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Proteintech
ORAI3 Polyclonal Antibody
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Product Details
25766-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ORAI3 Fusion Protein Ag22513 (1-100 aa encoded by BC006126)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
Immunogen sequence: MKGGEGDAG EQAPLNPEGE SPAGSATYRE FVHRGYLDLM GASQHSLRAL SWRRLYLSRA KLKASSRTSA LLSGFAMVAM VEVQLESDHE YPPGLLVAFS A (1-100 aa encoded by BC006126)
Target Information
ORAI3 is a protein coding gene that is involved in calcium signaling and regulation of calcium homeostasis. It is a member of the ORAI family of proteins that form calcium release-activated calcium (CRAC) channels in the plasma membrane of cells. These channels are activated by depletion of calcium from the endoplasmic reticulum, leading to an influx of calcium ions into the cytoplasm. ORAI3 has been implicated in a variety of physiological processes, including T-cell activation, muscle contraction, and neurotransmitter release. Dysregulation of ORAI3 expression or function has been associated with various diseases, including immune disorders, cancer, and cardiovascular disease
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium release-activated calcium channel 3; Protein orai-3; Transmembrane protein 142C
Gene Aliases: 9930124N15; BC061259; ORAI3; TMEM142C
UniProt ID: (Human) Q9BRQ5, (Mouse) Q6P8G8
Entrez Gene ID: (Human) 93129, (Mouse) 269999
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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