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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Oncostatin M Antibodies

          Proteintech

          OSM Polyclonal Antibody

          1 Reference
          View all (27) Oncostatin M antibodies

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          Datasheet
          Protocols
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          Datasheet
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          Cite OSM Polyclonal Antibody

          • Antibody Testing Data (7)
          OSM Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          OSM Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 7

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          OSM Antibody (27792-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 27792-1-AP (OSM antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          OSM Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          OSM Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          OSM Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          OSM Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          OSM Antibody in Western Blot (WB)
          OSM Antibody in Western Blot (WB)
          OSM Antibody in Western Blot (WB)

          Product Details

          27792-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:500
          -

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          OSM Fusion Protein Ag27093 (26-221 aa encoded by BC011589)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.27 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: AAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNRSRR (26-221 aa encoded by BC011589)

          Target Information

          Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: MGC20461; Oncostatin-M; OSM

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          Gene Aliases: OSM

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          UniProt ID: (Human) P13725, (Rat) Q65Z15

          View more View less

          Entrez Gene ID: (Human) 5008, (Rat) 289747

          View more View less

          Function(s)
          cytokine activity oncostatin-M receptor binding growth factor activity
          Process(es)
          immune response peripheral nervous system development positive regulation of cell proliferation negative regulation of cell proliferation response to heat positive regulation of peptidyl-serine phosphorylation oncostatin-M-mediated signaling pathway regulation of growth tyrosine phosphorylation of Stat3 protein tyrosine phosphorylation of Stat5 protein tyrosine phosphorylation of Stat1 protein positive regulation of MAPK cascade negative regulation of meiotic nuclear division positive regulation of transcription from RNA polymerase II promoter negative regulation of hormone secretion behavioral response to pain positive regulation of peptidyl-tyrosine phosphorylation positive regulation of apoptotic signaling pathway positive regulation of acute inflammatory response multicellular organism development cell proliferation positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of cell division
          It has to be done as per old AB suggested Products section.
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