Product References
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin.
Molecular cell
Nguyen TN,Sawa-Makarska J,Khuu G,Lam WK,Adriaenssens E,Fracchiolla D,Shoebridge S,Bernklau D,Padman BS,Skulsuppaisarn M,Lindblom RSJ,Martens S,Lazarou M
Thu May 18 00:00:00 UTC 2023
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin.
Molecular cell
Nguyen TN,Sawa-Makarska J,Khuu G,Lam WK,Adriaenssens E,Fracchiolla D,Shoebridge S,Bernklau D,Padman BS,Skulsuppaisarn M,Lindblom RSJ,Martens S,Lazarou M
Thu May 18 00:00:00 UTC 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 UTC 2023
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
International immunopharmacology
Jiang Y,Li Y,Zhang Y,Hu D,Zhang S,Wang C,Huang S,Zhang A,Jia Z,You R
Wed Mar 01 00:00:00 UTC 2023
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
Molecular cell
Le Guerroué F,Bunker EN,Rosencrans WM,Nguyen JT,Basar MA,Werner A,Chou TF,Wang C,Youle RJ
Thu Mar 16 00:00:00 UTC 2023
A cellular taxonomy of the adult human spinal cord.
Neuron
Yadav A,Matson KJE,Li L,Hua I,Petrescu J,Kang K,Alkaslasi MR,Lee DI,Hasan S,Galuta A,Dedek A,Ameri S,Parnell J,Alshardan MM,Qumqumji FA,Alhamad SM,Wang AP,Poulen G,Lonjon N,Vachiery-Lahaye F,Gaur P,Nalls MA,Qi YA,Maric D,Ward ME,Hildebrand ME,Mery PF,Bourinet E,Bauchet L,Tsai EC,Phatnani H,Le Pichon CE,Menon V,Levine AJ
Wed Feb 01 00:00:00 UTC 2023
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Journal of ethnopharmacology
Zhou Y,Luo D,Shi J,Yang X,Xu W,Gao W,Guo Y,Zhao Q,Xie X,He Y,Du G,Pang X
Thu Aug 10 00:00:00 UTC 2023
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.
Journal of ethnopharmacology
Zhou Y,Luo D,Shi J,Yang X,Xu W,Gao W,Guo Y,Zhao Q,Xie X,He Y,Du G,Pang X
Thu Aug 10 00:00:00 UTC 2023
BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α.
Molecular psychiatry
Lu JJ,Wu PF,He JG,Li YK,Long LH,Yao XP,Yang JH,Chen HS,Zhang XN,Hu ZL,Chen Z,Wang F,Chen JG
Fri Dec 01 00:00:00 UTC 2023
Roles of Optineurin and Extracellular Vesicles in Glaucomatous Retinal Cell Loss.
Current medical science
Duan CY,Fan WL,Chen F
Sat Apr 01 00:00:00 UTC 2023
Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice.
Nature microbiology
Zheng Y,Wang L,Liu Q,Xian H,Zhang C,Cai S,Yang S,Jin S,Cui J
Mon May 01 00:00:00 UTC 2023
WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP.
Autophagy
Lu G,Tan HWS,Schmauck-Medina T,Wang L,Chen J,Cho YL,Chen K,Zhang JZ,He W,Wu Y,Xia D,Zhou J,Fang EF,Fang L,Liu W,Shen HM
Thu Dec 01 00:00:00 UTC 2022
In Skeletal Muscle Fibers, Protein Kinase Subunit CSNK2A1/CK2α Is Required for Proper Muscle Homeostasis and Structure and Function of Neuromuscular Junctions.
Cells
Merholz M,Jian Y,Wimberg J,Gessler L,Hashemolhosseini S
Wed Dec 07 00:00:00 UTC 2022
Evaluating mitophagy in embryonic stem cells by using fluorescence-based imaging.
Frontiers in cell and developmental biology
Liu K,Li X,Li Z,Cao J,Li X,Xu Y,Liu L,Zhao T
Tue Oct 04 00:00:00 UTC 2022
Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma.
