Product References
Protective Effect of Limosilactobacillus fermentum ME-3 against the Increase in Paracellular Permeability Induced by Chemotherapy or Inflammatory Conditions in Caco-2 Cell Models.
International journal of molecular sciences
De Gregorio A,Serafino A,Krasnowska EK,Superti F,Di Fazio MR,Fuggetta MP,Hammarberg Ferri I,Fiorentini C
33-1500 was used in Immunocytochemistry to demonstrate that ME-3 prevents the IRI-induced increment in paracellular permeability, possibly by modulating the expression and localization of cell junction components.
Sat Mar 25 00:00:00 UTC 2023
Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice.
Frontiers in pharmacology
Berezin CT,Bergum N,Torres Lopez GM,Vigh J
33-1500 was used in Immunohistochemistry to suggest that reduced P-gp expression mediates retinal morphine accumulation upon systemic delivery, and in turn, potential effects on circadian photoentrainment.
Wed Jul 19 00:00:00 UTC 2023
Defined Differentiation of Human Pluripotent Stem Cells to Brain Microvascular Endothelial-Like Cells for Modeling the Blood-Brain Barrier.
Methods in molecular biology (Clifton, N.J.)
Foreman KL,Shusta EV,Palecek SP
33-1500 was used in Immunocytochemistry to provide a detailed, step-by-step protocol for differentiation of human pluripotent stem cells (hPSCs) to cells exhibiting key characteristics of BMECs, including paracellular and transcellular transport resistance and transporter function that enable modeling the human BBB.
Mon Jun 12 00:00:00 UTC 2023
Interaction between mitochondrial homeostasis and barrier function in lipopolysaccharide-induced endothelial cell injury.
International journal of experimental pathology
Zhu W,Liu X,Luo L,Huang X,Wang X
33-1500 was used in Western Blot to investigate the effects of mitochondrial homeostasis on lipopolysaccharide (LPS)-induced endothelial cell barrier function and the mechanisms that underlie these effects.
Fri Dec 01 00:00:00 UTC 2023
Supplemental wheat germ modulates phosphorylation of STAT3 in the gut and NF-κBp65 in the adipose tissue of mice fed a Western diet.
Current developments in nutrition
Ojo BA,Alake SE,Kaur A,Wong SY,Keirns B,Ritchey JW,Chowanadisai W,Lin D,Clarke S,Smith BJ,Lucas EA
33-1500 was used in Western Blotting to show the potential of WG to influence vital regulatory pathways in the gut and adipose tissue which may reduce the chronic inflammatory burden on these tissues that are important targets in obesity and insulin resistance.
Sun Jan 01 00:00:00 UTC 2023
Dose- and Segment-Dependent Disturbance of Rat Gut by Ionizing Radiation: Impact of Tight Junction Proteins.
International journal of molecular sciences
Livanova AA,Fedorova AA,Zavirsky AV,Krivoi II,Markov AG
33-1500 was used in Western Blot to demonstrate the dose- and segment-specificity of tight junction (TJ) alteration in ionizing radiation (IR)-induced gastrointestinal injury in rats.
Mon Jan 16 00:00:00 UTC 2023
Functional Blood-Brain Barrier Model with Tight Connected Minitissue by Liquid Substrates Culture.
Advanced healthcare materials
Liu N,Zhu Y,Yu K,Gu Z,Lv S,Chen Y,He C,Fu J,He Y
33-1500 was used in Immunocytochemistry to present a new blood-brain barrier (BBB) model with a high-cell spatial density and tightly connected biomimetic minitissue.
Wed Feb 01 00:00:00 UTC 2023
Inhibition of microfold cells ameliorates early pathological phenotypes by modulating microglial functions in Alzheimer's disease mouse model.
Journal of neuroinflammation
Kim N,Ju IG,Jeon SH,Lee Y,Jung MJ,Gee MS,Cho JS,Inn KS,Garrett-Sinha LA,Oh MS,Lee JK
33-1500 was used in Western Blot to provide evidence that the inhibiting M cells can prevent AD progression, with therapeutic implications.
Mon Nov 27 00:00:00 UTC 2023
Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease.
Fluids and barriers of the CNS
Haferkamp U,Hartmann C,Abid CL,Brachner A,Höchner A,Gerhartl A,Harwardt B,Leckzik S,Leu J,Metzger M,Nastainczyk-Wulf M,Neuhaus W,Oerter S,Pless O,Rujescu D,Jung M,Appelt-Menzel A
33-1500 was used in Immunocytochemistry to suggest that different brain cell types of the NVU have unique roles in maintaining barrier integrity that vary under healthy and LOAD conditions..
Tue Oct 31 00:00:00 UTC 2023
Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson's disease.
Cell reports
Schmit KJ,Garcia P,Sciortino A,Aho VTE,Pardo Rodriguez B,Thomas MH,Gérardy JJ,Bastero Acha I,Halder R,Cialini C,Heurtaux T,Ostahi I,Busi SB,Grandmougin L,Lowndes T,Singh Y,Martens EC,Mittelbronn M,Buttini M,Wilmes P
33-1500 was used in Western Blot to study whether fiber deprivation and exposure to bacterial curli, a protein cross-seeding with αSyn, individually or together, exacerbate disease in the enteric and central nervous systems of a transgenic PD mouse model.
Tue Sep 26 00:00:00 UTC 2023
Therapeutic effect of human ApoA-I-Milano variant in aged transgenic mouse model of Alzheimer's disease.
British journal of pharmacology
Solé M,Marazuela P,Castellote L,Bonaterra-Pastra A,Giménez-Llort L,Hernández-Guillamon M
33-1500 was used in Western Blotting to show the potential therapeutic applicability of a safe and non-invasive treatment based on peripheral administration of hrApoA-I-M in Alzheimer's disease.
Tue Aug 01 00:00:00 UTC 2023
Validation and characterization of a novel blood-brain barrier platform for investigating traumatic brain injury.
Scientific reports
Bolden CT,Skibber MA,Olson SD,Zamorano Rojas M,Milewicz S,Gill BS,Cox CS
33-1500 was used in Immunocytochemistry to develop and validate a novel in vitro platform that closely mimics the physiologic parameters of the blood-brain barrier (BBB), including fluidic shear stress and hemodynamic conditions, enabling the characterization of BBB functional properties and its response to ischemic, inflammatory, and metabolic cues.
Tue Sep 26 00:00:00 UTC 2023
Validation and characterization of a novel blood-brain barrier platform for investigating traumatic brain injury.
Scientific reports
Bolden CT,Skibber MA,Olson SD,Zamorano Rojas M,Milewicz S,Gill BS,Cox CS
33-1500 was used in Immunocytochemistry to develop and validate a novel in vitro platform that closely mimics the physiologic parameters of the blood-brain barrier (BBB), including fluidic shear stress and hemodynamic conditions, enabling the characterization of BBB functional properties and its response to ischemic, inflammatory, and metabolic cues.
Tue Sep 26 00:00:00 UTC 2023
An in vitro model for vitamin A transport across the human blood-brain barrier.
eLife
Est CB,Murphy RM
33-1500 was used in Immunocytochemistry to describe herein provide a platform for deeper exploration of the regulatory mechanisms of retinol trafficking to the human brain.
Tue Nov 07 00:00:00 UTC 2023
Transcriptional Signature of Valproic Acid-Induced Neural Tube Defects in Human Spinal Cord Organoids.
International journal of stem cells
Lee JH,Shaker MR,Park SH,Sun W
33-1500 was used in Immunohistochemistry to demonstrate that hSCOs provide a valuable biological resource for dissecting the molecular pathways underlying the currently unknown human neurulation process using destructive biological analysis tools.
Thu Nov 30 00:00:00 UTC 2023
Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M).
Cells
Awad K,Barmeyer C,Bojarski C,Nagel O,Lee IM,Schweiger MR,Schulzke JD,Bücker R
33-1500 was used in Immunohistochemistry (Frozen) to investigate the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type IBS.
Thu Jan 05 00:00:00 UTC 2023
A Monoclonal Human Alveolar Epithelial Cell Line ("Arlo") with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Carius P,Jungmann A,Bechtel M,Grißmer A,Boese A,Gasparoni G,Salhab A,Seipelt R,Urbschat K,Richter C,Meier C,Bojkova D,Cinatl J,Walter J,Schneider-Daum N,Lehr CM
33-1500 was used in Immunocytochemistry to describe the generation of a novel monoclonal cell line Arlo derived from the polyclonal human alveolar epithelium lentivirus immortalized cell line hAELVi.
Wed Mar 01 00:00:00 UTC 2023
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction.
Journal of biomedical science
Chou HC,Cheng CM,Yang CH,Lin TY,Liu YW,Tan TH,Chen YR
33-1500 was used in Western Blotting to reveal that DUSP3 is an important TJ regulatory protein and its decrease may be involved in progression of epithelial cancers.
Wed Jun 15 00:00:00 UTC 2022
Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke.
Aging and disease
Zhang Q,Liu C,Shi R,Zhou S,Shan H,Deng L,Chen T,Guo Y,Zhang Z,Yang GY,Wang Y,Tang Y
33-1500 was used in Immunohistochemistry-immunofluorescence to conclude that astrocytes undergo a phenotypic shift over time after ischemic stroke.
Wed Jun 01 00:00:00 UTC 2022
Streptococcal autolysin promotes dysfunction of swine tracheal epithelium by interacting with vimentin.
PLoS pathogens
Meng Y,Wang Q,Ma Z,Li W,Niu K,Zhu T,Lin H,Lu C,Fan H
33-1500 was used in Western Blotting to investigate the mechanism through which Streptococcus suis serotype 2 penetrates the respiratory barrier.
Mon Aug 01 00:00:00 UTC 2022
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Translational stroke research
Yu R,Kim NS,Li Y,Jeong JY,Park SJ,Zhou B,Oh WJ
33-1500 was used in Immunohistochemistry to investigate whether Sema3E-Plexin-D1 signaling was involved in cerebrovascular remodeling after ischemic injury.
Tue Feb 01 00:00:00 UTC 2022
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Fluids and barriers of the CNS
Williams LM,Fujimoto T,Weaver RR,Logsdon AF,Evitts KM,Young JE,Banks WA,Erickson MA
33-1500 was used in Western Blot to study responses to disease-relevant stimuli in proliferating vs. more quiescent endothelial cell states.
Sat Feb 05 00:00:00 UTC 2022
Differences in Behavior between Normal and Atopic Keratinocytes in Culture: Pilot Studies.
Veterinary sciences
Marsella R,Ahrens K,Wilkes R
33-1500 was used in Immunocytochemistry-immunofluorescence to investigate TEER in normal and atopic keratinocytes.
Thu Jun 30 00:00:00 UTC 2022
Morphological, biochemical, and transcriptomic characterization of iPSC-derived human RPE cells from normal and Smith-Lemli-Opitz syndrome patients.
Molecular vision
Farkas MH,Skelton LA,Ramachandra-Rao S,Au E,Fliesler SJ
33-1500 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to characterize in vitro models of human RPE SLOS pathology utilizing two SLOS patient-derived induced pluripotent stem cell-derived RPE (iPSC-RPE) cell lines-″mild″ SLOS (CWI) and ″severe″ SLOS (A2)-versus a normal human iPSC-RPE cell line (DYS) and performed comparative transcriptomic, morphological, and biochemical analyses.
Thu Dec 22 00:00:00 UTC 2022
Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.
Nature communications
Senabouth A,Daniszewski M,Lidgerwood GE,Liang HH,Hernández D,Mirzaei M,Keenan SN,Zhang R,Han X,Neavin D,Rooney L,Lopez Sanchez MIG,Gulluyan L,Paulo JA,Clarke L,Kearns LS,Gnanasambandapillai V,Chan CL,Nguyen U,Steinmann AM,McCloy RA,Farbehi N,Gupta VK,Mackey DA,Bylsma G,Verma N,MacGregor S,Watt MJ,Guymer RH,Powell JE,Hewitt AW,Pébay A
33-1500 was used in Immunocytochemistry to uncover important differences in retinal pigment epithelium homeostasis associated with geographic atrophy.
Tue Jul 26 00:00:00 UTC 2022
High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats.
Pharmaceutics
Yang J,Betterton RD,Williams EI,Stanton JA,Reddell ES,Ogbonnaya CE,Dorn E,Davis TP,Lochhead JJ,Ronaldson PT
33-1500 was used in Immunohistochemistry (Frozen) to show that BBB integrity is altered following a single high APAP dose, results that are relevant to patients abusing or misusing APAP and/or APAP/opioid combination products.
Wed Apr 27 00:00:00 UTC 2022
FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis.
Frontiers in immunology
Yang Y,Yao M,Zeng J,Zheng D,Li Q,Ni Y,Xiao X
33-1500 was used in Western Blot, Immunohistochemistry (Frozen) to show that it is also possible for viruses to break through the BTB and enter the immunoprivileged testicular microenvironment via this mechanism.
Mon Aug 29 00:00:00 UTC 2022
FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis.
Frontiers in immunology
Yang Y,Yao M,Zeng J,Zheng D,Li Q,Ni Y,Xiao X
33-1500 was used in Western Blot, Immunohistochemistry (Frozen) to show that it is also possible for viruses to break through the BTB and enter the immunoprivileged testicular microenvironment via this mechanism.
Mon Aug 29 00:00:00 UTC 2022
Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes.
Microscopy (Oxford, England)
Ishikawa S,Nikaido M,Otani T,Ogata K,Iida H,Inai Y,Tamaoki S,Inai T
33-1500 was used in Immunocytochemistry-immunofluorescence to find that treatment of K38 3D culture with HX531 improves cellular morphology by reducing intercellular spaces, increasing desmosomal and tight junction proteins as well as transepithelial electrical resistance.
Mon Jun 06 00:00:00 UTC 2022
Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies.
Translational vision science & technology
Wood JPM,Chidlow G,Halliday LA,Casson RJ,Selva D,Sun M
33-1500 was used in Immunohistochemistry to show that the rat LG can serve as a useful surrogate for the human equivalent, but there exist specific tissue differences meaning that caution must be observed when translating results to patients.
Tue Nov 01 00:00:00 UTC 2022
Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies.
Translational vision science & technology
Wood JPM,Chidlow G,Halliday LA,Casson RJ,Selva D,Sun M
33-1500 was used in Immunohistochemistry to show that the rat LG can serve as a useful surrogate for the human equivalent, but there exist specific tissue differences meaning that caution must be observed when translating results to patients.
Tue Nov 01 00:00:00 UTC 2022
The dietary fibre rhamnogalacturonan improves intestinal epithelial barrier function in a microbiota-independent manner.
British journal of pharmacology
Baggio CH,Shang J,Gordon MH,Stephens M,von der Weid PY,Nascimento AM,Román Y,Cipriani TR,MacNaughton WK
33-1500 was used in Immunocytochemistry to find that a polysaccharide, rhamnogalacturonan (RGal), from the plant Acmella oleracea, has direct effects on intestinal epithelial barrier function and determine the mechanism whereby RGal enhances epithelial barrier function.
Sat Jan 01 00:00:00 UTC 2022
Astrocytic VEGFA: An essential mediator in blood-brain-barrier disruption in Parkinson's disease.
Glia
Lan G,Wang P,Chan RB,Liu Z,Yu Z,Liu X,Yang Y,Zhang J
33-1500 was used in Western Blotting to illustrate that oligomeric α-syn is critically involved in PD-associated BBB disruption, in a process that is mediated by astrocyte-derived VEGFA.
Tue Feb 01 00:00:00 UTC 2022
Voglibose Regulates the Secretion of GLP-1 Accompanied by Amelioration of Ileal Inflammatory Damage and Endoplasmic Reticulum Stress in Diabetic KKAy Mice.
International journal of molecular sciences
Fu Y,Ji W,Liu Q,Zhang L,Li C,Huan Y,Lei L,Gao X,Chen L,Feng C,Lei L,Zhai J,Li P,Cao H,Liu S,Shen Z
33-1500 was used in Western Blotting to show that voglibose enhanced the secretion of GLP-1, which contributed to the glycemic control in KKAy mice at least in part by regulating intestinal inflammation and the expression of ERS factors.
Wed Dec 14 00:00:00 UTC 2022
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.
Life science alliance
Grelet S,Fréreux C,Obellianne C,Noguchi K,Howley BV,Dalton AC,Howe PH
33-1500 was used in Western Blotting to identify how primary tumor cell EMT could trigger tumor axonogenesis and metastasis and validate the correlation between the EMT program and axonogenesis in the context of human breast carcinomas.
Tue Feb 01 00:00:00 UTC 2022
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.
Life science alliance
Grelet S,Fréreux C,Obellianne C,Noguchi K,Howley BV,Dalton AC,Howe PH
33-1500 was used in Western Blotting to identify how primary tumor cell EMT could trigger tumor axonogenesis and metastasis and validate the correlation between the EMT program and axonogenesis in the context of human breast carcinomas.
Tue Feb 01 00:00:00 UTC 2022
Curcumin Mitigates TNFα-Induced Caco-2 Cell Monolayer Permeabilization Through Modulation of NF-κB, ERK1/2, and JNK Pathways.
Molecular nutrition & food research
Iglesias DE,Cremonini E,Oteiza PI,Fraga CG
33-1500 was used in Western Blotting to study the capacity of curcumin to inhibit tumor necrosis alpha (TNFα)-induced inflammation, oxidative stress, and loss of intestinal barrier integrity, characterizing the underlying mechanisms.Caco-2 cell monolayers are incubated with TNFα (10 ng mL-1 ), in the absence or presence of curcumin.
Tue Nov 01 00:00:00 UTC 2022
Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
Nature communications
Gonschior H,Schmied C,Van der Veen RE,Eichhorst J,Himmerkus N,Piontek J,Günzel D,Bleich M,Furuse M,Haucke V,Lehmann M
33-1500 was used in Immuno-assay to suggest that nanoscale segregation of distinct channel-forming claudins enables barrier function combined with specific paracellular ion flux across tight junctions.
Thu Aug 25 00:00:00 UTC 2022
Astrocytic responses to high glucose impair barrier formation in cerebral microvessel endothelial cells.
American journal of physiology. Regulatory, integrative and comparative physiology
Garvin J,Semenikhina M,Liu Q,Rarick K,Isaeva E,Levchenko V,Staruschenko A,Palygin O,Harder D,Cohen S
33-1500 was used in Western Blotting to provide insight into gliovascular adaptations to increased glucose levels resulting in impaired cellular cross talk between astrocytes and CMEC, which could be one explanation for cerebral BBB disruption in diabetic conditions.
Wed Jun 01 00:00:00 UTC 2022
Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice.
Frontiers in pharmacology
Miao Y,Zhang Q,Yuan Z,Wang J,Xu Y,Chai Y,Du M,Yu Q,Zhang L,Jiang Z
33-1500 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to demonstrate that gut-liver axis plays a vital part in the progression of GTW-induced hepatotoxicity.
Tue Dec 06 00:00:00 UTC 2022
Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice.
Frontiers in pharmacology
Miao Y,Zhang Q,Yuan Z,Wang J,Xu Y,Chai Y,Du M,Yu Q,Zhang L,Jiang Z
33-1500 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to demonstrate that gut-liver axis plays a vital part in the progression of GTW-induced hepatotoxicity.
Tue Dec 06 00:00:00 UTC 2022
ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions.
Cells
Haas AJ,Zihni C,Krug SM,Maraspini R,Otani T,Furuse M,Honigmann A,Balda MS,Matter K
33-1500 was used in Western Blotting to reveal that reciprocal regulation between ZO-1 and cell mechanics controls tight junction assembly and epithelial morphogenesis, and that, in a second, tension-independent step, ZO-1 is required to assemble morphologically and structurally fully assembled and functionally normal tight junctions.
Fri Nov 25 00:00:00 UTC 2022
HIV-1 gp120 and tobacco smoke synergistically disrupt the integrity of the blood-brain barrier.
European journal of cell biology
Bhalerao A,Cucullo L
33-1500 was used in Western Blot to suggest that a potential synergistic effect between smoke exposure and gp120 can worsen the loss of BBB viability, possibly exacerbating NeuroAIDS progression.
