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Invitrogen
OX40 Polyclonal Antibody
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FIGURE: 1 / 2
OX40 Antibody (PA5-81619) in WB
Western Blot using OX40 Polyclonal Antibody (Product # PA5-81619) at 1:500 dilution. Lane A: MOLT4 Whole Cell Lysate, Lane B: THP1 Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti- RabbitIgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 30 kDa. Observed band size: 47 kDa.
Product Details
PA5-81619
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the C-terminus of the Rat OX40/TNFRSF4/CD134
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2788814
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Rat OX40/TNFRSF4/CD134.
Target Information
OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system. When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents. OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer. They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD134; MRC OX40; OX40 antigen; OX40L receptor; Tax-transcriptionally activated glycoprotein 1; tumor necrosis factor (ligand) superfamily member 4; Tumor necrosis factor receptor superfamily member 4; tumor necrosis factor superfamily, member 4
Gene Aliases: Ox40; Tnfrsf4; Txgp1; Txgp1l
UniProt ID: (Rat) P15725
Entrez Gene ID: (Rat) 25572
inflammatory response
cellular defense response
programmed cell death
positive regulation of B cell proliferation
tumor necrosis factor-mediated signaling pathway
T cell proliferation
regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of protein kinase activity
negative regulation of transcription, DNA-templated
negative regulation of cytokine secretion
positive regulation of immunoglobulin secretion
negative regulation of activation-induced cell death of T cells
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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