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Invitrogen
OTUD7B Polyclonal Antibody
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Product Details
PA5-110068
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 530-700 of human OTUD7B (NP_064590.2).
Conjugate
Form
Liquid
Concentration
0.99 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855479
Product Specific Information
Immunogen sequence: SKPGGVGTGL GGSSGTETLE KKKKNSLKSW KGGKEEAAGD GPVSEKPPAE SVGNGGSKYS QEVMQSLSIL RTAMQGEGKF IFVGTLKMGH RHQYQEEMIQ RYLSDAEERF LAEQKQKEAE RKIMNGGIGG GPPPAKKPEP DAREEQPTGP PAESRAMAFS TGYPGDFTIP R
Target Information
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cellular zinc finger anti-NF-kappa-B protein; cellular zinc finger anti-NF-kappaB Cezanne; Cezanne; OTU domain containing 7B; OTU domain-containing protein 7B; TRAF binding domain containing 2; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne; zinc finger, A20 domain containing 1
Gene Aliases: 2900060B22Rik; 4930463P07Rik; AI462125; CEZANNE; OTUD7B; RGD1308111; Trabid2; ZA20D1
UniProt ID: (Human) Q6GQQ9, (Mouse) B2RUR8
Entrez Gene ID: (Human) 56957, (Rat) 310677, (Mouse) 229603
negative regulation of transcription from RNA polymerase II promoter
mucosal immune response
proteolysis
protein deubiquitination
negative regulation of interleukin-8 production
protein K11-linked deubiquitination
negative regulation of I-kappaB kinase/NF-kappaB signaling
protein K63-linked deubiquitination
protein K48-linked deubiquitination
negative regulation of protein localization to nucleus
immune system process
immune response
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
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