Product References
A Feedback Loop between TGF-β1 and ATG5 Mediated by miR-122-5p Regulates Fibrosis and EMT in Human Trabecular Meshwork Cells.
Current issues in molecular biology
Chakraborthy M,Rao A
AHB0052 was used in Immunocytochemistry to show that TGF-β1 induces autophagy in primary HTM cells and a positive feedback loop exists between TGF-β1 and ATG5 that regulated TGF downstream effects mainly mediated by Smad3 signaling with miR-122-5p also playing a role.
Mon Mar 13 00:00:00 UTC 2023
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys.
Signal transduction and targeted therapy
Tu Z,Yan S,Han B,Li C,Liang W,Lin Y,Ding Y,Wei H,Wang L,Xu H,Ye J,Li B,Li S,Li XJ
AHB0052 was used in Western Blot to demonstrate for the first time that tauopathy can trigger Aβ pathology in the primate spinal cord and provide new insight into the pathogenesis and treatment of tauopathy.
Fri Sep 22 00:00:00 UTC 2023
Passive immunization against phosphorylated tau improves features of Huntington's disease pathology.
Molecular therapy : the journal of the American Society of Gene Therapy
Alpaugh M,Masnata M,de Rus Jacquet A,Lepinay E,Denis HL,Saint-Pierre M,Davies P,Planel E,Cicchetti F
AHB0052 was used in Dot blot to suggest that attenuating tau pathology could mitigate behavioral and molecular hallmarks associated with Huntington's disease.
Wed Apr 06 00:00:00 UTC 2022
The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice.
Aging and disease
Xu B,He Y,Liu L,Ye G,Chen L,Wang Q,Chen M,Chen Y,Long D
AHB0052 was used in Dot blot to suggest that prolonged running may improve memory in preclinical AD via slowing down the amyloid pathology and preventing the loss of synaptic contacts.
Mon Jul 11 00:00:00 UTC 2022
Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer's disease.
Alzheimer's research & therapy
Rofo F,Metzendorf NG,Saubi C,Suominen L,Godec A,Sehlin D,Syvänen S,Hultqvist G
AHB0052 was used in Enzyme-linked immunosorbent assay to show that a one-time injection of a BBB-penetrating NEP shows the potential to reduce, the likely most toxic, Aβ oligomers in the brain in addition to monomers. Also, Aβ aggregates in the blood were reduced.
Mon Dec 05 00:00:00 UTC 2022
Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19.
Nature communications
Charnley M,Islam S,Bindra GK,Engwirda J,Ratcliffe J,Zhou J,Mezzenga R,Hulett MD,Han K,Berryman JT,Reynolds NP
AHB0052 was used in Immunohistochemistry-immunofluorescence to suggest that cytotoxic aggregates of SARS-CoV-2 proteins may trigger neurological symptoms in COVID-19.
Mon Jun 13 00:00:00 UTC 2022
High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC-DAD-Q/TOF-MS/MS.
Acta pharmaceutica Sinica. B
Guo M,Zhu F,Qiu W,Qiao G,Law BY,Yu L,Wu J,Tang Y,Yu C,Qin D,Zhou X,Wu A
AHB0052 was used in Dot Blot to utilize high throughput screening to potentially identify natural medicines to treat Aβ aggregations in Alzheimer’s.
Fri Apr 01 00:00:00 UTC 2022
Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models.
Alzheimer's research & therapy
Lee HY,Yoon S,Lee JH,Park K,Jung Y,Cho I,Lee D,Shin J,Kim K,Kim S,Kim J,Kim K,Han SH,Kim SM,Kim HJ,Kim HY,Kim I,Kim YS
AHB0052 was used in Western Blotting to suggest that YIAD002 interferes with intermolecular β-sheet fibrillation by directly interacting with KLVFFA and IGLMVG domains of Aβ.
Tue Nov 29 00:00:00 UTC 2022
Reduced Expression of Voltage-Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by Aβ1-42.
Neural plasticity
Li S,Yan GJ,Tan YX,Xue LL,Wang TH,Zhao HR,Lu MN,Zhang HX,Mei R,Dong XH,Liu LN,Wang D,Xiyang YB
AHB0052 was used in Dot Blot to provide novel evidence indicating that Navβ2 plays crucial roles in the repair of neuronal injury induced by Aβ1-42 both in vivo and in vitro.
Tue Nov 22 00:00:00 UTC 2022
Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ.
Alzheimer's research & therapy
Jo KW,Lee D,Cha DG,Oh E,Choi YH,Kim S,Park ES,Kim JK,Kim KT
AHB0052 was used in Dot blot to study how gossypetin showed protective effects against AD by enhancing microglial Aβ phagocytosis.
Fri Oct 21 00:00:00 UTC 2022
The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease.
British journal of pharmacology
An SSA,Shim KH,Kang S,Kim YK,Subedi L,Cho H,Hong SM,Tan MA,Jeon R,Chang KA,Kim SY
AHB0052 was used in Western Blotting to investigate the inhibitory effects of SPA1413 on both amyloid-β fibrilization and oligomerization to treat Alzheimer's disease.
Tue Mar 01 00:00:00 UTC 2022
Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions.
Acta neuropathologica
Johari M,Sarparanta J,Vihola A,Jonson PH,Savarese M,Jokela M,Torella A,Piluso G,Said E,Vella N,Cauchi M,Magot A,Magri F,Mauri E,Kornblum C,Reimann J,Stojkovic T,Romero NB,Luque H,Huovinen S,Lahermo P,Donner K,Comi GP,Nigro V,Hackman P,Udd B
AHB0052 was used in Immunocytochemistry to show that overexpressed SMPX localized to stress granules and slowed down their clearance.
Sun Aug 01 00:00:00 UTC 2021
Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice.
Cell death and differentiation
Santamaria G,Brandi E,Vitola P,Grandi F,Ferrara G,Pischiutta F,Vegliante G,Zanier ER,Re F,Uccelli A,Forloni G,de Rosbo NK,Balducci C
AHB0052 was used in Immunohistochemistry to demonstrate that in vivo systemic administration of secretome collected from MSC exposed in vitro to AD mouse brain homogenates (MSC-CS), fully replicates the cell-mediated neuroreparative effects in APP/PS1 AD mice.
