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Proteintech
ORM2 Monoclonal Antibody (4E9H10)
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Product Details
66217-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4E9H10
Immunogen
ORM2-Specific Fusion Protein Ag18984 (1-201 aa encoded by BC015964)
Conjugate
Form
Liquid
Concentration
0.78 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can specifically recognize ORM2. It recognizes a band about 45 kDa in human plasma which may be due to the glycosylation of ORM2 or the dimer formation of the protein.
Immunogen sequence: MALSWVLTV LSLLPLLEAQ IPLCANLVPV PITNATLDRI TGKWFYIASA FRNEEYNKSV QEIQATFFYF TPNKTEDTIF LREYQTRQNQ CFYNSSYLNV QRENGTVSRY EGGREHVAHL LFLRDTKTLM FGSYLDDEKN WGLSFYADKP ETTKEQLGEF YEALDCLCIP RSDVMYTDWK KDKCEPLEKQ HEKERKQEEG ES (1-201 aa encoded by BC015964)
Target Information
AGP (a 1-acid Glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/mL, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to diagnose inflammatory conditions. Multiple AGP genes exist, including AGP-1, AGP-2, AGP-3 and AGP-8. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AGP 2; Alpha-1-acid glycoprotein 2; alpha-1-acid glycoprotein, type 2; OMD 2; OMD2; Orosomucoid-2; Orosomucoid2
Gene Aliases: AGP-B; AGP-B'; AGP2; ORM2
UniProt ID: (Human) P19652
Entrez Gene ID: (Human) 5005
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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