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Product Details
CF500195
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2B6
Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 25-252 of human OSM
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC20461; Oncostatin-M; OSM
Gene Aliases: OSM
UniProt ID: (Human) P13725
Entrez Gene ID: (Human) 5008
positive regulation of acute inflammatory response
immune response
multicellular organism development
peripheral nervous system development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to heat
positive regulation of peptidyl-serine phosphorylation
oncostatin-M-mediated signaling pathway
regulation of growth
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
negative regulation of meiotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
negative regulation of hormone secretion
behavioral response to pain
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell division
positive regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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