Fri Jan 01 00:00:00 UTC 2021
Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish.
Frontiers in molecular neuroscience
Pakdaman Y,Denker E,Austad E,Norton WHJ,Rolfsnes HO,Bindoff LA,Tzoulis C,Aukrust I,Knappskog PM,Johansson S,Ellingsen S
AHB0052 was used in Dot blot to examine the effects of impaired C-terminus of Hsc70-interacting protein ubiquitin ligase activity in zebrafish (Danio rerio).
Tue Oct 12 00:00:00 UTC 2021
Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish.
Frontiers in molecular neuroscience
Pakdaman Y,Denker E,Austad E,Norton WHJ,Rolfsnes HO,Bindoff LA,Tzoulis C,Aukrust I,Knappskog PM,Johansson S,Ellingsen S
AHB0052 was used in Dot blot to examine the effects of impaired C-terminus of Hsc70-interacting protein ubiquitin ligase activity in zebrafish (Danio rerio).
Tue Oct 12 00:00:00 UTC 2021
The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice.
Frontiers in aging neuroscience
Varinthra P,Ganesan K,Huang SP,Chompoopong S,Eurtivong C,Suresh P,Wen ZH,Liu IY
AHB0052 was used in Immunohistochemistry to demonstrate that the compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) is effective in enhancing fear memory retrieval of wild-type and 3xTg-AD mice by reducing the expression of TNF-α, COX-2, and iNOS. It also found that 4-PSB-2 helps increase dendritic spine density, postsynaptic density protein-95 (PSD-95) expression, and long-term potentiation (LTP) in the hippocampus of 3xTg-AD mice.
Tue Feb 23 00:00:00 UTC 2021
NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle.
Cell reports
Romani M,Sorrentino V,Oh CM,Li H,de Lima TI,Zhang H,Shong M,Auwerx J
AHB0052 was used in Immunohistochemistry (Frozen) to provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases.
Tue Jan 19 00:00:00 UTC 2021
NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle.
Cell reports
Romani M,Sorrentino V,Oh CM,Li H,de Lima TI,Zhang H,Shong M,Auwerx J
AHB0052 was used in Immunohistochemistry (Frozen) to provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases.
Tue Jan 19 00:00:00 UTC 2021
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
Nature communications
Martin TG,Myers VD,Dubey P,Dubey S,Perez E,Moravec CS,Willis MS,Feldman AM,Kirk JA
AHB0052 was used in Immunohistochemistry to indicate BAG3-mediated sarcomere turnover is fundamental for myofilament functional maintenance.
Wed May 19 00:00:00 UTC 2021
Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.
Nature communications
Martin TG,Myers VD,Dubey P,Dubey S,Perez E,Moravec CS,Willis MS,Feldman AM,Kirk JA
AHB0052 was used in Immunohistochemistry to indicate BAG3-mediated sarcomere turnover is fundamental for myofilament functional maintenance.
Wed May 19 00:00:00 UTC 2021
The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.
Acta neuropathologica communications
Vandenabeele M,Veys L,Lemmens S,Hadoux X,Gelders G,Masin L,Serneels L,Theunis J,Saito T,Saido TC,Jayapala M,De Boever P,De Strooper B,Stalmans I,van Wijngaarden P,Moons L,De Groef L
AHB0052 was used in Immunohistochemistry to suggest that the AppNL-G-F retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD.
Wed Jan 06 00:00:00 UTC 2021
The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.
Acta neuropathologica communications
Vandenabeele M,Veys L,Lemmens S,Hadoux X,Gelders G,Masin L,Serneels L,Theunis J,Saito T,Saido TC,Jayapala M,De Boever P,De Strooper B,Stalmans I,van Wijngaarden P,Moons L,De Groef L
AHB0052 was used in Immunohistochemistry to suggest that the AppNL-G-F retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD.
Wed Jan 06 00:00:00 UTC 2021
The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.
Acta neuropathologica communications
Vandenabeele M,Veys L,Lemmens S,Hadoux X,Gelders G,Masin L,Serneels L,Theunis J,Saito T,Saido TC,Jayapala M,De Boever P,De Strooper B,Stalmans I,van Wijngaarden P,Moons L,De Groef L
AHB0052 was used in Immunohistochemistry to suggest that the AppNL-G-F retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD.
Wed Jan 06 00:00:00 UTC 2021
Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function.
Nature communications
Palanikumar L,Karpauskaite L,Al-Sayegh M,Chehade I,Alam M,Hassan S,Maity D,Ali L,Kalmouni M,Hunashal Y,Ahmed J,Houhou T,Karapetyan S,Falls Z,Samudrala R,Pasricha R,Esposito G,Afzal AJ,Hamilton AD,Kumar S,Magzoub M
AHB0052 was used in Dot Blot to demonstrate the successful application of a bona fide small-molecule amyloid inhibitor as a potent anticancer agent.
Fri Jun 25 00:00:00 UTC 2021
Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function.
Nature communications
Palanikumar L,Karpauskaite L,Al-Sayegh M,Chehade I,Alam M,Hassan S,Maity D,Ali L,Kalmouni M,Hunashal Y,Ahmed J,Houhou T,Karapetyan S,Falls Z,Samudrala R,Pasricha R,Esposito G,Afzal AJ,Hamilton AD,Kumar S,Magzoub M
AHB0052 was used in Dot Blot to demonstrate the successful application of a bona fide small-molecule amyloid inhibitor as a potent anticancer agent.
Fri Jun 25 00:00:00 UTC 2021
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells.
Nature communications
Cascella R,Chen SW,Bigi A,Camino JD,Xu CK,Dobson CM,Chiti F,Cremades N,Cecchi C
Published figure using Oligomer A11 polyclonal antibody (Product # AHB0052) in Western Blot
Mon Mar 22 00:00:00 UTC 2021
Fusobacterium nucleatum secretes amyloid-like FadA to enhance pathogenicity.