Clinical and translational medicine
Zhuang A,Chai P,Wang S,Zuo S,Yu J,Jia S,Ge S,Jia R,Zhou Y,Shi W,Xu X,Ruan J,Fan X
Sat Jan 01 00:00:00 UTC 2022
Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation.
Cell death & disease
Hou M,Shao Z,Zhang S,Liu X,Fan P,Jiang M,Zhao Y,Xiao R,Yuan H
Mon Apr 18 00:00:00 UTC 2022
Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation.
Cell death & disease
Hou M,Shao Z,Zhang S,Liu X,Fan P,Jiang M,Zhao Y,Xiao R,Yuan H
Mon Apr 18 00:00:00 UTC 2022
Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.
mBio
Hernandez D,Walsh S,Saavedra Sanchez L,Dickinson MS,Coers J
Wed Oct 26 00:00:00 UTC 2022
PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease.
Acta pharmacologica Sinica
Wang XJ,Qi L,Cheng YF,Ji XF,Chi TY,Liu P,Zou LB
Mon Aug 01 00:00:00 UTC 2022
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Liu D,Zhao Z,She Y,Zhang L,Chen X,Ma L,Cui J
Tue Feb 15 00:00:00 UTC 2022
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Liu D,Zhao Z,She Y,Zhang L,Chen X,Ma L,Cui J
Tue Feb 15 00:00:00 UTC 2022
Panax notoginseng saponins protect PC12 cells against Aβ induced injury via promoting parkin-mediated mitophagy.
Journal of ethnopharmacology
Jiang Y,Li H,Huang P,Li S,Li B,Huo L,Zhong J,Pan Z,Li Y,Xia X
Tue Mar 01 00:00:00 UTC 2022
The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling.
Frontiers in pharmacology
Zhang R,Ozgen S,Luo H,Krigman J,Zhao Y,Xin G,Sun N
Sat Oct 15 00:00:00 UTC 2022
A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
Redox biology
Deng Q,Yang S,Sun L,Huang K,Dong K,Zhu Y,Cao Y,Li Y,Wu S,Huang R
Tue Feb 01 00:00:00 UTC 2022
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.
Cell host & microbe
Walsh SC,Reitano JR,Dickinson MS,Kutsch M,Hernandez D,Barnes AB,Schott BH,Wang L,Ko DC,Kim SY,Valdivia RH,Bastidas RJ,Coers J
Wed Dec 14 00:00:00 UTC 2022
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
Free radical biology & medicine
Li Y,Jiang Y,Zhou W,Wu Y,Zhang S,Ding G,Zhang Y,Zhang A,Huang S,Jia Z,You R
Tue Mar 01 00:00:00 UTC 2022
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
The Journal of cell biology
Oshima Y,Cartier E,Boyman L,Verhoeven N,Polster BM,Huang W,Kane M,Lederer WJ,Karbowski M
Mon Jun 07 00:00:00 UTC 2021
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Wang W,Qin Y,Song H,Wang L,Jia M,Zhao C,Gong M,Zhao W
Tue Jun 01 00:00:00 UTC 2021
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Biochemical pharmacology
Sun H,Ou T,Hu J,Yang Z,Lei Q,Li Y,Wang G,Li Y,Wu K,Wang S,Wu S
Sun Aug 01 00:00:00 UTC 2021
TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro.
Nature communications
Baek M,Choe YJ,Bannwarth S,Kim J,Maitra S,Dorn GW,Taylor JP,Paquis-Flucklinger V,Kim NC
Fri Mar 26 00:00:00 UTC 2021
Autophagy Receptor Protein Tax1-Binding Protein 1/TRAF6-Binding Protein Is a Cellular Substrate of Enteroviral Proteinase.
Frontiers in microbiology
Mohamud Y,Xue YC,Liu H,Ng CS,Bahreyni A,Luo H
Tue Jun 22 00:00:00 UTC 2021
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
Autophagy
Franco-Iborra S,Plaza-Zabala A,Montpeyo M,Sebastian D,Vila M,Martinez-Vicente M
Mon Mar 01 00:00:00 UTC 2021
The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury.
