OPRM1 Antibody (704009) in ICC/IF
HEK-293 cells stably transfected with MOR were grown on poly-L-lysine-coated coverslips overnight. After 24 h, cells were either not treated or treated with 10 µM DAMGO for 30 min. Cells were then fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with MOR1 Recombinant Rabbit Monoclonal Antibody (Product # 704009, 1:1,000 dilution) Cells were then incubated with ... View More
Product Details
704009
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
13H5L13
Immunogen
Peptide corresponding to Rat MOR1 aa 386-398 and human MOR1 aa 388-400
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3073994
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Target Information
The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hMOP; KIAA0403; M-OR-1; MOP; MOR-1; MOR-1C; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; Mu-type opioid receptor; MUOR1; Opioid mu receptor; Opioid Receptor; Opioid receptor B; opioid receptor, mu 1; OTTHUMP00000017463
Gene Aliases: LMOR; M-OR-1; MOP; MOR; MOR1; MORA; OPRM; OPRM1; Oprrm1; Ror-b
UniProt ID: (Human) P35372, (Rat) P33535
Entrez Gene ID: (Human) 4988, (Rat) 25601
G-protein alpha-subunit binding
G-protein coupled receptor activity
beta-endorphin receptor activity
voltage-gated calcium channel activity
protein binding
protein C-terminus binding
protein domain specific binding
filamin binding
G-protein beta-subunit binding
morphine receptor activity
neuropeptide binding
opioid receptor activity
acute inflammatory response to antigenic stimulus
immune response
G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
locomotory behavior
sensory perception of pain
adenylate cyclase-inhibiting opioid receptor signaling pathway
response to food
positive regulation of appetite
response to lipopolysaccharide
opioid receptor signaling pathway
wound healing
response to cocaine
response to morphine
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
negative regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
behavioral response to ethanol
positive regulation of neurogenesis
negative regulation of cytosolic calcium ion concentration
regulation of sensory perception of pain
excitatory postsynaptic potential
negative regulation of Wnt protein secretion
positive regulation of ERK1 and ERK2 cascade
calcium ion transmembrane transport
response to growth factor
cellular response to morphine
regulation of N-methyl-D-aspartate selective glutamate receptor activity
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
chemical synaptic transmission
sensory perception
negative regulation of cell proliferation
response to radiation
cellular response to stress
eating behavior
estrous cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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