EMBO reports
Meng Q,Gao Q,Mehrazarin S,Tangwanichgapong K,Wang Y,Huang Y,Pan Y,Robinson S,Liu Z,Zangiabadi A,Lux R,Papapanou PN,Guo XE,Wang H,Berchowitz LE,Han YW
AHB0052 was used in Immunocytochemistry to provide a potential mechanistic link between periodontal disease and CRC and suggests anti-amyloid therapies as possible interventions for Fn-mediated disease processes.
Mon Jul 05 00:00:00 UTC 2021
Fusobacterium nucleatum secretes amyloid-like FadA to enhance pathogenicity.
EMBO reports
Meng Q,Gao Q,Mehrazarin S,Tangwanichgapong K,Wang Y,Huang Y,Pan Y,Robinson S,Liu Z,Zangiabadi A,Lux R,Papapanou PN,Guo XE,Wang H,Berchowitz LE,Han YW
AHB0052 was used in Immunocytochemistry to provide a potential mechanistic link between periodontal disease and CRC and suggests anti-amyloid therapies as possible interventions for Fn-mediated disease processes.
Mon Jul 05 00:00:00 UTC 2021
Primary Human Trabecular Meshwork Model for Pseudoexfoliation.
Cells
Chakraborty M,Sahay P,Rao A
AHB0052 was used in Immunocytochemistry to create a workable in vitro model of pseudoexfoliation syndrome (PXF) using primary human TM (HTM) cell lines simulating human disease.
Tue Dec 07 00:00:00 UTC 2021
Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform.
Communications chemistry
Chien HM,He RY,Lee CC,Huang YA,Hung IJ,Hou KT,Hsiao JC,Lu PC,Agnihotri D,Hwang E,Huang JJ
AHB0052 was used in Western Blotting to highlight the toxicity of GA DPRs oligomers, which is a key step toward elucidating the pathological roles of C9orf72 DPRs.
Fri Jul 23 00:00:00 UTC 2021
Pneumonia initiates a tauopathy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Balczon R,Lin MT,Lee JY,Abbasi A,Renema P,Voth SB,Zhou C,Koloteva A,Michael Francis C,Sodha NR,Pittet JF,Wagener BM,Bell J,Choi CS,Ventetuolo CE,Stevens T
AHB0052 was used in Dot Blot, ELISA, Immunohistochemistry, Neutralization, Western Blot, Sample Prep to test the hypothesis that pneumonia-elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment of long-term potentiation; and, (3) inhibit long-term potentiation dependent upon tau.
Wed Sep 01 00:00:00 UTC 2021
Pneumonia initiates a tauopathy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Balczon R,Lin MT,Lee JY,Abbasi A,Renema P,Voth SB,Zhou C,Koloteva A,Michael Francis C,Sodha NR,Pittet JF,Wagener BM,Bell J,Choi CS,Ventetuolo CE,Stevens T
AHB0052 was used in Dot Blot, ELISA, Immunohistochemistry, Neutralization, Western Blot, Sample Prep to test the hypothesis that pneumonia-elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment of long-term potentiation; and, (3) inhibit long-term potentiation dependent upon tau.
Wed Sep 01 00:00:00 UTC 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Acta neuropathologica communications
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Marcilla I,Marti-Andres G,Caballero MC,Riverol M,Tuñon MT,Fraser PE,Luquin MR
AHB0052 was used in Immunohistochemistry to show that the involvement of amylin, pancreatic α-synuclein, Aβ, PrP and tau in the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson's disease.
Thu Apr 08 00:00:00 UTC 2021
Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration.
Signal transduction and targeted therapy
Narendran S,Pereira F,Yerramothu P,Apicella I,Wang SB,Ambati K,Hirahara S,Kim Y,Ambati M,Ambati VL,Huang P,Varshney A,Nagasaka Y,Fukuda S,Baker KL,Marion KM,Deussing JM,Sadda SR,Gelfand BD,Ambati J
AHB0052 was used in Western Blotting to demonstrate that amyloid-β oligomers (AβOs) induce activation of the NLRP3 inflammasome in the mouse sub-retinal pigmented epithelium (RPE) in vivo and that RPE expression of the purinergic ATP receptor P2RX7, an upstream mediator of NLRP3 inflammasome activation, is required for AβO-induced RPE degeneration.
Wed Apr 14 00:00:00 UTC 2021
Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs.
Nature communications
Lee D,Park D,Kim I,Lee SW,Lee W,Hwang KS,Lee JH,Lee G,Yoon DS
AHB0052 was used in Antibody Capture to demonstrate that this strategy with PNAC can identify effective drugs for eliminating oligomeric aggregates.
Wed Jan 27 00:00:00 UTC 2021
Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice.
Alzheimer's research & therapy
Son G,Yoo SJ,Kang S,Rasheed A,Jung DH,Park H,Cho B,Steinbusch HWM,Chang KA,Suh YH,Moon C
AHB0052 was used in Immunohistochemistry to show that partial olfactory dysfunction closely associated with peripheral OSN's loss could be a leading cause of AD-related hyposmia, a characteristic of early AD.
Mon Jan 04 00:00:00 UTC 2021
Microglial remodeling of actin network by Tau oligomers, via G protein-coupled purinergic receptor, P2Y12R-driven chemotaxis.
Traffic (Copenhagen, Denmark)
Das R,Chinnathambi S
AHB0052 was used in Western Blotting to propose that microglia can modulate the membrane-associated actin structure and incorporate P2Y12R to perceive the axis and rate of chemotaxis in Tauopathy.
Sat May 01 00:00:00 UTC 2021
Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse Model.
Journal of neurotrauma
Perez Garcia G,De Gasperi R,Tschiffely AE,Gama Sosa MA,Abutarboush R,Kawoos U,Statz JK,Ciarlone S,Reed E,Jeyarajah T,Perez GM,Otero-Pagan A,Pryor D,Hof PR,Cook DG,Gandy S,Elder GA,Ahlers ST
AHB0052 was used in Dot blot to subject APP/presenilin 1 transgenic mice (APP/PS1 Tg) to an extended sequence of repetitive low-level blast exposures (34.5 kPa) administered three times per week over eight weeks.