Fri Dec 16 00:00:00 UTC 2022
Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice.
Neural regeneration research
Deng LD,Qi L,Suo Q,Wu SJ,Mamtilahun M,Shi RB,Liu Z,Sun JF,Tang YH,Zhang ZJ,Yang GY,Wang JX
33-1500 was used in Western Blotting to show that low-intensity ultrasound stimulation attenuated BBB disruption and edema formation, which suggests it may have therapeutic use in ischemic brain disease as a protector of BBB integrity.
Thu Sep 01 00:00:00 UTC 2022
Aeromonas sobria Serine Protease Degrades Several Protein Components of Tight Junctions and Assists Bacterial Translocation Across the T84 Monolayer.
Frontiers in cellular and infection microbiology
Ueda M,Kobayashi H,Seike S,Takahashi E,Okamoto K,Yamanaka H
33-1500 was used in Western Blotting to investigate the effect of Aeromonas sobria serine protease on tight junctions (TJs) in T84 cells.
Wed Apr 06 00:00:00 UTC 2022
Endothelial Unc5B controls blood-brain barrier integrity.
Nature communications
Boyé K,Geraldo LH,Furtado J,Pibouin-Fragner L,Poulet M,Kim D,Nelson B,Xu Y,Jacob L,Maissa N,Agalliu D,Claesson-Welsh L,Ackerman SL,Eichmann A
33-1500 was used in Western Blot to identify Netrin-1-Unc5B signaling as a ligand-receptor pathway that regulates BBB integrity.
Fri Mar 04 00:00:00 UTC 2022
Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.
The British journal of dermatology
El-Chami C,Foster AR,Johnson C,Clausen RP,Cornwell P,Haslam IS,Steward MC,Watson REB,Young HS,O'Neill CA
33-1500 was used in Immunohistochemistry to investigate whether osmolytes can modify tight junctions.
Mon Mar 01 00:00:00 UTC 2021
Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function.
Current biology : CB
Broussard JA,Koetsier JL,Hegazy M,Green KJ
33-1500 was used in Western Blot, Immunohistochemistry to demonstrate that the desmosome-IF network is a critical contributor to the cytoskeletal-adhesive machinery that supports the polarized function of the epidermis.
Mon Aug 09 00:00:00 UTC 2021
Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function.
Current biology : CB
Broussard JA,Koetsier JL,Hegazy M,Green KJ
33-1500 was used in Western Blot, Immunohistochemistry to demonstrate that the desmosome-IF network is a critical contributor to the cytoskeletal-adhesive machinery that supports the polarized function of the epidermis.
Mon Aug 09 00:00:00 UTC 2021
Alveolar epithelial glycocalyx shedding aggravates the epithelial barrier and disrupts epithelial tight junctions in acute respiratory distress syndrome.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Li J,Qi Z,Li D,Huang X,Qi B,Feng J,Qu J,Wang X
33-1500 was used in Immunocytochemistry to demonstrate that shedding of the alveolar epithelial glycocalyx aggravates the epithelial barrier and damages epithelial TJ proteins in ARDS, with the underlying mechanism involving the effect of HPA on ZO-1.
Fri Jan 01 00:00:00 UTC 2021
AIM2 deletion enhances blood-brain barrier integrity in experimental ischemic stroke.
CNS neuroscience & therapeutics
Xu SY,Bian HJ,Shu S,Xia SN,Gu Y,Zhang MJ,Xu Y,Cao X
33-1500 was used in Western Blot to explore the effects of AIM2 on the BBB integrity in mice with middle cerebral artery occlusion induced injury and in oxygen-glucose deprivation/reoxygenation induced human brain microvascular endothelial cells.
Fri Oct 01 00:00:00 UTC 2021
Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Winkler L,Blasig R,Breitkreuz-Korff O,Berndt P,Dithmer S,Helms HC,Puchkov D,Devraj K,Kaya M,Qin Z,Liebner S,Wolburg H,Andjelkovic AV,Rex A,Blasig IE,Haseloff RF
33-1500 was used in Immunohistochemistry to assess the effects of claudin 3 deficiency and stress factors on the BBB and its tight junctions.
Fri Jan 01 00:00:00 UTC 2021
Melatonin maintains inner blood-retinal barrier via inhibition of p38/TXNIP/NF-κB pathway in diabetic retinopathy.
Journal of cellular physiology
Tang L,Zhang C,Yang Q,Xie H,Liu D,Tian H,Lu L,Xu JY,Li W,Xu G,Qiu Q,Liu K,Luo D,Xu GT,Zhang J
33-1500 was used in Western Blotting to show that in diabetic rat retinas, the leakage of iBRB and the expression of inflammatory factors (VEGF, TNF-α, IL-1β, ICAM-1, and MMP9) increased dramatically, while the expression of tight junction proteins (ZO-1, occludin, JAM-A, and claudin-5) decreased significantly.
Sun Aug 01 00:00:00 UTC 2021
Melatonin maintains inner blood-retinal barrier via inhibition of p38/TXNIP/NF-κB pathway in diabetic retinopathy.
Journal of cellular physiology
Tang L,Zhang C,Yang Q,Xie H,Liu D,Tian H,Lu L,Xu JY,Li W,Xu G,Qiu Q,Liu K,Luo D,Xu GT,Zhang J
33-1500 was used in Western Blotting to show that in diabetic rat retinas, the leakage of iBRB and the expression of inflammatory factors (VEGF, TNF-α, IL-1β, ICAM-1, and MMP9) increased dramatically, while the expression of tight junction proteins (ZO-1, occludin, JAM-A, and claudin-5) decreased significantly.
Sun Aug 01 00:00:00 UTC 2021
Diammonium glycyrrhizinate lipid ligand ameliorates lipopolysaccharide-induced acute lung injury by modulating vascular endothelial barrier function.
Experimental and therapeutic medicine
Liu MM,Zhou J,Ji D,Yang J,Huang YP,Wang Q
33-1500 was used in Immunohistochemistry (Paraffin) to investigate the effects of diammonium glycyrrhizinate lipid ligand (DGLL) treatment on acute lung injury (ALI) and pulmonary edema induced by lipopolysaccharide (LPS) in Sprague-Dawley rats.
Thu Apr 01 00:00:00 UTC 2021
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.
Nature communications
Pediaditakis I,Kodella KR,Manatakis DV,Le CY,Hinojosa CD,Tien-Street W,Manolakos ES,Vekrellis K,Hamilton GA,Ewart L,Rubin LL,Karalis K
33-1500 was used in Immunohistochemistry to enable research into the dynamics of cell-cell interactions in human synucleinopathies and serve as a testing platform for target identification and validation of novel therapeutics.
Fri Oct 08 00:00:00 UTC 2021
Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries.
eLife
Olivera GC,Ross EC,Peuckert C,Barragan A
33-1500 was used in Immunohistochemistry-immunofluorescence to reveal that the initial passage of T. gondii to the central nervous system occurs principally across cortical capillaries and that the integrity of the microvascular BBB restricts parasite transit, which conversely is exacerbated by the inflammatory response.
Wed Dec 08 00:00:00 UTC 2021
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β.
Nature aging
Montagne A,Nikolakopoulou AM,Huuskonen MT,Sagare AP,Lawson EJ,Lazic D,Rege SV,Grond A,Zuniga E,Barnes SR,Prince J,Sagare M,Hsu CJ,LaDu MJ,Jacobs RE,Zlokovic BV
33-1500 was used in Immunohistochemistry to show that, compared to APOE3, APOE4 accelerates blood-brain barrier (BBB) breakdown, loss of cerebral blood flow, neuronal loss and behavioral deficits independently of amyloid-β.
Tue Jun 01 00:00:00 UTC 2021
Epithelial Barrier Integrity Profiling: Combined Approach Using Cellular Junctional Complex Imaging and Transepithelial Electrical Resistance.
SLAS discovery : advancing life sciences R & D
Pell TJ,Gray MB,Hopkins SJ,Kasprowicz R,Porter JD,Reeves T,Rowan WC,Singh K,Tvermosegaard KB,Yaqub N,Wayne GJ
33-1500 was used in Immunocytochemistry to demonstrate measurable changes in barrier integrity in cells grown under conditions known to perturb epithelial cell function.
Sun Aug 01 00:00:00 UTC 2021
Endothelial Thioredoxin-Interacting Protein Depletion Reduces Hemorrhagic Transformation in Hyperglycemic Mice after Embolic Stroke and Thrombolytic Therapy.
Pharmaceuticals (Basel, Switzerland)
Salman M,Ismael S,Li L,Ahmed HA,Puchowicz MA,Ishrat T
33-1500 was used in Western Blot to test the hypothesis that endothelial-specific thioredoxin-interacting protein knock-out mice will be more resistant to the neurovascular damage associated with hyperglycemia in embolic stroke.
Mon Sep 27 00:00:00 UTC 2021
Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
International journal of molecular sciences
Droessler L,Cornelius V,Markov AG,Amasheh S
33-1500 was used in Western Blot, Immunohistochemistry to analyze functional, molecular and regulatory effects of Tumor necrosis factor alpha (TNFα) in a newly established non-transformed jejunal enterocyte model, namely IPEC-J2 monolayers.
Sat Aug 14 00:00:00 UTC 2021
Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
International journal of molecular sciences
Droessler L,Cornelius V,Markov AG,Amasheh S
33-1500 was used in Western Blot, Immunohistochemistry to analyze functional, molecular and regulatory effects of Tumor necrosis factor alpha (TNFα) in a newly established non-transformed jejunal enterocyte model, namely IPEC-J2 monolayers.
Sat Aug 14 00:00:00 UTC 2021
Brain endothelial LRP1 maintains blood-brain barrier integrity.
Fluids and barriers of the CNS
Storck SE,Kurtyka M,Pietrzik CU
33-1500 was used in Western Blot to supplement previous results and show that brain endothelial Lrp1 ablation results in protease-mediated tight junction degradation, P-glycoprotein (P-gp) reduction and a loss of BBB integrity.
Sat Jun 19 00:00:00 UTC 2021
Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics.
Nutrients
Nunes S,Viana SD,Preguiça I,Alves A,Fernandes R,Teodoro JS,Matos P,Figueirinha A,Salgueiro L,André A,Silva S,Jarak I,Carvalho RA,Cavadas C,Rolo AP,Palmeira CM,Pintado MM,Reis F
33-1500 was used in Immunohistochemistry (Frozen) to evaluate the effects of BJ on glucose, insulin, and lipid profiles; gut microbiota composition; intestinal barrier integrity; and metabolic endotoxemia, as well as on hepatic metabolic surrogates, including several related to mitochondria bioenergetics.
Tue Nov 23 00:00:00 UTC 2021
Effects of 1,2-Dimethylhydrazine on Barrier Properties of Rat Large Intestine and IPEC-J2 Cells.
International journal of molecular sciences
Bekusova V,Droessler L,Amasheh S,Markov AG
33-1500 was used in Western Blotting to show that the increase of claudin-4 in rat colon after chronic DMH exposure was consistent with the acute effect of DMH on IPEC-J2 cells, which may indicate an essential role of this protein in colorectal cancer development.
Fri Sep 24 00:00:00 UTC 2021
Lactobacillus casei and Epidermal Growth Factor Prevent Osmotic Stress-Induced Tight Junction Disruption in Caco-2 Cell Monolayers.
Cells
Samak G,Rao R,Rao R
33-1500 was used in Immunocytochemistry-immunoflourescence to suggest that L. casei and EGF ameliorate osmotic stress-induced disruption of apical junctional complexes and barrier dysfunction in the intestinal epithelium by distinct signaling mechanisms.
Sat Dec 18 00:00:00 UTC 2021
Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C.
Frontiers in cellular neuroscience
Van Hoecke L,Van Cauwenberghe C,Dominko K,Van Imschoot G,Van Wonterghem E,Castelein J,Xie J,Claeys W,Vandendriessche C,Kremer A,Borghgraef P,De Rycke R,Hecimovic S,Vandenbroucke RE
33-1500 was used in immunohistochemistry (paraffin) to reveal for the first time that the choroid plexus and CSF EVs might play a role in the brain-related pathogenesis of NPC1.
Tue Nov 02 00:00:00 UTC 2021
Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice.
Cell reports
Chang CS,Liao YC,Huang CT,Lin CM,Cheung CHY,Ruan JW,Yu WH,Tsai YT,Lin IJ,Huang CH,Liou JS,Chou YH,Chien HJ,Chuang HL,Juan HF,Huang HC,Chan HL,Liao YC,Tang SC,Su YW,Tan TH,Bäumler AJ,Kao CY
33-1500 was used in Proximity Ligation Assay to demonstrate if dual-specificity phosphatase 6 (Dusp6) knockout enhances baseline colon barrier integrity and ameliorates dextran sulfate sodium (DSS)-induced colonic injury.
Tue Nov 23 00:00:00 UTC 2021
PerfuPul-A Versatile Perfusable Platform to Assess Permeability and Barrier Function of Air Exposed Pulmonary Epithelia.
Frontiers in bioengineering and biotechnology
Carius P,Dubois A,Ajdarirad M,Artzy-Schnirman A,Sznitman J,Schneider-Daum N,Lehr CM
33-1500 was used in Immunocytochemistry to present a versatile perfusable platform that combines the advantages of well-based filter supports with the benefits of perfusion, to assess barrier permeability of and aerosol deposition on ALI cultured pulmonary epithelial cells.
Tue Oct 26 00:00:00 UTC 2021
Bazedoxifene, a Selective Estrogen Receptor Modulator, Promotes Functional Recovery in a Spinal Cord Injury Rat Model.
International journal of molecular sciences
Kim Y,Roh EJ,Joshi HP,Shin HE,Choi H,Kwon SY,Sohn S,Han I
33-1500 was used in Immunocytochemistry to examine the effects of BZA in a rat spinal cord injury (SCI) model.
Tue Oct 12 00:00:00 UTC 2021
Epithelial-Specific TLR4 Knockout Challenges Current Evidence of TLR4 Homeostatic Control of Gut Permeability.
Inflammatory intestinal diseases
Crame EE,Bowen JM,Secombe KR,Coller JK,François M,Leifert W,Wardill HR
33-1500 was used in Immunohistochemistry to support the use of the Tlr4ΔIEC line in future models interrogating health and disease, confirming no confounding effects of genetic manipulation.
Wed Dec 01 00:00:00 UTC 2021
Radiation-induced abscopal reproductive effect is driven by TNF-α/p38 MAPK/Rac1 axis in Sertoli cells.
Theranostics
Hu S,Zhu L,Song Y,Zhao X,Chen Q,Pan Y,Zhang J,Bai Y,Zhang H,Shao C
33-1500 was used in Western Blot to show that YWHAZ-mediated Rac1 nuclear translocation plays central roles in RIARE, and TNF-α/p38 MAPK/Rac1 axis can be employed as a therapeutic target against RIARE for young male patients receiving hypofractionated radiotherapy.
Fri Jul 30 00:00:00 UTC 2021
The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study.
International journal of molecular sciences
Le Phan TH,Park SY,Jung HJ,Kim MW,Cho E,Shim KS,Shin E,Yoon JH,Maeng HJ,Kang JH,Oh SH
33-1500 was used in Western Blot to investigate the tight junction-modulating effects of processed Aloe vera gel.
Thu Jun 17 00:00:00 UTC 2021
The Role of Intestinal Dysbacteriosis Induced Arachidonic Acid Metabolism Disorder in Inflammaging in Atherosclerosis.
Frontiers in cellular and infection microbiology
Sun Y,Wu D,Zeng W,Chen Y,Guo M,Lu B,Li H,Sun C,Yang L,Jiang X,Gao Q
33-1500 was used in Immunohistochemistry (Frozen) to explore the underlying mechanism of how ageing aggravates atherosclerosis advancement.
Fri Jul 02 00:00:00 UTC 2021
Transport of Dietary Anti-Inflammatory Peptide, γ-Glutamyl Valine (γ-EV), across the Intestinal Caco-2 Monolayer.
Nutrients
Guha S,Alvarez S,Majumder K
33-1500 was used in Western Blot, Immunocytochemistry to elucidate the mechanism of transport of γ-EV across Caco-2 cells.
Sat Apr 24 00:00:00 UTC 2021
Transport of Dietary Anti-Inflammatory Peptide, γ-Glutamyl Valine (γ-EV), across the Intestinal Caco-2 Monolayer.
Nutrients
Guha S,Alvarez S,Majumder K
33-1500 was used in Western Blot, Immunocytochemistry to elucidate the mechanism of transport of γ-EV across Caco-2 cells.
Sat Apr 24 00:00:00 UTC 2021
High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors.
Journal of neuroinflammation
Seguella L,Pesce M,Capuano R,Casano F,Pesce M,Corpetti C,Vincenzi M,Maftei D,Lattanzi R,Del Re A,Sarnelli G,Gulbransen BD,Esposito G
33-1500 was used in Immunohistochemistry to test the hypothesis that anxiogenic and depressive-like behaviors driven by consuming a HFD involve compromised duodenal barrier integrity and subsequent phenotypic changes to glia and neurons along the gut-brain axis.
Sun May 16 00:00:00 UTC 2021
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
Biology
Huang X,Oshima T,Tomita T,Fukui H,Miwa H
33-1500 was used in Western Blot to suggest that butyrate is the main component of SCFAs to alleviate barrier dysfunction and that claudin-2 is the major target of this SCFA.
Tue Mar 09 00:00:00 UTC 2021
Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model.
Frontiers in cellular neuroscience
Heyburn L,Abutarboush R,Goodrich S,Urioste R,Batuure A,Wheel J,Wilder DM,Arun P,Ahlers ST,Long JB,Sajja VS
33-1500 was used in Western Blotting to show that cumulative effects of repeated low-level BOP may increase the vulnerability to injury of the brain by disrupting neurovascular architecture, which may lead to downstream deleterious effects on behavior and cognition.
Wed Mar 10 00:00:00 UTC 2021
Recombinant Annexin A2 Administration Improves Neurological Outcomes After Traumatic Brain Injury in Mice.
Frontiers in pharmacology
Cheng C,Wang X,Jiang Y,Li Y,Liao Z,Li W,Yu Z,Whalen MJ,Lok J,Dumont AS,Liu N,Wang X
33-1500 was used in Western Blot to test the hypothesis that Annexin A2 (ANXA2) might be a candidate for the development of cerebrovascular therapy in targeting early blood-brain barrier integrity disruption from post-traumatic brain injury, as well subacute/delayed cerebrovascular remodeling.
Fri Aug 20 00:00:00 UTC 2021
Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration.
Cell reports. Medicine
Mihi B,Gong Q,Nolan LS,Gale SE,Goree M,Hu E,Lanik WE,Rimer JM,Liu V,Parks OB,Lewis AN,Agrawal P,Laury ML,Kumar P,Huang E,Bidani SS,Luke CJ,Kolls JK,Good M
33-1500 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to investigate the role of IL-22 in the neonatal intestine under homeostatic and inflammatory conditions by using a mouse model of NEC.
Tue Jun 15 00:00:00 UTC 2021
Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers.
Fluids and barriers of the CNS
Kadry H,Noorani B,Bickel U,Abbruscato TJ,Cucullo L
33-1500 was used in Western Blot to quantitatively assess the damaging effects of tobacco smoke and electronic cigarettes and the protective effects of metformin on blood-brain barrier integrity.
Tue Jun 22 00:00:00 UTC 2021
Fractalkine Is Linked to the Necrosome Pathway in Acute Pulmonary Inflammation.
Frontiers in medicine
Ngamsri KC,Gamper-Tsigaras J,Reutershan J,Konrad FM
33-1500 was used in Western Blot to link CX3CL1 to the necrosome complex in pulmonary inflammation and demonstrate a pivotal role of the necrosome complex in human PMNs.