Redox biology
Wang Y,Zhu J,Liu Z,Shu S,Fu Y,Liu Y,Cai J,Tang C,Liu Y,Yin X,Dong Z
Fri Jan 01 00:00:00 UTC 2021
The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury.
Redox biology
Wang Y,Zhu J,Liu Z,Shu S,Fu Y,Liu Y,Cai J,Tang C,Liu Y,Yin X,Dong Z
Fri Jan 01 00:00:00 UTC 2021
Coordinate regulation of the senescent state by selective autophagy.
Developmental cell
Lee Y,Kim J,Kim MS,Kwon Y,Shin S,Yi H,Kim H,Chang MJ,Chang CB,Kang SB,Kim VN,Kim JH,Kim JS,Elledge SJ,Kang C
Mon May 17 00:00:00 UTC 2021
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Life sciences
Tai Y,Pu M,Yuan L,Guo H,Qiao J,Lu H,Wang G,Chen J,Qi X,Tao Z,Ren J
Thu Jul 01 00:00:00 UTC 2021
Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.
Human molecular genetics
Liu X,Wang Q,Shao Z,Zhang S,Hou M,Jiang M,Du M,Li J,Yuan H
Mon May 31 00:00:00 UTC 2021
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Cell death & disease
Zhang C,Nie P,Zhou C,Hu Y,Duan S,Gu M,Jiang D,Wang Y,Deng Z,Chen J,Chen S,Wang L
Wed Feb 24 00:00:00 UTC 2021
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Scientific reports
Schlütermann D,Berleth N,Deitersen J,Wallot-Hieke N,Friesen O,Wu W,Stuhldreier F,Sun Y,Berning L,Friedrich A,Mendiburo MJ,Peter C,Wiek C,Hanenberg H,Stefanski A,Stühler K,Stork B
Mon Jul 05 00:00:00 UTC 2021
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy.
Acta pharmaceutica Sinica. B
Tang Y,Wang L,Yi T,Xu J,Wang J,Qin JJ,Chen Q,Yip KM,Pan Y,Hong P,Lu Y,Shen HM,Chen HB
Wed Dec 01 00:00:00 UTC 2021
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Molecular cell
Zellner S,Schifferer M,Behrends C
Thu Mar 18 00:00:00 UTC 2021
PINK1-mediated mitophagy maintains pluripotency through optineurin.
Cell proliferation
Wang C,Liu K,Cao J,Wang L,Zhao Q,Li Z,Zhang H,Chen Q,Zhao T
Sat May 01 00:00:00 UTC 2021
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro.
Cell death discovery
Zhang S,Shao Z,Liu X,Hou M,Cheng F,Lei D,Yuan H
Mon Mar 15 00:00:00 UTC 2021
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro.
Cell death discovery
Zhang S,Shao Z,Liu X,Hou M,Cheng F,Lei D,Yuan H
Mon Mar 15 00:00:00 UTC 2021
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro.
Cell death discovery
Zhang S,Shao Z,Liu X,Hou M,Cheng F,Lei D,Yuan H
Mon Mar 15 00:00:00 UTC 2021
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro.
Cell death discovery
Zhang S,Shao Z,Liu X,Hou M,Cheng F,Lei D,Yuan H
Mon Mar 15 00:00:00 UTC 2021
Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1.
Cryobiology
Taylor D,Germano J,Song Y,Hadj-Moussa H,Marek-Iannucci S,Dhanji R,Sin J,Czer LSC,Storey KB,Gottlieb RA
Fri Oct 01 00:00:00 UTC 2021
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
Molecular cell
Sarraf SA,Shah HV,Kanfer G,Pickrell AM,Holtzclaw LA,Ward ME,Youle RJ
Thu Dec 03 00:00:00 UTC 2020
The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.
Autophagy
Zheng L,Shu WJ,Li YM,Mari M,Yan C,Wang D,Yin ZH,Jiang W,Zhou Y,Okamoto K,Reggiori F,Klionsky DJ,Song Z,Du HN
Sat Aug 01 00:00:00 UTC 2020
UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway.