Mon Nov 15 00:00:00 UTC 2021
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Autophagy
Ho PW,Leung CT,Liu H,Pang SY,Lam CS,Xian J,Li L,Kung MH,Ramsden DB,Ho SL
AHB0052 was used in Western Blotting to show mutant mouse embryonic fibroblasts expressing either SNCA or CMA recognition 'KFERQ'-like motif conjugated with photoactivated-PAmCherry showed slower cellular clearance compared to WT by 28% and 34%, respectively.
Sat Feb 01 00:00:00 UTC 2020
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Autophagy
Ho PW,Leung CT,Liu H,Pang SY,Lam CS,Xian J,Li L,Kung MH,Ramsden DB,Ho SL
AHB0052 was used in Western Blotting to show mutant mouse embryonic fibroblasts expressing either SNCA or CMA recognition 'KFERQ'-like motif conjugated with photoactivated-PAmCherry showed slower cellular clearance compared to WT by 28% and 34%, respectively.
Sat Feb 01 00:00:00 UTC 2020
The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates.
Molecular neurobiology
Riad A,Lengyel-Zhand Z,Zeng C,Weng CC,Lee VM,Trojanowski JQ,Mach RH
AHB0052 was used in Dot Blot to suggest that the complex may potentially be a novel pharmacological target to decrease neuronal Aβ42 internalization and accumulation, which may represent a new strategy for inhibiting the rate of neurotoxicity, neurodegeneration, and progression of AD.
Tue Sep 01 00:00:00 UTC 2020
Targeting Hsc70-based autophagy to eliminate amyloid β oligomers.
Biochemical and biophysical research communications
Dou J,Su P,Xu C,Wen Z,Mao Z,Li W
AHB0052 was used in Western Blotting to demonstrate that the peptide targeting Hsc70-based autophagy can effectively eliminate Aβ oligomers and have superior neuroprotective activity.
Thu Apr 16 00:00:00 UTC 2020
Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3.
Biochemistry
Price D,Dorandish S,Williams A,Iwaniec B,Stephens A,Marshall K,Guthrie J,Heyl D,Evans HG
AHB0052 was used in ELISA to study the varying conformations of amyloid-β when bound to the substrates HN, AChE, and IGFBP-3.
Tue Jun 02 00:00:00 UTC 2020
Inhibition of acetylcholinesterase activity and β-amyloid oligomer formation by 6-bromotryptamine A, a multi-target anti-Alzheimer's molecule.
Oncology letters
Jin X,Wang M,Shentu J,Huang C,Bai Y,Pan H,Zhang D,Yuan Z,Zhang H,Xiao X,Wu X,Ding L,Wang Q,He S,Cui W
AHB0052 was used in Western Blotting to study targets for improving short-term learning and memory in Alzheimer's patients.
Sat Feb 01 00:00:00 UTC 2020
Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer's Disease.
Nutrients
Snow WM,Cadonic C,Cortes-Perez C,Adlimoghaddam A,Roy Chowdhury SK,Thomson E,Anozie A,Bernstein MJ,Gough K,Fernyhough P,Suh M,Albensi BC
Published figure using Oligomer A11 polyclonal antibody (Product # AHB0052) in Western Blot
Mon Nov 23 00:00:00 UTC 2020
Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm.
The European journal of neuroscience
Cristóvão AC,Campos FL,Je G,Esteves M,Guhathakurta S,Yang L,Beal MF,Fonseca BM,Salgado AJ,Queiroz J,Sousa N,Bernardino L,Alves G,Yoon KS,Kim YS
AHB0052 was used in Dot blot to carry out an explorative study that allowed to characterize an improved PQ-based rat model that recapitulates cardinal features of PD and may represent an attractive tool to investigate several mechanisms underlying the various aspects of PD pathogenesis as well as for the validation of the efficacy of new therapeutic approaches that targets different mechanisms involved in PD neurodegeneration.
Sat Aug 01 00:00:00 UTC 2020
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
The Journal of biological chemistry
Abskharon R,Seidler PM,Sawaya MR,Cascio D,Yang TP,Philipp S,Williams CK,Newell KL,Ghetti B,DeTure MA,Dickson DW,Vinters HV,Felgner PL,Nakajima R,Glabe CG,Eisenberg DS
AHB0052 was used in Western Blotting to report the formation of in vitro tau oligomers formed by an ionic liquid (IL15).
Fri Jul 31 00:00:00 UTC 2020
Capturing Amyloid-β Oligomers by Stirring with Microscaled Iron Oxide Stir Bars into Magnetic Plaques to Reduce Cytotoxicity toward Neuronal Cells.
Nanomaterials (Basel, Switzerland)
Tsai YC,Luo JC,Liu TI,Lu IL,Shen MY,Chuang CY,Chern CS,Chiu HC
AHB0052 was used in Immunocytochemistry to demonstrate the rapid capture of oAβ42 by MSB under magnetic stirring and its potential for AD treatment.
Tue Jun 30 00:00:00 UTC 2020
β2 -adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Campos JC,Baehr LM,Ferreira ND,Bozi LHM,Andres AM,Ribeiro MAC,Gottlieb RA,Bodine SC,Ferreira JCB
AHB0052 was used in Western Blotting to suggest autophagy as a critical downstream effector of β2 -adrenoceptor signaling pathway in skeletal muscle.
Wed Apr 01 00:00:00 UTC 2020
β2 -adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Campos JC,Baehr LM,Ferreira ND,Bozi LHM,Andres AM,Ribeiro MAC,Gottlieb RA,Bodine SC,Ferreira JCB
AHB0052 was used in Western Blotting to suggest autophagy as a critical downstream effector of β2 -adrenoceptor signaling pathway in skeletal muscle.
Wed Apr 01 00:00:00 UTC 2020
Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo.
Cell
Nil Z,Hervás R,Gerbich T,Leal P,Yu Z,Saraf A,Sardiu M,Lange JJ,Yi K,Unruh J,Slaughter B,Si K
AHB0052 was used in Western Blotting to identification of a prion-like protein, Herzog, through a multimodal screen in Drosophila melanogaster, herzog functions as a membrane-associated phosphatase and controls embryonic patterning.