Fri Apr 02 00:00:00 UTC 2021
Nano-scale architecture of blood-brain barrier tight-junctions.
eLife
Sasson E,Anzi S,Bell B,Yakovian O,Zorsky M,Deutsch U,Engelhardt B,Sherman E,Vatine G,Dzikowski R,Ben-Zvi A
33-1500 was used in Immunohistochemistry to provide a unique perspective of BBB TJs and open new directions for understanding TJ functionality in biological barriers, ultimately enabling restoration in disease or modulation for drug delivery.
Fri Dec 24 00:00:00 UTC 2021
Regulation of Intestinal Epithelial Barrier and Immune Function by Activated T Cells.
Cellular and molecular gastroenterology and hepatology
Le N,Mazahery C,Nguyen K,Levine AD
33-1500 was used in Immunocytochemistry to conclude that bidirectional communication between T cells and epithelium mediates a biphasic response in barrier integrity that is facilitated by the balance between structural proteins partitioning in the mobile lateral phase vs the tight junction complex and cell morphology.
Mon Dec 20 00:00:00 UTC 2021
Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome.
Molecular neurobiology
Ismael S,Nasoohi S,Yoo A,Mirzahosseini G,Ahmed HA,Ishrat T
33-1500 was used in Western Blotting to investigate whether verapamil, an established TXNIP inhibitor, may provide protection against hyperglycemic stroke and tPA-induced blood-brain barrier (BBB) disruption.
Sun Aug 01 00:00:00 UTC 2021
Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis.
Molecular metabolism
Hasan NM,Johnson KF,Yin J,Baetz NW,Fayad L,Sherman V,Blutt SE,Estes MK,Kumbhari V,Zachos NC,Kovbasnjuk O
33-1500 was used in Immunocytochemistry to investigate the mechanisms behind the efficacy of bariatric surgery (BS) in treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel.
Mon Feb 01 00:00:00 UTC 2021
Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions.
STAR protocols
Nishihara H,Gastfriend BD,Kasap P,Palecek SP,Shusta EV,Engelhardt B
33-1500 was used in Immunocytochemistry to demonstrate a method for differentiating human pluripotent stem cells into brain microvascular endothelial cell-like cells.
Fri Jun 18 00:00:00 UTC 2021
Gut-Kidney Axis on Chip for Studying Effects of Antibiotics on Risk of Hemolytic Uremic Syndrome by Shiga Toxin-Producing Escherichia coli.
Toxins
Lee Y,Kim MH,Alves DR,Kim S,Lee LP,Sung JH,Park S
33-1500 was used in Immunocytochemistry to suggest that GKA on chip is very useful for simultaneous observation of O157 infections and Stx2 poisoning in gut and kidney cells, making it suitable for studying the effects of antibiotics on the risk of HUS.
Tue Nov 02 00:00:00 UTC 2021
Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice.
Cell host & microbe
Seo B,Jeon K,Moon S,Lee K,Kim WK,Jeong H,Cha KH,Lim MY,Kang W,Kweon MN,Sung J,Kim W,Park JH,Ko G
33-1500 was used in Immunocytochemistry to demonstrate that Roseburia spp. improve the gut ecosystem and prevent leaky gut, leading to ameliorated ALDs.
Wed Jan 08 00:00:00 UTC 2020
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice.
The Journal of clinical investigation
Raju P,Shashikanth N,Tsai PY,Pongkorpsakol P,Chanez-Paredes S,Steinhagen PR,Kuo WT,Singh G,Tsukita S,Turner JR
33-1500 was used in an ELISA assay to define the impact of claudin-2 channels on disease using mice models.
Thu Oct 01 00:00:00 UTC 2020
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Acta neuropathologica
Devraj G,Guérit S,Seele J,Spitzer D,Macas J,Khel MI,Heidemann R,Braczynski AK,Ballhorn W,Günther S,Ogunshola OO,Mittelbronn M,Ködel U,Monoranu CM,Plate KH,Hammerschmidt S,Nau R,Devraj K,Kempf VAJ
33-1500 was used in Immunohistochemistry to demonstrate paracellular migration of bacteria across BBB and a critical role for HIF-1α/VEGF therein and hence propose targeting this pathway to prevent BBB dysfunction and ensuing brain damage in infections.
Sat Aug 01 00:00:00 UTC 2020
Quantitative analysis and virulence phenotypes of atypical enteropathogenic Escherichia coli (EPEC) acquired from diarrheal stool samples from a Midwest US hospital.
Gut microbes
Carlino MJ,Kralicek SE,Santiago SA,Sitaraman LM,Harrington AT,Hecht GA
33-1500 was used in Immunocytochemistry to isolate and characterize EPEC from diarrhea samples identified as EPEC positive by BioFire Gastrointestinal Panel (GIP).
Mon Nov 09 00:00:00 UTC 2020
Bifidobacterium longum alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation.
Gut microbes
Zhou C,Fang X,Xu J,Gao J,Zhang L,Zhao J,Meng Y,Zhou W,Han X,Bai Y,Li Z,Zou D
33-1500 was used in Western Blotting to evaluate the precise effects of B. longum on IBS via regulation of Paneth cell function.
Mon Nov 09 00:00:00 UTC 2020
Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress.
Oxidative medicine and cellular longevity
Qu S,Zhang C,Liu D,Wu J,Tian H,Lu L,Xu GT,Liu F,Zhang J
33-1500 was used in Western Blotting to demonstrate that metformin maintained the barrier functions of RPE cells both in vivo and in vitro.
Wed Dec 16 00:00:00 UTC 2020
Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Oxidative medicine and cellular longevity
Xu X,Zhang X,Gao L,Liu C,You K
33-1500 was used in Western Blot, Immunohistochemistry to investigate how neonatal hyperoxia affected the expression of key tight junction proteins and inflammatory factors (IL-6 and TNF-α) in the developing rat kidneys and elucidated their correlation with renal injury.
Tue Sep 07 00:00:00 UTC 2021
Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Oxidative medicine and cellular longevity
Xu X,Zhang X,Gao L,Liu C,You K
33-1500 was used in Western Blot, Immunohistochemistry to investigate how neonatal hyperoxia affected the expression of key tight junction proteins and inflammatory factors (IL-6 and TNF-α) in the developing rat kidneys and elucidated their correlation with renal injury.
Tue Sep 07 00:00:00 UTC 2021
Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kumar H,Lim CS,Choi H,Joshi HP,Kim KT,Kim YH,Park CK,Kim HM,Han IB
33-1500 was used in Western Blotting to report the expression and contribution of TRPV4 in the pathology of scarring and endothelial and secondary damage after SCI.
Wed Feb 26 00:00:00 UTC 2020
Bacteria Remediate the Effects of Food Additives on Intestinal Function in an in vitro Model of the Gastrointestinal Tract.
Frontiers in nutrition
Malik M,Subedi S,Marques CNH,Mahler GJ
33-1500 was used in Immunocytochemistry-immunoflourescence to develop and establish a physiologically relevant model of the upper gastrointestinal tract to study the complex interactions between food additives, individual bacterial species, and intestinal function.
Thu May 13 00:00:00 UTC 2021
Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma.
Journal of cellular physiology
Semina EV,Rubina KA,Shmakova AA,Rysenkova KD,Klimovich PS,Aleksanrushkina NA,Sysoeva VY,Karagyaur MN,Tkachuk VA
33-1500 was used in Western Blotting to show that urokinase-type plasminogen activator receptor (uPAR) expression is essential for maintaining the epithelial phenotype in Neuro2a cells and that uPAR silencing promotes epithelial-mesenchymal transition (EMT) and increased cell migration.
Tue Sep 01 00:00:00 UTC 2020
Herpes Simplex Virus 1-Induced Blood-Brain Barrier Damage Involves Apoptosis Associated With GM130-Mediated Golgi Stress.
Frontiers in molecular neuroscience
He Q,Liu H,Huang C,Wang R,Luo M,Lu W
33-1500 was used in Western Blot to reveal an association between the GA and the BBB during HSV-1 infection and identify potentially novel targets for protecting the BBB and therapeutic approaches for patients with HSE.
Mon Sep 28 00:00:00 UTC 2020
Intestinal vitamin D receptor signaling ameliorates dextran sulfate sodium-induced colitis by suppressing necroptosis of intestinal epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shi Y,Cui X,Sun Y,Zhao Q,Liu T
33-1500 was used in Immunocytochemistry to offer some theoretical basis for a novel treatment of IBD in clinical practice.
Thu Oct 01 00:00:00 UTC 2020
Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Torices S,Roberts SA,Park M,Malhotra A,Toborek M
33-1500 was used in Western Blotting to identify a novel mechanism involved in HIV-1 infection contributing to a better understanding of the HIV-1 pathology and the associated neuroinflammatory responses.
Tue Dec 01 00:00:00 UTC 2020
Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation.
The American journal of pathology
Garcia G,Paul S,Beshara S,Ramanujan VK,Ramaiah A,Nielsen-Saines K,Li MMH,French SW,Morizono K,Kumar A,Arumugaswami V
33-1500 was used in Immunohistochemistry to study the pathophysiological mechanisms of Zika virus-mediated ocular and neuronal pathology.
Wed Apr 01 00:00:00 UTC 2020
Transplantation of iPS-derived vascular endothelial cells improves white matter ischemic damage.
Journal of neurochemistry
Xu B,Kurachi M,Shimauchi-Ohtaki H,Yoshimoto Y,Ishizaki Y
33-1500 was used in Immunohistochemistry to suggest that internal vascular endothelial cell transplantation can be used to treat demyelination and brain dysfunction cause by white matter infarct.
Mon Jun 01 00:00:00 UTC 2020
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
Journal of neurochemistry
Wu J,He J,Tian X,Luo Y,Zhong J,Zhang H,Li H,Cen B,Jiang T,Sun X
33-1500 was used in Immunocytochemistry-immunoflourescence to investigate the effects of miRNA-9-5p on brain function in traumatic brain injury using rat models.
Mon Jun 01 00:00:00 UTC 2020
Interaction of alcohol with time of eating on markers of circadian dyssynchrony and colon tissue injury.
Chemico-biological interactions
Bishehsari F,Preuss F,Mirbagheri SS,Zhang L,Shaikh M,Keshavarzian A
33-1500 was used in SDS-PAGE to study the interaction of alcohol with an abnormal eating pattern on markers of circadian dyssynchrony and colonic barrier integrity.
Wed Jul 01 00:00:00 UTC 2020
Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex.
Journal of neurogastroenterology and motility
Lee JY,Kim N,Choi YJ,Park JH,Ashktorab H,Smoot DT,Lee DH
33-1500 was used in Western Blotting to determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex.
Thu Apr 30 00:00:00 UTC 2020
N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.
Oncology reports
Pérez AG,Andrade-Da-Costa J,De Souza WF,De Souza Ferreira M,Boroni M,De Oliveira IM,Freire-Neto CA,Fernandes PV,De Lanna CA,Souza-Santos PT,Morgado-Díaz JA,De-Freitas-Junior JCM
33-1500 was used in Western Blotting to identify a mechanism integrating receptor tyrosine kinase signalling and N-glycosylation for the regulation of claudin-3 levels in colorectal cancer.
Thu Oct 01 00:00:00 UTC 2020
Nicotine directly affects milk production in lactating mammary epithelial cells concurrently with inactivation of STAT5 and glucocorticoid receptor in vitro.
Toxicology in vitro : an international journal published in association with BIBRA
Kobayashi K,Tsugami Y,Suzuki N,Suzuki T,Nishimura T
33-1500 was used in Immunohistochemistry to investigate whether nicotine directly affects milk production in lactating mammary epithelial cells.
Sun Mar 01 00:00:00 UTC 2020
The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis.
Molecular biology of the cell
Dowdell AS,Cartwright IM,Goldberg MS,Kostelecky R,Ross T,Welch N,Glover LE,Colgan SP
33-1500 was used in Western Blot, Immunocytochemistry to identify HIF transcriptional targets in Intestinal epithelial cells.
Tue Sep 15 00:00:00 UTC 2020
The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis.
Molecular biology of the cell
Dowdell AS,Cartwright IM,Goldberg MS,Kostelecky R,Ross T,Welch N,Glover LE,Colgan SP
33-1500 was used in Western Blot, Immunocytochemistry to identify HIF transcriptional targets in Intestinal epithelial cells.
Tue Sep 15 00:00:00 UTC 2020
CRISPR-Mediated Isogenic Cell-SELEX Approach for Generating Highly Specific Aptamers Against Native Membrane Proteins.
Cellular and molecular bioengineering
Rosch JC,Neal EH,Balikov DA,Rahim M,Lippmann ES
33-1500 was used in Western Blot, Immunocytochemistry to indicate that highly specific aptamers can be isolated with a SELEX strategy that utilizes isogenic cell lines.
Thu Oct 01 00:00:00 UTC 2020
CRISPR-Mediated Isogenic Cell-SELEX Approach for Generating Highly Specific Aptamers Against Native Membrane Proteins.
Cellular and molecular bioengineering
Rosch JC,Neal EH,Balikov DA,Rahim M,Lippmann ES
33-1500 was used in Western Blot, Immunocytochemistry to indicate that highly specific aptamers can be isolated with a SELEX strategy that utilizes isogenic cell lines.
Thu Oct 01 00:00:00 UTC 2020
Hypertonic saline improves brain edema resulting from traumatic brain injury by suppressing the NF-κB/IL-1β signaling pathway and AQP4.
Experimental and therapeutic medicine
Zhang H,Liu J,Liu Y,Su C,Fan G,Lu W,Feng L
33-1500 was used in Western Blotting to investigate the therapeutic mechanism of hypertonic saline (HS) in brain edema in terms of aquaporins and inflammatory factors.
Sun Nov 01 00:00:00 UTC 2020
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Nature communications
Samson AL,Zhang Y,Geoghegan ND,Gavin XJ,Davies KA,Mlodzianoski MJ,Whitehead LW,Frank D,Garnish SE,Fitzgibbon C,Hempel A,Young SN,Jacobsen AV,Cawthorne W,Petrie EJ,Faux MC,Shield-Artin K,Lalaoui N,Hildebrand JM,Silke J,Rogers KL,Lessene G,Hawkins ED,Murphy JM
33-1500 was used in Immunocytochemistry-immunoflourescence to identify MLKL trafficking and plasma membrane accumulation as crucial necroptosis checkpoints.
Fri Jun 19 00:00:00 UTC 2020
miR-1323 Promotes Cell Migration in Lung Adenocarcinoma by Targeting Cbl-b and Is an Early Prognostic Biomarker.
Frontiers in oncology
Zhao H,Zheng C,Wang Y,Hou K,Yang X,Cheng Y,Che X,Xie S,Wang S,Zhang T,Kang J,Liu Y,Pan D,Qu X,Hu X,Fan Y
33-1500 was used in Western Blotting to determine the clinical significance of miR-1323 in the prognosis of patients with lung cancer and the potential mechanism.
Mon Sep 28 00:00:00 UTC 2020
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers.
Scientific reports
Cray P,Sheahan BJ,Cortes JE,Dekaney CM
33-1500 was used in Immunocytochemistry-immunoflourescence to conclude that doxorubicin increases paracellular transit of macromolecules through intestinal epithelium.
Tue Dec 08 00:00:00 UTC 2020
The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions.
Current biology : CB
Tan B,Yatim SMJM,Peng S,Gunaratne J,Hunziker W,Ludwig A
33-1500 was used in Immunocytochemistry and Western Blotting to study the architecture of the apical junctional complex in fully polarized MDCK-II cells.
Mon Jul 20 00:00:00 UTC 2020
The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions.
Current biology : CB
Tan B,Yatim SMJM,Peng S,Gunaratne J,Hunziker W,Ludwig A
33-1500 was used in Immunocytochemistry and Western Blotting to study the architecture of the apical junctional complex in fully polarized MDCK-II cells.
Mon Jul 20 00:00:00 UTC 2020
Adverse Effects of Coumestrol and Genistein on Mammary Morphogenesis and Future Milk Production Ability of Mammary Epithelial Cells.
Advanced biosystems
Kumai A,Tsugami Y,Wakasa H,Suzuki N,Suzuki T,Nishimura T,Kobayashi K
33-1500 was used in Immunohistochemistry to investigate the role of phytoestrogens on mammary structure development and milk production in mammary epithelial cells.
Wed Apr 01 00:00:00 UTC 2020
Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis.
Biomedicines
Lin EY,Lai HJ,Cheng YK,Leong KQ,Cheng LC,Chou YC,Peng YC,Hsu YH,Chiang HS
33-1500 was used in Immunohistochemistry-immunofluorescence to study the effects of intravenous administration of DNase I on NET activity and how this impacts gut epithelial barrier function in acute colitis.
Wed Aug 05 00:00:00 UTC 2020
Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction.
Redox biology
Jiang J,Huang K,Xu S,Garcia JGN,Wang C,Cai H
33-1500 was used in Western Blotting to identify a novel, selective and causal role of NOX4 (versus other NOX isoforms) in inducing lung EC barrier dysfunction and injury/mortality in a preclinical CLP-induced septic model, which involves redox-sensitive activation of CaMKII/ERK1/2/MLCK pathway. Targeting NOX4 may therefore prove to an innovative therapeutic option that is markedly effective in treating ALI/ARDS.
Tue Sep 01 00:00:00 UTC 2020
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
Cell death & disease
Shi Y,Liu Z,Cui X,Zhao Q,Liu T
33-1500 was used in Western Blotting to identify that intestinal vitamin D receptor knockout protected against oxazolone-induced colitis in mice by blocking Th2 cell response and reducing the function of intestinal invariant natural killer T cells.
Mon Jun 15 00:00:00 UTC 2020
Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure.
Toxins
Hanyu H,Yokoi Y,Nakamura K,Ayabe T,Tanaka K,Uno K,Miyajima K,Saito Y,Iwatsuki K,Shimizu M,Tadaishi M,Kobayashi-Hattori K
33-1500 was used in Immunohistochemistry to explore the toxic effects of DON on intestinal barrier functions and stem cells after DON microinjection (luminal exposure) or addition to a culture medium (basolateral exposure) using three-dimensional mouse intestinal organoids (enteroids).
Thu Sep 24 00:00:00 UTC 2020
MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes.
Scientific reports
Hu H,Hone EA,Provencher EAP,Sprowls SA,Farooqi I,Corbin DR,Sarkar SN,Hollander JM,Lockman PR,Simpkins JW,Ren X
33-1500 was used in Immunohistochemistry (Frozen) to discovery of new mechanisms and treatments for cerebrovascular and neurodegenerative diseases such as stroke.
Mon Feb 24 00:00:00 UTC 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
33-1500 was used in Immunocytochemistry-immunofluorescence to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 UTC 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
33-1500 was used in Immunocytochemistry-immunofluorescence to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 UTC 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
33-1500 was used in Immunocytochemistry-immunofluorescence to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 UTC 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
33-1500 was used in Immunocytochemistry-immunofluorescence to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 UTC 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
33-1500 was used in Immunocytochemistry-immunofluorescence to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 UTC 2020
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature.
Cell and tissue research
Franke WW,Domke LM,Dörflinger Y,Zimbelmann R
33-1500 was used in Immunocytochemistry-immunofluorescence to discuss possible methodological reasons for the maintenance of this incorrect cell type classification in the literature and emphasize the value of molecular analyses using multiple cell type-specific markers, also with respect to physiology and medical sciences.
Wed Jan 01 00:00:00 UTC 2020
Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels.
International journal of molecular sciences
Markov AG,Fedorova AA,Kravtsova VV,Bikmurzina AE,Okorokova LS,Matchkov VV,Cornelius V,Amasheh S,Krivoi II
33-1500 was used in Western Blotting to confirm that circulating ouabain can functionally and tissue-specifically affect barrier properties of epithelial and endothelial tissues via Na,K-ATPase-mediated modulation of claudins expression.
Fri Jul 17 00:00:00 UTC 2020
Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model.
Pharmaceutics
Chaves C,Do TM,Cegarra C,Roudières V,Tolou S,Thill G,Rocher C,Didier M,Lesuisse D
33-1500 was used in Immunocytochemistry-immunoflourescence to compare the blood-brain barrier features of NHP transciptome of isolated brain microcapillaries and in vitro-selected brain endothelial cells.