Cells
Chen T,Zhang W,Huang B,Chen X,Huang C
Wed May 13 00:00:00 UTC 2020
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Nature communications
Choi I,Zhang Y,Seegobin SP,Pruvost M,Wang Q,Purtell K,Zhang B,Yue Z
Fri Mar 13 00:00:00 UTC 2020
Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.
Cell death and differentiation
Wong SW,Huang BW,Hu X,Ho Kim E,Kolb JP,Padilla RJ,Xue P,Wang L,Oguin TH,Miguez PA,Tseng HC,Ko CC,Martinez J
Wed Jan 01 00:00:00 UTC 2020
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Autophagy
Thayer JA,Awad O,Hegdekar N,Sarkar C,Tesfay H,Burt C,Zeng X,Feldman RA,Lipinski MM
Wed Jan 01 00:00:00 UTC 2020
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Autophagy
Thayer JA,Awad O,Hegdekar N,Sarkar C,Tesfay H,Burt C,Zeng X,Feldman RA,Lipinski MM
Wed Jan 01 00:00:00 UTC 2020
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase.
The Journal of biological chemistry
Homma K,Takahashi H,Tsuburaya N,Naguro I,Fujisawa T,Ichijo H
Fri Mar 06 00:00:00 UTC 2020
Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells.
Oncology letters
Li S,Yang H,Zhao M,Gong L,Wang Y,Lv Z,Quan Y,Wang Z
Tue Dec 01 00:00:00 UTC 2020
Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Xia B,Yu J,He T,Liu X,Su J,Wang M,Wang J,Zhu Y
Sat Feb 01 00:00:00 UTC 2020
GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon.
Infection and immunity
Zhang Z,Gu H,Li Q,Zheng J,Cao S,Weng C,Jia H
Mon Apr 20 00:00:00 UTC 2020
Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis.
Science advances
Rimessi A,Pozzato C,Carparelli L,Rossi A,Ranucci S,De Fino I,Cigana C,Talarico A,Wieckowski MR,Ribeiro CMP,Trapella C,Rossi G,Cabrini G,Bragonzi A,Pinton P
Fri May 01 00:00:00 UTC 2020
Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.
The Journal of cell biology
Yamano K,Kikuchi R,Kojima W,Hayashida R,Koyano F,Kawawaki J,Shoda T,Demizu Y,Naito M,Tanaka K,Matsuda N
Mon Sep 07 00:00:00 UTC 2020
Topology-dependent, bifurcated mitochondrial quality control under starvation.
Autophagy
Zhou Y,Long Q,Wu H,Li W,Qi J,Wu Y,Xiang G,Tang H,Yang L,Chen K,Li L,Bao F,Li H,Wang Y,Li M,Liu X
Sun Mar 01 00:00:00 UTC 2020
Quantitative patterns of motor cortex proteinopathy across ALS genotypes.
Acta neuropathologica communications
Nolan M,Scott C,Gamarallage MP,Lunn D,Carpenter K,McDonough E,Meyer D,Kaanumalle S,Santamaria-Pang A,Turner MR,Talbot K,Ansorge O
Thu Jul 02 00:00:00 UTC 2020
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
Molecular cell
D'Amico D,Mottis A,Potenza F,Sorrentino V,Li H,Romani M,Lemos V,Schoonjans K,Zamboni N,Knott G,Schneider BL,Auwerx J
Thu Feb 21 00:00:00 UTC 2019
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
Molecular cell
D'Amico D,Mottis A,Potenza F,Sorrentino V,Li H,Romani M,Lemos V,Schoonjans K,Zamboni N,Knott G,Schneider BL,Auwerx J
Thu Feb 21 00:00:00 UTC 2019
The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau).
Autophagy
Xu Y,Zhang S,Zheng H
Mon Apr 01 00:00:00 UTC 2019
The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau).
