Proteintech

ORM1 Polyclonal Antibody

ORM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ORM1 Antibody (16439-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human liver tissue slide using (Product # 16439-1-AP) ORM1 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

ORM1 Antibody in Immunoprecipitation (IP)

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Product Details

16439-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ORM1 Fusion Protein Ag9758 (25-201 aa encoded by BC026238)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes a band about 44 kDa in human plasma which may be due to the glycosylation of ORM1 or the dimer formation of the protein.

Immunogen sequence: NLVPVPITN ATLDRITGKW FYIASAFRNE EYNKSVQEIQ ATFFYFTPNK TEDTIFLREY QTRQDQCIYN TTYLNVQREN GTISRYVGGQ EHFAHLLILR DTKTYMLAFD VNDEKNWGLS VYADKPETTK EQLGEFYEAL DCLRIPKSDV VYTDWKKDKC EPLEKQHEKE RKQEEGES (25-201 aa encoded by BC026238 )

Target Information

ORM1 is an acute phase plasma protein synthesized by the liver. The protein is believed to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, also regulates the extravasation of the cells during infection and inflammation. ORM1 is a major acute phase reactant, both in human and in rat. In human plasma, ORM1 (44 kDa) is found at levels of 0.5-1.4 mg/mL. Its concentration in blood plasma is elevated during acute inflammation, such as trauma, malignancies, myocardial infarction, rheumatoid arthritis, bacterial infections, after major surgery, in cases of chronic pain etc, and can be used for the diagnosis of inflammatory conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis.

Nature metabolism

Zhou B,Luo Y,Ji N,Hu C,Lu Y

Thu Sep 01 00:00:00 UTC 2022

Urine Proteome in Distinguishing Hepatic Steatosis in Patients with Metabolic-Associated Fatty Liver Disease.

Diagnostics (Basel, Switzerland)

Liu CH,Zheng S,Wang S,Wu D,Jiang W,Zeng Q,Wei Y,Zhang Y,Tang H

Tue Jun 07 00:00:00 UTC 2022

Thapsigargin suppresses alpha 1-acid glycoprotein secretion independently of N-glycosylation and ER stress.

Biochemical and biophysical research communications

Goto N,Shibutani S,Miura N,Watanabe R,Iwata H

Fri May 07 00:00:00 UTC 2021

Thapsigargin suppresses alpha 1-acid glycoprotein secretion independently of N-glycosylation and ER stress.

Biochemical and biophysical research communications

Goto N,Shibutani S,Miura N,Watanabe R,Iwata H

Fri May 07 00:00:00 UTC 2021

An acute phase protein α₁-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action.

Scientific reports

Watanabe H,Fujimura R,Hiramoto Y,Murata R,Nishida K,Bi J,Imafuku T,Komori H,Maeda H,Mukunoki A,Takeo T,Nakagata N,Tanaka M,Matsushita K,Fukagawa M,Maruyama T

Mon Apr 12 00:00:00 UTC 2021

Orosomucoid 1 promotes epirubicin resistance in breast cancer by upregulating the expression of matrix metalloproteinases 2 and 9.

Bioengineered

Qiong L,Yin J

Wed Dec 01 00:00:00 UTC 2021

α₁-Acid Glycoprotein Attenuates Adriamycin-Induced Nephropathy via CD163 Expressing Macrophage Induction.

Kidney360

Fujimura R,Watanabe H,Nishida K,Fujiwara Y,Koga T,Bi J,Imafuku T,Kobayashi K,Komori H,Miyahisa M,Maeda H,Tanaka M,Matsushita K,Wada T,Fukagawa M,Maruyama T

Thu May 28 00:00:00 UTC 2020

α₁-Acid Glycoprotein Attenuates Adriamycin-Induced Nephropathy via CD163 Expressing Macrophage Induction.

Kidney360

Fujimura R,Watanabe H,Nishida K,Fujiwara Y,Koga T,Bi J,Imafuku T,Kobayashi K,Komori H,Miyahisa M,Maeda H,Tanaka M,Matsushita K,Wada T,Fukagawa M,Maruyama T

Thu May 28 00:00:00 UTC 2020

FXR-Gankyrin axis is involved in development of pediatric liver cancer.

Carcinogenesis

Valanejad L,Lewis K,Wright M,Jiang Y,D'Souza A,Karns R,Sheridan R,Gupta A,Bove K,Witte D,Geller J,Tiao G,Nelson DL,Timchenko L,Timchenko N

Sat Jul 01 00:00:00 UTC 2017

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

British journal of cancer

Jin Y,Wang J,Ye X,Su Y,Yu G,Yang Q,Liu W,Yu W,Cai J,Chen X,Liang Y,Chen Y,Wong BH,Fu X,Sun H

Tue Mar 01 00:00:00 UTC 2016

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation.

Nature communications

Mobin MB,Gerstberger S,Teupser D,Campana B,Charisse K,Heim MH,Manoharan M,Tuschl T,Stoffel M

Mon Sep 26 00:00:00 UTC 2016

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation.

Nature communications

Mobin MB,Gerstberger S,Teupser D,Campana B,Charisse K,Heim MH,Manoharan M,Tuschl T,Stoffel M

Mon Sep 26 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: AGP 1; Alpha-1-acid glycoprotein; Alpha-1-acid glycoprotein 1; alpha-1-acid glycoprotein-2; bM340H1.2 (orosomucoid 1); epididymis secretory sperm binding protein Li 153w; OMD; OMD 1; Orosomucoid; Orosomucoid-1

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Gene Aliases: AGP; Agp-1; Agp-2; AGP-A; AGP1; Agpa1; HEL-S-153w; OMD; ORM; Orm-1; ORM1

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UniProt ID: (Human) P02763, (Rat) P02764, (Mouse) Q60590

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Entrez Gene ID: (Human) 5004, (Rat) 24614, (Mouse) 18405

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Function(s)

protein binding drug binding

Process(es)

platelet degranulation regulation of immune system process acute-phase response inflammatory response negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production acute inflammatory response to antigenic stimulus chronic inflammatory response to antigenic stimulus transport response to organic cyclic compound organ regeneration response to lipopolysaccharide response to vitamin E response to drug cellular response to retinoic acid cellular response to growth hormone stimulus cellular response to glucocorticoid stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ORM1 Polyclonal Antibody

ORM1 Antibody (16439-1-AP) in IHC (P)

Product Details

16439-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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