Proteintech

OS9 Polyclonal Antibody

OS9 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

OS9 Antibody (10061-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HEK-293 cells using 10061-1-AP (OS9 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

OS9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

10061-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OS9 Fusion Protein Ag0106 (125-435 aa encoded by BC000532)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize all three isoforms of OS-9.

Immunogen sequence: GRHIQQYHM EDSEIKGEVL YLGYYQSAFD WDDETAKASK QHRLKRYHSQ TYGNGSKCDL NGRPREAEVR FLCDEGAGIS GDYIDRVDEP LSCSYVLTIR TPRLCPHPLL RPPPSAAPQA ILCHPSLQPE EYMAYVQRQA DSKQYGDKII EELQDLGPQV WSETKSGVAP QKMAGASPTK DDSKDSDFWK MLNEPEDQAP GGEEVPAEEQ DPSPEAADSA SGAPNDFQNN VQVKVIRSPA DLIRFIEELK GGTKKGKPNI GQEQPVDDAA EVPQREPEKE RGDPERQREM EEEEDEDEDE DEDEDERQLL GE (125-435 aa encoded by BC000532)

Target Information

OS9 is an ER glycoprotein found in the intralumenal level and highly expressed in tumor tissue. The OS9 gene is transcriptionally induced upon activation of the Ire1/Xbp1 ER-stress pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1.

Cell & bioscience

Ye Y,Baek SH,Ye Y,Zhang T

Mon Mar 21 00:00:00 UTC 2022

Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1.

Cell & bioscience

Ye Y,Baek SH,Ye Y,Zhang T

Mon Mar 21 00:00:00 UTC 2022

Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant.

The FEBS journal

Fujimori T,Kamiya Y,Nagata K,Kato K,Hosokawa N

Fri Mar 01 00:00:00 UTC 2013

Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant.

The FEBS journal

Fujimori T,Kamiya Y,Nagata K,Kato K,Hosokawa N

Fri Mar 01 00:00:00 UTC 2013

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.

The Journal of biological chemistry

Iida Y,Fujimori T,Okawa K,Nagata K,Wada I,Hosokawa N

Fri May 13 00:00:00 UTC 2011

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.

The Journal of biological chemistry

Iida Y,Fujimori T,Okawa K,Nagata K,Wada I,Hosokawa N

Fri May 13 00:00:00 UTC 2011

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans.

The Journal of biological chemistry

Hosokawa N,Kamiya Y,Kamiya D,Kato K,Nagata K

Fri Jun 19 00:00:00 UTC 2009

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans.

The Journal of biological chemistry

Hosokawa N,Kamiya Y,Kamiya D,Kato K,Nagata K

Fri Jun 19 00:00:00 UTC 2009

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

Nature cell biology

Christianson JC,Shaler TA,Tyler RE,Kopito RR

Sat Mar 01 00:00:00 UTC 2008

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

Nature cell biology

Christianson JC,Shaler TA,Tyler RE,Kopito RR

Sat Mar 01 00:00:00 UTC 2008

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

The Journal of biological chemistry

Hosokawa N,Wada I,Nagasawa K,Moriyama T,Okawa K,Nagata K

Fri Jul 25 00:00:00 UTC 2008

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

The Journal of biological chemistry

Hosokawa N,Wada I,Nagasawa K,Moriyama T,Okawa K,Nagata K

Fri Jul 25 00:00:00 UTC 2008

OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.

The Journal of biological chemistry

Wang Y,Fu X,Gaiser S,Köttgen M,Kramer-Zucker A,Walz G,Wegierski T

Fri Dec 14 00:00:00 UTC 2007

OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.

The Journal of biological chemistry

Wang Y,Fu X,Gaiser S,Köttgen M,Kramer-Zucker A,Walz G,Wegierski T

Fri Dec 14 00:00:00 UTC 2007

OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.

The Journal of biological chemistry

Wang Y,Fu X,Gaiser S,Köttgen M,Kramer-Zucker A,Walz G,Wegierski T

Fri Dec 14 00:00:00 UTC 2007

OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.

The Journal of biological chemistry

Wang Y,Fu X,Gaiser S,Köttgen M,Kramer-Zucker A,Walz G,Wegierski T

Fri Dec 14 00:00:00 UTC 2007

Bioinformatics

Protein Aliases: Amplified in osteosarcoma 9; endoplasmic reticulum lectin 2; erlectin 2; osteosarcoma amplified 9, endoplasmic reticulum associated protein; osteosarcoma amplified 9, endoplasmic reticulum lectin; Protein OS-9

View more View less

Gene Aliases: ERLEC2; OS-9; OS9

View more View less

UniProt ID: (Human) Q13438

View more View less

Entrez Gene ID: (Human) 10956

View more View less

Function(s)

glycoprotein binding protease binding protein binding carbohydrate binding

Process(es)

protein targeting protein retention in ER lumen protein ubiquitination ER-associated ubiquitin-dependent protein catabolic process response to endoplasmic reticulum stress protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of retrograde protein transport, ER to cytosol endoplasmic reticulum mannose trimming

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

OS9 Polyclonal Antibody

OS9 Antibody (10061-1-AP) in ICC/IF

Product Details

10061-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!