Thu Sep 05 00:00:00 UTC 2019
Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.
Neuron
Gasset-Rosa F,Lu S,Yu H,Chen C,Melamed Z,Guo L,Shorter J,Da Cruz S,Cleveland DW
AHB0052 was used in Immunocytochemistry-immunoflourescence to identify a neuronal cell death mechanism that can be initiated by transient-stress-induced cytosolic de-mixing of TDP-43.
Wed Apr 17 00:00:00 UTC 2019
Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging.
Proceedings of the National Academy of Sciences of the United States of America
Beckman D,Ott S,Donis-Cox K,Janssen WG,Bliss-Moreau E,Rudebeck PH,Baxter MG,Morrison JH
AHB0052 was used in Immunohistochemistry to present findings that support the use of monkeys as a platform to understand age-related vulnerabilities of the primate brain, which may help develop effective disease modifying therapies for treatment of Alzheimer's disease (AD) and related dementias.
Thu Dec 26 00:00:00 UTC 2019
Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.
Aging cell
Zhang J,Chen B,Lu J,Wu Y,Wang S,Yao Z,Zhu L,Qiao Y,Sun Q,Qin W,Zhao Q,Jia J,Wei C
AHB0052 was used in Western Blotting to indicate that the cerebral amyloid beta dimer plats an important role in Alzheimer's disease pathogenesis, so targeting this dimer is a promising strategy for preventing this disease.
Thu Aug 01 00:00:00 UTC 2019
Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen.
Journal of cellular and molecular medicine
Bonito-Oliva A,Schedin-Weiss S,Younesi SS,Tiiman A,Adura C,Paknejad N,Brendel M,Romin Y,Parchem RJ,Graff C,Vukojević V,Tjernberg LO,Terenius L,Winblad B,Sakmar TP,Graham WV
AHB0052 was used in Dot blot to develop a method to create monoclonal antibodies that are conformation-sensitive and sequence-independent and can target more than one type of protofibril species.
Fri Mar 01 00:00:00 UTC 2019
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Nature communications
Spangenberg E,Severson PL,Hohsfield LA,Crapser J,Zhang J,Burton EA,Zhang Y,Spevak W,Lin J,Phan NY,Habets G,Rymar A,Tsang G,Walters J,Nespi M,Singh P,Broome S,Ibrahim P,Zhang C,Bollag G,West BL,Green KN
AHB0052 was used in Immunohistochemistry to describe the structure, formulation, and efficacy of PLX5622, which allows for sustained microglial depletion and identify roles of microglia in initiating plaque pathogenesis.
Wed Aug 21 00:00:00 UTC 2019
Microglia as modulators of exosomal alpha-synuclein transmission.
Cell death & disease
Xia Y,Zhang G,Han C,Ma K,Guo X,Wan F,Kou L,Yin S,Liu L,Huang J,Xiong N,Wang T
AHB0052 was used in Western Blotting to determine the contribution of α-synuclein-associated exosomes to the initiation and progression of Parkinson's disease.
Wed Feb 20 00:00:00 UTC 2019
Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation.
PloS one
van Diggelen F,Hrle D,Apetri M,Christiansen G,Rammes G,Tepper A,Otzen DE
AHB0052 was used in Dot blot to aggregate α-synuclein in the presence of 4-hydroxynonenal and docosahexaenoic acid, and purify the α-synuclein oligomers using size exclusion chromatography.
Thu Dec 26 00:00:00 UTC 2019
Baicalein suppresses Repeat Tau fibrillization by sequestering oligomers.
Archives of biochemistry and biophysics
Sonawane SK,Balmik AA,Boral D,Ramasamy S,Chinnathambi S
AHB0052 was used in Dot blot to find the aggregation inhibitory properties of Baicalein for the repeat Tau.
Wed Oct 30 00:00:00 UTC 2019
Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury.
EBioMedicine
Wang W,Hou TT,Jia LF,Wu QQ,Quan MN,Jia JP
AHB0052 was used in Western Blotting to identify the specific amyloid-Β oligomer assembly that contributes to neuronal injury and cognitive deficits.
Mon Apr 01 00:00:00 UTC 2019
A hyperthermophilic protein G variant engineered via directed evolution prevents the formation of toxic SOD1 oligomers.
Proteins
Dagan B,Oren O,Banerjee V,Taube R,Papo N
AHB0052 was used in Flow cytometry/Cell sorting to identify a variant, which we designated HTB1M3 , that bound strongly to SOD1 misfolded mutants but not to wild-type SOD1.
Sun Sep 01 00:00:00 UTC 2019
Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology.
eLife
Zhang P,Fan B,Yang P,Temirov J,Messing J,Kim HJ,Taylor JP
AHB0052 was used in Immunocytochemistry-immunoflourescence to demonstrate that persistent assembly of stress granules is cytotoxic and is accompanied by the evolution of SGs to cytoplasmic inclusions that recapitulate the pathology of amyotrophic lateral sclerosis-frontotemporal dementia.
Wed Mar 20 00:00:00 UTC 2019
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1.
Journal of Alzheimer's disease : JAD
Vasquez V,Mitra J,Perry G,Rao KS,Hegde ML
AHB0052 was used in Immunocytochemistry-immunoflourescence to develop an SH-SY5Y line harbouring Tet-ON SNCA cDNA cassette that allows for induction of controlled α-synuclein expression after neuronal differentiation.
Tue Oct 08 00:00:00 UTC 2019
Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease.
Acta neuropathologica communications
Borin M,Saraceno C,Catania M,Lorenzetto E,Pontelli V,Paterlini A,Fostinelli S,Avesani A,Di Fede G,Zanusso G,Benussi L,Binetti G,Zorzan S,Ghidoni R,Buffelli M,Bolognin S
Fri Jul 13 00:00:00 UTC 2018
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism.