Autophagy
Xu Y,Zhang S,Zheng H
Mon Apr 01 00:00:00 UTC 2019
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Autophagy
Li H,Ham A,Ma TC,Kuo SH,Kanter E,Kim D,Ko HS,Quan Y,Sardi SP,Li A,Arancio O,Kang UJ,Sulzer D,Tang G
Tue Jan 01 00:00:00 UTC 2019
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Autophagy
Li H,Ham A,Ma TC,Kuo SH,Kanter E,Kim D,Ko HS,Quan Y,Sardi SP,Li A,Arancio O,Kang UJ,Sulzer D,Tang G
Tue Jan 01 00:00:00 UTC 2019
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab.
Oncogene
Wang D,Xu Q,Yuan Q,Jia M,Niu H,Liu X,Zhang J,Young CY,Yuan H
Wed May 01 00:00:00 UTC 2019
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab.
Oncogene
Wang D,Xu Q,Yuan Q,Jia M,Niu H,Liu X,Zhang J,Young CY,Yuan H
Wed May 01 00:00:00 UTC 2019
Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ.
Molecular reproduction and development
Lin Y,Liang A,He Y,Li Z,Li Z,Wang G,Sun F
Sun Sep 01 00:00:00 UTC 2019
Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis.
EMBO reports
Cairó M,Campderrós L,Gavaldà-Navarro A,Cereijo R,Delgado-Anglés A,Quesada-López T,Giralt M,Villarroya J,Villarroya F
Wed May 01 00:00:00 UTC 2019
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.
Nature communications
Ferreira JCB,Campos JC,Qvit N,Qi X,Bozi LHM,Bechara LRG,Lima VM,Queliconi BB,Disatnik MH,Dourado PMM,Kowaltowski AJ,Mochly-Rosen D
Fri Jan 18 00:00:00 UTC 2019
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Nature communications
Cheng G,Zhang Q,Pan J,Lee Y,Ouari O,Hardy M,Zielonka M,Myers CR,Zielonka J,Weh K,Chang AC,Chen G,Kresty L,Kalyanaraman B,You M
Fri May 17 00:00:00 UTC 2019
Acteoside inhibits autophagic apoptosis of retinal ganglion cells to rescue glaucoma-induced optic atrophy.
Journal of cellular biochemistry
Chen Q,Xi X,Zeng Y,He Z,Zhao J,Li Y
Thu Aug 01 00:00:00 UTC 2019
Acteoside inhibits autophagic apoptosis of retinal ganglion cells to rescue glaucoma-induced optic atrophy.
Journal of cellular biochemistry
Chen Q,Xi X,Zeng Y,He Z,Zhao J,Li Y
Thu Aug 01 00:00:00 UTC 2019
Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology.
eLife
Zhang P,Fan B,Yang P,Temirov J,Messing J,Kim HJ,Taylor JP
Wed Mar 20 00:00:00 UTC 2019
Demethylation of the HACE1 gene promoter inhibits the proliferation of human liver cancer cells.
Oncology letters
Yu Z,Li Y,Han T,Liu Z
Wed May 01 00:00:00 UTC 2019
Demethylation of the HACE1 gene promoter inhibits the proliferation of human liver cancer cells.
Oncology letters
Yu Z,Li Y,Han T,Liu Z
Wed May 01 00:00:00 UTC 2019
Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review.
Molecular genetics & genomic medicine
Yu H,Yu W,Luo SS,Yang YJ,Liu FT,Zhang Y,Chen Y,Sun YM,Wu JJ
Fri Mar 01 00:00:00 UTC 2019
Activation of PINK1-Parkin-dependent mitophagy in Tri-ortho-cresyl phosphate-treated Neuro2a cells.
Chemico-biological interactions
Wang Y,Zhang C,Shen Z,Kou R,Xie K,Song F
Thu Aug 01 00:00:00 UTC 2019
STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism.