Wed Oct 14 00:00:00 UTC 2020
Association of Hyperuricemia With Immune Disorders and Intestinal Barrier Dysfunction.
Frontiers in physiology
Lv Q,Xu D,Zhang X,Yang X,Zhao P,Cui X,Liu X,Yang W,Yang G,Xing S
33-1500 was used in Western Blotting to show that the abundance of inflammation-related microbiota increased in hyperuricemic mice.
Tue Apr 19 00:00:00 UTC 2022
DL-3n-Butylphthalide Improves Blood-Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion.
Frontiers in cellular neuroscience
Mamtilahun M,Wei Z,Qin C,Wang Y,Tang Y,Shen FX,Tian HL,Zhang Z,Yang GY
33-1500 was used in Western Blot, Immunohistochemistry to conclude that NBP protected blood-brain barrier integrity and attenuated brain injury in the acute phase of ischemic stroke by decreasing AQP4 expression and MMP-9 enzyme activity.
Sat Jan 30 00:00:00 UTC 2021
DL-3n-Butylphthalide Improves Blood-Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion.
Frontiers in cellular neuroscience
Mamtilahun M,Wei Z,Qin C,Wang Y,Tang Y,Shen FX,Tian HL,Zhang Z,Yang GY
33-1500 was used in Western Blot, Immunohistochemistry to conclude that NBP protected blood-brain barrier integrity and attenuated brain injury in the acute phase of ischemic stroke by decreasing AQP4 expression and MMP-9 enzyme activity.
Sat Jan 30 00:00:00 UTC 2021
Astragalus mongholicus Bunge and Panax Notoginseng Formula (A&P) Combined With Bifidobacterium Contribute a Renoprotective Effect in Chronic Kidney Disease Through Inhibiting Macrophage Inflammatory Response in Kidney and Intestine.
Frontiers in physiology
Rui-Zhi T,Hui D,Jian-Chun L,Xia Z,Xiao-Jia W,Dan W,Jun-Ming F,Li W
33-1500 was used in Western Blotting to explore the role of A&P and Bifidobacterium combination treatment in regulation of inflammatory response of macrophage in kidney and intestine of CKD mouse, as well as the potential molecular mechanism.
Fri Dec 18 00:00:00 UTC 2020
P-glycoprotein Expression Is Upregulated in a Pre-Clinical Model of Traumatic Brain Injury.
Neurotrauma reports
Vita SM,Redell JB,Maynard ME,Zhao J,Grill RJ,Dash PK,Grayson BE
33-1500 was used in Immunohistochemistry to suggest that increased expression of Pgp after rmCHI may reduce the brain accumulation of therapeutic drugs that are Pgp substrates.
Thu Nov 11 00:00:00 UTC 2021
Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and Short-Chain Fatty Acids in Spontaneous Type 2 Diabetic KKAy Mice.
Frontiers in pharmacology
Cao H,Li C,Lei L,Wang X,Liu S,Liu Q,Huan Y,Sun S,Shen Z
33-1500 was used in Western Blotting to find that the combination of BBR and Sta is more effective than BBR alone in blood glucose control, improvement of insulin resistance and islet functions, inflammatory mediators decrease, and maintenance of intestinal barrier integrity.
Sat Mar 30 00:00:00 UTC 2024
Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats.
Pharmaceutics
Nunes S,Viana SD,Preguiça I,Alves A,Fernandes R,Teodoro JS,Figueirinha A,Salgueiro L,Silva S,Jarak I,Carvalho RA,Cavadas C,Rolo AP,Palmeira CM,Pintado MM,Reis F
33-1500 was used in Immunohistochemistry (Frozen) to investigate the effects of long-term blueberry consumption in healthy rats, revealing that while blueberries enhanced antioxidant activity and influenced metabolic markers in the blood and gut.
Sat Nov 14 00:00:00 UTC 2020
Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin.
Particle and fibre toxicology
Smyth T,Veazey J,Eliseeva S,Chalupa D,Elder A,Georas SN
33-1500 was used in Immunocytochemistry-immunoflourescence to determine the effect of diesel exhaust exposure on airway epithelial barrier function and composition using in vitro and in vivo model systems.
Thu Oct 15 00:00:00 UTC 2020
Impact of viral disease hypophagia on pig jejunal function and integrity.
PloS one
Helm ET,Curry SM,De Mille CM,Schweer WP,Burrough ER,Gabler NK
33-1500 was used in Western Blotting to determine the impact of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and feed intake on parameters of jejunal function and integrity in growing pigs.
Fri Apr 10 00:00:00 UTC 2020
The cerebrovascular and neurological impact of chronic smoking on post-traumatic brain injury outcome and recovery: an in vivo study.
Journal of neuroinflammation
Sivandzade F,Alqahtani F,Sifat A,Cucullo L
33-1500 was used in Western Blotting to investigate the mechanisms underlying the exacerbation of TBI injury by TS using a weight drop model.
Mon Apr 27 00:00:00 UTC 2020
Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.
Cell reports
Haas AJ,Zihni C,Ruppel A,Hartmann C,Ebnet K,Tada M,Balda MS,Matter K
33-1500 was used in Immunocytochemistry to investigate if tight junctions carry a mechanical load by using a tension sensor based on ZO-1.
Tue Jul 21 00:00:00 UTC 2020
Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.
Gastroenterology
Tapia R,Perez-Yepez EA,Carlino MJ,Karandikar UC,Kralicek SE,Estes MK,Hecht GA
33-1500 was used in Immunocytochemistry-immunoflourescence to investigate the distribution, localisation and impact of CLAMP knock-down in migrating SKCO-15 cells using scratch-wound assays, and in and human intestinal enteroids established from biopsies of a single donor.
Sun Dec 01 00:00:00 UTC 2019
Faecal Proteases from Pouchitis Patients Activate Protease Activating Receptor-2 to Disrupt the Epithelial Barrier.
Journal of Crohn's & colitis
Hoffman S,Aviv Cohen N,Carroll IM,Tulchinsky H,Borovok I,Dotan I,Maharshak N
33-1500 was used in Western Blotting to study the relationship between faecal proteolytic activity and protease activating receptor activation in epithelial barrier dysfunction and determine the source of proteases.
Tue Dec 10 00:00:00 UTC 2019
Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota.
Gut microbes
Jang YJ,Kim WK,Han DH,Lee K,Ko G
33-1500 was used in Western Blotting to evaluate immunometabolic functions of novel Lactobacillus fermentum strains (KBL374 and KBL375) isolated from feces of healthy Koreans.
Mon Feb 10 00:00:00 UTC 2020
Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits.
Glia
Farfara D,Feierman E,Richards A,Revenko AS,MacLeod RA,Norris EH,Strickland S
33-1500 was used in Western Blotting to highlight the important role of regulated plasma C1INH as it acts as a gatekeeper to the brain via the neurovascular system.
Mon Jul 01 00:00:00 UTC 2019
The Differentiation-Associated Keratinocyte Protein Cornifelin Contributes to Cell-Cell Adhesion of Epidermal and Mucosal Keratinocytes.
The Journal of investigative dermatology
Wagner T,Beer L,Gschwandtner M,Eckhart L,Kalinina P,Laggner M,Ellinger A,Gruber R,Kuchler U,Golabi B,Tschachler E,Mildner M
33-1500 was used in Immunohistochemistry-immunofluorescence to indicate that CNFN is a structural component of the cell adhesion system of differentiated KCs in both epidermis and oral mucosa.
Fri Nov 01 00:00:00 UTC 2019
Role of Cav-1 in HIV-1 Tat-Induced Dysfunction of Tight Junctions and Aβ-Transferring Proteins.
Oxidative medicine and cellular longevity
Zou M,Huang W,Jiang W,Wu Y,Chen Q
33-1500 was used in Western Blotting to evaluate the role of caveolin-1 in HIV-1 Tat-induced dysfunction of tight junction and amyloid Β-peptide- transferring proteins.
Fri Dec 13 00:00:00 UTC 2019
A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes.
Journal of virology
Madigan VJ,Tyson TO,Yuziuk JA,Pillai M,Moller-Tank S,Asokan A
33-1500 was used in Immunocytochemistry-immunoflourescence to show Crumbs 3, an apical polarity determinant, also influences the ability of virions to bind and enter the cells.
Fri Nov 01 00:00:00 UTC 2019
Parasympathectomy increases resting secretion of the submandibular gland in minipigs in the long term.
Journal of cellular physiology
Zhang XM,Huang Y,Cong X,Qu LH,Zhang K,Wu LL,Zhang Y,Yu GY
33-1500 was used in Western Blotting to investigate the long-term effect of parasympathectomy on the secretion of SMGs in minipigs.
Sat Jun 01 00:00:00 UTC 2019
DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins.
Chinese medical journal
Ye ZY,Xing HY,Wang B,Liu M,Lv PY
33-1500 was used in Immunohistochemistry to investigate the potential effect of DL-3-n-butylphthalide on the tight junction proteins claudin-5, zonula occludens-1, and occludin during brain ischemia.
Wed Jun 05 00:00:00 UTC 2019
Pharmacological stimulation of G-protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells.
International immunopharmacology
Moonwiriyakit A,Koval M,Muanprasat C
33-1500 was used in Immunocytochemistry to investigate the effect of GPR40 stimulation on proinflammatory cytokine (TNFα and IL-1β)-induced tight junction disruption in human airway epithelial Calu-3 cells using GW9508, a GPR40 agonist.
Thu Aug 01 00:00:00 UTC 2019
Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA.
Gut pathogens
Harrer A,Bücker R,Boehm M,Zarzecka U,Tegtmeyer N,Sticht H,Schulzke JD,Backert S
33-1500 was used in Immunofluorescence in immunohistochemistry on frozen tissues to investigate the interaction of high temperature requirement protein A with the host protein occludin, a tight junction strand component.
Thu Oct 01 00:00:00 UTC 2020
Effects of supplemental calcium and vitamin D on tight-junction proteins and mucin-12 expression in the normal rectal mucosa of colorectal adenoma patients.
Molecular carcinogenesis
Mandle HB,Jahan FA,Bostick RM,Baron JA,Barry EL,Yacoub R,Merrill J,Rutherford RE,Seabrook ME,Fedirko V
33-1500 was used in Immunohistochemistry-immunofluorescence to investigated supplemental calcium and/or vitamin D3 effects on intestinal barrier function-related biomarkers in colorectal adenoma patients.
Mon Jul 01 00:00:00 UTC 2019
Enhanced gastrointestinal passive paracellular permeability contributes to the obesity-associated hyperoxaluria.
American journal of physiology. Gastrointestinal and liver physiology
Bashir M,Meddings J,Alshaikh A,Jung D,Le K,Amin R,Ratakonda S,Sharma S,Granja I,Satti M,Asplin J,Hassan H
33-1500 was used in Western Blotting to test the hypothesis that the obesity-associated enhanced intestinal paracellular permeability contributes to obesity-associated hyperoxaluria by increasing passive paracellular intestinal oxalate absorption.
Tue Jan 01 00:00:00 UTC 2019
Activation of the Ca2+ sensing receptor and the PKC/WNK4 downstream signaling cascade induces incorporation of ZO-2 to tight junctions and its separation from 14-3-3.
Molecular biology of the cell
Amaya E,Alarcón L,Martín-Tapia D,Cuellar-Pérez F,Cano-Cortina M,Ortega-Olvera JM,Cisneros B,Rodriguez AJ,Gamba G,González-Mariscal L
33-1500 was used in Immunocytochemistry to investigate the molecular mechanism through which extracellular Ca2+ triggers the appearance of ZO-2 at TJs in epithelial cells and reveal the novel interaction between ZO-2 and 14-3-3 proteins, which is critical for ZO-2 protection and intracellular traffic.
Thu Aug 15 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
33-1500 was used in Immunocytochemistry and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
33-1500 was used in Immunocytochemistry and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
33-1500 was used in Immunocytochemistry and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
33-1500 was used in Immunocytochemistry and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
33-1500 was used in Immunocytochemistry and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.
Clinical & experimental ophthalmology
Zhang C,Xie H,Yang Q,Yang Y,Li W,Tian H,Lu L,Wang F,Xu JY,Gao F,Wang J,Jin C,Xu G,Xu GT,Zhang J
33-1500 was used in Immunocytochemistry and Western Blotting to study in vitro with ARPE-19 cells confirmed these changes, and the protective effect of EPO was abolished by sEPOR. Gö6976 and digoxin rescued the tight junction and barrier function in glyoxal-treated ARPE-19 cells.In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema.
Sun Dec 01 00:00:00 UTC 2019
Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection.
Frontiers in microbiology
Martins Gomes SF,Westermann AJ,Sauerwein T,Hertlein T,Förstner KU,Ohlsen K,Metzger M,Shusta EV,Kim BJ,Appelt-Menzel A,Schubert-Unkmeir A
33-1500 was used in Immunocytochemistry-immunoflourescence to study Neisseria meningitidis host pathogen interactions.
Wed Sep 30 00:00:00 UTC 2020
Prediction of Drug Permeability Using In Vitro Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.
BioResearch open access
Ohshima M,Kamei S,Fushimi H,Mima S,Yamada T,Yamamoto T
33-1500 was used in Immunocytochemistry-immunoflourescence to conclude that iPSC-BBB models make it possible to predict BBB permeability, and employing coculturing can improve iPSC-BBB function.
Thu Oct 01 00:00:00 UTC 2020
The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.
Fluids and barriers of the CNS
Katt ME,Mayo LN,Ellis SE,Mahairaki V,Rothstein JD,Cheng L,Searson PC
33-1500 was used in Immunocytochemistry-immunoflourescence to suggest that the accumulation of defects in brain microvascular endothelial cells may ultimately lead to impairment of the BBB and that accumulated defects that result in positive feedback may lead to unrelated central nervous system diseases.
Mon Jul 15 00:00:00 UTC 2019
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
Cell stem cell
Vatine GD,Barrile R,Workman MJ,Sances S,Barriga BK,Rahnama M,Barthakur S,Kasendra M,Lucchesi C,Kerns J,Wen N,Spivia WR,Chen Z,Van Eyk J,Svendsen CN
33-1500 was used in Immunocytochemistry-immunoflourescence to create a neurovascular unit that recapitulates complex BBB functions.
Thu Jun 06 00:00:00 UTC 2019
Assessing the protective effect of rosiglitazone against electronic cigarette/tobacco smoke-induced blood-brain barrier impairment.
BMC neuroscience
Sivandzade F,Cucullo L
33-1500 was used in Western Blotting to investigate the role of rosiglitazone in smoking/e-cigarette-induced blood-brain barrier impairment.
Thu Apr 04 00:00:00 UTC 2019
Placental growth factor negatively regulates retinal endothelial cell barrier function through suppression of glucose-6-phosphate dehydrogenase and antioxidant defense systems.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Huang H,Lennikov A,Saddala MS,Gozal D,Grab DJ,Khalyfa A,Fan L
33-1500 was used in Western Blot to report that placental growth factor (PlGF) negatively affects the endothelial cell (EC) barrier function through a novel regulatory mechanism.
Sun Dec 01 00:00:00 UTC 2019
Capturing the Onset of Bacterial Pulmonary Infection in Acini-On-Chips.
Advanced biosystems
Artzy-Schnirman A,Zidan H,Elias-Kirma S,Ben-Porat L,Tenenbaum-Katan J,Carius P,Fishler R,Schneider-Daum N,Lehr CM,Sznitman J
33-1500 was used in Immunocytochemistry to develop microfluidic-based acini-on-chips that mimic more closely the native acinar airways at a true scale with an anatomically inspired, multigeneration alveolated tree are presented and an inhalation-like maneuver.
Sun Sep 01 00:00:00 UTC 2019
Preventive Effect of Spontaneous Physical Activity on the Gut-Adipose Tissue in a Mouse Model That Mimics Crohn's Disease Susceptibility.
Cells
Maillard F,Vazeille E,Sauvanet P,Sirvent P,Bonnet R,Combaret L,Chausse P,Chevarin C,Otero YF,Delcros G,Chavanelle V,Boisseau N,Barnich N
33-1500 was used in Western Blotting to assess the preventive effect of spontaneous physical activity on the gut-adipose tissue in a mouse model that mimics Crohn's disease susceptibility.
Wed Jan 09 00:00:00 UTC 2019
Occludin knockdown is not sufficient to induce transepithelial macromolecule passage.
Tissue barriers
Richter JF,Hildner M,Schmauder R,Turner JR,Schumann M,Reiche J
33-1500 was used in Immunocytochemistry-immunoflourescence to study the role of Occludin in macromolecule passage at single cell-cell junctions.
Tue Jul 21 00:00:00 UTC 2020
Occludin knockdown is not sufficient to induce transepithelial macromolecule passage.
Tissue barriers
Richter JF,Hildner M,Schmauder R,Turner JR,Schumann M,Reiche J
33-1500 was used in Immunocytochemistry-immunoflourescence to study the role of Occludin in macromolecule passage at single cell-cell junctions.
Tue Jul 21 00:00:00 UTC 2020
Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.
Cellular and molecular gastroenterology and hepatology
Kiyohara H,Sujino T,Teratani T,Miyamoto K,Arai MM,Nomura E,Harada Y,Aoki R,Koda Y,Mikami Y,Mizuno S,Naganuma M,Hisamatsu T,Kanai T
33-1500 was used in Immunohistochemistry-immunofluorescence to show that skin inflammation may contribute to pathogenic conditions in the gut via immunologic and microbiological changes.
Mon Apr 29 00:00:00 UTC 2019
Fusarium Mycotoxins Disrupt the Barrier and Induce IL-6 Release in a Human Placental Epithelium Cell Line.
Toxins
Seyed Toutounchi N,Hogenkamp A,Varasteh S,Van't Land B,Garssen J,Kraneveld AD,Folkerts G,Braber S
33-1500 was used in Immunocytochemistry-immunoflourescence to investigate the effects of Fusarium mycotoxins on human placental epithelial cells.
Thu Nov 14 00:00:00 UTC 2019
Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice.
eLife
Benz F,Wichitnaowarat V,Lehmann M,Germano RF,Mihova D,Macas J,Adams RH,Taketo MM,Plate KH,Guérit S,Vanhollebeke B,Liebner S
33-1500 was used in Immunocytochemistry-immunoflourescence to show that egulating the SFO vessel barrier may influence neuronal function in the context of water homeostasis.
Mon Apr 01 00:00:00 UTC 2019
High intensity interval training promotes total and visceral fat mass loss in obese Zucker rats without modulating gut microbiota.
PloS one
Maillard F,Vazeille E,Sauvanet P,Sirvent P,Combaret L,Sourdrille A,Chavanelle V,Bonnet R,Otero YF,Delcros G,Barnich N,Boisseau N
33-1500 was used in Western Blotting to compare the effects of moderate-intensity continuous training and high-intensity interval training on the gut-adipose tissue cross-talk in obese Zucker rats.
Mon Dec 23 00:00:00 UTC 2019
TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice.
Brain, behavior, and immunity
Cheng Y,Desse S,Martinez A,Worthen RJ,Jope RS,Beurel E
33-1500 was used in Western Blotting to study factors that regulate recovery from major depressive disorder.
Thu Mar 01 00:00:00 UTC 2018
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.
Neuron
Park MH,Lee JY,Park KH,Jung IK,Kim KT,Lee YS,Ryu HH,Jeong Y,Kang M,Schwaninger M,Gulbins E,Reichel M,Kornhuber J,Yamaguchi T,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS
33-1500 was used in Western Blot, Immunohistochemistry to reveal a novel role for ASM in the control of neurovascular function in aging, suggesting that ASM may represent a new therapeutic target for anti-aging.
Wed Oct 10 00:00:00 UTC 2018
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.
Neuron
Park MH,Lee JY,Park KH,Jung IK,Kim KT,Lee YS,Ryu HH,Jeong Y,Kang M,Schwaninger M,Gulbins E,Reichel M,Kornhuber J,Yamaguchi T,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS
33-1500 was used in Western Blot, Immunohistochemistry to reveal a novel role for ASM in the control of neurovascular function in aging, suggesting that ASM may represent a new therapeutic target for anti-aging.