The Journal of experimental medicine
Mukherjee A,Morales-Scheihing D,Salvadores N,Moreno-Gonzalez I,Gonzalez C,Taylor-Presse K,Mendez N,Shahnawaz M,Gaber AO,Sabek OM,Fraga DW,Soto C
AHB0052 was used in Immunodepletion to suggest that the pathologic and clinical alterations of type-2 diabetes may be transmissible through mechanism similar to prion disease propagation.
Mon Sep 04 00:00:00 UTC 2017
Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.
Brain : a journal of neurology
Rodriguez-Rodriguez P,Sandebring-Matton A,Merino-Serrais P,Parrado-Fernandez C,Rabano A,Winblad B,Ávila J,Ferrer I,Cedazo-Minguez A
AHB0052 was used in Immunoprecipitation to suggest that insulin retention in hyperphosphorylated tau-bearing neurons is a causative factor for the insulin resistance observed in tauopathies, and describe a novel neuropathological concept with important therapeutic implications.
Fri Dec 01 00:00:00 UTC 2017
Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice.
EMBO molecular medicine
Yang SH,Lee DK,Shin J,Lee S,Baek S,Kim J,Jung H,Hah JM,Kim Y
AHB0052 was used in western blot to explore the role of necrostatin-1 in Alzheimer's disease
Sun Jan 01 00:00:00 UTC 2017
Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice.
EMBO molecular medicine
Yang SH,Lee DK,Shin J,Lee S,Baek S,Kim J,Jung H,Hah JM,Kim Y
AHB0052 was used in western blot to explore the role of necrostatin-1 in Alzheimer's disease
Sun Jan 01 00:00:00 UTC 2017
Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ye X,Feng T,Tammineni P,Chang Q,Jeong YY,Margolis DJ,Cai H,Kusnecov A,Cai Q
AHB0052 was used in Immunohistochemistry to identify that dynein-Snapin-mediated retrograde transport regulates β-site amyloid precursor protein (APP) cleaving enzyme 1 trafficking in axons and APP processing at presynaptic terminals.
Wed Mar 08 00:00:00 UTC 2017
Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Taguchi YV,Liu J,Ruan J,Pacheco J,Zhang X,Abbasi J,Keutzer J,Mistry PK,Chandra SS
AHB0052 was used in Western Blotting to show that acid ceramidase 1 and glucocerebrosidase (GBA)2 enzymes are attractive therapeutic targets for treating mutant GBA-associated Parkinson's disease.
Wed Oct 04 00:00:00 UTC 2017
Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.
The Journal of pathology
De Smet F,Saiz Rubio M,Hompes D,Naus E,De Baets G,Langenberg T,Hipp MS,Houben B,Claes F,Charbonneau S,Delgado Blanco J,Plaisance S,Ramkissoon S,Ramkissoon L,Simons C,van den Brandt P,Weijenberg M,Van England M,Lambrechts S,Amant F,D'Hoore A,Ligon KL,Sagaert X,Schymkowitz J,Rousseau F
AHB0052 was used in Immunohistochemistry to highlight several unexpected clinical, biological and therapeutically unexplored parallels between cancer and neurodegeneration.
Mon May 01 00:00:00 UTC 2017
A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes.
Scientific reports
Lee D,Lee WS,Lim S,Kim YK,Jung HY,Das S,Lee J,Luo W,Kim KT,Chung SK
AHB0052 was used in a Dot blot to evaluate the therapeutic potential of AAD-66 for the treatment of Alzheimer's disease.
Thu Oct 26 00:00:00 UTC 2017
Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain.
The Journal of biological chemistry
Kovachev PS,Banerjee D,Rangel LP,Eriksson J,Pedrote MM,Martins-Dinis MMDC,Edwards K,Cordeiro Y,Silva JL,Sanyal S
AHB0052 was used in Dot blot to propose that structured RNAs prevent p53C aggregation through surface interaction and play a role in regulation of the tumour suppressor protein.
Fri Jun 02 00:00:00 UTC 2017
Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
Acta neuropathologica
LaClair KD,Donde A,Ling JP,Jeong YH,Chhabra R,Martin LJ,Wong PC
AHB0052 was used in dot blot to ask if nuclear depletion of TDP-43 contributes to Alzheimer's disease pathogenesis
Thu Dec 01 00:00:00 UTC 2016
Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly.
Free radical biology & medicine
Domínguez M,de Oliveira E,Odena MA,Portero M,Pamplona R,Ferrer I
AHB0052 was used to study the regional vulnerability in middle age that increases in the elderly by using redox proteomic profiling of neuroketal-adducted proteins in the human brain
Wed Jun 01 00:00:00 UTC 2016
Intracellular soluble α-synuclein oligomers reduce pyramidal cell excitability.
The Journal of physiology
Kaufmann TJ,Harrison PM,Richardson MJ,Pinheiro TJ,Wall MJ
AHB0052 was used in immunocytochemistry to assess reduction of pyramidal cell excitability due to intracellular solube alpha-synuclein oligomers
Sun May 15 00:00:00 UTC 2016
A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.
Scientific reports
Zha J,Liu XM,Zhu J,Liu SY,Lu S,Xu PX,Yu XL,Liu RT
AHB0052 was used in dot blot to demonstrate the protective effects of an oligomer-specific single-chain variable fragment antibody in Parkinson's disease and Huntington's disease mouse models
Tue Nov 08 00:00:00 UTC 2016
Methionine oxidation reduces lag-times for amyloid-β(1-40) fiber formation but generates highly fragmented fibers.
Biochimica et biophysica acta
Gu M,Viles JH
AHB0052 was used in western blot to study the reduction of lag-times for amyloid-beta (1-40) fiber formation but generates highly fragmented fibers due to methionine oxidation
Thu Sep 01 00:00:00 UTC 2016
Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Atkin G,Moore S,Lu Y,Nelson RF,Tipper N,Rajpal G,Hunt J,Tennant W,Hell JW,Murphy GG,Paulson H
AHB0052 was used in immunohistochemistry - frozen section and immunoprecipitation to investigate the role of Fbxo2 in regulating NMDAR subunits in the brain
Wed Apr 15 00:00:00 UTC 2015
DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology
Muñoz P,Cardenas S,Huenchuguala S,Briceño A,Couve E,Paris I,Segura-Aguilar J
AHB0052 was used in immunocytochemistry to test if DT-diaphorase has a protective role in alpha synuclein neurotoxicity
Fri May 01 00:00:00 UTC 2015
Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species.