Nature communications
Xian H,Yang Q,Xiao L,Shen HM,Liou YC
Fri May 03 00:00:00 UTC 2019
Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
EMBO molecular medicine
Palomo GM,Granatiero V,Kawamata H,Konrad C,Kim M,Arreguin AJ,Zhao D,Milner TA,Manfredi G
Mon Oct 01 00:00:00 UTC 2018
Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
EMBO molecular medicine
Palomo GM,Granatiero V,Kawamata H,Konrad C,Kim M,Arreguin AJ,Zhao D,Milner TA,Manfredi G
Mon Oct 01 00:00:00 UTC 2018
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
EMBO reports
Furuya N,Kakuta S,Sumiyoshi K,Ando M,Nonaka R,Suzuki A,Kazuno S,Saiki S,Hattori N
Sat Dec 01 00:00:00 UTC 2018
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
EMBO reports
Furuya N,Kakuta S,Sumiyoshi K,Ando M,Nonaka R,Suzuki A,Kazuno S,Saiki S,Hattori N
Sat Dec 01 00:00:00 UTC 2018
Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.
JCI insight
Andres AM,Tucker KC,Thomas A,Taylor DJ,Sengstock D,Jahania SM,Dabir R,Pourpirali S,Brown JA,Westbrook DG,Ballinger SW,Mentzer RM,Gottlieb RA
Thu Feb 23 00:00:00 UTC 2017
Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.
JCI insight
Andres AM,Tucker KC,Thomas A,Taylor DJ,Sengstock D,Jahania SM,Dabir R,Pourpirali S,Brown JA,Westbrook DG,Ballinger SW,Mentzer RM,Gottlieb RA
Thu Feb 23 00:00:00 UTC 2017
Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes.
Toxins
Puri M,La Pietra L,Mraheil MA,Lucas R,Chakraborty T,Pillich H
Tue Sep 05 00:00:00 UTC 2017
Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes.
Toxins
Puri M,La Pietra L,Mraheil MA,Lucas R,Chakraborty T,Pillich H
Tue Sep 05 00:00:00 UTC 2017
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Nature communications
Gundry C,Marco S,Rainero E,Miller B,Dornier E,Mitchell L,Caswell PT,Campbell AD,Hogeweg A,Sansom OJ,Morton JP,Norman JC
Wed Mar 15 00:00:00 UTC 2017
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Nature communications
Gundry C,Marco S,Rainero E,Miller B,Dornier E,Mitchell L,Caswell PT,Campbell AD,Hogeweg A,Sansom OJ,Morton JP,Norman JC
Wed Mar 15 00:00:00 UTC 2017
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Cell
Zhong Z,Umemura A,Sanchez-Lopez E,Liang S,Shalapour S,Wong J,He F,Boassa D,Perkins G,Ali SR,McGeough MD,Ellisman MH,Seki E,Gustafsson AB,Hoffman HM,Diaz-Meco MT,Moscat J,Karin M
Thu Feb 25 00:00:00 UTC 2016
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Cell
Zhong Z,Umemura A,Sanchez-Lopez E,Liang S,Shalapour S,Wong J,He F,Boassa D,Perkins G,Ali SR,McGeough MD,Ellisman MH,Seki E,Gustafsson AB,Hoffman HM,Diaz-Meco MT,Moscat J,Karin M
Thu Feb 25 00:00:00 UTC 2016
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.
The Journal of cell biology
Nguyen TN,Padman BS,Usher J,Oorschot V,Ramm G,Lazarou M
Mon Dec 19 00:00:00 UTC 2016
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.
The Journal of cell biology
Nguyen TN,Padman BS,Usher J,Oorschot V,Ramm G,Lazarou M
Mon Dec 19 00:00:00 UTC 2016
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.
European journal of immunology
Slowicka K,Vereecke L,Mc Guire C,Sze M,Maelfait J,Kolpe A,Saelens X,Beyaert R,van Loo G
Fri Apr 01 00:00:00 UTC 2016
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.
European journal of immunology
Slowicka K,Vereecke L,Mc Guire C,Sze M,Maelfait J,Kolpe A,Saelens X,Beyaert R,van Loo G
Fri Apr 01 00:00:00 UTC 2016
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.
Biochemical and biophysical research communications
Zhang J,Chen K,Wang L,Wan X,Shrestha C,Zhou J,Mo Z
Fri Aug 05 00:00:00 UTC 2016
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.