Wed Oct 10 00:00:00 UTC 2018
Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB.
PLoS pathogens
Bruening J,Lasswitz L,Banse P,Kahl S,Marinach C,Vondran FW,Kaderali L,Silvie O,Pietschmann T,Meissner F,Gerold G
33-1500 was used in Immunocytochemistry-immunoflourescence to show that HCV and Plasmodium highjack selective CD81 interactions, including CAPN5 and CBLB for HCV, to invade cells.
Sun Jul 01 00:00:00 UTC 2018
High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors.
The American journal of pathology
Tawiah A,Moreau F,Kumar M,Tiwari S,Falguera J,Chadee K
33-1500 was used in Western Blot to conclude that high MUC2 output during colitis impairs goblet cell migration and wound healing by reducing production of growth factors critical in wound repair.
Sat Sep 01 00:00:00 UTC 2018
Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture.
Disease models & mechanisms
Pereira MT,Malik M,Nostro JA,Mahler GJ,Musselman LP
33-1500 was used in Immunohistochemistry to examine the effects of food additives on gut barrier function.
Wed Nov 28 00:00:00 UTC 2018
Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
Biotechnology journal
Stebbins MJ,Lippmann ES,Faubion MG,Daneman R,Palecek SP,Shusta EV
33-1500 was used in Flow cytometry/Cell sorting to elucidate the roles of RA signaling in iPSC-derived BMEC differentiation, and identifies directed agonist approaches that can improve BMEC fidelity for drug screening studies while also distinguishing potential nuclear receptor targets to explore in BBB dysfunction and therapy.
Thu Feb 01 00:00:00 UTC 2018
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.
Virulence
Liu J,Ma'ayeh S,Peirasmaki D,Lundström-Stadelmann B,Hellman L,Svärd SG
33-1500 was used in Western Blotting to characterise the role of the three main cysteine proteases secreted by Giardia intestinalis in the development of Giardiasis.
Mon Dec 31 00:00:00 UTC 2018
Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac.
American journal of physiology. Cell physiology
Amoozadeh Y,Anwer S,Dan Q,Venugopal S,Shi Y,Branchard E,Liedtke E,Ailenberg M,Rotstein OD,Kapus A,Szászi K
33-1500 was used in Immunocytochemistry to study the mechanisms underlying the expression of Cldn-2.
Thu Mar 01 00:00:00 UTC 2018
Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity.
American journal of physiology. Gastrointestinal and liver physiology
Jin Y,Ibrahim D,Magness ST,Blikslager AT
33-1500 was used in Immunohistochemistry (Frozen) to demonstrate that in the absence of CIC-2, adherens junctions are disrupted, revealing critical functions of the junctional structures, such as maintenance of homeostasis and differentiation.
Sat Dec 01 00:00:00 UTC 2018
TLR4/PKCα/occludin signaling pathway may be related to blood‑brain barrier damage.
Molecular medicine reports
Tang Z,Guo D,Xiong L,Wu B,Xu X,Fu J,Kong L,Liu Z,Xie C
33-1500 was used in Immunocytochemistry-immunoflourescence to determine the role of the toll-like receptor 4 (TLR4)/protein kinase Cα (PKCα)/occludin signaling pathway in blood-brain barrier dysfunction.
Sun Jul 01 00:00:00 UTC 2018
A novel occludin-targeting monoclonal antibody prevents hepatitis C virus infection in vitro.
Oncotarget
Okai K,Ichikawa-Tomikawa N,Saito AC,Watabe T,Sugimoto K,Fujita D,Ono C,Fukuhara T,Matsuura Y,Ohira H,Chiba H
33-1500 was used in Western Blotting to reveal that the anti-hOCLN-EC2 mAb 67-2 showed no adverse effects on cell viability or the barrier function of tight junctions.
Fri Mar 30 00:00:00 UTC 2018
A novel occludin-targeting monoclonal antibody prevents hepatitis C virus infection in vitro.
Oncotarget
Okai K,Ichikawa-Tomikawa N,Saito AC,Watabe T,Sugimoto K,Fujita D,Ono C,Fukuhara T,Matsuura Y,Ohira H,Chiba H
33-1500 was used in Western Blotting to reveal that the anti-hOCLN-EC2 mAb 67-2 showed no adverse effects on cell viability or the barrier function of tight junctions.
Fri Mar 30 00:00:00 UTC 2018
Chronic stress-associated visceral hyperalgesia correlates with severity of intestinal barrier dysfunction.
Pain
Creekmore AL,Hong S,Zhu S,Xue J,Wiley JW
33-1500 was used in Western Blotting to demonstrate that visceral pain and increased colon permeability positively correlate (0.6008, P = 0.0084).
Sat Sep 01 00:00:00 UTC 2018
Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation.
Cell death & disease
Zhan R,Zhao M,Zhou T,Chen Y,Yu W,Zhao L,Zhang T,Wang H,Yang H,Jin Y,He Q,Yang X,Guo X,Willard B,Pan B,Huang Y,Chen Y,Chui D,Zheng L
33-1500 was used in Western Blotting to suggest the significance of dapsone in protecting brain microvessels under lipid metabolic disorders.
Thu Jun 07 00:00:00 UTC 2018
Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions.
Oncotarget
Trumpi K,Frenkel N,Peters T,Korthagen NM,Jongen JMJ,Raats D,van Grevenstein H,Backes Y,Moons LM,Lacle MM,Koster J,Zwijnenburg D,Borel Rinkes IHM,Kranenburg O
33-1500 was used in Immunocytochemistry-immunoflourescence to study the stromal cell types that contribute to aggressive tumour cell behaviour.
Fri Apr 13 00:00:00 UTC 2018
Inhibition of MicroRNA-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation.
Journal of the American Heart Association
Pena-Philippides JC,Gardiner AS,Caballero-Garrido E,Pan R,Zhu Y,Roitbak T
33-1500 was used in Immunocytochemistry-immunoflourescence and Western blot to investigate the influence of microRNA-155 on the barrier characteristics of human primary brain microvascular endothelial cells.
Tue Jun 26 00:00:00 UTC 2018
Inhibition of MicroRNA-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation.
Journal of the American Heart Association
Pena-Philippides JC,Gardiner AS,Caballero-Garrido E,Pan R,Zhu Y,Roitbak T
33-1500 was used in Immunocytochemistry-immunoflourescence and Western blot to investigate the influence of microRNA-155 on the barrier characteristics of human primary brain microvascular endothelial cells.
Tue Jun 26 00:00:00 UTC 2018
Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs.
Tissue barriers
Chen H,Lu R,Zhang YG,Sun J
33-1500 was used in Western Blotting to study the role of the vitamin D receptor in lung barrier integrity.
Mon Apr 01 00:00:00 UTC 2019
Cerebrovascular Injury After Serial Exposure to Chronic Stress and Abstinence from Methamphetamine Self-Administration.
Scientific reports
Natarajan R,Mitchell CM,Harless N,Yamamoto BK
33-1500 was used in Western Blotting to examine the co-morbid cerebrovascular effects observed during abstinence from self-administered methamphetamine, following exposure to chronic unpredictable stress.
Thu Jul 12 00:00:00 UTC 2018
Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model.
Frontiers in cellular neuroscience
Shigemoto-Mogami Y,Hoshikawa K,Sato K
33-1500 was used in Western Blotting to investigate the interaction of microglia with blood-brain barrier cells.
Thu Oct 01 00:00:00 UTC 2020
Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.
eNeuro
Cottier KE,Galloway EA,Calabrese EC,Tome ME,Liktor-Busa E,Kim J,Davis TP,Vanderah TW,Largent-Milnes TM
33-1500 was used in Western Blotting to demonstrate the ability of cortical spreading depression (CSD) events to produce transient, time-dependent changes in blood-brain barrier (BBB) permeability when allodynia is present and to mediate access of clinically relevant therapeutics (i.e., sumatriptan) to the CNS.
Wed Feb 27 00:00:00 UTC 2019
Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.
Respiratory research
Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS
33-1500 was used in Immunohistochemistry-immunofluorescence to study the role played by Protein Kinase R-like Endoplasmic Reticulum Kinase in transmitting mechanosensory signals to the alveolar epithelium.
Wed Aug 22 00:00:00 UTC 2018
Elastin-PLGA hybrid electrospun nanofiber scaffolds for salivary epithelial cell self-organization and polarization.
Acta biomaterialia
Foraida ZI,Kamaldinov T,Nelson DA,Larsen M,Castracane J
33-1500 was used in Immunocytochemistry to investigate the potential of elastin to generate elastin hybrid nano-fibres that have favourable physical and biochemical properties for regeneration of the salivary glands.
Sun Oct 15 00:00:00 UTC 2017
Sesamin alleviates blood-brain barrier disruption in mice with experimental traumatic brain injury.
Acta pharmacologica Sinica
Liu YL,Xu ZM,Yang GY,Yang DX,Ding J,Chen H,Yuan F,Tian HL
33-1500 was used in Immunohistochemistry to show that sesamin may be a promising potential therapeutic intervention for preventing disruption of the blood-brain barrier (BBB) after traumatic brain injury (TBI).
Wed Nov 01 00:00:00 UTC 2017
Sesamin alleviates blood-brain barrier disruption in mice with experimental traumatic brain injury.
Acta pharmacologica Sinica
Liu YL,Xu ZM,Yang GY,Yang DX,Ding J,Chen H,Yuan F,Tian HL
33-1500 was used in Immunohistochemistry to show that sesamin may be a promising potential therapeutic intervention for preventing disruption of the blood-brain barrier (BBB) after traumatic brain injury (TBI).
Wed Nov 01 00:00:00 UTC 2017
Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin.
Experimental cell research
Nighot PK,Leung L,Ma TY
33-1500 was used in Immunocytochemistry-immunoflourescence to study the mechanism of ClC-2-mediated tight junction barrier function and intracellular trafficking of occludin.
Wed Mar 01 00:00:00 UTC 2017
EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity.
Cellular microbiology
Tapia R,Kralicek SE,Hecht GA
33-1500 was used in Western Blotting to demonstrate that enteropathogenic Escherichia coli displaces Crb3 and Pals1 from the apical membrane to the cytoplasm of cultured intestinal epithelial cells and colonocytes of infected mice.
Wed Nov 01 00:00:00 UTC 2017
Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.
Molecular and cellular biochemistry
Sivagurunathan S,Palanisamy K,Arunachalam JP,Chidambaram S
331500 was used in immunocytochemistry and western blot to report the presence of PIWI-like proteins in somatic cells and the possible role of HIWI2 in preserving the functional integrity of epithelial cells
Wed Mar 01 00:00:00 UTC 2017
Hepatocytes cocultured with Sertoli cells in bioreactor favors Sertoli barrier tightness in rat.
Journal of applied toxicology : JAT
Zeller P,Legendre A,Jacques S,Fleury MJ,Gilard F,Tcherkez G,Leclerc E
331500 was used in immunocytochemistry to propose using an integrated insert in a dynamic microfluidic platform for toxicological testing
Wed Mar 01 00:00:00 UTC 2017
TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK.
PloS one
Ni Y,Teng T,Li R,Simonyi A,Sun GY,Lee JC
331500 was used in western blot to explore the responses of occludin to stimulation by TNFalpha, IL-1beta and LPS in an immortalized human cerebral endothelial cell line
Fri Aug 25 00:00:00 UTC 2017
NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma.
Oncotarget
Neri L,Lasa M,Elosegui-Artola A,D'Avola D,Carte B,Gazquez C,Alve S,Roca-Cusachs P,Iñarrairaegui M,Herrero J,Prieto J,Sangro B,Aldabe R
33-1500 was used in Immunocytochemistry-immunoflourescence to show that hNatB subunits are upregulated in hepatocellular carcinoma tumours compared to non-tumour tissue and that this upregulation is associated with microscopic vascular invasion.
Tue Jun 20 00:00:00 UTC 2017
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.
Nature communications
Benedicto I,Lehmann GL,Ginsberg M,Nolan DJ,Bareja R,Elemento O,Salfati Z,Alam NM,Prusky GT,Llanos P,Rabbany SY,Maminishkis A,Miller SS,Rafii S,Rodriguez-Boulan E
33-1500 was used in Immunofluorescence to show that expression of extracellular matrix-related genes changes dramatically over outer blood-retina barrier establishment.
Fri May 19 00:00:00 UTC 2017
Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double-stranded RNA.
Immunity, inflammation and disease
Blume C,Reale R,Held M,Loxham M,Millar TM,Collins JE,Swindle EJ,Morgan H,Davies DE
33-1500 was used in Immunocytochemistry-immunoflourescence to examine the cellular crosstalk between airway epithelial and endothelial cells to regulate barrier functions during exposure to double-stranded RNA.
Wed Mar 01 00:00:00 UTC 2017
Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress.
Scientific reports
Mohamed R,Sharma I,Ibrahim AS,Saleh H,Elsherbiny NM,Fulzele S,Elmasry K,Smith SB,Al-Shabrawey M,Tawfik A
33-1500 was used in Immunocytochemistry-immunoflourescence to suggest activation of oxidative stress as a possible mechanism of hyperhomocysteinemia induced retinal endothelial cell dysfunction.
Wed Sep 20 00:00:00 UTC 2017
Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.
Proceedings of the National Academy of Sciences of the United States of America
Lou N,Takano T,Pei Y,Xavier AL,Goldman SA,Nedergaard M
33-1500 was used in immunohistochemistry to assess purinergic receptor P2RY12-dependent microglial closure to blood-brain barrier injuries
Tue Jan 26 00:00:00 UTC 2016
Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke.
Neurobiology of disease
Zhang Z,Yan J,Shi H
331500 was used in western blot to test if hypoxia inducible factor-1 activation contributes to hyperglycemia-aggravated blood brain barrier disruption in an ischemic stroke model
Tue Nov 01 00:00:00 UTC 2016
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.
ALTEX
Kuehn A,Kletting S,de Souza Carvalho-Wodarz C,Repnik U,Griffiths G,Fischer U,Meese E,Huwer H,Wirth D,May T,Schneider-Daum N,Lehr CM
33-1500 was used in immunocytochemistry to utilize human alveolar epithelial cells expressing tight junctions as an air-blood barrier model
Tue Jan 17 00:00:00 UTC 2017
TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea.
Molecular cancer therapeutics
Wardill HR,Bowen JM,Van Sebille YZ,Secombe KR,Coller JK,Ball IA,Logan RM,Gibson RJ
331500 was used in immunohistochemistry - paraffin section to study the role of TLR4 in irinotecan-induced diarrhea
Tue Nov 01 00:00:00 UTC 2016
Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Castro V,Bertrand L,Luethen M,Dabrowski S,Lombardi J,Morgan L,Sharova N,Stevenson M,Blasig IE,Toborek M
33-1500 was used in ELISA, immunocytochemistry, and western blot to analyze control of HIV transcription in brain pericytes by occludin via regulation of SIRT-1 activation
Tue Mar 01 00:00:00 UTC 2016
Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model.
Molecular pharmaceutics
Clark PA,Al-Ahmad AJ,Qian T,Zhang RR,Wilson HK,Weichert JP,Palecek SP,Kuo JS,Shusta EV
33-1500 was used in immunocytochemistry to examine trafficking of cancer-targeting alkylphosphocholine analogues across the blood brain barrier
Tue Sep 06 00:00:00 UTC 2016
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.
American journal of physiology. Gastrointestinal and liver physiology
Ronaghan NJ,Shang J,Iablokov V,Zaheer R,Colarusso P,Dion S,Désilets A,Leduc R,Turner JR,MacNaughton WK
331500 was used in immunocytochemistry and western blot to investigate how serine proteases increase transepithelial electrical resistance
Thu Sep 01 00:00:00 UTC 2016
Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells.
Methods (San Diego, Calif.)
Stebbins MJ,Wilson HK,Canfield SG,Qian T,Palecek SP,Shusta EV
33-1500 was used in immunocytochemistry to describe methods to differentiate and characterize hPSC-derived brain microvascular endothelial cells
Sun May 15 00:00:00 UTC 2016
Can Monitoring Fetal Intestinal Inflammation Using Heart Rate Variability Analysis Signal Incipient Necrotizing Enterocolitis of the Neonate?
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Liu HL,Garzoni L,Herry C,Durosier LD,Cao M,Burns P,Fecteau G,Desrochers A,Patey N,Seely AJ,Faure C,Frasch MG
33-1500 was used in immunohistochemistry - paraffin section to determine if monitoring of fetal intestinal inflammation by heart rate variability analysis can signal incipient necrotizing enterocolitis of the neonate
Fri Apr 01 00:00:00 UTC 2016
Vitamin D/VDR signaling attenuates lipopolysaccharide‑induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier.
Molecular medicine reports
Shi YY,Liu TJ,Fu JH,Xu W,Wu LL,Hou AN,Xue XD
33-1500 was used in immunohistochemistry - paraffin section and western blot to test if vitamin D signaling ameliorates lipopolysaccharide-induced acute lung injury by altering barrier integrity
Mon Feb 01 00:00:00 UTC 2016
The impact of lactoferrin with different levels of metal saturation on the intestinal epithelial barrier function and mucosal inflammation.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Majka G,Więcek G,Śróttek M,Śpiewak K,Brindell M,Koziel J,Marcinkiewicz J,Strus M
331500 was used in immunohistochemistry to study how iron-depleted, iron-saturated, and manganese-saturated forms of lactoferrin govern intestinal barrier function
Thu Dec 01 00:00:00 UTC 2016
Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Wardill HR,Logan RM,Bowen JM,Van Sebille YZ,Gibson RJ
33-1500 was used in immunohistochemistry to assess epithelial tight junctions, cytokine production, and matrix metalloproteinase profiles in patients undergoing chemotherapy.
Fri Apr 01 00:00:00 UTC 2016
Nectin-3 Is Increased in the Cell Junctions of the Uterine Epithelium at Implantation.
Reproductive sciences (Thousand Oaks, Calif.)
Poon CE,Madawala RJ,Dowland SN,Murphy CR
33-1500 was used in immunohistochemistry - frozen section, immunoprecipitation, and western blot to study the increase of nectin-3 in the cell junctions of the uterine epithelium at implantation
Tue Nov 01 00:00:00 UTC 2016
Occludin-Knockout Human Hepatic Huh7.5.1-8-Derived Cells Are Completely Resistant to Hepatitis C Virus Infection.
Biological & pharmaceutical bulletin
Shirasago Y,Shimizu Y,Tanida I,Suzuki T,Suzuki R,Sugiyama K,Wakita T,Hanada K,Yagi K,Kondoh M,Fukasawa M
33-1500 was used in western blot determine the contribution of occludin to hepatitis C virus infection
Sun May 01 00:00:00 UTC 2016
Salmonella enteritidis Effector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway.
The Journal of biological chemistry
Lin Z,Zhang YG,Xia Y,Xu X,Jiao X,Sun J
331500 was used in western blot to examine the role of Salmonella AvrA during infection
Fri Dec 23 00:00:00 UTC 2016
HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability.
The Journal of biological chemistry
Qian YW,Li C,Jiang AP,Ge S,Gu P,Fan X,Li TS,Jin X,Wang JH,Wang ZL
33-1500 was used in immunocytochemistry to demonstrate a novel mechanism by which HIV-1 invades ocular tissues and promotes translocation or invasion by additional pathogens
Fri Oct 28 00:00:00 UTC 2016
Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with β-casein expression in mammary epithelial cells.
Biochimica et biophysica acta
Kobayashi K,Tsugami Y,Matsunaga K,Oyama S,Kuki C,Kumura H
33-1500 was used in immunohistochemistry - paraffin section to characterize induction of lactation-specific tight junctions concurrent with beta-casein expression in mammary epithelial cells due to prolactin and glucocorticoid signaling
Mon Aug 01 00:00:00 UTC 2016
ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development.
PloS one
Kwon J,Jeong SM,Choi I,Kim NH
33-1500 was used in immunocytochemistry to characterize cell junction assembly in early porcine embryo development by ADAM10
Fri Aug 19 00:00:00 UTC 2016
Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding.