Journal of neuropathology and experimental neurology
López-González I,Schlüter A,Aso E,Garcia-Esparcia P,Ansoleaga B,LLorens F,Carmona M,Moreno J,Fuso A,Portero-Otin M,Pamplona R,Pujol A,Ferrer I
AHB0052 was used in dot blot to study neuroinflammation-related gene regulation during normal aging and in sporadic Alzheimer disease in mice
Wed Apr 01 00:00:00 UTC 2015
Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells.
Neuroscience research
Meng P,Yoshida H,Tanji K,Matsumiya T,Xing F,Hayakari R,Wang L,Tsuruga K,Tanaka H,Mimura J,Kosaka K,Itoh K,Takahashi I,Kawaguchi S,Imaizumi T
AHB0052 was used in western blot to assess the effect of carnosic acid on apoptosis induced by Aβ42 or Aβ43 in human neuroblastoma cells.
Fri May 01 00:00:00 UTC 2015
The domestic cat as a natural animal model of Alzheimer's disease.
Acta neuropathologica communications
Chambers JK,Tokuda T,Uchida K,Ishii R,Tatebe H,Takahashi E,Tomiyama T,Une Y,Nakayama H
AHB0052 was used in Dot Blot to suggest that amyloid-β oligomers are more important than senile plaques for neurofibrillary tangles formation and the subsequent neurodegeneration.
Thu Dec 10 00:00:00 UTC 2015
Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function.
ACS chemical neuroscience
Mastroeni D,Khdour OM,Arce PM,Hecht SM,Coleman PD
AHB0052 was used in western blot to investigate the link between metabolic and epigenetic deficits on reduced mitochondrial function
Wed Apr 15 00:00:00 UTC 2015
Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration.
Cell reports
Liu P,Reed MN,Kotilinek LA,Grant MK,Forster CL,Qiang W,Shapiro SL,Reichl JH,Chiang AC,Jankowsky JL,Wilmot CM,Cleary JP,Zahs KR,Ashe KH
AHB0052 was used in Western Blotting to refine our understanding of the pathogenicity of AΒ oligomers in vivo.
Tue Jun 23 00:00:00 UTC 2015
Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation.
FEBS letters
Morozova OA,Gupta S,Colby DW
AHB0052 was used in Dot Blot, ELISA, Immunohistochemistry, Neutralization, Western Blot, Misc to show that prefibrillar huntingtin (HTT) oligomers, isolated from Huntington's disease (HD) affected human brain samples or mouse models, stimulate polyglutamine amyloid formation.
Wed Jul 08 00:00:00 UTC 2015
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
Nature communications
Condello C,Yuan P,Schain A,Grutzendler J
AHB0052 was used in immunohistochemistry to investigate the relationship between beta-amyloid plaques and microglia
Thu Jan 29 00:00:00 UTC 2015
Cytotoxic helix-rich oligomer formation by melittin and pancreatic polypeptide.
PloS one
Singh PK,Ghosh D,Tewari D,Mohite GM,Carvalho E,Jha NN,Jacob RS,Sahay S,Banerjee R,Bera AK,Maji SK
AHB0052 was used in western blot to examine the aggregation and toxicity of melittin and pancreatic polypeptide
Thu Feb 25 00:00:00 UTC 2016
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus.
PloS one
Du LY,Chang LY,Ardiles AO,Tapia-Rojas C,Araya J,Inestrosa NC,Palacios AG,Acosta ML
AHB0052 was used in ELISA and immunohistochemistry to study the retina of Octodon degus for Alzheimer's disease-related protein expression
Tue May 10 00:00:00 UTC 2016
Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease.
The Journal of pathology
Smith BR,Santos MB,Marshall MS,Cantuti-Castelvetri L,Lopez-Rosas A,Li G,van Breemen R,Claycomb KI,Gallea JI,Celej MS,Crocker SJ,Givogri MI,Bongarzone ER
AHB0052 was used in western blot to study cellular inclusions in the Krabbe brain.
Tue Apr 01 00:00:00 UTC 2014
Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: a comparative study with the respective full-length parent polypeptides.
European journal of medicinal chemistry
Tomasello MF,Sinopoli A,Attanasio F,Giuffrida ML,Campagna T,Milardi D,Pappalardo G
AHB0052 was used in immunocytochemistry to characterize the structure of human islet polypeptide or amylin.
Mon Jun 23 00:00:00 UTC 2014
Functional amyloids in the mouse sperm acrosome.
Molecular and cellular biology
Guyonnet B,Egge N,Cornwall GA
AHB0052 was used in immunocytochemistry and western blot to study the role of the amyloid core of the acrosomal matrix in sperm-zona pellucida interactions
Tue Jul 01 00:00:00 UTC 2014
Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model.
Journal of neurotrauma
Washington PM,Morffy N,Parsadanian M,Zapple DN,Burns MP
AHB0052 was used in western blot to study Abeta agggregation and oligomerization induced in a murine model of Alzheimer's disease by experimental traumatic brain injury
Wed Jan 01 00:00:00 UTC 2014
Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease.
Nature communications
Pujadas L,Rossi D,Andrés R,Teixeira CM,Serra-Vidal B,Parcerisas A,Maldonado R,Giralt E,Carulla N,Soriano E
AHB0052 was used in immunoprecipitation to study the role of the Reelin pathway in Alzheimer's disease pathogenesis.
Thu Mar 06 00:00:00 UTC 2014
Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease.
Nature communications
Pujadas L,Rossi D,Andrés R,Teixeira CM,Serra-Vidal B,Parcerisas A,Maldonado R,Giralt E,Carulla N,Soriano E
AHB0052 was used in immunoprecipitation to study the role of the Reelin pathway in Alzheimer's disease pathogenesis.
Thu Mar 06 00:00:00 UTC 2014
RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain.
PloS one
Wang H,Wang R,Xu S,Lakshmana MK
AHB0052 was used in western blot to show that RanBP9 overexpression accelerates loss of synaptic proteins in the murine brain.