Biochemical and biophysical research communications
Zhang J,Chen K,Wang L,Wan X,Shrestha C,Zhou J,Mo Z
Fri Aug 05 00:00:00 UTC 2016
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nature communications
Nakazawa S,Oikawa D,Ishii R,Ayaki T,Takahashi H,Takeda H,Ishitani R,Kamei K,Takeyoshi I,Kawakami H,Iwai K,Hatada I,Sawasaki T,Ito H,Nureki O,Tokunaga F
Wed Aug 24 00:00:00 UTC 2016
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nature communications
Nakazawa S,Oikawa D,Ishii R,Ayaki T,Takahashi H,Takeda H,Ishitani R,Kamei K,Takeyoshi I,Kawakami H,Iwai K,Hatada I,Sawasaki T,Ito H,Nureki O,Tokunaga F
Wed Aug 24 00:00:00 UTC 2016
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Nature
Lazarou M,Sliter DA,Kane LA,Sarraf SA,Wang C,Burman JL,Sideris DP,Fogel AI,Youle RJ
Thu Aug 20 00:00:00 UTC 2015
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Nature
Lazarou M,Sliter DA,Kane LA,Sarraf SA,Wang C,Burman JL,Sideris DP,Fogel AI,Youle RJ
Thu Aug 20 00:00:00 UTC 2015
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Human molecular genetics
Tao Z,Wang H,Xia Q,Li K,Li K,Jiang X,Xu G,Wang G,Ying Z
Fri May 01 00:00:00 UTC 2015
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.
Human molecular genetics
Tao Z,Wang H,Xia Q,Li K,Li K,Jiang X,Xu G,Wang G,Ying Z
Fri May 01 00:00:00 UTC 2015
Interaction between optineurin and the bZIP transcription factor NRL.
Cell biology international
Wang C,Hosono K,Ohtsubo M,Ohishi K,Gao J,Nakanishi N,Hikoya A,Sato M,Hotta Y,Minoshima S
Wed Jan 01 00:00:00 UTC 2014
Interaction between optineurin and the bZIP transcription factor NRL.
Cell biology international
Wang C,Hosono K,Ohtsubo M,Ohishi K,Gao J,Nakanishi N,Hikoya A,Sato M,Hotta Y,Minoshima S
Wed Jan 01 00:00:00 UTC 2014
Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.
PloS one
Gao J,Ohtsubo M,Hotta Y,Minoshima S
Thu Dec 03 00:00:00 UTC 2015
Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.
PloS one
Gao J,Ohtsubo M,Hotta Y,Minoshima S
Thu Dec 03 00:00:00 UTC 2015
Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina.
Molecular biology reports
Meng Q,Xiao Z,Yuan H,Xue F,Zhu Y,Zhou X,Yang B,Sun J,Meng B,Sun X,Cheng F
Wed Feb 01 00:00:00 UTC 2012
Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina.
Molecular biology reports
Meng Q,Xiao Z,Yuan H,Xue F,Zhu Y,Zhou X,Yang B,Sun J,Meng B,Sun X,Cheng F
Wed Feb 01 00:00:00 UTC 2012
Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina.
Molecular biology reports
Meng Q,Xiao Z,Yuan H,Xue F,Zhu Y,Zhou X,Yang B,Sun J,Meng B,Sun X,Cheng F
Wed Feb 01 00:00:00 UTC 2012
Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina.
Molecular biology reports
Meng Q,Xiao Z,Yuan H,Xue F,Zhu Y,Zhou X,Yang B,Sun J,Meng B,Sun X,Cheng F
Wed Feb 01 00:00:00 UTC 2012
Optineurin in neurodegenerative diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Osawa T,Mizuno Y,Fujita Y,Takatama M,Nakazato Y,Okamoto K
Thu Dec 01 00:00:00 UTC 2011
Optineurin in neurodegenerative diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Osawa T,Mizuno Y,Fujita Y,Takatama M,Nakazato Y,Okamoto K
Thu Dec 01 00:00:00 UTC 2011
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.
Acta neuropathologica
Al-Sarraj S,King A,Troakes C,Smith B,Maekawa S,Bodi I,Rogelj B,Al-Chalabi A,Hortobágyi T,Shaw CE
Thu Dec 01 00:00:00 UTC 2011