Cell cycle (Georgetown, Tex.)
Fykerud TA,Knudsen LM,Totland MZ,Sørensen V,Dahal-Koirala S,Lothe RA,Brech A,Leithe E
33-1500 was used in Immunocytochemistry to study the mechanisms involved in the remodelling of gap junctions during mitosis, and identify actin-based plasma membrane bridges connecting mitotic cells with adjacent cells during rounding.
Tue Nov 01 00:00:00 UTC 2016
Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration.
Oncotarget
Ibrahim AS,Mander S,Hussein KA,Elsherbiny NM,Smith SB,Al-Shabrawey M,Tawfik A
33-1500 was used in immunocytochemistry and immunohistochemistry to study disruption of retinal pigment epithelial structure and function with features of age-related macular degeneration caused by hyperhomocysteinemia
Tue Feb 23 00:00:00 UTC 2016
Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.
Immunity
Lee JS,Tato CM,Joyce-Shaikh B,Gulen MF,Cayatte C,Chen Y,Blumenschein WM,Judo M,Ayanoglu G,McClanahan TK,Li X,Cua DJ
33-1500 was used in immunohistochemistry - frozen section to propose that IL-17-producing gammadelta T cells help to maintain and protect the intestinal mucosa
Tue Oct 20 00:00:00 UTC 2015
Control of cell-cell forces and collective cell dynamics by the intercellular adhesome.
Nature cell biology
Bazellières E,Conte V,Elosegui-Artola A,Serra-Picamal X,Bintanel-Morcillo M,Roca-Cusachs P,Muñoz JJ,Sales-Pardo M,Guimerà R,Trepat X
33-1500 was used in immunohistochemistry to elucidate the contributions of cell-cell adhesion proteins to intercellular force and epithelial tissue dynamics.
Wed Apr 01 00:00:00 UTC 2015
Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice.
Hepatology (Baltimore, Md.)
Scull MA,Shi C,de Jong YP,Gerold G,Ries M,von Schaewen M,Donovan BM,Labitt RN,Horwitz JA,Gaska JM,Hrebikova G,Xiao JW,Flatley B,Fung C,Chiriboga L,Walker CM,Evans DT,Rice CM,Ploss A
33-1500 was used in western blot to identify cellular determinants of interspecies hepatitis C virus transmission and establish an immunocompetent model system
Wed Jul 01 00:00:00 UTC 2015
Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers.
Biomaterials
Staat C,Coisne C,Dabrowski S,Stamatovic SM,Andjelkovic AV,Wolburg H,Engelhardt B,Blasig IE
33-1500 was used in immunocytochemistry to investigate the role of claudin-1/claudin-5 in epithelial/endothelial barriers
Mon Jun 01 00:00:00 UTC 2015
Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.
Neurobiology of disease
Pienaar IS,Lee CH,Elson JL,McGuinness L,Gentleman SM,Kalaria RN,Dexter DT
33-1500 was used in immunohistochemistry to investigate the efficacy of deep-brain stimulation on microvascular integrity in the subthalamic nucleus in Parkinson disease.
Sun Feb 01 00:00:00 UTC 2015
Impact of cigarette smoke extract and hyperglycemic conditions on blood-brain barrier endothelial cells.
Fluids and barriers of the CNS
Prasad S,Sajja RK,Park JH,Naik P,Kaisar MA,Cucullo L
33-1500 was used in Western Blotting to investigate the additive pattern in the release of angiogenic and inflammatory factors, following concomitant exposure to hyperglycemic conditions and cigarette smoke extracts.
Fri Jul 24 00:00:00 UTC 2015
Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Brkic M,Balusu S,Van Wonterghem E,Gorlé N,Benilova I,Kremer A,Van Hove I,Moons L,De Strooper B,Kanazir S,Libert C,Vandenbroucke RE
33-1500 was used in immunohistochemistry to study the effects of Aβ on the functionality of the blood-CSF barrier.
Wed Sep 16 00:00:00 UTC 2015
Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Watari A,Hashegawa M,Yagi K,Kondoh M
33-1500 was used in immunocytochemistry and western blot to investigate the effect of homoharringtonine on intestinal epithelial permeability and its mechanism
Thu Jan 01 00:00:00 UTC 2015
Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells.
Journal of cell science
Cong X,Zhang Y,Li J,Mei M,Ding C,Xiang RL,Zhang LW,Wang Y,Wu LL,Yu GY
33-1500 was used in immunocytochemistry and western blot to propose that claudin-4 is required for mAChR-modulated paracellular permeability of epithelial cells and investigate the mechanism
Mon Jun 15 00:00:00 UTC 2015
Modulation of transepithelial electric resistance (TEER) in reconstructed human epidermis by excipients known to permeate intestinal tight junctions.
Experimental dermatology
Abdayem R,Callejon S,Portes P,Kirilov P,Demarne F,Pirot F,Jannin V,Haftek M
33-1500 was used in immunohistochemistry to compare the effects of two excipients applied to emerged reconstructed human epidermis
Tue Sep 01 00:00:00 UTC 2015
Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin.
Journal of neuroscience research
Zhao YY,Zhao LN,Wang P,Miao YS,Liu YH,Wang ZH,Ma J,Li Z,Li ZQ,Xue YX
33-1500 was used in immunocytochemistry and western blot to elucidate the effects and mechanism of miR-18a on the permeability of the blood-tumor barrier.
Tue Dec 01 00:00:00 UTC 2015
Host endoplasmic reticulum COPII proteins control cell-to-cell spread of the bacterial pathogen Listeria monocytogenes.
Cellular microbiology
Gianfelice A,Le PH,Rigano LA,Saila S,Dowd GC,McDivitt T,Bhattacharya N,Hong W,Stagg SM,Ireton K
33-1500 was used in Immunocytochemistry-immunoflourescence to demonstrate the role of COPII proteins in controlling Listeria monocytogenes spread.
Mon Jun 01 00:00:00 UTC 2015
(-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity.
Archives of biochemistry and biophysics
Contreras TC,Ricciardi E,Cremonini E,Oteiza PI
33-1500 was used in western blot to study the efficacy of (-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity.
Fri May 01 00:00:00 UTC 2015
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Casselbrant A,Elias E,Fändriks L,Wallenius V
33-1500 was used in western blot to study tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery
Fri Jan 15 00:00:00 UTC 2016
Isolation and characterization of an Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus.
Japanese journal of infectious diseases
Shirasago Y,Sekizuka T,Saito K,Suzuki T,Wakita T,Hanada K,Kuroda M,Abe R,Fukasawa M
33-1500 was used in western blot to develop an efficient system to culture hepatitis C virus
Tue Dec 01 00:00:00 UTC 2015
Opioid receptor delta as a global modulator of skin differentiation and barrier function repair.
International journal of cosmetic science
Chajra H,Amstutz B,Schweikert K,Auriol D,Redziniak G,Lefèvre F
33-1500 was used in immunohistochemistry to investigate the role of opioid receptor delta in skin differentiation and barrier function repair
Sat Aug 01 00:00:00 UTC 2015
Expression and function of transcription factor AP-2? in early embryonic development of porcine parthenotes.
Reproduction, fertility, and development
Lee SH,Kwon JW,Choi I,Kim NH
33-1500 was used in immunohistochemistry to characterize transcription factor AP-2gamma in early embryonic development of porcine parthenotes
Wed Jan 07 00:00:00 UTC 2015
Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model.
Physiological reports
Wu S,Yi J,Zhang YG,Zhou J,Sun J
33-1500 was used in western blot to investigate the deficiency of intestine and microbiome in an amyotrophic lateral sclerosis mouse model
Wed Apr 01 00:00:00 UTC 2015
Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics.
PloS one
Blume C,Reale R,Held M,Millar TM,Collins JE,Davies DE,Morgan H,Swindle EJ
33-1500 was used in immunocytochemistry to study the use of microfluidics in temporal monitoring of differentiated human airway epithelial cells
Wed Jun 01 00:00:00 UTC 2016
Cell culture-derived HCV cannot infect synovial fibroblasts.
Scientific reports
Nadeem AE,Thomas P,Ulf ML,Elena N,Anggakusuma A,Mohamed BM,Frank P,Patrick B
33-1500 was used in western blot to assess the capacity of primary synovial fibroblasts to support hepatitis C virus propagation
Tue Dec 08 00:00:00 UTC 2015
JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis.
Nature communications
Tuncay H,Brinkmann BF,Steinbacher T,Schürmann A,Gerke V,Iden S,Ebnet K
33-1500 was used in Immunocytochemistry-immunoflourescence to examine the contribution of junctional adhesion molecule-A to the regulation of planar spindle orientation during mitosis.
Wed Aug 26 00:00:00 UTC 2015
A novel mouse model for stable engraftment of a human immune system and human hepatocytes.
PloS one
Strick-Marchand H,Dusséaux M,Darche S,Huntington ND,Legrand N,Masse-Ranson G,Corcuff E,Ahodantin J,Weijer K,Spits H,Kremsdorf D,Di Santo JP
33-1500 was used in Immunohistochemistry-immunofluorescence to develop a novel mouse model for stable engraftment of a human immune system and human hepatocytes.
Tue Mar 15 00:00:00 UTC 2016
NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation.
Tissue barriers
Ward C,Schlingmann B,Stecenko AA,Guidot DM,Koval M
33-1500 was used in immunohistochemistry to investigate the effect of NF-kappaB inhibitors on lung epithelial tight junctions in the absence of inflammation.
Fri Apr 03 00:00:00 UTC 2015
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.
Oncotarget
Momeny M,Saunus JM,Marturana F,McCart Reed AE,Black D,Sala G,Iacobelli S,Holland JD,Yu D,Da Silva L,Simpson PT,Khanna KK,Chenevix-Trench G,Lakhani SR
33-1500 was used in western blot to study human breast cancer cell lines and how Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration
Sat Feb 28 00:00:00 UTC 2015
Comparable mRNA expression of inflammatory markers but lower claudin-1 mRNA levels in foreskin tissue of HSV-2 seropositive versus seronegative asymptomatic Kenyan young men.
BMJ open
Röhl M,Tjernlund A,Mehta SD,Pettersson P,Bailey RC,Broliden K
33-1500 was used in immunohistochemistry (frozen) to test if foreskin tissue samples from asymptomatic HSV-2 seropositive men had signs of inflammation at the molecular level.
Wed Feb 18 00:00:00 UTC 2015
TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells.
Nature immunology
Gerlach K,Hwang Y,Nikolaev A,Atreya R,Dornhoff H,Steiner S,Lehr HA,Wirtz S,Vieth M,Waisman A,Rosenbauer F,McKenzie AN,Weigmann B,Neurath MF
33-1500 was used in immunohistochemistry - frozen section to study the role of TH9 cells in ulcerative colitis
Tue Jul 01 00:00:00 UTC 2014
Complete replication of hepatitis B virus and hepatitis C virus in a newly developed hepatoma cell line.
Proceedings of the National Academy of Sciences of the United States of America
Yang D,Zuo C,Wang X,Meng X,Xue B,Liu N,Yu R,Qin Y,Gao Y,Wang Q,Hu J,Wang L,Zhou Z,Liu B,Tan D,Guan Y,Zhu H
33-1500 was used in immunocytochemistry to identify a cell line that supports the entire life cycle of hepatitis B and hepatitis C viruses
Tue Apr 01 00:00:00 UTC 2014
Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia.
The American journal of pathology
Tawfik A,Markand S,Al-Shabrawey M,Mayo JN,Reynolds J,Bearden SE,Ganapathy V,Smith SB
33-1500 was used in immunohistochemistry to evaluate the cystathionine-beta-synthase heterozygous mice as a model of mild to moderate hyperhomocysteinemia
Mon Sep 01 00:00:00 UTC 2014
Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma.
Journal of neurosurgery
Jakimovski D,Schneider H,Frei K,Kennes LN,Bertalanffy H
33-1500 was used in immunohistochemistry - frozen section to study the role of tight junction alterations in cavernous malformations
Mon Sep 01 00:00:00 UTC 2014
Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways.
International journal of molecular medicine
Lei Q,Qiang F,Chao D,Di W,Guoqian Z,Bo Y,Lina Y
33-1500 was used in western blot to demonstrate that emodin attenuates LPS- and hypoxia/reoxygenation-induced intestinal epithelial barrier dysfunction by inhibiting the HIF-1alpha and NF-kappaB signaling pathways, which regulate tight junctions.
Mon Dec 01 00:00:00 UTC 2014
Effect of retinoic acid on the tight junctions of the retinal pigment epithelium-choroid complex of guinea pigs with lens-induced myopia in vivo.
International journal of molecular medicine
Wang S,Liu S,Mao J,Wen D
33-1500 was used in immunohistochemistry and western blot to study the effect of retinoic acid on the tight junctions of the retinal pigment epithelium-choroid complex of guinea pigs
Tue Apr 01 00:00:00 UTC 2014
Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion.
Journal of cell science
Van Itallie CM,Tietgens AJ,Aponte A,Fredriksson K,Fanning AS,Gucek M,Anderson JM
33-1500 was used in Immunocytochemistry to express E-cadherin fused to biotin ligase in MDCK epithelial cells, and identify neighbouring proteins that are biotinylated.
Sat Feb 15 00:00:00 UTC 2014
Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion.
Journal of cell science
Van Itallie CM,Tietgens AJ,Aponte A,Fredriksson K,Fanning AS,Gucek M,Anderson JM
33-1500 was used in Immunocytochemistry to express E-cadherin fused to biotin ligase in MDCK epithelial cells, and identify neighbouring proteins that are biotinylated.
Sat Feb 15 00:00:00 UTC 2014
Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.
Cell cycle (Georgetown, Tex.)
Qiao X,Roth I,Féraille E,Hasler U
33-1500 was used in immunocytochemistry to study the contribution of ZO-1, -2, and -3 on collecting duct cell proliferation.
Mon Aug 31 00:00:00 UTC 2015
CAR expression in human embryos and hESC illustrates its role in pluripotency and tight junctions.
Reproduction (Cambridge, England)
Krivega M,Geens M,Van de Velde H
33-1500 was used in immunohistochemistry to investigate the role of CAR in pluripotency and tight junctions of human embryos and stem cells.
Sat Nov 01 00:00:00 UTC 2014
The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.
Nature communications
Vitiello E,Ferreira JG,Maiato H,Balda MS,Matter K
33-1500 was used in immunocytochemistry to study how DLC2 regulates cell junction maintenance and planar spindle positioning.
Thu Dec 18 00:00:00 UTC 2014
Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes.
PloS one
Boyer-Di Ponio J,El-Ayoubi F,Glacial F,Ganeshamoorthy K,Driancourt C,Godet M,Perrière N,Guillevic O,Couraud PO,Uzan G
33-1500 was used in immunocytochemistry to study cord blood as a source of circulating endothelial progenitor cells that can be directed towards specialized endothelial phenotypes
Tue Nov 18 00:00:00 UTC 2014
The role of lipolysis stimulated lipoprotein receptor in breast cancer and directing breast cancer cell behavior.
PloS one
Reaves DK,Fagan-Solis KD,Dunphy K,Oliver SD,Scott DW,Fleming JM
33-1500 was used in western blot to investigate the role of lipolysis stimulated lipoprotein receptor in aggressive breast cancer behavior
Tue Jan 13 00:00:00 UTC 2015
Aldosterone modulates endothelial permeability and endothelial nitric oxide synthase activity by rearrangement of the actin cytoskeleton.
Hypertension (Dallas, Tex. : 1979)
Kirsch T,Beese M,Wyss K,Klinge U,Haller H,Haubitz M,Fiebeler A
33-1500 was used in Immunocytochemistry to examine whether aldosterone alters endothelial integrity and modifies paracellular permeability.
Fri Feb 01 00:00:00 UTC 2013
Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes.
The Journal of investigative dermatology
Kirschner N,Rosenthal R,Furuse M,Moll I,Fromm M,Brandner JM
33-1500 was used in immunocytochemistry and western blot to examine the contribution of various tight junction proteins in keratinocytes.
Wed May 01 00:00:00 UTC 2013
Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle.
Clinical science (London, England : 1979)
Cheng YL,Lan KH,Lee WP,Tseng SH,Hung LR,Lin HC,Lee FY,Lee SD,Lan KH
33-1500 was used in western blot to elucidate the anti-viral effect of amiodarone on HCV life cycle.
Fri Nov 01 00:00:00 UTC 2013
Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry.
Journal of virology
Kim S,Ishida H,Yamane D,Yi M,Swinney DC,Foung S,Lemon SM
33-1500 was used in western blot to study the roles of MAPK-related kinase and MKNK-1 in HCV replication and cellular entry.
Mon Apr 01 00:00:00 UTC 2013
Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.
The American journal of pathology
Kissoon-Singh V,Moreau F,Trusevych E,Chadee K
33-1500 was used in immunohistochemistry (frozen) to examine innate responses to Entamoeba histolytica in wild-type and MUC-2-deficient mice.
Fri Mar 01 00:00:00 UTC 2013
ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions.
Journal of cell science
Maiers JL,Peng X,Fanning AS,DeMali KA
33-1500 was used in Western Blotting to identify α-catenin binding to ZO-1 as a new mechanism for coupling the assembly of the epithelial barrier to cell-to-cell adhesion.
Sun Sep 01 00:00:00 UTC 2013
A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids.
American journal of physiology. Gastrointestinal and liver physiology
Stenman LK,Holma R,Eggert A,Korpela R
33-1500 was used in immunohistochemistry to elucidate role of bile acids in fat-induced barrier dysfunction.
Fri Feb 01 00:00:00 UTC 2013
Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer.
Carcinogenesis
Kyuno D,Kojima T,Yamaguchi H,Ito T,Kimura Y,Imamura M,Takasawa A,Murata M,Tanaka S,Hirata K,Sawada N
33-1500 was used in immunocytochemistry to study regulatory mechanisms that modulate Snail and claudin-1 via a PKCalpha during the epithelial-mesenchymal transition of pancreatic cancer cells
Sat Jun 01 00:00:00 UTC 2013
Papillomavirus E6 oncoprotein up-regulates occludin and ZO-2 expression in ovariectomized mice epidermis.
Experimental cell research
Hernández-Monge J,Garay E,Raya-Sandino A,Vargas-Sierra O,Díaz-Chávez J,Popoca-Cuaya M,Lambert PF,González-Mariscal L,Gariglio P
33-1500 was used in immunohistochemistry (frozen) to investigate the expression of the tight junction proteins occludin, claudin-1 and ZO-2 in the epidermis of female mice.
Tue Oct 15 00:00:00 UTC 2013
Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods.
Neurotoxicology and teratology
Szczepkowska A,Lagaraine C,Robert V,Dufourny L,Thiéry JC,Skipor J
33-1500 was used in western blot to examine the photoperiodically different concentration of polychlorinated biphenyls in the cerebrospinal fluid in sheep.
Mon Dec 30 00:00:00 UTC 2013
Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano.
Cell and tissue research
Someya M,Kojima T,Ogawa M,Ninomiya T,Nomura K,Takasawa A,Murata M,Tanaka S,Saito T,Sawada N
33-1500 was used in immunocytochemistry and immunohistochemistry to report that tight junctions are physiological regulated by sex hormones during the menstrual cycle.
Fri Nov 01 00:00:00 UTC 2013
Ion transport in human pancreatic duct epithelium, Capan-1 cells, is regulated by secretin, VIP, acetylcholine, and purinergic receptors.
Pancreas
Wang J,Novak I
33-1500 was used in immunocytochemistry to develop a solid model of polarized epithelium for human pancreatic ducts to study ion transport.
Mon Apr 01 00:00:00 UTC 2013
On fundamental cellular processes for emergence of collective epithelial movement.
Biology open
Hirashima T,Hosokawa Y,Iino T,Nagayama M
33-1500 was used in immunocytochemistry to study collective cell movement.
Mon Jul 15 00:00:00 UTC 2013
Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.