Wed Sep 17 00:00:00 UTC 2014
The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Younan ND,Sarell CJ,Davies P,Brown DR,Viles JH
AHB0052 was used in dot blot to study interaction between prion protein and amyloid-β.
Wed May 01 00:00:00 UTC 2013
Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficits.
PloS one
Chu C,Zhang X,Ma W,Li L,Wang W,Shang L,Fu P
AHB0052 was used in western blot to characterize the novel autophagy inducer, GTM-1, and assess its effect in an Alzheimer's disease model.
Mon Sep 29 00:00:00 UTC 2014
Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.
PloS one
Mastroeni D,Chouliaras L,Grover A,Liang WS,Hauns K,Rogers J,Coleman PD
AHB0052 was used in immunocytochemistry to discuss the contribution of reduced nuclear transcription regulators to Alzheimer's disease
Tue Jul 02 00:00:00 UTC 2013
Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.
PloS one
Mastroeni D,Chouliaras L,Grover A,Liang WS,Hauns K,Rogers J,Coleman PD
AHB0052 was used in immunocytochemistry to discuss the contribution of reduced nuclear transcription regulators to Alzheimer's disease
Tue Jul 02 00:00:00 UTC 2013
A comparative analysis of the aggregation behavior of amyloid-β peptide variants.
FEBS letters
Vandersteen A,Hubin E,Sarroukh R,De Baets G,Schymkowitz J,Rousseau F,Subramaniam V,Raussens V,Wenschuh H,Wildemann D,Broersen K
Fri Nov 30 00:00:00 UTC 2012
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.
Autophagy
Zheng L,Terman A,Hallbeck M,Dehvari N,Cowburn RF,Benedikz E,Kågedal K,Cedazo-Minguez A,Marcusson J
AHB0052 was used in immunocytochemistry to study the contribution of macroautophagy to lysosomal Aβ accumulation.
Thu Dec 01 00:00:00 UTC 2011
Application of immunosignatures to the assessment of Alzheimer's disease.
Annals of neurology
Restrepo L,Stafford P,Magee DM,Johnston SA
Mon Aug 01 00:00:00 UTC 2011
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
PloS one
Maarouf CL,Daugs ID,Kokjohn TA,Walker DG,Hunter JM,Kruchowsky JC,Woltjer R,Kaye J,Castaño EM,Sabbagh MN,Beach TG,Roher AE
AHB0052 was used in western blot to examine the brains of non-demented high pathology controls individuals for mechanisms that protect against Alzheimer's disease
Fri May 18 00:00:00 UTC 2012
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
PloS one
Ohmi K,Zhao HZ,Neufeld EF
AHB0052 was used in Immunohistochemistry to propose that it is the extralysosomal glypican that would be harmful to neurons, because its heparan sulfate branches could potentiate the formation of Ptau and beta amyloid aggregates.
Tue Apr 10 00:00:00 UTC 2012
Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol.
The Journal of biological chemistry
Trikha S,Jeremic AM
Fri Oct 14 00:00:00 UTC 2011
Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol.
The Journal of biological chemistry
Trikha S,Jeremic AM
Fri Oct 14 00:00:00 UTC 2011
Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy.
Circulation
Gianni D,Li A,Tesco G,McKay KM,Moore J,Raygor K,Rota M,Gwathmey JK,Dec GW,Aretz T,Leri A,Semigran MJ,Anversa P,Macgillivray TE,Tanzi RE,del Monte F
AHB0052 was used in Immunohistochemistry to characterise fibrillar and oligomeric assemblies in the hearts of idiopathic dilated cardiomyopathy patients.
Tue Mar 16 00:00:00 UTC 2010
Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability.
The European journal of neuroscience
Feng LR,Federoff HJ,Vicini S,Maguire-Zeiss KA
AHB0052 was used in western blot to study direct synuclein-induced cell membrane changes
Thu Jul 01 00:00:00 UTC 2010
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice.
The Journal of biological chemistry
Donkin JJ,Stukas S,Hirsch-Reinshagen V,Namjoshi D,Wilkinson A,May S,Chan J,Fan J,Collins J,Wellington CL
Fri Oct 29 00:00:00 UTC 2010
Age-related accumulation of Reelin in amyloid-like deposits.
Neurobiology of aging
Knuesel I,Nyffeler M,Mormède C,Muhia M,Meyer U,Pietropaolo S,Yee BK,Pryce CR,LaFerla FM,Marighetto A,Feldon J
AHB0052 was used in immunohistochemistry - free floating to examine the Reelin accumulation of Reelin in amyloid-like deposits during ageing.
Fri May 01 00:00:00 UTC 2009
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
PloS one
Willuweit A,Velden J,Godemann R,Manook A,Jetzek F,Tintrup H,Kauselmann G,Zevnik B,Henriksen G,Drzezga A,Pohlner J,Schoor M,Kemp JA,von der Kammer H
Fri Nov 20 00:00:00 UTC 2009
Mutations of presenilin genes in dilated cardiomyopathy and heart failure.
American journal of human genetics
Li D,Parks SB,Kushner JD,Nauman D,Burgess D,Ludwigsen S,Partain J,Nixon RR,Allen CN,Irwin RP,Jakobs PM,Litt M,Hershberger RE
Fri Dec 01 00:00:00 UTC 2006
Neuritic deposits of amyloid-beta peptide in a subpopulation of central nervous system-derived neuronal cells.
Molecular and cellular biology
Muresan Z,Muresan V
AHB0052 was used in immunocytochemistry and western blot to study the time course of Abeta accumulation
Sat Jul 01 00:00:00 UTC 2006
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.
Nature neuroscience
Cleary JP,Walsh DM,Hofmeister JJ,Shankar GM,Kuskowski MA,Selkoe DJ,Ashe KH
Sat Jan 01 00:00:00 UTC 2005
Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death.
The Journal of pharmacology and experimental therapeutics
Sun F,Anantharam V,Latchoumycandane C,Kanthasamy A,Kanthasamy AG
Sat Oct 01 00:00:00 UTC 2005