Proceedings of the National Academy of Sciences of the United States of America
Breiderhoff T,Himmerkus N,Stuiver M,Mutig K,Will C,Meij IC,Bachmann S,Bleich M,Willnow TE,Müller D
Tue Aug 28 00:00:00 UTC 2012
The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeability.
Proceedings of the National Academy of Sciences of the United States of America
Tash BR,Bewley MC,Russo M,Keil JM,Griffin KA,Sundstrom JM,Antonetti DA,Tian F,Flanagan JM
Tue Jul 03 00:00:00 UTC 2012
Anti-retroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro.
Antiviral research
Sandmann L,Wilson M,Back D,Wedemeyer H,Manns MP,Steinmann E,Pietschmann T,von Hahn T,Ciesek S
33-1500 was used in western blot to test if drugs used in highly active antiretroviral therapy increase susceptibility to HCV infection.
Mon Oct 01 00:00:00 UTC 2012
Acquisition of an enhanced aggressive phenotype in human lung cancer cells selected by suboptimal doses of cisplatin following cell deattachment and reattachment.
Cancer letters
Hsieh JL,Lu CS,Huang CL,Shieh GS,Su BH,Su YC,Lee CH,Chang MY,Wu CL,Shiau AL
33-1500 was used in western blot to study non-small cell lung carcinoma cell lines treated with cisplatin, doxorubicin, and gemcitabine.
Wed Aug 01 00:00:00 UTC 2012
HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells.
Cellular and molecular life sciences : CMLS
Yan J,Zhang Z,Shi H
33-1500 was used in western blot to determine the role of hypoxia-inducible factor-1 in high glucose-induced endothelial permeability of the blood brain barrier.
Sun Jan 01 00:00:00 UTC 2012
Modulation of tight junction proteins in the perineurium to facilitate peripheral opioid analgesia.
Anesthesiology
Rittner HL,Amasheh S,Moshourab R,Hackel D,Yamdeu RS,Mousa SA,Fromm M,Stein C,Brack A
33-1500 was used in immunohistochemistry - paraffin section to assess the effects of opioids on tight junction proteins
Fri Jun 01 00:00:00 UTC 2012
Multiple effects of Honokiol on the life cycle of hepatitis C virus.
Liver international : official journal of the International Association for the Study of the Liver
Lan KH,Wang YW,Lee WP,Lan KL,Tseng SH,Hung LR,Yen SH,Lin HC,Lee SD
33-1500 was used in western blot to report that Honokiol inhibits hepatitis C virus infection in vitro.
Sun Jul 01 00:00:00 UTC 2012
Tricellulin expression in normal and neoplastic human pancreas.
Histopathology
Korompay A,Borka K,Lotz G,Somorácz A,Törzsök P,Erdélyi-Belle B,Kenessey I,Baranyai Z,Zsoldos F,Kupcsulik P,Bodoky G,Schaff Z,Kiss A
33-1500 was used in immunohistochemistry to examine the expression of tricellulin in normal human pancreas, and in primary exocrine and endocrine pancreatic tumors.
Tue May 01 00:00:00 UTC 2012
Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells.
Journal of virology
Da Costa D,Turek M,Felmlee DJ,Girardi E,Pfeffer S,Long G,Bartenschlager R,Zeisel MB,Baumert TF
33-1500 was used in Flow cytometry/Cell sorting to examine the entire hepatitis C life cycle, and the relevant host factors restricting infection to hepatocytes.
Thu Nov 01 00:00:00 UTC 2012
A new approach on the gastric absorption of anthocyanins.
Food & function
Fernandes I,de Freitas V,Reis C,Mateus N
33-1500 was used in immunocytochemistry to describe an in vitro model of the gastric barrier using moderately differentiated adenocarcinoma stomach cells.
Tue May 01 00:00:00 UTC 2012
Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa.
American journal of physiology. Lung cellular and molecular physiology
Nguyen Hoang AT,Chen P,Juarez J,Sachamitr P,Billing B,Bosnjak L,Dahlén B,Coles M,Svensson M
33-1500 was used in immunohistochemistry (frozen) to establish and characterize a three-dimensional organotypic model of the human airway mucosa.
Sun Jan 15 00:00:00 UTC 2012
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Journal of cell science
Guillemot L,Schneider Y,Brun P,Castagliuolo I,Pizzuti D,Martines D,Jond L,Bongiovanni M,Citi S
33-1500 was used in Western Blotting to conclude that cingulin is dispensable for tight junction structure and barrier function, and is embedded in signalling networks controlling claudin-2 expression.
Thu Nov 01 00:00:00 UTC 2012
Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
American journal of physiology. Heart and circulatory physiology
Cheung TM,Ganatra MP,Peters EB,Truskey GA
33-1500 was used in immunocytochemistry and western blot to study permeability and tight junctions in endothelial cells derived from human cord blood.
Sat Dec 01 00:00:00 UTC 2012
Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium.
Investigative ophthalmology & visual science
Peng S,Gan G,Rao VS,Adelman RA,Rizzolo LJ
Fri Jul 27 00:00:00 UTC 2012
Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium.
Investigative ophthalmology & visual science
Peng S,Gan G,Rao VS,Adelman RA,Rizzolo LJ
Fri Jul 27 00:00:00 UTC 2012
3D single molecule tracking with multifocal plane microscopy reveals rapid intercellular transferrin transport at epithelial cell barriers.
Biophysical journal
Ram S,Kim D,Ober RJ,Ward ES
33-1500 was used in Immunocytochemistry-immunoflourescence to reveal the complexity of the 3D trafficking pathways in epithelial cell barriers.
Wed Oct 03 00:00:00 UTC 2012
Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.
PloS one
Kelsey L,Katoch P,Johnson KE,Batra SK,Mehta PP
33-1500 was used in western blot to assess the effect of 9-cis-retinoic acid and all-trans retinoic acid on the formation and degradation of gap junctions and junctional communication in cancer cells
Thu Aug 30 00:00:00 UTC 2012
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
PLoS genetics
Morel AP,Hinkal GW,Thomas C,Fauvet F,Courtois-Cox S,Wierinckx A,Devouassoux-Shisheboran M,Treilleux I,Tissier A,Gras B,Pourchet J,Puisieux I,Browne GJ,Spicer DB,Lachuer J,Ansieau S,Puisieux A
33-1500 was used in western blot to report the consequences of modulating PP2A phosphatase activity in human mammary epithelial cells
Wed Sep 26 00:00:00 UTC 2012
Tight junction defects in patients with atopic dermatitis.
The Journal of allergy and clinical immunology
De Benedetto A,Rafaels NM,McGirt LY,Ivanov AI,Georas SN,Cheadle C,Berger AE,Zhang K,Vidyasagar S,Yoshida T,Boguniewicz M,Hata T,Schneider LC,Hanifin JM,Gallo RL,Novak N,Weidinger S,Beaty TH,Leung DY,Barnes KC,Beck LA
33-1500 was used in Immunohistochemistry-immunofluorescence to evaluate the expression/function of the tight junction protein claudin-1 in epithelium from atopic dermatitis and nonatopic subjects.
Tue Mar 01 00:00:00 UTC 2011
Tight junction defects in patients with atopic dermatitis.
The Journal of allergy and clinical immunology
De Benedetto A,Rafaels NM,McGirt LY,Ivanov AI,Georas SN,Cheadle C,Berger AE,Zhang K,Vidyasagar S,Yoshida T,Boguniewicz M,Hata T,Schneider LC,Hanifin JM,Gallo RL,Novak N,Weidinger S,Beaty TH,Leung DY,Barnes KC,Beck LA
33-1500 was used in Immunohistochemistry-immunofluorescence to evaluate the expression/function of the tight junction protein claudin-1 in epithelium from atopic dermatitis and nonatopic subjects.
Tue Mar 01 00:00:00 UTC 2011
CD44 regulates tight-junction assembly and barrier function.
The Journal of investigative dermatology
Kirschner N,Haftek M,Niessen CM,Behne MJ,Furuse M,Moll I,Brandner JM
Fri Apr 01 00:00:00 UTC 2011
CD44 regulates tight-junction assembly and barrier function.
The Journal of investigative dermatology
Kirschner N,Haftek M,Niessen CM,Behne MJ,Furuse M,Moll I,Brandner JM
Fri Apr 01 00:00:00 UTC 2011
Adenosine receptor signaling modulates permeability of the blood-brain barrier.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Carman AJ,Mills JH,Krenz A,Kim DG,Bynoe MS
33-1500 was used in immunocytochemistry to show that adenosine receptor signaling modulates blood brain barrier permeability in vivo.
Wed Sep 14 00:00:00 UTC 2011
Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles.
Journal of virology
Ciesek S,Westhaus S,Wicht M,Wappler I,Henschen S,Sarrazin C,Hamdi N,Abdelaziz AI,Strassburg CP,Wedemeyer H,Manns MP,Pietschmann T,von Hahn T
33-1500 was used in western blot to investigate how the differences between human and murine occludin contribute to hepatitis C virus spread.
Mon Aug 01 00:00:00 UTC 2011
Hypoxia increases transepithelial electrical conductance and reduces occludin at the plasma membrane in alveolar epithelial cells via PKC-ζ and PP2A pathway.
American journal of physiology. Lung cellular and molecular physiology
Caraballo JC,Yshii C,Butti ML,Westphal W,Borcherding JA,Allamargot C,Comellas AP
Fri Apr 01 00:00:00 UTC 2011
Relocalization of cell adhesion molecules during neoplastic transformation of human fibroblasts.
International journal of oncology
Belgiovine C,Chiodi I,Mondello C
33-1500 was used in western blot to investigate neoplastic transformation of telomerase in immortalized human fibroblasts.
Tue Nov 01 00:00:00 UTC 2011
Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells.
Experimental cell research
Kojima T,Takasawa A,Kyuno D,Ito T,Yamaguchi H,Hirata K,Tsujiwaki M,Murata M,Tanaka S,Sawada N
33-1500 was used in immunocytochemistry and western blot to elucidate the role and regulation of marvelD3 in normal epithelial cells and cancer cells.
Sat Oct 01 00:00:00 UTC 2011
Lipid raft-dependent adhesion of Giardia intestinalis trophozoites to a cultured human enterocyte-like Caco-2/TC7 cell monolayer leads to cytoskeleton-dependent functional injuries.
Cellular microbiology
Humen MA,Pérez PF,Liévin-Le Moal V
33-1500 was used in immunocytochemistry to determine the mechanisms by which Gardia intestinalis induces host intestinal epithelium alterations
Tue Nov 01 00:00:00 UTC 2011
Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.
Cell and tissue research
Kyuno D,Kojima T,Ito T,Yamaguchi H,Tsujiwaki M,Takasawa A,Murata M,Tanaka S,Hirata K,Sawada N
33-1500 was used in western blot to assess the changes in claudins function via PKCα activation in pancreatic cancer cells.
Thu Dec 01 00:00:00 UTC 2011
GM1 expression in caco-2 cells: characterisation of a fundamental passage-dependent transformation of a cell line.
Journal of pharmaceutical sciences
Jahn KA,Biazik JM,Braet F
33-1500 was used in immunocytochemistry to characterize distinct, flat and island-forming Caco-2 cells.
Thu Sep 01 00:00:00 UTC 2011
Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions.
The Biochemical journal
Jain S,Suzuki T,Seth A,Samak G,Rao R
Fri Jul 15 00:00:00 UTC 2011
Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions.
The Biochemical journal
Jain S,Suzuki T,Seth A,Samak G,Rao R
Fri Jul 15 00:00:00 UTC 2011
Tight junction proteins vary in the choroid plexus of ewes according to photoperiod.
Brain research
Lagaraine C,Skipor J,Szczepkowska A,Dufourny L,Thiery JC
33-1500 was used in western blot to compare the tight junction proteins in the choroid plexus of ewes exposed to short or long days.
Wed Jun 01 00:00:00 UTC 2011
Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration.
Journal of viral hepatitis
Bürgel B,Friesland M,Koch A,Manns MP,Wedemeyer H,Weissenborn K,Schulz-Schaeffer WJ,Pietschmann T,Steinmann E,Ciesek S
33-1500 was used in western blot to test if cells originating from the brain or central nervous system are permissive for HCV cell entry, RNA replication, and virus assembly
Mon Aug 01 00:00:00 UTC 2011
Renal ischemia-reperfusion injury causes intercalated cell-specific disruption of occludin in the collecting duct.
Histochemistry and cell biology
Lee SY,Shin JA,Kwon HM,Weiner ID,Han KH
33-1500 was used in immunohistochemistry - paraffin section and western blot to determine the effects of ischemia-reperfusion injury on expression and distribution of the tight junction proteins in rat kidney.
Thu Dec 01 00:00:00 UTC 2011
Comparison of tight junction protein expression in the ciliary epithelia of mouse, rabbit, cat and human eyes.
Biotechnic & histochemistry : official publication of the Biological Stain Commission
Karim MJ,Biswas S,Bhattacherjee P,Paterson CA
33-1500 was used in immunohistochemistry to investigate if the expression pattern of tight junction proteins in mice, rabbits, and cats resemble those of humans
Wed Jun 01 00:00:00 UTC 2011
FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells.
American journal of physiology. Renal physiology
Lubarski I,Asher C,Garty H
33-1500 was used in western blot to determine the effects of FXYD5 on the paracellular permeability using a mouse kidney collecting duct cell line.
Thu Dec 01 00:00:00 UTC 2011
Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.
PloS one
Kwon Y,Cukierman E,Godwin AK
33-1500 was used in western blot to study the role of adhesion mlecules and proteases in the penetration/invasion of ovarian tumor cells into extracellular matrices.
Tue Apr 19 00:00:00 UTC 2011
Glucocorticosteroids increase cell entry by hepatitis C virus.
Gastroenterology
Ciesek S,Steinmann E,Iken M,Ott M,Helfritz FA,Wappler I,Manns MP,Wedemeyer H,Pietschmann T
33-1500 was used in western blot to discuss the impact of corticosteroid treatment on hepatitis C virus recurrence after liver transplantation
Sat May 01 00:00:00 UTC 2010
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.
Proceedings of the National Academy of Sciences of the United States of America
Ploss A,Khetani SR,Jones CT,Syder AJ,Trehan K,Gaysinskaya VA,Mu K,Ritola K,Rice CM,Bhatia SN
33-1500 was used in immunocytochemistry to show that the entire hepatitis C virus life cycle is recapitulated in micropatterned cocultures of primary human hepatocytes
Tue Feb 16 00:00:00 UTC 2010
ASPP2 regulates epithelial cell polarity through the PAR complex.
Current biology : CB
Cong W,Hirose T,Harita Y,Yamashita A,Mizuno K,Hirano H,Ohno S
33-1500 was used in immunocytochemistry to investigate the regulatory mechanisms of the PAR complex
Tue Aug 10 00:00:00 UTC 2010
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.
Diabetes
Leal EC,Martins J,Voabil P,Liberal J,Chiavaroli C,Bauer J,Cunha-Vaz J,Ambrósio AF
Fri Oct 01 00:00:00 UTC 2010
Fhit regulates invasion of lung tumor cells.
Oncogene
Joannes A,Bonnomet A,Bindels S,Polette M,Gilles C,Burlet H,Cutrona J,Zahm JM,Birembaut P,Nawrocki-Raby B
33-1500 was used in immunocytochemistry and western blot to examine the role of Fhit during tumor cell invasion
Thu Feb 25 00:00:00 UTC 2010
The SR-BI partner PDZK1 facilitates hepatitis C virus entry.
PLoS pathogens
Eyre NS,Drummer HE,Beard MR
33-1500 was used in immunocytochemistry and western blot to elucidate the role of PDZK1 in scavenger receptor class B type I-mediate hepatitis C virus entry
Thu Oct 07 00:00:00 UTC 2010
c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells.
Journal of cellular physiology
Kojima T,Fuchimoto J,Yamaguchi H,Ito T,Takasawa A,Ninomiya T,Kikuchi S,Ogasawara N,Ohkuni T,Masaki T,Hirata K,Himi T,Sawada N
33-1500 was used in immunocytochemistry and western blot to test if the c-Jun N-terminal kinase pathway regulates tricellulin
Mon Nov 01 00:00:00 UTC 2010
Vectorial TGFbeta signaling in polarized intestinal epithelial cells.
Journal of cellular physiology
Yakovich AJ,Huang Q,Du J,Jiang B,Barnard JA
33-1500 was used in immunocytochemistry to determine the localization of TGFbeta receptors and ligand secretion in polarizing colonic cells
Sun Aug 01 00:00:00 UTC 2010
Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells.
The American journal of pathology
Yamaguchi H,Kojima T,Ito T,Kimura Y,Imamura M,Son S,Koizumi J,Murata M,Nagayama M,Nobuoka T,Tanaka S,Hirata K,Sawada N
33-1500 was used in immunocytochemistry to examine the expression of tight junction proteins in normal human pancreatic duct epithelial cells
Sun Aug 01 00:00:00 UTC 2010
Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation.
American journal of physiology. Gastrointestinal and liver physiology
de La Serre CB,Ellis CL,Lee J,Hartman AL,Rutledge JC,Raybould HE
33-1500 was used in immunohistochemistry to use rats to test if changes in gut epithelial function and microbiota are diet- or obesity-associated
Sun Aug 01 00:00:00 UTC 2010
Differential effects of testosterone and TGF-β3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier.
Experimental cell research
Su L,Mruk DD,Lee WM,Cheng CY
33-1500 was used in immunocytochemistry and western blot to study protein trafficking in Sertoli cells
Fri Oct 15 00:00:00 UTC 2010
Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy.
Acta histochemica
Nicholson MD,Lindsay LA,Murphy CR
33-1500 was used in immunohistochemistry - frozen section and western blot to examine the cellular distributions of tight junction components during early pregnancy and under various hormonal regimens
Thu Mar 04 00:00:00 UTC 2010
E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells.
The Journal of biological chemistry
Chakraborty S,Mitra S,Falk MM,Caplan SH,Wheelock MJ,Johnson KR,Mehta PP
Fri Apr 02 00:00:00 UTC 2010
Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown.
PloS one
Haarmann A,Deiss A,Prochaska J,Foerch C,Weksler B,Romero I,Couraud PO,Stoll G,Rieckmann P,Buttmann M
33-1500 was used in immunocytochemistry to determine the regulation of JAM-A expression in brain endothelial cells and evaluate sJAM-A as a biomarker of blood-brain barrier function
Thu Oct 21 00:00:00 UTC 2010
Mouse adenovirus type 1-induced breakdown of the blood-brain barrier.
Journal of virology
Gralinski LE,Ashley SL,Dixon SD,Spindler KR
Tue Sep 01 00:00:00 UTC 2009
Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways.
Proteomics
Matsumoto M,Oyamada K,Takahashi H,Sato T,Hatakeyama S,Nakayama KI
33-1500 was used in western blot to measure tyrosine-phosphorylated proteins abundance in T cell, B cells, and nonlymphoid cells
Wed Jul 01 00:00:00 UTC 2009
Barrier function of cultivated limbal and oral mucosal epithelial cell sheets.
Investigative ophthalmology & visual science
Shimazaki J,Higa K,Kato N,Satake Y
33-1500 was used in immunohistochemistry - frozen section to observe the barrier function of cultivated limbal and oral mucosal epithelial sheets
Tue Dec 01 00:00:00 UTC 2009
Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome.
American journal of physiology. Gastrointestinal and liver physiology
Tian J,Hao L,Chandra P,Jones DP,Willams IR,Gewirtz AT,Ziegler TR
33-1500 was used in western blot to assess the effects of dietary glutamine or oral antibiotics on the gut barrier function in a rat model of short bowel syndrome
Sun Feb 01 00:00:00 UTC 2009
RAB13 participates in ectoplasmic specialization dynamics in the rat testis.
Biology of reproduction
Mruk DD,Lau AS
33-1500 was used in Immunoprecipitation to demonstrate the participation of RAB-13 in the dynamics of ectoplasmic specialisation in the testis.
Sun Mar 01 00:00:00 UTC 2009
RAB13 participates in ectoplasmic specialization dynamics in the rat testis.
Biology of reproduction
Mruk DD,Lau AS
33-1500 was used in Immunoprecipitation to demonstrate the participation of RAB-13 in the dynamics of ectoplasmic specialisation in the testis.
Sun Mar 01 00:00:00 UTC 2009
Effects of di(2-ethylhexyl) phthalate on gap and tight junction protein expression in the testis of prepubertal rats.
Microscopy research and technique
Sobarzo CM,Lustig L,Ponzio R,Suescun MO,Denduchis B
33-1500 was used in immunohistochemistry - frozen section and western blot to test if di(2-ethylhexyl) phthalate alters the expression of testicular gap and tight junction proteins
Sun Nov 01 00:00:00 UTC 2009
Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.
Histochemistry and cell biology
Son S,Kojima T,Decaens C,Yamaguchi H,Ito T,Imamura M,Murata M,Tanaka S,Chiba H,Hirata K,Sawada N
33-1500 was used in immunocytochemistry to study the role of claudin-2 in bile canalicular formation
Sun Mar 01 00:00:00 UTC 2009
Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide.
The Journal of surgical research
Waldow T,Witt W,Janke A,Ulmer A,Buzin A,Matschke K
33-1500 was used in western blot to test if pre-treatment with nitric oxide before ischemia and reperfusion injury affects cell junction proteins and vascular endothelial growth factor
Sun Nov 01 00:00:00 UTC 2009
Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.
Medical molecular morphology
Ohkuni T,Kojima T,Ogasawara N,Masaki T,Ninomiya T,Kikuchi S,Go M,Takano K,Himi T,Sawada N
33-1500 was used in immunohistochemistry to determine the expression and localization of tricellulin
Tue Dec 01 00:00:00 UTC 2009
Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes.
Liver international : official journal of the International Association for the Study of the Liver
Kojima T,Takano K,Yamamoto T,Murata M,Son S,Imamura M,Yamaguchi H,Osanai M,Chiba H,Himi T,Sawada N
33-1500 was used in immunocytochemistry to determine whether transforming growth factor-beta down-regulates claudin-1 expression to induce epithelial to mesenchymal transition
Tue Apr 01 00:00:00 UTC 2008
The keratin-binding protein Albatross regulates polarization of epithelial cells.
The Journal of cell biology
Sugimoto M,Inoko A,Shiromizu T,Nakayama M,Zou P,Yonemura S,Hayashi Y,Izawa I,Sasoh M,Uji Y,Kaibuchi K,Kiyono T,Inagaki M
33-1500 was used in western blot to elucidate how the keratin intermediate filament network is involved in the establishment and maintenance of cell polarity
Mon Oct 06 00:00:00 UTC 2008
Regulation of epidermal tight-junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains.
The Journal of investigative dermatology
Ohnemus U,Kohrmeyer K,Houdek P,Rohde H,Wladykowski E,Vidal S,Horstkotte MA,Aepfelbacher M,Kirschner N,Behne MJ,Moll I,Brandner JM
33-1500 was used in immunocytochemistry, immunohistochemistry - frozen section, and western blot to determine the fate of tight junction proteins in the skin during bacterial colonization and infection
Tue Apr 01 00:00:00 UTC 2008
Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile.
Stem cells (Dayton, Ohio)
Van Hoof D,Braam SR,Dormeyer W,Ward-van Oostwaard D,Heck AJ,Krijgsveld J,Mummery CL
33-1500 was used in immunocytochemistry to use mass spectroscopy to identify proteins that contribute to adhesion of human embryonic stem cells
Sat Nov 01 00:00:00 UTC 2008
Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia.
Journal of neurochemistry
McCaffrey G,Seelbach MJ,Staatz WD,Nametz N,Quigley C,Campos CR,Brooks TA,Davis TP
33-1500 was used in western blot to test the effect of lambda-carrageenan-induced peripheral inflammatory pain on occludin.
Mon Sep 01 00:00:00 UTC 2008
Hepatocyte nuclear factor-4alpha promotes differentiation of intestinal epithelial cells in a coculture system.
American journal of physiology. Gastrointestinal and liver physiology
Lussier CR,Babeu JP,Auclair BA,Perreault N,Boudreau F
33-1500 was used in immunocytochemistry to develop and characterize a mesenchymal-epithelial coculture system to identify transcriptional regulators of intestinal epithelial cell differentiation
Fri Feb 01 00:00:00 UTC 2008
Early events in HIV transmission through a human reconstructed vaginal mucosa.
AIDS (London, England)
Bouschbacher M,Bomsel M,Verronèse E,Gofflo S,Ganor Y,Dezutter-Dambuyant C,Valladeau J
33-1500 was used in immunohistochemistry - paraffin section to study translocation of HIV across the vaginal pluristratified epithelium
Fri Jul 11 00:00:00 UTC 2008
Validation of in vitro cell culture models of the blood-brain barrier: tightness characterization of two promising cell lines.
Journal of pharmaceutical sciences
Neuhaus W,Plattner VE,Wirth M,Germann B,Lachmann B,Gabor F,Noe CR
33-1500 was used in immunocytochemistry to characterize two cell lines to study the blood-brain barrier
Mon Dec 01 00:00:00 UTC 2008
Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media.
Neuroscience letters
Neuhaus W,Wirth M,Plattner VE,Germann B,Gabor F,Noe CR
33-1500 was used in immunocytochemistry to study tight junction proteins in ECV304 cells
Wed Dec 03 00:00:00 UTC 2008
Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.
Journal of molecular histology
Takano K,Kojima T,Ogasawara N,Go M,Kikuchi S,Ninomiya T,Kurose M,Koizumi J,Kamekura R,Murata M,Tanaka S,Chiba H,Himi T,Sawada N
33-1500 was used in immunohistochemistry - frozen section to study M cells in the epithelial barrier of the human adenoid
Sun Jun 01 00:00:00 UTC 2008
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Molecular membrane biology
Paschoud S,Citi S
33-1500 was used in immunocytochemistry and western blot to study the effects of cingulin overexpression
Tue Jan 01 00:00:00 UTC 2008
Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin.
Endocrinology
Gorodeski GI
33-1500 was used in Western Blotting to study the mechanisms involved in the remodelling of occludin by oestrogen receptor-alpha signalling.
Mon Jan 01 00:00:00 UTC 2007
Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function.
Investigative ophthalmology & visual science
Mandell KJ,Berglin L,Severson EA,Edelhauser HF,Parkos CA
33-1500 was used in immunocytochemistry to quantify junctional adhesion molecule-A expression in human corneal endothelium and retinal pigment epithelium and examine the impact of a junctional adhesion molecule-A function-blocking antibody on the permeab
Sat Sep 01 00:00:00 UTC 2007
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture.
Experimental cell research
Hernandez S,Chavez Munguia B,Gonzalez-Mariscal L
33-1500 was used in immunocytochemistry to ascertain the role of ZO-2 in epithelial cells
Tue May 01 00:00:00 UTC 2007
Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells.
Cell and tissue research
Qi B,Fujita-Yoshigaki J,Michikawa H,Satoh K,Katsumata O,Sugiya H
Sun Jul 01 00:00:00 UTC 2007
Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis.
Neuroscience
Morgan L,Shah B,Rivers LE,Barden L,Groom AJ,Chung R,Higazi D,Desmond H,Smith T,Staddon JM
33-1500 was used in immunohistochemistry - frozen section to analyze lumbar spinal cord proteins present in naive and experimental autoimmune encephalomyelitis rats
Fri Jul 13 00:00:00 UTC 2007
The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation.
Molecular biology of the cell
Stucke VM,Timmerman E,Vandekerckhove J,Gevaert K,Hall A
33-1500 was used in immunocytochemistry to report that the hDlg1-MPP7 complex promotes epithelial cell polarity and tight junction formation
Tue May 01 00:00:00 UTC 2007
Establishment and characterization of a primary canine duodenal epithelial cell culture.
In vitro cellular & developmental biology. Animal
Golaz JL,Vonlaufen N,Hemphill A,Burgener IA
33-1500 was used in immunocytochemistry to establish and characterize a primary canine duodenal epithelial cell culture
Thu Oct 04 00:00:00 UTC 2007
Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex.
Histochemistry and cell biology
Anstrom JA,Thore CR,Moody DM,Brown WR
33-1500 was used in immunohistochemistry to test if the expression of tight junction proteins increases in vessels of germinal matrix and cortex with gestational age
Thu Feb 01 00:00:00 UTC 2007
The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha.
Molecular endocrinology (Baltimore, Md.)
Dhasarathy A,Kajita M,Wade PA
33-1500 was used in immunocytochemistry and western blot to elucidate the role of Snail in the epithelial to mesenchymal transition
Sat Dec 01 00:00:00 UTC 2007
Contacts and cooperation between cells depend on the hormone ouabain.
Proceedings of the National Academy of Sciences of the United States of America
Larre I,Ponce A,Fiorentino R,Shoshani L,Contreras RG,Cereijido M
33-1500 was used in immunocytochemistry to study ouabain-sensitive and -resistant MDCK cells
Tue Jul 18 00:00:00 UTC 2006
The tight junction proteins claudin-7 and -8 display a different subcellular localization at Henle's loops and collecting ducts of rabbit kidney.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Gonzalez-Mariscal L,Namorado Mdel C,Martin D,Sierra G,Reyes JL
33-1500 was used in immunohistochemistry to determine the distribution of claudins-7 and -8 in rabbit Henle's loops and collecting ducts
Fri Sep 01 00:00:00 UTC 2006
Tight junctions and compression therapy in chronic venous insufficiency.
International journal of molecular medicine
Herouy Y,Kahle B,Idzko M,Eberth I,Norgauer J,Pannier F,Rabe E,Jünger M,Bruckner-Tuderman L
33-1500 was used in western blot to measure tight junction mRNA and protein levels in patients with edema, venous leg ulcers, and healthy controls
Sat Jul 01 00:00:00 UTC 2006
Collagen-immobilized poly(vinyl alcohol) as an artificial cornea scaffold that supports a stratified corneal epithelium.
Journal of biomedical materials research. Part B, Applied biomaterials
Miyashita H,Shimmura S,Kobayashi H,Taguchi T,Asano-Kato N,Uchino Y,Kato M,Shimazaki J,Tanaka J,Tsubota K
33-1500 was used in immunocytochemistry to evaluate a new biocompatible artificial cornea scaffold
Sun Jan 01 00:00:00 UTC 2006
Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine.
Histochemistry and cell biology
Schierack P,Nordhoff M,Pollmann M,Weyrauch KD,Amasheh S,Lodemann U,Jores J,Tachu B,Kleta S,Blikslager A,Tedin K,Wieler LH
33-1500 was used in immunocytochemistry to characterize a permanent porcine intestinal epithelial cell line to use as an in vitro infection model
Wed Mar 01 00:00:00 UTC 2006
Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.
Cancer research
Polette M,Gilles C,Nawrocki-Raby B,Lohi J,Hunziker W,Foidart JM,Birembaut P
Thu Sep 01 00:00:00 UTC 2005
Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.
Cancer research
Polette M,Gilles C,Nawrocki-Raby B,Lohi J,Hunziker W,Foidart JM,Birembaut P
Thu Sep 01 00:00:00 UTC 2005
Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo.
Laboratory investigation; a journal of technical methods and pathology
Shifflett DE,Clayburgh DR,Koutsouris A,Turner JR,Hecht GA
Sat Oct 01 00:00:00 UTC 2005
Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo.
Laboratory investigation; a journal of technical methods and pathology
Shifflett DE,Clayburgh DR,Koutsouris A,Turner JR,Hecht GA
Sat Oct 01 00:00:00 UTC 2005
Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium.
American journal of physiology. Gastrointestinal and liver physiology
Weng XH,Beyenbach KW,Quaroni A
Fri Apr 01 00:00:00 UTC 2005
Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium.
American journal of physiology. Gastrointestinal and liver physiology
Weng XH,Beyenbach KW,Quaroni A
Fri Apr 01 00:00:00 UTC 2005
Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine.
American journal of physiology. Gastrointestinal and liver physiology
Basuroy S,Sheth P,Mansbach CM,Rao RK
Mon Aug 01 00:00:00 UTC 2005
Role of microtubules in estradiol-17beta-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity.
American journal of physiology. Gastrointestinal and liver physiology
Mottino AD,Crocenzi FA,Pozzi EJ,Veggi LM,Roma MG,Vore M
Tue Feb 01 00:00:00 UTC 2005
Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter.
Pediatric research
Ballabh P,Hu F,Kumarasiri M,Braun A,Nedergaard M
33-1500 was used in Immunohistochemistry to find that claudin-5, occludin, and JAM-1 were expressed as early as 16 wk in GM, cortex, and white matter.
Sat Oct 01 00:00:00 UTC 2005
Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.
The Journal of biological chemistry
Jacob C,Yang PC,Darmoul D,Amadesi S,Saito T,Cottrell GS,Coelho AM,Singh P,Grady EF,Perdue M,Bunnett NW
Fri Sep 09 00:00:00 UTC 2005
Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.
The Journal of biological chemistry
Jacob C,Yang PC,Darmoul D,Amadesi S,Saito T,Cottrell GS,Coelho AM,Singh P,Grady EF,Perdue M,Bunnett NW
Fri Sep 09 00:00:00 UTC 2005
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
Proceedings of the National Academy of Sciences of the United States of America
Kahle KT,Macgregor GG,Wilson FH,Van Hoek AN,Brown D,Ardito T,Kashgarian M,Giebisch G,Hebert SC,Boulpaep EL,Lifton RP
Tue Oct 12 00:00:00 UTC 2004
Aberrant expression of tight junction-related proteins ZO-1, claudin-1 and occludin in synovial sarcoma: an immunohistochemical study with ultrastructural correlation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Billings SD,Walsh SV,Fisher C,Nusrat A,Weiss SW,Folpe AL
33-1500 was used in immunohistochemistry - paraffin section to examine tight junction protein expression and localization in synovial sarcoma samples
Sun Feb 01 00:00:00 UTC 2004
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
Molecular cancer research : MCR
Bordin M,D'Atri F,Guillemot L,Citi S
33-1500 was used in immunocytochemistry and western blot to test if HDAC inhibitors affect the expression of tight junction proteins
Wed Dec 01 00:00:00 UTC 2004
Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation.
The Journal of clinical endocrinology and metabolism
Zeng R,Li X,Gorodeski GI
33-1500 was used in immunocytochemistry, immunoprecipitation, and western blot to investigate the effects of estrogen on transcervical tight-junctional resistance
Fri Oct 01 00:00:00 UTC 2004
Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms.
American journal of physiology. Cell physiology
McLaughlin J,Padfield PJ,Burt JP,O'Neill CA
Mon Nov 01 00:00:00 UTC 2004
Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms.
American journal of physiology. Cell physiology
McLaughlin J,Padfield PJ,Burt JP,O'Neill CA
Mon Nov 01 00:00:00 UTC 2004
Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
American journal of physiology. Cell physiology
Badizadegan K,Wheeler HE,Fujinaga Y,Lencer WI
Mon Nov 01 00:00:00 UTC 2004
The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells.
Journal of cell science
Sundberg U,Beauchemin N,Obrink B
33-1500 was used in immunocytochemistry to elucidate the localization of CEACAM1 isoforms
Mon Mar 01 00:00:00 UTC 2004
Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Go M,Kojima T,Takano K,Murata M,Ichimiya S,Tsubota H,Himi T,Sawada N
33-1500 was used in immunohistochemistry - frozen section to examine the expression and function of tight junctions in the epithelium of human palatine tonsils from patients with tonsillar hypertrophy or recurrent tonsillitis
Wed Dec 01 00:00:00 UTC 2004
Alteration of tight and adherens junctions on 50-Hz magnetic field exposure in Madin Darby canine kidney (MDCK) cells.
TheScientificWorldJournal
Somosy Z,Forgács Z,Bognár G,Horváth K,Horváth G
33-1500 was used in immunohistochemistry to assess the effect of 50-Hz magnetic field exposures on the subcellular distribution of proteins found in adherens and tight junctions
Wed Oct 20 00:00:00 UTC 2004
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
The British journal of dermatology
Malminen M,Koivukangas V,Peltonen J,Karvonen SL,Oikarinen A,Peltonen S
33-1500 was used in immunohistochemistry to discuss methods to study tight junctions.
Fri Aug 01 00:00:00 UTC 2003
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.
American journal of physiology. Cell physiology
Colegio OR,Van Itallie C,Rahner C,Anderson JM
Sun Jun 01 00:00:00 UTC 2003
Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins.
American journal of physiology. Cell physiology
Yoo J,Nichols A,Mammen J,Calvo I,Song JC,Worrell RT,Matlin K,Matthews JB
Fri Aug 01 00:00:00 UTC 2003
Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins.
American journal of physiology. Cell physiology
Yoo J,Nichols A,Mammen J,Calvo I,Song JC,Worrell RT,Matlin K,Matthews JB
Fri Aug 01 00:00:00 UTC 2003
Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression.
American journal of physiology. Heart and circulatory physiology
Witt KA,Mark KS,Hom S,Davis TP
Mon Dec 01 00:00:00 UTC 2003
Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation.
American journal of physiology. Gastrointestinal and liver physiology
Rafiee P,Ogawa H,Heidemann J,Li MS,Aslam M,Lamirand TH,Fisher PJ,Graewin SJ,Dwinell MB,Johnson CP,Shaker R,Binion DG
Mon Dec 01 00:00:00 UTC 2003
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
The Journal of biological chemistry
Yu AS,Enck AH,Lencer WI,Schneeberger EE
Fri May 09 00:00:00 UTC 2003
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
The Journal of biological chemistry
Yu AS,Enck AH,Lencer WI,Schneeberger EE
Fri May 09 00:00:00 UTC 2003
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties.
Genes & development
Gudjonsson T,Villadsen R,Nielsen HL,Rønnov-Jessen L,Bissell MJ,Petersen OW
33-1500 was used in immunohistochemistry - frozen section to isolate and characterize a human breast epithelial cell line with stem cell properties
Fri Mar 15 00:00:00 UTC 2002
Decreased distribution of lung epithelial junction proteins after intratracheal antigen or lipopolysaccharide challenge: correlation with neutrophil influx and levels of BALF sE-cadherin.
American journal of respiratory cell and molecular biology
Evans SM,Blyth DI,Wong T,Sanjar S,West MR
33-1500 was used in immunohistochemistry (frozen) to determine the distribution of airway junctional complex proteins after antigen or lipopolysaccharide challenge.
Tue Oct 01 00:00:00 UTC 2002
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells.
Journal of cell science
Amasheh S,Meiri N,Gitter AH,Schöneberg T,Mankertz J,Schulzke JD,Fromm M
Sun Dec 15 00:00:00 UTC 2002
Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition.
Human pathology
Busch C,Hanssen TA,Wagener C,OBrink B
33-1500 was used in immunohistochemistry to study CEACAM1 in prostate cancer samples.
Fri Mar 01 00:00:00 UTC 2002
[Malignant fibrous histiocytoma of the eyelid].
Journal francais d'ophtalmologie
Rossi P,Ducasse A,Pluot M,Brugniart C,Gotzamanis A,Jouhaud F
Sun Dec 01 00:00:00 UTC 2002
Applications of epithelial cell culture in studies of drug transport.
Methods in molecular biology (Clifton, N.J.)
Tavelin S,Gråsjö J,Taipalensuu J,Ocklind G,Artursson P
33-1500 was used in immunocytochemistry to review applications of epithelial cell culture in studies of drug transport
Tue Nov 12 00:00:00 UTC 2002
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability.
The Journal of clinical investigation
Van Itallie C,Rahner C,Anderson JM
Tue May 01 00:00:00 UTC 2001
Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes.
The Journal of investigative dermatology
Pummi K,Malminen M,Aho H,Karvonen SL,Peltonen J,Peltonen S
33-1500 was used in immunohistochemistry - paraffin section and western blot to test if tight junction antigens are present in adult and developing human epidermis.
Thu Nov 01 00:00:00 UTC 2001
